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名中医邱健益气活血和中解毒方辨治慢性重度萎缩性胃炎(胃癌前病变)临证体会

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中国中医药现代远程教育 2024年第16期22卷 92-94页

作者：王念亮邱健许赋瑜黄祎李家淼福建中医药大学附属福鼎医院中医内科一区福建福鼎355200 福建省屏南县中医院中医科福建屏南352300

邱健主任从事中医临床工作40余年,精研医术,倡导“中和”学术思想。邱主任在辨证论治慢性重度萎缩性胃炎(胃癌前病变)方面有自身独到见解,认为其基本病机为“正虚血瘀,浊毒内蕴”,故以“益气活血,和中解毒”为基本治则,以自拟益气活血... 详细信息

邱健主任从事中医临床工作40余年,精研医术,倡导“中和”学术思想。邱主任在辨证论治慢性重度萎缩性胃炎(胃癌前病变)方面有自身独到见解,认为其基本病机为“正虚血瘀,浊毒内蕴”,故以“益气活血,和中解毒”为基本治则,以自拟益气活血和中解毒方为主加减化裁,使方证相符,临床效果显著。

关键词：胃痞慢性重度萎缩性胃炎胃癌前病变益气活血和中解毒方邱健名医经验中和医派

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基于“盐制入肾”理论的盐牛膝炮制研究进展

江西中医药大学学报 2024年第2期36卷 113-118页

作者：钟思敏钟凌云卢兴美刘斌周颖邓琦徐福余罗红兵江西中医药大学南昌330004 江西省质量和标准化研究院南昌330004

不同中药都有其各自的性味及归经,但多数药物存在一药多味、一药归多经的特点。为使药物直达病所,常使用特定的辅料炮制药材,引药归经,使得药物效强力专,保证临床疗效。盐是常用的炮制辅料之一,且盐有引药入肾的作用,故古代医家常使用... 详细信息

不同中药都有其各自的性味及归经,但多数药物存在一药多味、一药归多经的特点。为使药物直达病所,常使用特定的辅料炮制药材,引药归经,使得药物效强力专,保证临床疗效。盐是常用的炮制辅料之一,且盐有引药入肾的作用,故古代医家常使用盐作为辅料炮制具有补肾作用的药物。牛膝具有补肝肾、强筋骨之功,也常采用盐制,以达到引药入肾的目的。在梳理牛膝炮制历史和盐制入肾古代及现代研究的基础上,收集了部分含有盐牛膝的古方,结合盐牛膝现代研究,从化学成分、药理药效变化等方面,总结盐牛膝“入肾”的炮制机理,为进一步研究盐牛膝炮制机理奠定基础,为研究中药盐制的共性规律提供思路。

关键词：炮制盐牛膝盐制入肾机制性味功效

Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients

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Oncology Research 2024年第2期32卷 339-351页

作者： JUAN SHEN WEIYU ZHANG QINQIN JIN fuyu GONG HEPING ZHANG HONGLIANG xu JIEJIE LI HUI YAO XIYA JIANG YINTING YANG LIN HONG JIE MEI YANG SONG SHUGUANG ZHOU School of Big Data and Artificial Intelligence Anhui Xinhua UniversityHefei230088China Department of Gynecology and Obstetrics Maternity and Child Healthcare Hospital Affiliated to Anhui Medical UniversityAnhui Province Maternity and Child Healthcare HospitalHefei230001China Department of Gynecology and Obstetrics The Fifth Clinical College of Anhui Medical UniversityHefei230032China Departments of Breast Surgery Fuyang Women and Children’s HospitalFuyang236000China Departments of Pathology Anhui Province Maternity and Child Health HospitalHefei230001China Department of Pain The First Affiliated Hospital of Anhui Medical UniversityHefei230032China Department of Gynecology and Obstetrics Linquan Maternity and Child Healthcare HospitalFuyang236400China

Invasive breast carcinoma(BRCA)is associated with poor prognosis and high risk of ***,it is critical to identify novel biomarkers for the prognostic assessment of ***:The expression data of polo-like kinase 1(PLK1)in BRCA and the corresponding clinical information were extracted from TCGA and GEO ***1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction(qRT-PCR)and western *** sample gene set enrichment analysis(ssGSEA)was performed to evaluate immune infiltration in the BRCA microenvironment,and the random forest(RF)and support vector machine(SVM)algorithms were used to screen for the hub infiltrating cells and calculate the immunophenoscore(IPS).The RF algorithm and COX regression model were applied to calculate survival risk scores based on the PLK1 expression and immune cell ***,a prognostic nomogram was constructed with the risk score and pathological stage,and its clinical potential was evaluated by plotting calibration charts and DCA *** application of the nomogram was further validated in an immunotherapy ***:PLK1 expression was significantly higher in the tumor samples in TCGA-BRCA ***,PLK1 expression level,age and stage were identified as independent prognostic factors of *** the IPS was unaffected by PLK1 expression,the TMB and MATH scores were higher in the PLK1-high group,and the TIDE scores were higher for the PLK1-low *** also identified 6 immune cell types with high infiltration,along with 11 immune cell types with low infiltration in the PLK1-high tumors.A risk score was devised using PLK1 expression and hub immune cells,which predicted the prognosis of BRCA *** addition,a nomogram was constructed based on the risk score and pathological staging,and showed good predictive ***:PLK1 expression and immune cell infiltration can predict post-immunotherapy pr

关键词： Breast invasive carcinoma(BRCA) Polo-like kinase 1(PLK 1) Random forest(RF) Support vector machine(SVM) Immune infiltration

Overexpression of aspen sucrose synthase gene promotes growth and development of transgenic Arabidopsis plants

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Advances in Bioscience and Biotechnology 2010年第5期1卷 426-438页

作者： fuyu xu Chandrashekhar P. Joshi 不详

In plants, sucrose synthase (SUS) enzymes catalyze conversion of sucrose into fructose and UDP-glucose in the presence of UDP. To investigate the impact of overexpression of heterologous SUS on the growth and development of Arabidopsis, we transformed Arabidopsis plants with an overexpression vector containing an aspen SUS gene (PtrSUS1). The genomic PCR confirmed the successful integration of PtrSUS1 transgene in the Arabidopsis genome. PtrSUS1 expression in transgenic Arabidopsis plants was confirmed by RT-PCR. The SUS activity was dramatically increased in all transgenic lines examined. The three selected transgenic PtrSUS1 lines exhibited faster growth and flowered about 10 days earlier compared to untransformed controls, and also possessed 133%, 139%, and 143% SUS activity compared to controls. Both fresh weights and dry biomass yields of the whole plants from these three selected transgenic lines were significantly increased to 125% of the controls. Transgenic PtrSUS1 lines also had a higher tolerance to higher concentration of sucrose which was reflective of the increased SUS activity in transgenic versus wild-type plants. The growth differences between wild-type and transgenic plants, either in root and hypocotyl length or in fresh and dry weight of whole plant, became more pronounced on the media containing higher sucrose concentrations. Taken together, these results showed that the early flowering, faster growth and increased tolerance to higher sucrose in transgenic lines were caused by the genome integration and constitutive expression of the aspen PtrSUS1 gene in transgenic Arabidopsis.

关键词： Arabidopsis Aspen Trees (Populus Tremuloides) Over-Expression Sucrose Synthase (SUS) SUS Enzyme Activity

In vitro demonstration of interactions among zinc-binding domains of cellulose synthases in Arabidopsis and aspen

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Advances in Bioscience and Biotechnology 2010年第3期1卷 152-161页

作者： fuyu xu Chandrashekhar P. Joshi 不详

Plant cellulose synthases (CesAs) are the key enzymes necessary for cellulose biosynthesis. In Arabidopsis, two distinct groups of three CesAs each are necessary for cellulose synthesis during primary and secondary cell wall formation. It has also been suggested that such three CesAs interact with each other to form plasma-membrane bound rosette complexes that are functional during cellulose production. However, in vivo demonstration of such assemblies of three CesAs into rosettes has not been possible. We used yeast two-hybrid assays to demonstrate the possible interactions among several CesAs from Arabidopsis and aspen via their N-terminal zinc-binding domains (ZnBDs). While strong positive interactions were detected among ZnBDs from secondary wall associated CesAs of both Arabidopsis and aspen, the intergeneric interactions between Arabidopsis and aspen CesAs were weak. Moreover, in aspen, three primary wall associated CesA ZnBDs positively interacted with each other as well as with secondary CesAs. These results suggest that ZnBDs from either primary or secondary CesAs, and even from different plant species could interact but are perhaps insufficient for specificities of such interactions among CesAs. These observations suggest that some other more specific interacting regions might exist within CesAs. It is also possible that some hitherto unknown mechanism exists in plants for assembling the rosette complexes with different compositions of CesAs. Understanding how cellulose is synthesized will have a direct impact on utilization of lignocellulosic biomass for bioenergy production.

关键词： Arabidopsis Cellulose Synthase Poplar Protein-Protein Interaction Yeast Two-Hybrid System Zinc-Binding Domain

固溶时效对Ti-5Al-3.5Fe-7Mo-4Cr合金组织与性能的影响

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金属热处理 2024年第5期49卷 100-105页

作者：赵倩董福宇吴福川张悦徐欣扬州市职业大学机械工程学院江苏扬州225012 沈阳工业大学材料科学与工程学院辽宁沈阳110870

通过室温拉伸性能测试、EBSD、SEM、TEM及XRD等分析手段,研究了固溶时效处理对自主设计新型低成本高强β钛合金Ti-5Al-3.5Fe-7Mo-4Cr组织和拉伸性能的影响。结果表明:相比在单相区热处理,试验β钛合金在两相区进行热处理后性能更优;两... 详细信息

通过室温拉伸性能测试、EBSD、SEM、TEM及XRD等分析手段,研究了固溶时效处理对自主设计新型低成本高强β钛合金Ti-5Al-3.5Fe-7Mo-4Cr组织和拉伸性能的影响。结果表明:相比在单相区热处理,试验β钛合金在两相区进行热处理后性能更优;两种固溶处理制度下,随着时效温度的增加,次生α相析出量和合金强度均先增加后降低,伸长率呈增加趋势;时效温度较高时,针状次生α相长大,间距增大。经过820℃×0.5 h固溶和440℃×8 h时效的钛合金达到良好的强-塑性匹配,抗拉强度为1257 MPa,屈服强度为1135 MPa,伸长率为4%,达到高强钛合金强度要求。试验β钛合金获得较高强度主要源于第二相强化,次生α相间距较小、α相体积分数增加和分层次尺寸结构对合金起到显著的强化效果。

关键词： Ti-Al-Fe-Mo-Crβ钛合金固溶时效组织拉伸性能

IN SITU OBSERVATION ON FORMATION OF BASKET DURING BAINITIC TRANSFORMATION

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Acta Metallurgica Sinica(English Letters) 1989年第4期2卷 298-300页

作者： WANG Yingshu SUN fuyu xu Wenchong Central Iron and Steel Research Institute,Ministry of Metallurgical Industry,Beijing,China Senior Engineer,Department No.13,Central Iron and Steel Research Institute,Ministry of Metallurgical Industry,Beijing,China

By means of riM-190 hot-stage microscopy,the in situ observation of α-β transformation in 12Cr2MoWVTiB steel has been carried *** sequence of the growth of ferritic needles composing bainitic basket has also been *** to the crystallographic analy- sis a multislip system transform model concerning the formation of basket has been proposed.

关键词： α-β transformation steel 12Cr2MoWVTiB ferritic needles basket

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配电网线路运检中的智能在线检测方法应用

集成电路应用 2024年第1期41卷 244-245页

作者：徐菁阳吴馥郁国网沛县供电公司江苏221600

阐述配电网线路运检特点、智能在线检测原理、检测特点和类型,分析智能配电网故障指示器的检测方法、智能配电终端、智能巡检的配电网运维管控平台、OCS系统的量测信息在线智能检测应用。

关键词：配电网线路运检智能检测在线监测

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邱健主任升降散论治外感热病的临证经验

中国中医药现代远程教育 2022年第1期20卷 82-84页

作者：李连勇邱健(指导) 许赋瑜福建中医药大学附属福鼎医院中医内科一区福建福鼎355200

邱健主任医师是全国第四批老中医药专家学术经验继承人,第三批全国优秀中医临床人才,全国基层名老中医药专家,全国基层中医特色重点脾胃病专科的学科带头人,从事中医临床37年,擅长治疗脾胃疾病及内科疑难杂病,精研医术,善用经方,积累了... 详细信息

邱健主任医师是全国第四批老中医药专家学术经验继承人,第三批全国优秀中医临床人才,全国基层名老中医药专家,全国基层中医特色重点脾胃病专科的学科带头人,从事中医临床37年,擅长治疗脾胃疾病及内科疑难杂病,精研医术,善用经方,积累了丰富的临床经验,临床运用升降散论治外感热病有独到的见解,认为“郁热”之病机贯穿于外感热病卫气营血各个阶段,可单纯因感受淫邪致郁,也可因内生之“郁热”外合六淫之邪而发病,遵循“火郁而发之”,崇尚升降散治以透发郁热、升清降浊,和气机,调卫气营血,和三焦,临床遵循“辨病+辨证”原则,以升降散为基础方随证治之,主要分为卫分热毒证、邪犯少阳证、肺热壅盛证、阳明热盛证、营血热盛证、湿热壅盛证六型随证加减,并注重因势利导,兼顾脾胃,调理饮食,顾护阴津,临床效果显著。

关键词：邱健升降散外感热病临证经验