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Intraoperative complication rates in cataract surgery performed by resident trainees and staff surgeons in a tertiary eyecare center in Hungary

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 586-590页

作者： Márton Magyar gábor lászló sándor lászló Ujváry Zoltán Zsolt Nagy gábor Tóth Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary

AIM: To compare the incidence of intraoperative complications during primary phacoemulsification(phaco) surgery between resident surgeons(residents) and staff surgeons(specialists) and to objectively determine the difficulty of stages in phaco surgery. METHODs: This retrospective study included cases of phaco cataract surgery performed between January and December 2019. There were no exclusion criteria. For each patient, demographics, clinical history, case complexity, type of surgeon, and operative details were reviewed. Primary outcomes included intraoperative complication rates and the objective measure of difficulty in the steps of the surgery performed by residents and ***: A total of 3272 cases were included;7.4%(n=241) of cases were performed by residents. The overall complication rate was 5.4%(n=177). The intraoperative complication rate was significantly higher(Psidents(n=33, 13.7%) than in specialists(n=144, 4.8%). The most frequent complications were posterior capsule tear(n=85, 2.6%), anterior capsule tear(n=50, 1.53%), zonular fiber loss(n=45, 1.38%), and dropped nucleus(n=15, 0.46%). Objectively, the most difficult steps during surgery were phaco in 66(60.0%), capsulorhexis in 21(19.1%), irrigation/aspiration in 13(11.8%), hydrodissection in 9(8.2%), and intraocular lens(IOl) implantation in 1(0.9%) case. CONClUsION: Intraoperative complication rates are higher in residents than in specialists. The order of objective difficulty in phaco surgery steps is in line with the subjective findings of other surveys, revealing that the most challenging parts of phaco surgery are phaco and capsulorhexis.

关键词： cataract intraoperative complications resident phacoemulsification staff surgeon

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Relationship between diabetes mellitus and cataract in Hungary

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 788-793页

作者： Anita Pék Dorottya szabó gábor lászlósándor gábor Tóth András Papp Zoltán Zsolt Nagy Hans limburg János Németh Department of Ophthalmology Semmelweis UniversityMária u.39.Budapest 1085Hungary Department of Ophthalmology Petz Aladár HospitalVasvári Pál u.2-4.Győr 9023Hungary Health Information services Nijenburg 32LC1613 Grootebroekthe Netherlands

AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in *** effects of DM on the cataract surgical results were also in the focus of ***:statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in *** cross-sectional,population-based,national survey included 3523 people aged 50 years and *** of the survey were examined *** acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were ***:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with *** the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,Pst independent influencing risk factor(OR=49.9%,Psence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual ***:DM appears to be one of the main risk factors for developing *** risk factors,such as age,sex and environment also play an influencing *** does not seem to affect the occurrence of cataract surgical complications.

关键词： cataract diabetes mellitus Rapid Assessment of Avoidable Blindness

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Uncorrected refractive errors are important causes of avoidable visual impairment in Hungary: re-evaluation of two existing national data sets

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 955-961页

作者： János Németh TennóDaiki gábor lászlósándor Hajnalka Keve Dorottya szabó gábor Tóth gergely Dankovics István Barna Hans limburg Zoltán Zsolt Nagy Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary Department of Media and Education Informatics Eötvös Loránd UniversityBudapest 1117Hungary Department of Ophthalmology Petz Aladár HospitalGyör 9024Hungary Comprehensive Health Test Program of Hungary Szentendre 2000Hungary Department of Internal Medicine and Oncology Semmelweis UniversityBudapest 1083Hungary Health Information services Grootebroek 1613The Netherlands

·AIM: To review existing data for the prevalence of corrected, uncorrected, and inadequately corrected refractive errors and spectacle wear in Hungary.·METHODs: Data from two nationwide cross-sectional studies were analysed. The Rapid Assessment of Avoidable Blindness study collected population-based representative national data on the prevalence of visual impairment due to uncorrected refractive errors and spectacle coverage in 3523 people aged ≥50y(group I). The Comprehensive Health Test Program of Hungary provided data on the use of spectacles in 80 290 people aged ≥18y(group Ⅱ).·REsUlTs: In group I, almost half of the survey population showed refractive errors for distant vision, about 10% of which were uncorrected(3.2% of all male participants and 5.0% of females). The distance spectacle coverage was 90.7%(91.9% in males;90.2% in females). The proportion of inadequate distance spectacles was found to be 33.1%. Uncorrected presbyopia was found in 15.7% of participants. In all age groups(group Ⅱ), 65.4% of females and 56.0% of males used distance spectacles,and approximately 28.9% of these spectacles were found to be inappropriate for dioptric power(with 0.5 dioptres or more). The prevalence of inaccurate distance spectacles was significantly higher in older age groups(71y and above) in both sexes.·CONClUsION: According to this population-based data, uncorrected refractive errors are not rare in Hungary. Despite recent national initiatives, fur ther steps are required to reduce uncorrected refractive errors and associated negative effects on vision, such as avoidable visual impairment.

关键词： refractive errors uncorrected refractive errors spectacle wear inaccurate spectacles visual impairment

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silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlógál sylvia Nürnberger Barbara schaedl James Ferguson Nicole swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). However, the use of tNgCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Revision of the genus Inouenola lászló,Ronkay & Witt,2010(lepidoptera,Noctuoidea,Nolidae,Nolini) with description of 6 new species

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Journal of Forestry Research 2015年第2期26卷 457-467页

作者： gyula M.lászló gábor Ronkay lászló Ronkay Fadrusz u.25 Budapest 1114Hungary Heterocera Press ltd. Szt.István krt.4Budapest 1137Hungary Department of Zoology Hungarian Natural History Museum

This paper contains the revision of the genus Inouenola la′szlo′,Ronkay ＆ Witt,2010 and presents the checklist of the known taxa and their distribution and the description of six new species（Inouenola brunneolinea... 详细信息

关键词： Inouenola Nolini Nolidae Noctuoidea New species New status south East Asia

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Crystallographically selective Nanopatterning of graphene on siO_(2)

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Nano Research 2010年第2期3卷 110-116页

作者： Péter Nemes-Incze gábor Magda Katalin Kamarás lászlóPéter Biró Research Institute for Technical Physics and Materials science PO Box 49H-1525 BudapestHungary Budapest University of Technology and Economics(BME) PO Box 91H-1521 BudapestHungary Research Institute for solid state Physics and Optics Hungarian Academy of SciencesPO Box 49H-1525 BudapestHungary

graphene has many advantageous properties,but its lack of an electronic band gap makes this two-dimensional material impractical for many nanoelectronic applications,for example,field-effect *** problem can be circumvented by opening up a confinement-induced gap,through the patterning of graphene into ribbons having widths of a few *** electronic properties of such ribbons depend on both their size and the crystallographic orientation of the ribbon ***,etching processes that are able to differentiate between the zigzag and armchair type edge terminations of graphene are highly sought *** this contribution we show that such an anisotropic,dry etching reaction is possible and we use it to obtain graphene ribbons with zigzag *** demonstrate that the starting positions for the carbon removal reaction can be tailored at will with precision.

关键词： graphene atomic force microscopy(AFM) etching nanoribbon zigzag

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sex-specific life-history strategies among immature jumping spiders:Differences in body parameters and behavior

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Current Zoology 2023年第5期69卷 535-551页

作者： lászlóMezőfi Viktor Markó DóraÁgnes Taranyi gábor Markó Institute of Plant Protection Hungarian University of Agriculture and Life SciencesBudapest 1118Hungary Institute of Viticulture and Enology Hungarian University of Agriculture and Life SciencesBudapest 1118Hungary

selection forces often generate sex-specific differences in various traits closely related to *** in adult spiders(Araneae),sexes often differ in coloration,body size,antipredator,or foraging behavior,such sex-related differences are less pronounced among ***,sex-specific life-history strategies may also be adaptive for ***,we hypothesized that among spiders,immature individuals show different life-history strategies that are expressed as sex-specific differences in body parameters and behavioral features,and also in their *** used immature individuals of a protandrous jumping spider,Carrhotus xanthogramma,and examined sex-related *** results showed that males have higher mass and larger prosoma than *** were more active and more risk tolerant than *** activity increased with time,and larger males tended to capture the prey faster than small ones,while females showed no such ***,females reacted to the threatening abiotic stimuli more with the increasing number of test *** both males and females,individuals with better body conditions tended to be more risk *** showed no sex-specific differences in interindividual behavioral consistency and in intraindividual behavioral variation in the measured behavioral ***,we also found evidence for behavioral syndromes(i.e.,correlation between different behaviors),where in males,only the activity correlated with the risk-taking behavior,but in females,all the measured behavioral traits were *** present study demonstrates that *** sexes follow different life-history strategies even before attaining maturity.

关键词： activity behavioral syndrome boldness intraindividual variability repeatability sexual dimorphism

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Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma

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World Journal of gastroenterology 2005年第32期11卷 5015-5018页

作者： Dénes grg János Regly-Mérei sándor Paku lászló Kopper Péter Nagy Department of Transplantation and surgerysemmelweis University BudapestHungary Third Department of surgerysemmelweis University BudapestHungary Joint Research Organization of the Hungarian Academy of sciences and semmelweis UniversityBudapest Hungary First Department of Pathology and Experimental Cancer Researchsemmelweis University BudapestHungary

AIM： To characterize the alpha-fetoprotein （AFP） positive and negative hepatocellular carcinoma （HCC） samples. METHODs： Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens： AFP,β-catenin, p53, CD44, MsH-2, MlH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups. REsUlTs： Twenty-one of the thirty-seven examined HCCs were AFP positive. seven with nudear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples. CONClUsION： AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data on in vivo human tumors.

关键词： Hepatocellular carcinoma Alpha-fetoprotein p53 β-catenin CD44

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Double-brooding and annual breeding success of great tits in urban and forest habitats

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Current Zoology 2022年第5期68卷 517-525页

作者： Boglárka Bukor gábor seress Ivett Pipoly Krisztina sándor Csenge sinkovics ErnőVincze András liker Behavioral Ecology Research group Center for Natural SciencesUniversity of PannoniaVeszprém H-8200Hungary MTA-PE Evolutionary Ecology Research group University of PannoniaVeszprém H-8200Hungary MTA-ElTE Comparative Ethology Research group BudapestHungary Department of Biology Theoretical Population Ecology and Evolution GroupLund UniversityLundSweden

Urban areas differ from natural habitats in several environmental features that influence the characteristics of animals living *** example,birds often start breeding seasonally earlier and fledge fewer offspring per brood in cities than in natural ***,longer breeding seasons in cities may increase the frequency of double-brooding in urban compared with nonurban populations,thus potentially increasing urban birds’annual reproductive output and resulting in lower habitat difference in reproductive success than estimated by studies focusing on first clutches *** this study,we investigated 2 urban and 2 forests great tit Parus major populations from 2013 to *** compared the probability of double-brooding and the total number of annually fledged chicks per female between urban and forest habitats,while controlling for the effects of potentially confounding *** was a trend for a higher probability of double-brooding in urban(44%of females)than in forest populations(36%),although this was not consistent between the 2 urban *** produced significantly fewer fledglings annually in the cities than in the forest sites,and this difference was present both within single-and double-brooded ***,double-brooded urban females produced a similar number of fledglings per season as single-brooded forest *** results indicate that double-brooding increases the reproductive success of female great tits in both habitats,but urban females cannot effectively compensate in this way for their lower reproductive output per ***,other mechanisms like increased post-fledging survival can mitigate habitat differences in reproductive success.

关键词： annual reproductive success habitat differences population self-sustainability second brood urban conservation

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Impact of proteolytic enzymes in colorectal cancer development and progression

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World Journal of gastroenterology 2014年第37期20卷 13246-13257页

作者： lászló Herszényi loránd Barabás István Hritz gábor István Zsolt Tulassay 2~nd Department of Medicine Semmelweis University 2~nd Department of surgery Semmelweis University 1~st Department of Medicine Fejér Megyei Szent Gy?rgy University Teaching Hospital

Tumor invasion and metastasis is a highly complicated, multi-step phenomenon. In the complex event of tumor progression, tumor cells interact with basement membrane and extracellular matrix components. Proteolytic enzymes(proteinases) are involved in the degradation of extracellular matrix, but also in cancer invasion and metastasis. The four categories of proteinases(cysteine-, serine-, aspartic-, and metalloproteinases) are named and classified according to the essential catalytic component in their active site. We and others have shown that proteolytic enzymes play a major role not only in colorectal cancer(CRC) invasion and metastasis, but also in malignant transformation of precancerous lesions into cancer. Tissue and serumplasma antigen concentrations of proteinases might be of great value in identifying patients with poor prognosis in CRC. Our results, in concordance with othersindicate the potential tumor marker impact of proteinases for the early diagnosis of CRC. In addition, proteinases may also serve as potential target molecules for therapeutic agents.

关键词： Proteinase Cathepsin Plasminogen activator Matrix metalloproteinase Colorectal cancer Adenoma Invasion Metastasis Biomarker Prognosis

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