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Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey

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World Journal of gastroenterology 2006年第48期12卷 7810-7814页

作者： Pierre Ingrand Jérme gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant Clinical research Center Poitiers University France Hepato-gastroenterology Centre Hospitalier Universitaire Nantes France Hepato-gastroenterology Centre Hospitalier Universitaire Saint-André Bordeaux France Hepato-gastroenterology Centre Hospitalier Universitaire Angers France Hepato-gastroenterology Centre Hospitalier Universitaire Reims France Hepato-gastroenterology Centre Hospitalier Gonesse France Hepato-gastroenterology Centre Hospitalier Argenteuil France Hepato-gastroenterology Centre Hospitalier Universitaire Amiens France Hepato-gastroenterology Centre Hospitalier Creil France Hepato-gastroenterology Centre Hospitalier Compiègne France Hepato-gastroenterology Centre Hospitalier Universitaire Poitiers France

AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. meTHODs: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. rEsULTs: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUsION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved.

关键词： Digestive bleeding Portal hypertension Cirrhosis Evaluation studies

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Constrained resource Allocation in OFDMA Downlink systems with partial CsIT

Constrained Resource Allocation in OFDMA Downlink Systems wi...

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2008 IEEE International Conference on Communications(ICC 2008)

作者： Felix Brah Luc Vandendorpe Jéröme Louveaux Communications and remote sensing Laboratory Université catholique de Louvain place du Levant 2 B-1348 Louvain-la-NeuveBelgium

Adaptive resource allocation algorithms based on perfect channel state information at the transmitter （CsIT） improve the performance of OFDMA ***,perfect CsIT is rarely possible due to channel estimation errors and channel feedback *** this paper,we consider practical subchannel assignment and power allocation strategies for downlink multiuser OFDMA systems,where the base station has imperfect *** goal is to maximize the expected weighted sum rate while satisfying users’ minimum data rate and system fairness requirements under total power *** use the Lagrange dual decomposition framework to derive an algorithm that efficiently finds the optimal *** results show the impact of the channel estimation error on the performance of the system and illustrate the trade-off between maximized expected weighted sum rate and the constraints.

关键词： resource management Downlink Channel estimation Feedback Base stations radio transmitters Delay estimation Lagrangian functions Frequency conversion Communications society

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pTC-1 observation of ion high-speed flow reversal in the near-Earth plasma sheet during substorm

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science China(Technological sciences) 2008年第10期51卷 1721-1730页

作者： H. rme I. DANDOUrAs C. M. CArr Centre d'Etude spatiale des rayonnements CEDEX 4 F-31028 Toulouse France The Blackett Laboratory Imperial College London SW7 2BW UK

Based on measurements of FgM and HIA on board TC-1 at its apogee on septem-ber 14, 2004, we analyzed the ion high-speed flows in the near-Earth plasma sheet observed during the substorm expansion phase. strong tailward high-speed flows (Vx ～ -350 km/s) were first seen at about X ～ -13.2 rE in near-Earth magnetotail, one minute later the flows reversed from tailward to earthward. The reversal process occurred quickly after the substorm expansion onset. The near-Earth magnetotail plasma sheet was one of key regions for substorm onset. Our analysis showed that the ion flow reversal from tailward to earthward was likely to be in close relation with the substorm expansion initiation and might play an important role in trigger-ing the substorm expansion onset.

关键词： near-Earth magnetotail magnetospheric substorm plasma sheet ion high speed flow

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肿瘤免疫治疗研究及临床应用中的几个问题

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国外医学（肿瘤学分册） 1991年第3期18卷 174-175页

作者： Qsband me & ross s 沈元津李昶亮

近10年来有大量的肿瘤免疫治疗的研究及临床应用文献,但这种治疗尚未能满意地被接受。为什么免疫治疗与临床应用尚有些矛盾?本文就此提出几个应在广泛有效治疗应用之前加以解决的基本问题。免疫病理生理问题按照免疫病理生理的观点,健... 详细信息

近10年来有大量的肿瘤免疫治疗的研究及临床应用文献,但这种治疗尚未能满意地被接受。为什么免疫治疗与临床应用尚有些矛盾?本文就此提出几个应在广泛有效治疗应用之前加以解决的基本问题。免疫病理生理问题按照免疫病理生理的观点,健康人的免疫系统都相似,但每个人的免疫障碍则各有其原因。人的免疫系统他复杂,有多方面的因素和影响,并有高度的特异性。并非所有肿瘤病人的宿主-肿瘤关系都是相同或相似的。事实上,在很多免疫治疗中可以看到治疗后的病人有不同的临床应答或反应。

关键词：肿瘤免疫疗法临床

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Doctor communication quality and Friends' attitudes influence complementary medicine use in inflammatory bowel disease

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World Journal of gastroenterology 2015年第12期21卷 3663-3670页

作者： réme Mountifield Jane M Andrews Antonina Mikocka-Walus Peter Bampton Department of gastro-enterology and Hepatology Flinders Medical Centre Flinders University of south Australia IBD service Department of Gastroenterology and Hepatology and School of Medicine University of Adelaide at Royal Adelaide Hospital school of Nursing and Midwifery University of South Australia

AIM: To examine the frequency of regular complementary and alternative therapy(CAM) use in three Australian cohorts of contrasting care setting and geography, and identify independent attitudinal and psychological predictors of CAM use across all cohorts. meTHODs: A cross sectional questionnaire was administered to inflammatory bowel disease(IBD) patients in 3 separate cohorts which differed by geographical region and care setting. Demographics and frequency of regular CAM use were assessed, along with attitudes towards IBD medication and psychological parameters such as anxiety, depression, personality traits and quality of life(QOL), and compared across cohorts. Independent attitudinal and psychological predictors of CAM use were determined using binary logistic regression analysis. rEsULTs: In 473 respondents(mean age 50.3 years, 60.2% female) regular CAM use was reported by45.4%, and did not vary between cohorts. Only 54.1%of users disclosed CAM use to their doctor. Independent predictors of CAM use which confirm those reported previously were: covert conventional medication dose reduction(P seeking psychological treatment(P rse effects of conventional medication(P = 0.043), and higher QOL(P redictors were CAM use by family or friends(P ssatisfaction with patient-doctor communication(P r depression scores(P sION: In addition to previously identified predictors of CAM use, these data show that physician attention to communication and the patient-doctor relationship is important as these factors influence CAM use. Patient reluctance to discuss CAM with physicians may promote greater reliance on social contacts to influence CAM decisions.

关键词： Complementary medicine Alternative therapy Therapy

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Diversified calcimicrobes in dendrolites of the Zhangxia Formation, Miaolingian series(Middle Cambrian) of the North China craton

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Journal of Palaeogeography 2021年第2期10卷 157-181页

作者： Ming-Xiang me Muhammad riaz Zhen-Wu Zhang Qing-Fen meng Yuan Hu school of Earth sciences and resources China University of GeosciencesBeijing 100083China state Key Laboratory of Biogeology and Environmental geology China University of GeosciencesBeijing 100083China state Key Laboratory of Oil and gas reservoir geology and Exploitation Chengdu University of TechnologyChengdu 610059China College of Energy resources Chengdu University of TechnologyChengdu 610059China Centre for geographical Information system University of the PunjabLahore 54590Pakistan.

As a type of non-laminated microbial carbonates, dendrolites are dominated by isolated dendritic clusters of calcimicrobes and are distinct from stromatolites and thrombolites. The dendrolites in the upper part of the Miaolingian Zhangxia Formation at Anjiazhuang section in Feicheng city of shandong Province, China, provide an excellent example for further understanding of both growth pattern and forming mechanism of dendrolites. These dendrolites are featured by sedimentary fabrics and composition of calcified microbes as follows.(1) The strata of massive limestones, composed of dendrolites with thickness of more than one hundred meters, intergrade with thick-bedded to massive leiolites, formimg the upper part of a third-order depositional sequence that constitutes a forced regressive systems tract.(2) A centimeter-sized bush-like fabric(shrub) typically produced by calcified microbes is similar to the mesoclot in thrombolites but distinctive from clotted fabrics of thrombolites. This bushlike fabric is actually constituted by diversified calcified microbes like the modern shrub as a result of gliding mobility of filamentous cyanobacteria. such forms traditionally include: the Epiphyton group(which actually has uncertain biological affinity), the Hedstroemia group which closely resembles modern rivulariacean cyanobacteria,and the possible calcified cyanobacteria of the Lithocodium–Bacinella group.(3) significantly, dense micrite of leiolite is associated with sponge fossils and burrows, and is covered by microstromatolite. The Lithocodium–Bacinella group is a controversial group of interpreted calcified cyanobacteria in the Cambrian that has also been widely observed and described in the mesozoic. Therefore, dendrolites with symbiosis of leiolites in the studied section provide an extraordinary example for further understanding of growing style of bush-like fabrics(shrubs) of the dendrolites dominated by cyanobacterial mats. Furthermore, the present research provid

关键词： Calcified microbe Dendrolite Leiolite Epiphyton Lithocodium–Bacinella Cambrian Miaolingian Zhangxia Formation

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Phenotypic and genotypic Characterization of Extended spectrum β-Lactamase Klebsiella pneumoniae and Fluorescent Pseudomonas spp. strains from Market garden Products and Their Watering Water in Benin (West Africa)

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Food and Nutrition sciences 2016年第3期7卷 192-204页

作者： Wassiyath Moussé Pacôme A. Noumavo Nicodème W. Chabi Haziz sina Majoie g. Tohoyessou Théodora A. Ahoyo Lamine Baba-Moussa Faculté des sciences et Techniques Abomey-Calavi Bénin Département du génie de Technologie Alimentaire Abomey-Calavi Bénin Département du génie de Biologie Humaine Abomey-CalaviBénin

Market garden products can carry several types of microorganisms, and their consumption is the source of many cases of food poisoning. This work aimed to improve food safety in Benin. In characterizing strains of K. pneumoniae and fluorescent Pseudomonas spp. at the biochemical and molecular level, the target was to identify contaminated watering water and garden products sold during Cotonou in both the dry and rainy seasons. A total of 164 samples of market garden products and 22 samples of watering water were investigated. The results showed that 5.91% of market garden products and watering water were contaminated by K. pneumoniae and 20.43% by fluorescent Pseudomonas spp. During the dry season, cabbage was most contaminated by fluorescent Pseudomonas spp. (50%). Pool water was more contaminated with K. pneumoniae (17%). All isolated strains were resistant to both amoxicillin and penicillin. All strains of K. pneumoniae and fluorescent Pseudomonas spp. were not resistant to imipenem, and 22% of them produced penicillinase. Among the 49 strains producing penicillinase isolated, 64.29% and 21.43% carried blasub>TEMsub> and blasub>sHVsub> respectively while 14.28% carried blasub>CTX-Msub> genes. In light of the previously-developed results and considering the importance of horticultural products in Beninese food habits, we must improve national awareness of the risk for foodborne illness.

关键词： Vegetables Klebsiella pneumoniae Fluorescent Pseudomonas spp. β-Lactamases Food safety

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若尔盖人-狼冲突现状与管理研究

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动物学杂志 2024年第1期59卷 29-36页

作者：何鹏辉纳么玖肖俊候于渊陈琦言迫张元姝岳颖戴强四川若尔盖湿地国家级自然保护区管理局若尔盖624500 中国科学院成都生物研究所成都610041 中国科学院大学北京100049

大中型食肉动物肇事事件导致人类与野生动物关系恶化,给生物多样性保护工作带来巨大的挑战。若尔盖湿地是我国三大湿地之一,湿地、草原分布广泛,生物多样性丰富,畜牧业发达,但近年来狼(Canis lupus)捕杀牲畜的肇事事件时有发生。为了解... 详细信息

大中型食肉动物肇事事件导致人类与野生动物关系恶化,给生物多样性保护工作带来巨大的挑战。若尔盖湿地是我国三大湿地之一,湿地、草原分布广泛,生物多样性丰富,畜牧业发达,但近年来狼(Canis lupus)捕杀牲畜的肇事事件时有发生。为了解若尔盖野生狼肇事件的空间分布以及牧民对人-狼冲突管理的看法,本研究于2022年对若尔盖县13个乡镇83个行政村进行走访调查。结果表明:(1)多数受访者(66.0%)认为在过去5年内,若尔盖县野生狼数量有所增加;(2)狼肇事事件具有明显的空间分异性,最严重的是包座乡。包座乡临近山区,该区域牧场面积广阔、牧民饲养牲畜数量多等原因导致该镇发生狼肇事事件较多;(3)对于狼肇事,绝大多数牧民(85.0%)更希望采取经济补偿或者驱赶措施,只有少数牧民(9.4%)希望采取捕杀的措施;(4)影响牧民对狼肇事管理措施的偏好因子中,受教育程度、年龄、民族以及被杀牲畜数量有显著影响。建议加强狼种群监测管理,采取措施减少狼捕杀牲畜,优化补偿机制,缓解当地牧民与狼之间的矛盾。本研究为当前若尔盖县野生动物保护和管理决策提供了依据,对其他地区大型食肉动物与当地居民冲突管理具有借鉴意义。

关键词：人兽冲突狼若尔盖湿地国家级自然保护区

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Drug therapy for Parkinson's disease: An update

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World Journal of Pharmacology 2015年第1期4卷 117-143页

作者： Omar me Abdel-salam Department of Toxicology and Narcotics Medical DivisionNational Research Centre

Parkinson's disease(PD) is the most common neurodegenerative movement disorder, affecting about 1% of the population above the age of 65. PD is characterized by a selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta. This results in a marked loss of striatal dopamine and the development of the characteristic features of the disease, i.e., bradykinesia, rest tremor, rigidity, gait abnormalities and postural instability. Other types of neurons/neurotransmitters are also involved in PD, including cholinergic, serotonergic, glutamatergic, adenosine, and gABAergic neurotransmission which might have relevance to the motor, non-motor, neuro-psychiatric and cognitive disturbances that occur in the course of the disease. The treatment of PD relies on replacement therapy with levodopa(L-dopa), the precursor of dopamine, in combination with a peripheral decarboxylase inhibitor(carbidopa or benserazide). The effect of L-dopa, however, declines over time together with the development of motor complications especially dyskinesia in a significant proportion of patients within 5 years of therapy. Other drugs include dopaminereceptor-agonists, catechol-O-methyltransferase inhibitors, monoamine oxidase type B(MAO-B) inhibitors, anticholinergics and adjuvant therapy with the antiviral drug and the N-methyl-D-aspartate glutamate receptor antagonist amantadine. Although, these medications can result in substantial improvements in parkinsonian symptoms, especially during the early stages of the disease, they are often not successful in advanced disease. Moreover, dopaminergic cell death continues over time, emphasizing the need for neuroprotective or neuroregenerative therapies. In recent years, research has focused on non-dopaminergic approach such as the use of A2 A receptor antagonists: istradefylline and preladenant or the calcium channel antagonist isradipine. safinamide is a selective and reversible inhibitor of MAO-B, a glutamate receptor inhibi

关键词： Parkinson disease Levodopa Dopaminergic drugs Neuroprotective agents Non-dopaminergic drugs Mitochondrial enhancers

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A case of atypical neurological symptoms and high cerebro-spinal fluid acetone level due to transdermal exposure to isopropanol

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World Journal of Emergency medicine 2023年第2期14卷 152-154页

作者： Côme Fruit sophie guillotin Marie Wolfrum Thomas Lanot Florent Battefort Pierre girardie Marie rafiq Nicolas Delcourt Poison Control Center Toulouse University HospitalToulouse 31509France Neurology Department Toulouse University HospitalToulouse 31509France Pharmacokinetics and Toxicology Laboratory Federative Institute of BiologyToulouse University HospitalToulouse 31509France Poison Control Center and INsErM 1214 Toulouse University HospitalToulouse 31509France

Dear editor, Isopropanol, also named 2-propanol or isopropyl alcohol(IPA), is a colorless, volatile liquid found in numerous household chemicals, such as cleaners and disinfectants, which typically contain a 70% solut... 详细信息

关键词： acetone typically alcohol

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