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Endoscopic treatment of biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants: lessons learned from single-balloon enteroscopy-assisted ERCP

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 509-514页

作者： Rodrigo garcés-Durán laurent Monino Pierre H Deprez Hubert Piessevaux Tom g Moreels Department of gastroenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endoscopic treatment of biliopancreatic pathology is challenging due to surgically altered anatomy after Whipple's pancreaticoduodenectomy. This study aimed to evaluate the feasibility and safety of single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography(sBE-ERCP) to treat biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants. Methods: We retrospectively analyzed 106 sBE-ERCP procedures in 46 patients with Whipple's variants. Technical and clinical success rates and adverse events were evaluated. Results: Biliary sBE-ERCP was performed in 34 patients and pancreatic sBE-ERCP in 17, including 5 with both indications. From a total of 106 sBE-ERCP procedures, 76 were biliary indication with technical success rate of 68/76(90%) procedures and clinical success rate of 30/34(88%) patients. Mild adverse event rate was 8/76(11%), without serious adverse events. From a total of 106 sBE-ERCP procedures, 30 were pancreatic indication with technical success rate of 24/30(80%) procedures( P = 0.194 vs. biliary sBEERCP) and clinical success rate of 11/17(65%) patients( P = 0.016 vs. biliary sBE-ERCP). Mild adverse event rate was 6/30(20%)( P = 0.194 vs. biliary sBE-ERCP), without serious adverse events. After sBE-ERCP failure, endoscopic ultrasound-guided drainage, percutaneous drainage and redo surgery were alternative therapeutic options. Conclusions: Biliopancreatic pathology after Whipple's pancreaticoduodenectomy variants can be treated using sBE-ERCP without serious adverse events. Technical and clinical success rates are high for biliary indications, whereas clinical success rate of pancreatic indications is significantly lower. sBE-ERCP can be considered as first-line treatment option in this patient group with surgically altered anatomy.

关键词： Enteroscopy Endoscopic retrograde cholangiopancreatography Pancreaticoduodenectomy surgically altered anatomy Whipple’s procedure

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genomic selection in plant breeding:Key factors shaping two decades of progress

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Molecular Plant 2024年第4期17卷 552-578页

作者： Admas Alemu Johanna Astrand Osval A.Montesinos-lópez Julio Isidro y sanchez Javier Fernandez-gónzalez Wuletaw Tadesse Ramesh R.Vetukuri Anders s.Carlsson Alf Ceplitis JoséCrossa Rodomiro Ortiz Aakash Chawade Department of Plant Breeding Swedish University of Agricultural SciencesAlnarpSweden lantmannen lantbruk SvalövSweden Facultad de Telematica University de ColimaColimaColima 28040Mexico Centro de Biotecnología y genómica de Plantas(CBgP UPM-INIA)Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo-UPM28223 MadridSpain International Center for Agricultural Research in the Dry Areas(ICARDA) RabatMorocco International Maize and Wheat Improvement Center(CIMMYT) Km 45Carretera México-VeracruzTexcocoMéxico 52640Mexico

genomic selection,the application of genomic prediction(gP)models to select candidate individuals,has significantly advanced in the past two decades,effectively accelerating genetic gains in plant *** article provides a holistic overview of key factors that have influenced gP in plant breeding during this *** delved into the pivotal roles of training population size and genetic diversity,and their relationship with the breeding population,in determining gP *** emphasis was placed on optimizing training population *** explored its benefits and the associated diminishing returns beyond an optimum *** was done while considering the balance between resource allocation and maximizing prediction accuracy through current optimization *** density and distribution of single-nucleotide polymorphisms,level of linkage disequilibrium,genetic complexity,trait heritability,statistical machine-learning methods,and non-additive effects are the other vital *** wheat,maize,and potato as examples,we summarize the effect of these factors on the accuracy of gP for various *** search for high accuracy in gP—theoretically reaching one when using the Pearson’s correlation as a metric—is an active research area as yet far from optimal for various *** hypothesize that with ultra-high sizes of genotypic and phenotypic datasets,effective training population optimization methods and support from other omics approaches(transcriptomics,metabolomics and proteomics)coupled with deep-learning algorithms could overcome the boundaries of current limitations to achieve the highest possible prediction accuracy,making genomic selection an effective tool in plant breeding.

关键词： genomic selection genetic gain genomic prediction optimization deep learning training population optimization

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Exploring the associations between skeletal muscle echogenicity and physical function in aging adults:A systematic review with meta-analyses

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Journal of sport and Health science 2024年第6期13卷 820-840页

作者： Dustin J.Oranchuk stephan g.Bodkin Katie l.Boncella Michael O.Harris-love Muscle Morphology Mechanicsand Performance LaboratoryDepartment of Physical Medicine and RehabilitationUniversity of Colorado Anschutz Medical CampusAuroraCO 80045USA Department of Physical Therapy

Background:Assessment and quantification of skeletal muscle within the aging population is vital for diagnosis,treatment,and injury/disease *** clinical availability of assessing muscle quality through diagnostic ultrasound presents an opportunity to be utilized as a screening tool for function-limiting ***,relationships between muscle echogenicity and clinical functional assessments require authoritative ***,we aimed to(a) synthesize the literature to assess the relationships between skeletal muscle echogenicity and physical function in older adults(≥60 years),(b) perform pooled analyses of relationships between skeletal muscle echogenicity and physical function,and(c) perform sub-analyses to determine between-muscle ***:CINAHl,Embase,MEDlINE,PubMed,and Web of science databases were systematically searched to identify articles relating skeletal muscle echogenicity to physical function in older ***-of-bias assessments were conducted along with funnel plot ***-analyses with and without sub-analyses for individual muscles were performed utilizing Fisher's Z transformation for the most common measures of physical ***'s Z was back-transformed to Pearson's r for ***:Fifty-one articles(n=5095,female=~2759,male=~2301,72.5± 5.8 years,mean±sD(1 study did not provide sex descriptors))were extracted for review,with previously unpublished data obtained from the authors of 13 *** rectus femoris(n=34) and isometric knee extension strength(n=22) were the most accessed muscle and physical qualities,*** relationship between quadriceps echogenicity and knee extensor strength was moderate(n=2924,r=-0.36(95% confidence interval:-0.38 to-0.32),p ll other meta-analyses(grip strength,walking speed,sit-to-stand,timed up-and-go) resulting in slightly weaker correlations(r:-0.34 to-0.23,all p sub-analyses determined minimal differences in predicti

关键词： Correlations Echo intensity Elderly Intramuscular fat strength

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Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan safak shenghan Wang Carmen Mota Reyes Ibrahim Halil gürcinar sergey Tokalov Nedim Can Cevik Kivanc görgülü Bengi su Yilmaz Emre Erdogan linhan Ye Qiaolin li Elif Arik sever samedÖzer güldal süyen Helmut Friess güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of general surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany graduate school of Health sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician scientist Professorship for Translational Pancreatic surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

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Double-brooding and annual breeding success of great tits in urban and forest habitats

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Current Zoology 2022年第5期68卷 517-525页

作者： Boglárka Bukor gábor seress Ivett Pipoly Krisztina sándor Csenge sinkovics ErnőVincze András liker Behavioral Ecology Research group Center for Natural SciencesUniversity of PannoniaVeszprém H-8200Hungary MTA-PE Evolutionary Ecology Research group University of PannoniaVeszprém H-8200Hungary MTA-ElTE Comparative Ethology Research group BudapestHungary Department of Biology Theoretical Population Ecology and Evolution GroupLund UniversityLundSweden

Urban areas differ from natural habitats in several environmental features that influence the characteristics of animals living *** example,birds often start breeding seasonally earlier and fledge fewer offspring per brood in cities than in natural ***,longer breeding seasons in cities may increase the frequency of double-brooding in urban compared with nonurban populations,thus potentially increasing urban birds’annual reproductive output and resulting in lower habitat difference in reproductive success than estimated by studies focusing on first clutches *** this study,we investigated 2 urban and 2 forests great tit Parus major populations from 2013 to *** compared the probability of double-brooding and the total number of annually fledged chicks per female between urban and forest habitats,while controlling for the effects of potentially confounding *** was a trend for a higher probability of double-brooding in urban(44%of females)than in forest populations(36%),although this was not consistent between the 2 urban *** produced significantly fewer fledglings annually in the cities than in the forest sites,and this difference was present both within single-and double-brooded ***,double-brooded urban females produced a similar number of fledglings per season as single-brooded forest *** results indicate that double-brooding increases the reproductive success of female great tits in both habitats,but urban females cannot effectively compensate in this way for their lower reproductive output per ***,other mechanisms like increased post-fledging survival can mitigate habitat differences in reproductive success.

关键词： annual reproductive success habitat differences population self-sustainability second brood urban conservation

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Therapeutic proteasome inhibition in experimental acute pancreatitis

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World Journal of gastroenterology 2007年第33期13卷 4452-4457页

作者： Tamás letoha liliána Z Fehér lászló Pecze Csaba somlai Ilona Varga József Kaszaki gábor Tóth Csaba Vizler lászló Tiszlavicz Tamás Takács Department of Medical Chemistry University of Szeged H-6720 Szeged Hungary Institute of Biochemistry Biological Research Center of the HungarianAcademy of Sciences H-6726 Szeged Hungary Department of genetics and Molecular Biology University of Szeged H-6726 Szeged Hungary Institute of surgical Research University of Szeged H-6720 Szeged Hungary Department of Pathology University of Szeged H-6720 Szeged Hungary First Department of Medicine University of Szeged H-6720 Szeged Hungary

AIM： To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of Mg132 （Z-leu-leu-leu-aldehyde） in an experimental model of acute pancreatitis. METHODs： Pancreatitis was induced in rats by two hourly intraperitoneal （ip） injections of cholecystokinin octapeptide （CCK; 2×100μg/kg） and the proteasome inhibitor Mg132 （10 mg/kg ip） was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK. REsUlTs： Administering the proteasome inhibitor Mg132 （at a dose of 10 mg/kg, ip） 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein （HsP72） and decreased DNA-binding of nuclear factor-κB （NF-κB）. Furthermore Mg132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress. CONClUsION： Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis.

关键词： Acute pancreatitis Cholecystokinin octapeptide Proteasome inhibition Nuclear factor-κB Heat shock proteins

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Impact of proteolytic enzymes in colorectal cancer development and progression

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World Journal of gastroenterology 2014年第37期20卷 13246-13257页

作者： lászló Herszényi loránd Barabás István Hritz gábor István Zsolt Tulassay 2~nd Department of Medicine Semmelweis University 2~nd Department of surgery Semmelweis University 1~st Department of Medicine Fejér Megyei Szent Gy?rgy University Teaching Hospital

Tumor invasion and metastasis is a highly complicated, multi-step phenomenon. In the complex event of tumor progression, tumor cells interact with basement membrane and extracellular matrix components. Proteolytic enzymes(proteinases) are involved in the degradation of extracellular matrix, but also in cancer invasion and metastasis. The four categories of proteinases(cysteine-, serine-, aspartic-, and metalloproteinases) are named and classified according to the essential catalytic component in their active site. We and others have shown that proteolytic enzymes play a major role not only in colorectal cancer(CRC) invasion and metastasis, but also in malignant transformation of precancerous lesions into cancer. Tissue and serumplasma antigen concentrations of proteinases might be of great value in identifying patients with poor prognosis in CRC. Our results, in concordance with othersindicate the potential tumor marker impact of proteinases for the early diagnosis of CRC. In addition, proteinases may also serve as potential target molecules for therapeutic agents.

关键词： Proteinase Cathepsin Plasminogen activator Matrix metalloproteinase Colorectal cancer Adenoma Invasion Metastasis Biomarker Prognosis

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Discrepancies between clinical and autopsy findings in patients who had an acute stroke

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stroke & Vascular Neurology 2022年第3期7卷 215-221页

作者： lilla Hudák Attila Csaba Nagy sarolta Molnár gábor Méhes Katalin Erzsébet Nagy lászlóOláh lászlóCsiba Department of Neurology University of Debrecen Faculty of MedicineDebrecenHungary Department of Preventive Medicine University of Debrecen Faculty of Public HealthDebrecenHungary Department of Pathology University of Debrecen Clinical CenterDebrecenHungary Doctoral school of Neuroscience University of Debrecen Faculty of MedicineDebrecenHungary

Objectives According to international observations,the incidence of clinical autopsies is declining worldwide,plummeting below 5%in the UsA and many European *** is an unfavourable trend as,in 7%-12%of cases,recent clinicopathological studies found discrepancies that might have changed the therapy or the outcome if known *** previous large-scale observations have examined varied patient populations,we aimed to focus on the differences between the clinical and pathological diagnostic findings in only patients who had a *** and methods We assessed the postmortem non-neuropathological and neuropathological findings of 534 consecutive patients who had a stroke who passed *** neoplasms,pneumonias,thromboembolisms and haemorrhagic transformations revealed only by autopsy were considered severe abnormalities;in addition,benign abnormalities important from an educational or scientific point of view were also *** In 26 of the 534 cases(4.9%),the presence of systemic neoplasms had already been confirmed in the clinical stage;however,8(1.5%)malignant tumours were only detected during ***,80(15%)thromboembolic events,73(13.6%)pneumonias and 66(18%)haemorrhagic transformations were only diagnosed at *** hospital stay(from admission to death)resulted in fewer discrepancies between clinical and autopsy diagnosis of thromboembolic events and pneumonias(pses,benign findings were *** While the type of acute stroke is reliably diagnosed with imaging techniques,postmortem autopsies are also important in patients who had a stroke as autopsies may reveal clinically silent diseases(eg,tumour),and contribute to knowing the actual incidence of stroke-related thromboembolic and pneumonia complications.

关键词： neoplasms clinical finding

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Prediction of the undrained shear strength of remolded soil with non-linear regression,fuzzy logic,and artificial neural network

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Journal of Mountain science 2024年第9期21卷 3108-3122页

作者： YÜNKÜl Kaan KARAÇOR Fatih gÜRBÜZ Ayhan BUDAK TahsinÖmür Department of Civil Engineering Faculty of Engineering and ArchitectureTokat Gaziosmanpaşa UniversityTokat 60100Türkiye Department of Civil Engineering Faculty of Engineering and ArchitectureKafkas UniversityKars 36000Türkiye Department of Civil Engineering Faculty of EngineeringGazi UniversityAnkara 06570Türkiye Ministry of Youth and sports Ankara 06090Türkiye

This study aims to predict the undrained shear strength of remolded soil samples using non-linear regression analyses,fuzzy logic,and artificial neural network modeling.A total of 1306 undrained shear strength results from 230 different remolded soil test settings reported in 21 publications were collected,utilizing six different measurement *** water content,plastic limit,and liquid limit were used as input parameters for fuzzy logic and artificial neural network modeling,liquidity index or water content ratio was considered as an input parameter for non-linear regression *** non-linear regression analyses,12 different regression equations were derived for the prediction of undrained shear strength of remolded ***-Forward backpropagation and the TANsIg transfer function were used for artificial neural network modeling,while the Mamdani inference system was preferred with trapezoidal and triangular membership functions for fuzzy logic *** experimental results of 914 tests were used for training of the artificial neural network models,196 for validation and 196 for *** was observed that the accuracy of the artificial neural network and fuzzy logic modeling was higher than that of the non-linear regression ***,a simple and reliable regression equation was proposed for assessments of undrained shear strength values with higher coefficients of determination.

关键词： Undrained shear strength liquidity index Water content ratio Non-linear regression Artificial neural networks Fuzzy logic

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Numerical Analysis of the Magnetic Dipole Effect on a Radiative Ferromagnetic liquid Flowing over a Porous stretched sheet

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Fluid Dynamics & Materials Processing 2024年第2期20卷 293-310页

作者： g.Dharmaiah F.Mebarek-Oudina K.s.Balamurugan N.Vedavathi Department of Mathematics Narasaraopeta Engineering CollegeNarasaraopetIndia Department of Physics Faculty of SciencesUniversity of 20 Août 1955-SkikdaSkikdaAlgeria Department of Mathematics RVR&JC College of EngineeringGunturIndia Department of Mathematics Koneru Lakshmaiah Education FoundationVaddeswaramIndia

The effects of a magnetic dipole on a nonlinear thermally radiative ferromagnetic liquidﬂowing over a stretched surface in the presence of Brownian motion and thermophoresis are *** means of a similarity transformation,ordinary differential equations are derived and solved afterwards using a numerical(the BVP4C)*** impact of various parameters,namely the velocity,temperature,concentration,is presented *** is shown that the nanoparticles properties,in conjunction with the magnetic dipole effect,can increase the thermal conductivity of the engineered nanoﬂuid and,consequently,the heat *** with earlier studies indicates high accuracy and effectiveness of the numerical *** increase in the Brow-nian motion parameter and thermophoresis parameter enhances the concentration and the related boundary *** skin-friction rises when the viscosity parameter is increased.A larger value of the ferromagnetic para-meter results in a higher skin-friction and,vice versa,in a smaller Nusselt number.

关键词： Brownian motion thermo-phoresis radiation magnetic dipole BVP4C non-linear

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