检索结果-南通市图书馆

C-reactive protein may be a prognostic factor for the whole gastroenteropancreatic neuroendocrine tumor group

World Journal of gastrointestinal Oncology 2019年第2期11卷 139-152页

作者： ?mer Koma? g?g?ksel bengi ?zgül Sa?ol Mesut Akarsu Department of Internal Medicine Dokuz Eylul University Faculty of Medicine Department of gastroenterology Dokuz Eylul University Faculty of Medicine Department of Pathology Dokuz Eylul University Faculty of Medicine

BACKgROUND Long non-coding RNAs(lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer(gC). Considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in gC is necessary.AIM To identify independent prognostic markers for the whole gastroenteropancreatic neuroendocrine tumor(gEP-NET) group.METHODS Ninety-three patients diagnosed with gEP-NETs within a specified period were included in this study. Patient data were retrospectively analyzed. The relationships between all independent variables and 5-year survival status calculated during the follow-up period(months) were assessed. In addition, the relationships between the independent variables were investigated.RESULTS When 5-year survival rate was compared, a statistically significant relationship between the age at diagnosis, male gender, tumor size, tumor stage, liver and/or distant metastasis, and tumor grade determined by the Ki-67 level and mitotic count, and the level of C-reactive protein(CRP), was observed. The meansurvival(overall survival) of the study group was 102.5 ± 6.3(SD) mo. The percentages of 1, 3 and 5-year survival were 90%, 72%, and 61%, respectively. In63 of 93 patients, Ki-67 and the mitotic count determined the same grade. The Ki-67 levels in 29 patients and the mitotic count in only 1 patient were in the higher grade. The risk of death increased by 4% for every 1 year increase at the diagnosis age and was 2.0-fold higher for male patients, 3.0-fold higher for g3 according to the mitotic count, 3.7-fold higher for g3 according to the Ki-67 level, 12.7-fold higher for cases with tumor stage 3 or 4 by a 1 cm increase in the ratio of 9% in tumor size, and 6.1-fold higher for patients with liver metastasis for every 1 mg/dL increase in the ratio of 1.5% in CRP level. There was a significant difference betw

关键词： gastroenteropancreatic neuroendocrine tumors C-reactive protein Prognostic factor Neuroendocrine tumors gastrointestinal system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical effectiveness of adding probiotics to a low FODMAP diet:Randomized double-blind placebo-controlled study

引用

World Journal of Clinical Cases 2021年第25期9卷 7417-7432页

作者： Beril Turan gög?ksel bengi Ruksan Cehreli Hale Akpınar Müjde Soytürk Department of Internal Medicine Dokuz Eylül UniversityIzmir 35000Turkey Department of gastroenterology Dokuz Eylul University IzmirIzmir 35000Turkey Department of Preventive Oncology Dokuz Eylül UniversityInstitute of Oncologyİzmir 35000Turkey

BACKgROUND There are various studies showing the relationship between irritable bowel syndrome(IBS)and diet,and some dietary adjustments are recommended to reduce symptoms.In recent years,there is a growing number of studies that show a 4-8 wk low fermentable oligo,di-and mono-saccharides and polyols(FODMAP)diet has a 50%-80%significant effect on symptoms in IBS patients.There is strong evidence suggesting that changes in fecal microbiota have an impact on IBS pathogenesis.Based on this argument,probiotics have been used in IBS treatment for a long time.As is seen,the FODMAP diet and probiotics are used separately in IBS treatment.AIM To evaluate the effectiveness of adding probiotics to a low FODMAP diet to control the symptoms in patients with IBS.METHODS The patients who were admitted to the gastroenterology Clinic of Dokuz Eylul University Hospital and diagnosed with IBS according to Rome IV criteria were enrolled into the study.They were randomized into 2 groups each of which consisted of 50 patients.All patients were referred to a dietitian to receive dietary recommendations for the low FODMAP diet with a daily intake of 9 g.The patients were asked to keep a diary of foods and beverages they consumed.The patients in group 1 were given supplementary food containing probiotics(2 g)once a day in addition to their low FODMAP diet,while the patients in group 2 were given a placebo once a day in addition to their low FODMAP diet.Visual analogue scale(VAS),the Bristol Stool Scale and IBS Symptom Severity Scale(IBSSSS)scores were evaluated before and after the 21 d treatment.RESULTS The rate of adherence of 85 patients,who completed the study,to the FODMAP restricted diet was 92%,being 90%in group 1 and 94%in group 2.The mean scores of VAS and IBS-SSS of the patients in group 1 before treatment were 4.6±2.7 and 310.0±78.4,respectively,and these scores decreased to 2.0±1.9 and 172.0±93.0 after treatment(both Pgroup 2 before treatment were 4.7±2.7 and 317.0±8

关键词： Irritable bowel syndrome Probiotics Low Fermentable Oligo,Di-and Mono-Saccharides and Polyols diet Visual Analogue Scale the Bristol Stool Scale Irritable Bowel Syndrome Symptom Severity Scale

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：