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Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis

Journal of geriatric cardiology 2014年第4期11卷 286-290页

作者： Hakan Erkan engin Hatem Mustafa Tank Agac Levent Korkmaz Teyyar gokdeniz Ahmet cagrl Aykan Ezgi Kalaycloglu Faruk Boyacl Omer Faruk clrakoglu Sukru celik Department of cardiology Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital Camhk Street Trabzon 61040 Turkey Department of cardiology Kafkas University Hospital Kars Turkey

Background QT dispersion （QTd） is a predictor of ventricular arrhythmia. Ventricular arrhythmia is an important factor influencing morbidity and mortality in patients with aortic stenosis. Surgical aortic valve replacement reduced the QTd in this patients group. However, the effect of transcatheter aortic valve implantation （TAVI） on QTd in patients with aortic stenosis is unknown. The aim of this study was to investigate the effect of TAVI on QTd in patients with aortic stenosis. Methods Patients with severe aortic stenosis, who were not candi-dates for surgical aortic valve replacement due to contraindications or high surgical risk, were included in the study. All patients underwent electrocardiographic and echocardiographic evaluation before, and at the 6th month after TAVI, computed QTd and left ventricular mass index （LVMI）. Results A total 30 patients were admitted to the study （mean age 83.2 ± 1.0 years, female 21 and male 9, mean valve area 0.7 ± 3 mm2）. Edwards SAPIEN heart valves, 23 mm （21 patients） and 26 mm （9 patients）, by the transfemoral approach were used in the TAVI procedures. All TAVI procedures were successful. Both QTd and LVMI at the 6th month after TAVI were significantly reduced com-pared with baseline values of QTd and LVMI before TAVI （73.8 ± 4 ms vs. 68 ± 2 ms, P=0.001 and 198 ± 51 g/m2 vs. 184 ± 40 g/m2, P=0.04, respectively）. There was a significant correlation between QTd and LVMI （r=0.646, P〈0.001）. conclusions QTd, which malign ventricular arrhythmia marker, and LVMI were significantly reduced after TAVI procedure. TAVI may decrease the possibility of ventricu-lar arrhythmia in patients with aortic stenosis.

关键词： Aortic stenosis QT dispersion Transcatheter aortic valve implantation

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ADAMTS-8 Activity in Synovial cells in Patients with Rheumatoid Arthritis

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Open Journal of Rheumatology and Autoimmune Diseases 2020年第3期10卷 125-131页

作者： Murat Baloğlu engin Deveci Şenay Deveci Department of Physical Therapy and Rehabilitation Diyarbakir Gazi Yasargil Education and Research Hospital Diyarbakir Turkey Department of Histology and Embryology School of Medicine Dicle University Diyarbakir Turkey Department of Medical Documentation Atatürk Health Vocational School Diyarbakir Turkey

Rheumatoid arthritis (RA), chronic, autoimmune causing joint stiffness, pain, fatigue and functional disorders is a disease. The aim of this study is to investigate the presence of ADAMTS-8 expression in cells in synovial fluid in rheumatoid arthritis patients. Patients with active RA were aspirated with arthro synthesis from the knee joint. Blood samples were taken from the patients at the same time, plasma samples were separated. Patients with sinovial fluid treated between 2019-2020 year in the Gazi Yaşargil Hospital Physical Therapy and Rehabilitation clinic were involved in the study that was consulted with knee pain and difficulty in performing their daily activities. Informed consent form was obtained from all of the patients (10 RA and 10 patients). CRP, RF and ESH results were statistically evaluated in patients with Control and Rheumatoid arthritis.

关键词： Romatoid Artrit Sinovial Fluid ADAMTS-8

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Discussion　About　the　Paper　＂The　Eigen－Problem　of　Matrix　in　Max－Algebra－Analysis　for　Operating　Period　of　A　class　of　DEDS＂

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Systems Science and Systems engineering 1996年第1期6卷 87-89页

作者： WAN Liangqiao(Dept.of Management engin.,Tianjin Institute of Technology,Tianjin 300191,china)

In this paper,we discuss the contents of paper[l] with the authors,point out that the conclustions in paper[1] about the periodicity of any N ×N square matrix are inappropriate,and make some notes on the problem abou... 详细信息

关键词： max-algebra discrete-event dynamic system eigenvalue critical circuit irreducible matrix

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Decision with grey correlation and AHP

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Systems Science and Systems engineering 1996年第1期6卷 103-110页

作者： ZHA Jingmin and ZHONg Donghua(Dept.of Hydraulicic engin.,Tianjin University,Tianjin 300072,china)

On the basis of the theories of grey system correlation degree and analytic hierarchy process,this paper studies the problem of plan decision for the exploitation of water conservancy *** to the data army of correlation degree,the optimized plan can be selected objectively and *** example given in this paper have proved the validity of the method.

关键词： exploitation plan of water conservancy project decision correlation degree AHP

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Evaluation of cA125 and NT-proBNP values in patients undergoing transcatheter aortic valve implantation

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Journal of geriatric cardiology 2015年第2期12卷 100-106页

作者： Huseyin Ayhan Haca Ahmet Kasapkara Tahir Durmaz Telat Keles cenk San Serdal Bastug Kemal Esref Erdogan Nihal Akar Bayram Emine Bilen Murat Akgay engin Bozkurt Faculty of Medicine Department of Cardiology Ytldtrtm Beyaztt University Ankara 06800 Turkey Department of cardiology Ankara Ataturk Education and Research Hospital Ankara 06800 Turkey Faculty of Medicine Department of Cardiovascular Surgery Yddtrtm Beyaztt University Ankara 06800 Turkey

Background Transcatheter aortic valve implantation （TAVI） is a minimally invasive, emerging therapy in surgically high risk, or in- operable patients. Parameters used for risk classification have some deficiencies in the selection of patients. The objective of this study is to evaluate the impact of TAVI on carbohydrate antigen 125 （cA125） and N-terminal pro brain-type natriuretic peptide （NT-proBNP） as biomarkers that have been used frequently in recent years, and also the relationship of these biomarkers to prognosis. Methods ＆ Results Transcatheter aortic valve implantation was practiced on 31 patients in this study. Then, cA125 and NT-proBNP levels studied in patients prior to and after the TAVI were evaluated. The patients were also grouped in accordance with their left ventrieular ejection fraction （LVEF） and cA125 levels （LVEF 〉 40% and 〈 40%; cA125 ≤ 35 U/L and 〉 35 U/L）. The TAVI operation was successfully performed in all patients. There was no in-hospital mortality and substantial improvement in functional capacity was detected at follow ups. In addition, a statistically significant decrease was detected in post-TAVI cA 125 and NT-proBNP levels of all patients （cA 125 83.8 ± 18.1 U/L vs. 64.3 ±14.2 U/L, P = 0.008; NT-proBNP： 4633.6± 627.6 pg/mL vs. 2866.3±536.8 pg/mL, P 〈 0.001）. In groups divided according to the cA125 levels, there was also statistically significant post-TAVI decline in cA125 levels. Within cA125 〉 35 U/L and LVEF 〈 40% groups, the permanent need for a pacemaker was required in one （3.2%） patient and mortality was observed in two （6.4%） patients after TAVI at follow up. conclusions The results show that TAVI can be performed effectively and reliably in patients with high baseline levels of cA125 and NT-proBNP. These biomarkers are reduced substantially with TAVI, while high biomarker levels are associated with undesired events, and certainly, these biomarkers can be used for risk classifications in patient selection for TAVI.

关键词： B-type natriuretic peptide Biomarker carbohydrate antigen Heart failure Transcatheter aortic valve implantation Risk score

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Simultaneous Intravitreal Ranibizumab and Dexamethasone Implant Administration at the Same Setting in Eyes with Severe Diabetic Macular Edema

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Open Journal of Ophthalmology 2016年第2期6卷 112-118页

作者： Ali Osman Saatci Ziya Ayhan ceren Durmaz engin Department of Ophthalmology Dokuz Eylul University Izmir Turkey

Aim: To share our experience in eyes with severe DME (exhibiting serous retinal detachment or large cysts) treated with simultaneous intravitreal ranibizumab and dexamethasone implant administration at the same setting as the first treatment step. Subjects and Results: Five eyes of three patients with DME who were either treatment naive or relatively undertreated were presented in this report. As optical coherence tomography exhibited serous retinal detachment or severe cystoid edema with large cysts, intravitreal ranibizumab and dexamethasone implant were simultaneously employed at the same setting as the first treatment step in those eyes. Panretinal photocoagulation was also commenced bilaterally a week after the start of injections when at least one eye had retinal neovascularization. Subsequent treatments of intravitreal ranibizumab and/or dexamethasone implant were administered. Patients were followed up for seven, eight and 13 months respectively. All five eyes achieved a relative anatomic stability and experienced visual improvement at the end of follow-up. conclusion: In some cases with severe DME with or without proliferative diabetic retinopathy, simultaneous intravitreal ranibizumab and dexamethasone implant administration at the same setting may be a better option to initiate the treatment over mono ranibizumab treatment. A randomized study comparing the mono anti-VEgF therapy and mono dexamethasone implant administration with simultaneous treatment may outline the place of this type of therapy in the treatment armamentarium of severe DME.

关键词： Dexamethasone Implant Diabetic Macular Edema Optical coherence Tomography Ozurdex Ranibizumab

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Scoring systems in prediciting mortality rate of patients applying emergency department

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Journal of Acute Disease 2018年第3期7卷 122-125页

作者： Tahtaci Rezan Arslan engin Deniz Kavalci cemil Izmir Katip celebi University Atatürk Research and Training Hospital Emergency Department IzmirTurkey Saglik Bilimleri University Diskapi Research and Training Hospital Emergency Department AnkaraTurkey Ankara Baskent University Hospital Emergency Department AnkaraTurkey

Objective: To compare the scoring systems used in intensive care units in terms of predictingthe mortality in emergency patients and to determine the most appropriate scoring system forurgent care. Methods: This study was carried out by retrospectively reviewing the files ofpatients admitted to Ankara Numune Training and Research Hospital emergency medicineclinic between October 1, 2010 and October 31, 2010 for non-traumatic reasons and admittedto any service of the hospital. This study calculated automatically with the data obtained fromthe patients files and records, and Acute Physiology and chronic Health Evaluation (APAcHEⅡ), Simplified Acute Physiology Score (SAPS Ⅱ), Modified Early Warning Score (MEW)and Sequential Organ Failure Assessment (SOFA) scores via internet. Patient files werereviewed and their outcomes (hospitalization, discharge, referral and mortality) were *** obtained data were entered in SPSS 18 and compared with the scores of APAcHE Ⅱ,SAPS Ⅱ, MEW and SOFA. Results: Based on area under the curve analysis, APAcE Ⅱ (0.799;95% cI: 0.746 to 0.845) showed the biggest area under the curve in terms of predicting thepatients mortality. However, there was no difference between four scoring system in terms ofpredicting the mortality. Age (Pctors formortality. conclusions: Scores such as APAcHE Ⅱ, SAPS Ⅱ, and SOFA, can not be used tomake an urgent decision on the first encounter with the patient even though they are successfulin predicting mortality. In this case, MEW could be recommended as the most useful *** a result, the use of scoring systems in emergency departments is useful and necessary. But,multi-centered and large patient group studies are needed.

关键词： Emergency Mortality Scoring systems

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Sexual and reproductive health needs of adolescent girls from conservative and low-income families in Erzurum, Turkey

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Health 2011年第6期3卷 370-377页

作者： Nesrin Reis Dilek Kilic Raziye engin Ozlem Karabulutlu Ataturk University Health Sciences Faculty Department of Nursing Erzurum Turkey

The objective of this survey was to determine the sexual and reproductive health needs of conservative and/or economically challenged adolescent girls. A total of 310 subjects (16.5 ± 2.2 years old), attending three private institutes teaching Islamic matter and the holy Quran and two private institutes teaching carpet-weaving in Erzurum, Turkey, were interviewed between November 2004 and February 2005. The ques-tionnaire covered knowledge on reproductive health and sexual matters to attain their feelings prior to their first menarche, their practices during menstruation, and their awareness of gynecological and sexually transmitted dis-eases as well as their attitudes toward and re-sponsiveness to domestic violence. Their re-sponses showed that these issues were con-sidered taboo and/or embarrassing to share. Also, a considerable percentage of the girls had no or limited knowledge on reproductive health and sexual matters and mismanaged gyneco-logical problems and domestic violence. More-over, those had knowledge revealed that their sources were non-scientific information from unprofessional individuals. In conclusion, the conservative and/or economically challenged adolescent girls who are not attending regular high schools need professional lectures on re-productive health and sexual matters.

关键词： Reproductive Health Sexual Health Adolescent girls

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Automated neurosurgical video segmentation and retrieval system

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Journal of Biomedical Science and engineering 2010年第6期3卷 618-624页

作者： engin Mendi Songul cecen Emre Ermisoglu coskun Bayrak 不详

Medical video repositories play important roles for many health-related issues such as medical imaging, medical research and education, medical diagnostics and training of medical professionals. Due to the increasing availability of the digital video data, indexing, annotating and the retrieval of the information are crucial. Since performing these processes are both computationally expensive and time consuming, automated systems are needed. In this paper, we present a medical video segmentation and retrieval research initiative. We describe the key components of the system including video segmentation engine, image retrieval engine and image quality assessment module. The aim of this research is to provide an online tool for indexing, browsing and retrieving the neurosurgical videotapes. This tool will allow people to retrieve the specific information in a long video tape they are interested in instead of looking through the entire content.

关键词： Video Processing Video Summarization Video Segmentation Image Retrieval Image Quality Assessment

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convexification　and　Hierarchical　Optimization　Algorithm　for　Distribution　of　Water　Supply　Systems

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Systems Science and Systems engineering 1996年第1期6卷 54-65页

作者： ZHONg Weijnn and XU Nanrong(Institute of Systems engin.,School of Management Southeast Univ.,Nanjing 210018,china)

This paper deals with the optimal distribution problem of large urban water supply systems in our *** mathematical model of the problem is *** possesses the separable,but nonconvex *** order for primal-dual methods to be applicable to this type of largescale and nonconvex optimization problem,a method by means of which a nonconvex problem is convexified is studied based on the principle of the multiplier methods in the *** decomposition-coordination optimization algorithm is proposed based on the convexification method and the multiplier *** algorithm has been simulated in some real urban water supply systems,and the satisfactory results are obtained.

关键词： Water supply system modelling hierarchical optimization distribution simulation

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