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Neural Regeneration Research 2012年第36期7卷 2929-2936页

作者： Osman zdel Demet Kalayci gülfizar szeri-varma Yilmaz Kiroglu selim Tümkaya Tuge Toker-Ugurlu Department of Psychiatry Faculty of MedicinePamukkale University Department of Psychiatry Antalya Training and Research Hospital Department of Radiology Faculty of MedicinePamukkale University

The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type I and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity.

关键词： bipolar disorder proton magnetic resonance spectroscopy medial prefrontal cortex N-asetylaspartate choline creatine degradation mood disorder neurochemical metabolite illness duration neural regeneration

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

MXene-Based Composites as Nanozymes in Biomedicine: A Perspective

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Nano-Micro Letters 2022年第12期14卷 447-463页

作者： siavash Iravani Rajender s.varma Faculty of Pharmacy and Pharmaceutical sciences Isfahan University of Medical SciencesIsfahanIran Regional Centre of Advanced Technologies and Materials Department of Physical ChemistryFaculty of SciencePalacky University in OlomoucSlechtitelu2778371 OlomoucCzech Republic

MXene-based nanozymes have garnered considerable attention because of their potential environmental and biomedical *** materials encompass alluring and manageable catalytic performances and physicochemical features,which make them suitable as(bio)sensors with high selectivity/sensitivity and ***-based structures with suitable electrical conductivity,biocompatibility,large surface area,optical/magnetic properties,and thermal/mechanical features can be applied in designing innovative nanozymes with area-dependent electrocatalytic *** the advances made,there is still a long way to deploy MXene-based nanozymes,especially in medical and healthcare applications;limitations pertaining the peroxidaselike activity and sensitivity/selectivity may restrict further practical applications of pristine ***,developing an efficient surface engineering tactic is still required to fabricate multifunctional MXene-based nanozymes with excellent *** obtain MXene-based nanozymes with unique physicochemical features and high stability,some crucial steps such as hybridization and modification ought to be ***,(nano)toxicological and long-term biosafety analyses along with clinical translation studies still need to be comprehensively *** very limited reports exist pertaining to the biomedical potentials of MXene-based nanozymes,the future explorations should transition toward the extensive research and detailed analyses to realize additional potentials of these structures in biomedicine with a focus on clinical and industrial *** this perspective,therapeutic,diagnostic,and theranostic applications of MXene-based nanozymes are deliberated with a focus on future per-spectives toward more successful clinical translational *** current state-of-the-art biomedical advances in the use of MXene-based nanozymes,as well as their developmental challenges and future prospects are also *** v

关键词： MXenes MXene-based nanozymes Therapeutics Diagnostics Theranostics

Wetting of MXenes and Beyond

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Nano-Micro Letters 2023年第8期15卷 141-153页

作者： Massoud Malaki Rajender s.varma Department of Mechanical Engineering Isfahan University of TechnologyDaneshgah e Sanati HwyKhomeyni ShahrIsfahan 84156‑83111Iran Regional Centre of Advanced Technologies and Materials Palacky University in OlomoucŠlechtitelů2778371 OlomoucCzech Republic

MXenes are a class of 2D nanomaterials with exceptional tailormade properties such as mechano-ceramic nature,rich chemistry,and hydrophilicity,to name a ***,one of the most challenging issues in any composite/hybrid system is the interfacial *** a superior integrity of a given composite system is a direct consequence of the proper *** wetting is a fundamental feature,dictating many physical and chemical attributes,most of the common nanomaterials possesses poor affinity due to hydrophobic nature,making them hard to be easily dispersed in a given *** to low contact angle,MXenes can offer themselves as an ideal candidate for manufacturing different nano-hybrid *** this review,it is aimed to particularly study the wettability of *** terms of the layout of the present study,MXenes are first briefly introduced,and then,the wettability phenomenon is discussed in *** reviewing the sporadic research efforts conducted to date,a particular attention is paid on the current challenges and research pitfalls to light up the future *** is strongly believed that taking the advantage of MXene’s rich hydrophilic surface may have a revolutionizing role in the fabrication of advanced materials with exceptional features.

关键词： MXene Wetting Hydrophilicity Composites 2D material

Plant Pollen grains:A Move Towards green Drug and Vaccine Delivery systems

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Nano-Micro Letters 2021年第8期13卷 218-230页

作者： siavash Iravani Rajender s.varma Faculty of Pharmacy and Pharmaceutical sciences Isfahan University of Medical SciencesIsfahanIran Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research InstitutePalackýUniversity in OlomoucŠlechtitelů2778371 OlomoucCzech Republic

Pollen grains and plant spores have emerged as innovative biomaterials for various applications such as drug/vaccine delivery,catalyst support,and the removal of heavy *** natural microcapsules comprising spore shells and pollen grain are designed for protecting the genetic materials of plants from exterior *** layers make up the shell,the outer layer(exine)that comprised largely of sporopollenin,and the inner layer(intine)that built chiefly of *** microcapsule shells,namely hollow sporopollenin exine capsules have some salient features such as homogeneity in size,non-toxic nature,resilience to both alkalis and acids,and the potential to withstand at elevated temperatures;they have displayed promising potential for the microencapsulation and the controlled drug delivery/*** important attribute of mucoadhesion to intestinal tissues can prolong the interaction of sporopollenin with the intestinal mucosa directing to an augmented effectiveness of nutraceutical or drug ***,current trends and prospects related to the application of plant pollen grains for the delivery of vaccines and drugs and vaccine are discussed.

关键词： Pollens sporopollenin Drug delivery Vaccine delivery Plant pollen grains Microcapsule shells

Investigation of the crystal structure and magnetic properties of Nd_(3-x)gdxCo_(11)B_4 borides

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Journal of Rare Earths 2011年第5期29卷 466-470页

作者： seluk Kervan Nazmiye Kervan Ayse zdemir Hseyin szeri Nevsehir University Faculty of Arts and SciencesPhysics Department TUBTAK-UME National Metrology Institute

Polycrystalline samples of pseudo-ternary intermetallic Nd3–xgdxCo11B4 （x=0,1,2,3） borides prepared by standard arc-melting were characterized by X-ray powder diffraction （XRPD）,magnetization and differential scanning calorimetry （DsC） measurements. The X-ray diffraction patterns indicated the hexagonal Ce3Co11B4-type structure with P6/mmm space group for each composition. The substitution of gd for Nd led to a decrease of the unit-cell parameters a and the unit-cell volume V,while the unit-cell parameter c increased linearly. Magnetic measurements indicated that all samples were ordered magnetically below the Curie temperature. The Curie temperatures increased as Nd was substituted by gd. The saturation magnetization at 4 K decreased upon the gd substitution up to x=1,and then increased.

关键词： intermetallics magnetically ordered materials magnetic measurements rare earths

stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

An sPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical structures

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Computer Modeling in Engineering & sciences 2025年第1期142卷 251-277页

作者： sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a smoothed Particle Hydrodynamics(sPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4sand model implemented in a three-phase,single-layer sPH framework.A staggered discretisation scheme based on the stress particle sPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the sPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower san Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the sPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the sPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4sand smoothed particle hydrodynamics(sPH)

Effect of Hydrolyzing Agents on the Properties of Poly(Ethylene glycol)-Fe_3O_4 Nanocomposite

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Nano-Micro Letters 2011年第2期3卷 79-85页

作者： E.Karaoglu H.Kavas A.Baykal M.s.Toprak H.szeri Department of Chemistry~b Fatih University Department of Physics Gebze Institute of Technology Functional Materials Division Royal Institute of Technology-KTH TUBITAK-UME National Metrology Institute

Poly(ethylene glycol)(PEg) assisted hydrothermal route has been used to study the influence of the hydrolyzing agent on the properties of PEg-iron oxide(Fe_3O_4) *** oxide nanoparticles(NPs),as confirmed by X-ray diffraction analysis,have been synthesized by a hydrothermal method in which Na OH and NH_3 were used as hydrolyzing *** of PEg-Fe_3O_4 nanocomposite was confirmed by Fourier transform infrared spectroscopy(FTIR).samples exhibit different crystallite sizes,which estimated based on line profile fitting as 10 nm for NH_3 and 8 nm for Na OH hydrolyzed *** average particle sizes obtained from transmission electron microscopy was respectively 174±3 nm for Na OH and 165±4 nm for NH3 gas hydrolyzed *** characterization results reveal superparamagnetic characteristics despite a large particle size,which indicate the absence of coupling between the nanocrystals due to the presence of polymer in the *** conductivity curve demonstrates that σDC is strongly temperature dependent.

关键词： Magnetite PEg Hydrothermal synthesis Conductivity Magnetization

surgery for inflammatory bowel disease

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World Journal of gastroenterology 2008年第17期14卷 2678-2690页

作者： John M Hwang Madhulika g varma Center for Colorectal surgery Department of Surgery University of California San Francisco

Despite the new and ever expanding array of medications for the treatment of inflammatory bowel disease (IBD), there are still clear indications for operative management of IBD and its complications. We present an ove... 详细信息

关键词： Crohn's disease Ulcerative colitis Operation surgical treatment Ileal pouch