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Keratinocyte growth factor-2 and autologous serum potentiate the regenerative effect of mesenchymal stem cells in cornea damage in rats

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 211-219页

作者： Ferda Alpaslan Pinarli gülsen okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak Department of Medical Biology and genetics Faculty of Medicine Ondokuz Mayis University Department of Ophthalmology Faculty of MedicineOndokuz Mayis University Department of Pediatric Hematology Faculty of MedicineOndokuz Mayis University Department of Pathology Faculty of Medicine Ondokuz Mayis University Department of Medical Biostatistics Faculty of MedicineOndokuz Mayis University

AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KgF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell *** marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial ***:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow *** I rats received AM+MSCs,group II rats AM+MSCs cultured with KgF-2,group III rats AM+MSCs cultured with KgF-2+AS,group IV rats only AM and group V rats,*** was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same *** effect was evaluated with clinical,histopathological and immunohistochemical *** engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain ***:Corneal healing was significantly better in groups I-III rats treated with MSC transplantation compared to group IV and group V rats with supportive treatment *** best results were obtained in group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of ***:We suggest that culture of MSCs with KgF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells.

关键词： corneal wound healing mesenchymal stem cells keratinocyte growth factor-2 autologous serum amniotic membrane

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Istanbul’s Resilience in Question:Resilience,Decision-Making Process,Planning Politics

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Journal of Civil Engineering and Architecture 2022年第12期16卷 579-592页

作者： Ayse Nur okten Department of City and Regional Planning Yıldız Technical UniversityTurkey

An important environmental issue related to planning is created by the political orientation of the government in *** in the new millennium,the government has focused on achieving economic growth and avoiding the global economic crises as its primary *** priorities resulted in efficiency-oriented planning policies in which the metropolitan city of Istanbul is the main field of operation because of its capacity to become a regional centre of finance in the global *** this respect,Istanbul is regarded to have the capacity of fuelling the economic boost because of its historic,strategic and environmental *** city has become a dynamic bundle of urban *** public areas such as parks,forests,seashores are subjected to land development;renewal projects transform deteriorated poor neighbourhoods into high income neighbourhoods or inner-city attractions for tourism or globally marketed business areas with high quality *** land which is reserved as potential green space for new developments in the plan is given new functions with high *** paper attempts to present how local government is pursuing these ends and legitimizing its means by abusing the earthquake risks,and how planning regulations are bent in order to pave the road for foreign and domestic *** actions are discussed in relation to the typology of planning approaches and the question of resilience.

关键词： Urban planning regional planning resilience

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Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension

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World Journal of gastroenterology 2003年第10期9卷 2325-2327页

作者： V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A okten N Tozun gastroenterology Institute Marmara University gastroenterology Department Medical Faculty Istanbul University Biochemistry Department Cerrahpasa Medical FacultyIstanbul University

AIM:Adrenomedullin (ADM) is a potent vasodilator peptide. ADM and nitric oxide (NO) are produced in vascular endothelial *** ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH).The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown,plasma ADM levels were studied in patients with NCPH,compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups. METHODS:There were 4 groups of *** 1 consisted of 27 patients (F/M:12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age:41±12 years),group 2 consisted of 14 patients (F/M:6/8) with compensated (Child-Pugh A) cirrhosis (mean age:46±4), group 3 consisted of 16 patients (F/M:6/10) with decompensated (Child-Pugh C) cirrhosis (mean age:47±12). Fourteen healthy subjects (F/M:6/8) (mean age:44±8) were used as controls in group *** level was measured by *** was determined as nitrite/nitrate level by chemoluminescence. RESULTS:ADM level in group 1 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL) and group 4 (84.1±31.5 pg/mL) (both Pgroup3 (324±93.7 pg/mL) (P=0.002).NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6 μmol/L) but was lower than that in group 3 (39±3.6 μmol/L) (for all three Pg correlation was observed between ADM and NO levels (r=0.827,Pgh in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated,Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis,and were significantly higher than those in patients with NCPH. Portal hypertension plays an important role in the increase of ADM and *** damage in cirrhosis may contribute to the increase in these paramete

关键词： Adult Comparative Study Female Humans Hypertension, Portal Liver Cirrhosis Male Middle Aged Nitrates Nitric Oxide Nitrites Peptides Vasodilation

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