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Effects of Melatonin on Ischemia-Reperfusion Injury in Rat Ovary:Histopathologic and Immunohistochemical Study

Open Journal of Obstetrics and gynecology 2015年第11期5卷 639-645页

作者： Deniz Balsak Cihan Togrul Cenap Ekinci Kerem Doga Seckin Mehmet Fatih Karsli Aysun Ekinci Ali Emre Tahaoglu Hanefi Bademkiran Zuat Acar Senem Yaman Tunc Engin Deveci günsen kirman Department of Obstetrics and gynecology School of Medicine Hospital University of Halic Istanbul Turkey Department of Obstetrics and gynecology School of Medicine University of Hitit Corum Turkey Department of Histology and Embryology School of Medicine Hospital University of Dicle Diyarbakir Turkey Department of Obstetrics and gynecology Kanuni Sultan Süleyman Education and Research Hospital Istanbul Turkey Department of Obstetrics and gynecology Dr. Sami Ulus Education and Research Hospital Ankara Turkey Department of Biochemistry Faculty of Medicine University of Dicle Diyarbakir Turkey Department of Obstetrics and gynecology Diyarbakir Gazi Yasargil Education and Research Hospital Diyarbakir Turkey Department of Obstetrics and gynecology Diyarbakir Obstetrics and Gynecology Hospital Diyarbakir Turkey Department of Obstetrics and gynecology Memory Hospital Diyarbakir Turkey Department of Obstetrics and gynecology School of Medicine Hospital University of Dicle Diyarbakir Turkey

Aim: To investigate the effect of melatonin on ischemia–reperfusion (I/R) injury in rat ovary. Material and Method: A total of 24 Wistar rats were divided into four groups. The rats were first numbered randomly and then randomly divided into four equal groups: sham, torsion, detorsion and melatonin groups. In group I (n = 6) sham, as well as in group II ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. In group IV, melatonin was dissolved in 1% ethanol just before use. Melatonin was injected 1 hour before torsion to the torsion plus melatonin group. Right ovaries were surgically removed in all groups. Result: Malondialdehyde (MDA) levels were measured. We suggested that administration of melatonin would be in treating ovaries from torsion/detorsion induced damage in humans. The histopathological changes such as vascular congestion, edema, hemorrhage, and follicular degeneration were found to be decreased in the melatonin + ischemia-reperfusion group. Ischemia-reperfusion group: PECAM-I expression is positive in vessel of the stromal area. The follicles and interfolicular area infiltrated with CD68 positive cells were increased in a time of ischemia-reperfusion exposure dependent manner. Conclusions: Melatonin after ischemia-reperfusion CD31 and CD68 expressions is weak, due to the reduction of the inflammatory effects and hemorrhage is thought that melatonin is effective.

关键词： Ischemia-Reperfusion Ovary Rat CD31 CD68

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Infective endocarditis complicated with cerebral and splenic infarction in a hemodialysis patient

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World Journal of Emergency Medicine 2013年第3期4卷 229-231页

作者： Ozge Duman Atilla Zeynep Temizyurek Egemen kirman Department of Emergency Medicine Tepecik Training and Research HospitalYenisehirIzmirTurkey

BACKgROUND:Infective endocarditis(IE) has a high risk of morbidity and mortality.Complications are often due to systemic embolization.We treated a 47-year-old hemodialysis man with infective endocarditis complicated with cerebral and splenic infarction.METHODS:The patient was brought to the emergency department because of altered mental status and fecal incontinence.Although he did not meet the Duke Criteria for IE diagnosis,clinical suspicions of IE warranted further diagnostic studies.Magnetic resonance imaging of the brain revealed cerebral infarction with abnormal neurological findings.An abdominal computerized tomography revealed an incidental and unexpected splenic infarction without physical findings.Echocardiography revealed a vegetative growth(-1.2×1 cm) over the mitral posterior leaflet with severe mitral valve regurgitation.Based on these results,the patient was diagnosed with IE complicated with severe cerebral and splenic infarction.RESULTS:The patient was treated with intravenous teicoplanin including gentamicin,subcutaneous low molecular weight heparin,and oral acetylsalicylic acid.Mitral valve replacement surgery was performed after the patient improved clinically.CONCLUSION:Emergency physicians should be aware of the life-threatening complications of IE,which may be presented subtly or without clinical evidence.

关键词： Infective endocarditis Cerebral infarction Splenic infarction

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自余弱弦图(英文)

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浙江大学学报（理学版） 2010年第2期37卷 131-136页

作者： MERAJUDDIN PARVEZ Ali kirman S A K PIRZADA S 阿里格尔穆斯林大学工程技术学院应用数学系印度202002 克什米尔大学数学系印度斯利那加

研究了一类自余(sc)弱弦图,即广义的自余弱弦图,得到了一些自余弱弦图的下边界和上边界.讨论了自余弱弦图的识别问题,特别地给出了一种O(m2)时间算法,能推断自余图是弱弦的还是非弱弦的,进一步作者编目了自余弱弦图的至少17种异体.

关键词：自余弱弦图双对偶

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从风险评估的角度评价美国疾病预防控制中心全国暴露报告生物监测数据：化学物的全面展望

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环境与职业医学 2013年第6期30卷 485-491页

作者： Lesa L.Aylward Christopher R.kirman Rita Schoeny Christopher J.Portier Sean M.Hays 汪源(译) 张晶(译) 郑轻舟(译) 王晓宇(译) 金泰廙(校) SummitToxicologyLLP FallsChurchVtliaUSA SmmnitToxicologyLLP OrangeVillageOhioUSA 3.OfficeofResearchandDevelopment U.S EnvironmentalProtectionAgency WashingtonDCUSA NationalCenterforEnvironmentalHealth/AgencyforToxicSubstancesandDiseaseRegistry AtlantaGeorgiaUSA SummitToxicologyLLP LyonsColoradOUSA 不详

[背景]《全国人体环境化学物暴露报告》[NER,美国疾病预防控制中心(2012)]中的生物监测数据提供了人体血液和尿液中存在的400种以上化学物及其浓度的信息。如今,用生物监测当量(biomonitoring equivalents,BEs)和其他基于风险的估值能... 详细信息

[背景]《全国人体环境化学物暴露报告》[NER,美国疾病预防控制中心(2012)]中的生物监测数据提供了人体血液和尿液中存在的400种以上化学物及其浓度的信息。如今,用生物监测当量(biomonitoring equivalents,BEs)和其他基于风险的估值能够从风险评估的角度解读这些生物监测数据。[目的]对NER中测定的生物标志物浓度与BE值和类似的风险估值进行比较,为NER中近130种分析物的测定水平提供一个全面的化学物风险评估展望。[方法]确定现有基于风险评估的生物标志物筛选值,包括BE值和德国人类生物监测委员会的人类生物监测-I值(humanbiomonitoring-I,HBM-I)。将NER人群生物标志物浓度的几何均数和95百分位数与可用的筛选值比较,得出特定化学物的危害系数(hazard quotients,HQs)或癌症风险估值。[结论]NER中大多数分析物的HQ值1×10-4,这表明暴露水平可能超过所公布的人类健康基准。本文首次从化学物的风险评估角度提出多种环境化学物的人群生物监测数据验证方法。比较所得结果可用来明确更详细的特定化学物数据测定和提出化学物风险管理和研究的重点。

关键词：生物监测生物监测当量血液癌症风险 CDC全国暴露报告危害系数 NHANES 风险评估尿液

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