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geodynamic evolution of the Earth over the Phanerozoic:Plate tectonic activity and palaeoclimatic indicators

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Journal of Palaeogeography 2015年第2期4卷 167-188页

作者： Christian Vérard Cyril Hochard Peter O.Baumgartner gérard m.stampfli Université de Lausanne (UNIL) Institut des Sciences de la Terre (ISTE)

During the last decades, numerous local reconstructions based on field geol- ogy were developed at the University of Lausanne （UNIL）. Team members of the UNIL partici- pated in the elaboration of a 600 ma to present global plate tectonic model deeply rooted in geological data, controlled by geometric and kinematic constraints and coherent with forces acting at plate boundaries. In this paper, we compare values derived from the tectonic model （ages of oceanic floor, production and subduction rates, tectonic activity） with a combination of chemical proxies （namely CO2, 87Sr/86Sr, glaciation evidence, and sea-level variations） known to be strongly in- fluenced by tectonics. One of the outstanding results is the observation of an overall decreas- ing trend in the evolution of the global tectonic activity, mean oceanic ages and plate velocities over the whole Phanerozoic. We speculate that the decreasing trend reflects the global cooling of the Earth system. Additionally, the parallel between the tectonic activity and CO2 together with the extension of glaciations confirms the generally accepted idea of a primary control of CO2 on climate and highlights the link between plate tectonics and CO2 in a time scale greater than 107 yr. Last, the wide variations observed in the reconstructed sea-floor production rates are in contradiction with the steady-state model hypothesized by some.

关键词： geodynamic plate tectonics plate model Phanerozoic palaeoclimate CO2,strontium glaciation

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阿尔卑斯山的增生过程:materhorn棱柱与Valaisan棱柱

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世界地质 1993年第1期 82-82页

作者： michel marthaler gerard m.stampfli 刘俊来

在欧洲Brianconnais半岛早白垩世向东迁移之后,Piemontese洋将发生俯冲,并将发育有一个增生棱柱。在阿尔卑斯山的内带已经发现了这种棱柱,比如在matterhorn区称为Tsate推覆体。该推覆体由“绢状片岩”(Schistes lustres)与蛇绿岩构成,... 详细信息

在欧洲Brianconnais半岛早白垩世向东迁移之后,Piemontese洋将发生俯冲,并将发育有一个增生棱柱。在阿尔卑斯山的内带已经发现了这种棱柱,比如在matterhorn区称为Tsate推覆体。该推覆体由“绢状片岩”(Schistes lustres)与蛇绿岩构成,它具有增生棱柱内同时发育的沉积作用与构造作用:由解体的蛇绿岩所分隔的早期叠瓦状构造岩片,其中最大岩片在顶部;在总体倒转序列中有部分正常岩系。这次俯冲作用伴随着高压/低温变

关键词：阿尔卑斯山推覆体纳布构造棱柱多面体 materhorn Valaisan 斜向碰撞

Permo–Triassic and Liassic Tethyan Oceanic Tracts within the Pontide Belt Along the Southern margin of Eurasia, Northern Anatolia

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Acta geologica Sinica(English Edition) 2017年第S1期91卷 33-34页

作者： E.SARIFAKIOgLU Y.DILEK m.SEVIN S.PEHLIVAN O.K EmIR A.mOLLER T.BAYANOVA I.UYSAL m.KELES general Directorate of mineral Research & Explor Department of geology & Env.Earth Science Miami University The University of Kansas Department of Geology geol.Inst.of the Kola Science Centre of the RAS Dept.of geol.Engineering Karadeniz Technical University makro Yet.madencilik

The Pontide belt in northern Turkey includes three major tectonic terranes,the Strandja massif（Sj m）,and the Istanbul（ISZ）and Sakarya Zones（SZ）(Fig.1).We present new age and geochemical data from ophiolites and ophiolitic mélanges within the Sakarya Zone and show that these mafic–ultramafic rocks are the remnants of Tethyan oceanic lithosphere formed in different tectonic *** main ophiolite occurrences investigated in this study along the Karakaya Suture（KS）are associated with the latest Triassic Cimmeride orogeny,and in the Küre–Yusufeli ophiolite belt are part of the Alpide *** Karakaya Suture Zone ophiolites in northern west Turkey are comprised mainly of the Denizgoren（?anakkale）ophiolite,Bo?azk?y（Bursa）,geyve（Sakarya）,Almac?k（Düzce）and?ele（Bolu）*** Denizg?ren ophiolite largely contains upper mantle peridotites,which are equivalents of the Permo–Triassic Lesvos peridotites and mélange units farther SW in the northern Aegean *** Bo?azk?y ophiolite includes serpentinite and metagabbro,and the Almac?k and geyve ophiolites display an almost complete Penrose–type sequence consisting of serpentinizeduppermantleperidotites,cumulate ultramafic–mafic rocks,isotropic gabbros,dolerite and plagiogranite dikes,and extrusive rocks.U–Pb zircon dating of plagiogranite dikes from?ele has revealed an igneous age of 260 ma,and 255,235,227 ma from Almac?k（Bozkurt et al.,2012a,b）.Consistent with the previouslypublished Permo–Triassic age,we obtained a 268.4±6.3 ma U–Pb zircon age from a plagiogranite dike within the Almacik ophiolite to the *** KS ophiolite belt containing the?ele,Almac?k,geyve ophiolites within the SZ extends westward into the Armutlu Peninsula and then into the Biga Peninsula（***?ren ophiolite）and most likely connects with the remnants of the Triassic meliata–meliac ocean basin（stampfli and Borel,2002）in the Balkan *** KS ophiolites also continue eastward within the Pontide Belt into the Elekda?ophiolite（e

关键词： Triassic and Liassic Tethyan Oceanic Tracts within the Pontide Belt Along the Southern margin of Eurasia rock KS Pb Permo Northern Anatolia

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EgFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe metges Erick gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain gourlaouen Corinne Alleaume Annie Wdowik Laurent miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel martin Claire stampfli Jean-Jacques Auger Alain Bargain murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre marie girardot Nathalie Heresbach Christian Laboisse Eric Lavoine gilles Lemasson Claire magois Sophie michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny marhuenda Delphine Déniel Lagadec Christian Riché Françoise grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène marquis Rennes France ICO René gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie médicale Laval France ARmOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EgFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EgFR status in a large cohort of mCRC patients who received cetuximab without preliminary EgFR screening, and assessing the correlation between EgFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EgFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EgFR-positive and EgFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EgFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EgFR-negative and EgFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EgFR expression as measured by currently available IHC technics.

关键词： metastatic Colorectal Cancer Cetuximab EgFR Expression