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Identification and global characterization of eccDNA reveals hallmarks in iron nanoparticles-treated breast cancer cells

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Genes & Diseases 2024年第2期11卷 532-534页

作者： Wenxiang Lu Ying Wang Tao Luo fuyu Li Yali Jiang Jinke Wang Weizhong Zhang Yunfei Bai State Key Lab of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China The Friendship Hospital of Ili Kazakh Autonomous Prefecture Ili & Jiangsu Joint Institute of HealthYiningXinjiang 835000China Department of Ophthalmology First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The biogenesis and functions of extrachromosomal circular DNA(eccDNA)have been studied for several ***,the heterogeneity of eccDNA is largely *** this study,we purified and sequenced eccDNA and RNA using a method that simultaneously extracts DNA and RNA from cultured cells treated with iron *** discovered that the characteristics of eccDNA are altered by iron stress,particularly on genic and CpG islands regions,suggesting a biogenesis mechanism induced by transcription.

关键词： breast nanoparticles characterization

Dual-Defect Engineering Strategy Enables High-Durability Rechargeable Magnesium-Metal Batteries

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Nano-Micro Letters 2024年第9期16卷 449-461页

作者： fuyu Chen Bai‑Qing Zhao Kaifeng Huang Xiu‑Fen Ma Hong‑Yi Li Xie Zhang Jiang Diao Jili Yue Guangsheng Huang Jingfeng Wang Fusheng Pan National Innovation Center for Lndustry‑Education Integration of Energy Storage Technology School of Materials Science and EngineeringChongqing UniversityChongqing 400044People’s Republic of China National Magnesium Alloy Material Engineering Technology Research Center Chongqing UniversityChongqing 400044People’s Republic of China Materials and Energy Division Beijing Computational Science Research CenterBeijing 100193People’s Republic of China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044People’s Republic of China

Rechargeable magnesium-metal batteries(RMMBs)are promising next-generation secondary batteries;however,their development is inhibited by the low capacity and short cycle lifespan of *** various strategies have been devised to enhance the Mg^(2+)migration kinetics and structural stability of cathodes,they fail to improve electronic conductivity,rendering the cathodes incompatible with magnesium-metal ***,we propose a dual-defect engineering strategy,namely,the incorporation of Mg^(2+)pre-intercalation defect(P-Mgd)and oxygen defect(Od),to simultaneously improve the Mg^(2+)migration kinetics,structural stability,and electronic conductivity of the cathodes of *** lamellar V_(2)O_(5)·nH_(2)O as a demo cathode material,we prepare a cathode comprising Mg_(0.07)V_(2)O_(5)·1.4H_(2)O nanobelts composited with reduced graphene oxide(MVOH/rGO)with P-Mgd and *** Od enlarges interlayer spacing,accelerates Mg^(2+)migration kinetics,and prevents structural collapse,while the P-Mgd stabilizes the lamellar structure and increases electronic ***,the MVOH/rGO cathode exhibits a high capacity of 197 mAh g^(−1),and the developed Mg foil//MVOH/rGO full cell demonstrates an incredible lifespan of 850 cycles at 0.1 A g^(−1),capable of powering a light-emitting *** proposed dual-defect engineering strategy provides new insights into developing high-durability,high-capacity cathodes,advancing the practical application of RMMBs,and other new secondary batteries.

关键词： Rechargeable magnesium-metal batteries Dual-defect engineering Vanadium-based cathode High durability Lamellar structure

Pushing the high-k scalability limit with a superparaelectric gate layer

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Journal of Advanced Ceramics 2024年第4期13卷 539-547页

作者： Kun Wang Chao Liu Yuan Zhang fuyu Lv Jun Ouyang Houbing Huang Rui-Long Yang Yu-Yao Zhao Hongbo Cheng Hanfei Zhu Xiaoming Shi Yun Tian Institute of Advanced Energy Materials and Chemistry Jinan Engineering Laboratory for Multi-scale Functional MaterialsSchool of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Key Laboratory for Liquid-Solid Structure Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China China Tobacco Shandong Industrial Co. Ltd.Jinan 250104China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Key Laboratory of Key Film Materials&Application for Equipments(Hunan Province) School of Material Sciences and EngineeringXiangtan UniversityXiangtan 411105China Advanced Research Institute of Multidisciplinary Science and School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China

To meet the expectation set by Moore’s law on transistors,the search for thickness-scalable high dielectric constant(k)gate layers has become an emergent research *** investigations have failed to solve the“polarizability–scalability–insulation robustness”*** this work,we show that this trilemma can be solved by using a gate layer of a high k ferroelectric oxide in its superparaelectric(SPE)*** the SPE,its polar order becomes local and is dispersed in an amorphous matrix with a crystalline size down to a few nanometers,leading to an excellent dimensional scalability and a good field-stability of the k *** an example,a stable high k value(37±3)is shown in ultrathin SPE films of(Ba_(0.95),Sr_(0.05))(Zr_(0.2),Ti_(0.8))O_(3)deposited on LaNiO_(3)-buffered Pt/Ti/SiO_(2)/(100)Si down to a 4 nm thickness,leading to a small equivalent oxide thickness of~0.46 *** aforementioned characteristic microstructure endows the SPE film a high breakdown strength(~10.5 MV·cm^(−1)for the 4 nm film),and hence ensures a low leakage current for the operation of the complementary metal oxide semiconductor(CMOS)***,a high electrical fatigue resistance is displayed by the SPE *** results reveal a great potential of superparaelectric materials as gate dielectrics in the next-generation microelectronics.

关键词： high-k transistors Moore's law superparaelectric insulation robustness

Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients

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Oncology Research 2024年第2期32卷 339-351页

作者： JUAN SHEN WEIYU ZHANG QINQIN JIN fuyu GONG HEPING ZHANG HONGLIANG XU JIEJIE LI HUI YAO XIYA JIANG YINTING YANG LIN HONG JIE MEI YANG SONG SHUGUANG ZHOU School of Big Data and Artificial Intelligence Anhui Xinhua UniversityHefei230088China Department of Gynecology and Obstetrics Maternity and Child Healthcare Hospital Affiliated to Anhui Medical UniversityAnhui Province Maternity and Child Healthcare HospitalHefei230001China Department of Gynecology and Obstetrics The Fifth Clinical College of Anhui Medical UniversityHefei230032China Departments of Breast Surgery Fuyang Women and Children’s HospitalFuyang236000China Departments of Pathology Anhui Province Maternity and Child Health HospitalHefei230001China Department of Pain The First Affiliated Hospital of Anhui Medical UniversityHefei230032China Department of Gynecology and Obstetrics Linquan Maternity and Child Healthcare HospitalFuyang236400China

Invasive breast carcinoma(BRCA)is associated with poor prognosis and high risk of ***,it is critical to identify novel biomarkers for the prognostic assessment of ***:The expression data of polo-like kinase 1(PLK1)in BRCA and the corresponding clinical information were extracted from TCGA and GEO ***1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction(qRT-PCR)and western *** sample gene set enrichment analysis(ssGSEA)was performed to evaluate immune infiltration in the BRCA microenvironment,and the random forest(RF)and support vector machine(SVM)algorithms were used to screen for the hub infiltrating cells and calculate the immunophenoscore(IPS).The RF algorithm and COX regression model were applied to calculate survival risk scores based on the PLK1 expression and immune cell ***,a prognostic nomogram was constructed with the risk score and pathological stage,and its clinical potential was evaluated by plotting calibration charts and DCA *** application of the nomogram was further validated in an immunotherapy ***:PLK1 expression was significantly higher in the tumor samples in TCGA-BRCA ***,PLK1 expression level,age and stage were identified as independent prognostic factors of *** the IPS was unaffected by PLK1 expression,the TMB and MATH scores were higher in the PLK1-high group,and the TIDE scores were higher for the PLK1-low *** also identified 6 immune cell types with high infiltration,along with 11 immune cell types with low infiltration in the PLK1-high tumors.A risk score was devised using PLK1 expression and hub immune cells,which predicted the prognosis of BRCA *** addition,a nomogram was constructed based on the risk score and pathological staging,and showed good predictive ***:PLK1 expression and immune cell infiltration can predict post-immunotherapy pr

关键词： Breast invasive carcinoma(BRCA) Polo-like kinase 1(PLK 1) Random forest(RF) Support vector machine(SVM) Immune infiltration

Moiré superlattices arising from growth induced by screw dislocations in layered materials

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Chinese Physics B 2024年第7期33卷 72-77页

作者：田伏钰 Muhammad Faizan 贺欣孙远慧张立军 State Key Laboratory of Integrated Optoelectronics Key Laboratory of Automobile Materials of MOE and College of Materials Science and Engineering Jilin UniversityChangchun 130012China Suzhou Laboratory Suzhou 215123China

Moiré superlattices(MSLs) are modulated structures produced from homogeneous or heterogeneous two-dimensional layers stacked with a twist angle and/or lattice mismatch. Enriching the methods for fabricating MSL and realizing the unique emergent properties are key challenges in its investigation. Here we recommend that the spiral dislocation driven growth is another optional method for the preparation of high quality MSL samples. The spiral structure stabilizes the constant out-of-plane lattice distance, causing the variations in electronic and optical properties. Taking SnS_(2) MSL as an example, we find prominent properties including large band gap reduction(~ 0.4 e V) and enhanced optical activity. Firstprinciples calculations reveal that these unusual properties can be ascribed to the locally enhanced interlayer interaction associated with the Moiré potential modulation. We believe that the spiral dislocation driven growth would be a powerful method to expand the MSL family and broaden their scope of application.

关键词： Moirésuperlattices interlayer interaction spiral dislocation layered materials

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基于改进Res-UNet网络的织物瑕疵图像识别方法

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毛纺科技 2024年第7期52卷 100-106页

作者：于光许张富宇河南经贸职业学院河南郑州450018

复杂花色织物的纹理和色彩常常是非规则的,导致织物表面瑕疵识别难度较高。针对上述问题,研究一种基于改进Res-UNet网络的织物表面瑕疵图像识别方法。采集织物图像并对其实施灰度化、去噪以及直方图均衡化处理,利用蝙蝠算法求取最佳提... 详细信息

复杂花色织物的纹理和色彩常常是非规则的,导致织物表面瑕疵识别难度较高。针对上述问题,研究一种基于改进Res-UNet网络的织物表面瑕疵图像识别方法。采集织物图像并对其实施灰度化、去噪以及直方图均衡化处理,利用蝙蝠算法求取最佳提取网络层数,通过增加特征提取网络层数改进Res-UNet网络,利用改进后的Res-UNet网络识别织物表面瑕疵,并且采用迁移学习算法进一步优化识别模型的参数,实现织物表面瑕疵准确识别。结果表明:本文方法应用下,无论是素色样本,还是花色样本,其识别系数均达到0.9以上,相比基于标签嵌入方法的织物瑕疵识别方法和双路高分辨率转换网络的布匹瑕疵检测方法,本文方法对复杂花色样本的轮廓系数识别更高,适用性更好,识别能力更强。

关键词：改进Res-UNet网络织物表面瑕疵图像采集预处理图像识别

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多配送中心半开放式冷链物流配送路径优化

复杂系统与复杂性科学 2024年第2期21卷 137-146页

作者：江雨燕尹莉王付宇安徽工业大学管理科学与工程学院安徽马鞍山243002

为了解决冷链物流服务的成本、质量以及运输产生的碳排放等问题,构建多中心半开放式冷链物流路径优化模型,并将各种动态变化融入该模型中。设计一种改进的NSGA-II算法并利用标准测试函数证实该算法具有较好的收敛性与多样性。通过算例实... 详细信息

为了解决冷链物流服务的成本、质量以及运输产生的碳排放等问题,构建多中心半开放式冷链物流路径优化模型,并将各种动态变化融入该模型中。设计一种改进的NSGA-II算法并利用标准测试函数证实该算法具有较好的收敛性与多样性。通过算例实验,结果表明:与不考虑碳排放方案相比,考虑碳排放方案的配送成本增加了19.00%,运输距离减少了5.16%,碳排放成本降低了13.03%;与初始配送方案相比,实时优化方案的配送成本下降了29.78%,碳排放成本下降了23.19%,客户满意度增幅14.49%;与单配送中心模式相比,多配送中心模式的配送成本降低了27.30%,碳排放成本降低了48.89%,客户满意度提高了13.11%,从而为冷链物流企业带来一定的管理启示。

关键词：冷链物流多配送中心动态路径优化改进的NSGA-II算法

突发自然灾害下的两阶段多目标应急物资中心选址问题研究

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安全与环境学报 2024年第2期24卷 654-665页

作者：王付宇王欣蕊安徽工业大学管理科学与工程学院安徽马鞍山243032 复杂系统多学科管理与控制安徽普通高校重点实验室(安徽工业大学) 安徽马鞍山243002

针对突发灾害情况下需求不确定的选址问题,构建最小化经济成本和最大化满意度的应急物资中心选址模型。首先,将选址问题划分为初期和后期的两阶段问题;其次,对物资需求量进行模糊需求预测,并使用可信性模糊机会约束规划将其转化为确定... 详细信息

针对突发灾害情况下需求不确定的选址问题,构建最小化经济成本和最大化满意度的应急物资中心选址模型。首先,将选址问题划分为初期和后期的两阶段问题;其次,对物资需求量进行模糊需求预测,并使用可信性模糊机会约束规划将其转化为确定型约束;最后,设计改进灰狼优化(Improved Grey Wolf Optimization,IGWO)算法求解问题。IGWO算法采用佳点集初始化种群,对收敛因子进行余弦规律的非线性变化,并在粒子群优化(Particle Swarm Optimization,PSO)算法个体记忆的启发下,设计个体位置更新公式。在用10个标准函数验证IGWO有效性的基础上,通过湖北省新型冠状病毒应急物资中心选址案例分析,表明IGWO算法能有效求解多目标选址问题,在提高满意度的基础上降低经济成本,且多阶段模型在平衡满意度和经济成本方面结果更优。

关键词：公共安全应急救援选址改进灰狼优化算法多目标优化模糊需求个体记忆

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水面无人艇单目视觉伺服自主控制研究综述

中国舰船研究 2024年第1期19卷 15-28页

作者：何红坤王宁张富宇韩冰大连海事大学船舶电气工程学院辽宁大连116026 大连海事大学轮机工程学院辽宁大连116026 江苏海洋大学海洋工程学院江苏连云港222005 上海船舶运输科学研究所上海200135

单目视觉伺服采用相机模仿人眼视觉功能,感知周围环境和测量运动状态,是提高无人艇航行感知与控制自主性的重要手段。首先,从基本原理出发,简述视觉伺服技术分类、相机透视投影原理和无人艇运动数学模型,为文献综述分析提供框架基础。然... 详细信息

单目视觉伺服采用相机模仿人眼视觉功能,感知周围环境和测量运动状态,是提高无人艇航行感知与控制自主性的重要手段。首先,从基本原理出发,简述视觉伺服技术分类、相机透视投影原理和无人艇运动数学模型,为文献综述分析提供框架基础。然后,根据任务复杂度,依次综述单目视觉伺服在无人艇航向控制、镇定控制、轨迹跟踪控制和集群控制等典型应用场景下的研究进展和挑战。最后,系统性地总结无人艇单目视觉伺服自主控制的潜在研究方向和发展趋势。

关键词：无人艇单目视觉伺服航向控制镇定控制轨迹跟踪控制集群控制