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Three cases of Solitary Peutz-Jeghers-type hamartomatous polyp in the duodenum

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World Journal of Gastroenterology 2008年第6期14卷 944-947页

作者： Seiyuu Suzuki Shoji Hirasaki fusao ikeda Eiichiro Yumoto Hiromichi Yamane Minoru Matsubara Department of Internal Medicine Sumitomo Besshi Hospital Niihama Japan

A solitary Peutz-Jeghers-type hamartomatous polyp in the duodenum is rare, and few reports have described its characteristic endoscopic features. We describe three cases of solitary Peutz-Jeghers-type hamartomatous polyp and their endoscopic findings in detail. The polyp in all of our three cases showed an irregularly lobular or nodular surface, whereas adenomas often show a regularly nodular or granular surface. The color of the polyp was whitish in all of our cases. In the present cases, close observation by endoscopy revealed that the solitary Peutz-Jeghers-type hamartomatous polyps looked whitish because of the presence of diffusely scattered white spots on the surface of the polyps. Duodenal polyps that exhibit the aforementioned endoscopic characteristics may be diagnosed as Peutz-Jeghers-type hamartomatous polyps and treated by polypectomy because of the malignant potential.

关键词： Duodenal polyp Hamartoma Peutz-Jeghers polyp

Treatment of over 20 mm gastric cancer by endoscopic submucosal dissection using an insulation-tipped diathermic knife

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World Journal of Gastroenterology 2007年第29期13卷 3981-3984页

作者： Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujita fusao ikeda Hideaki Taniguchi Eiichiro Yumoto Seiyuu Suzuki From Second Department of Internal Medicine Sumitomo Besshi Hospital 3-1 Ohji-cho Niihama 792-8543 Japan

AIM： To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife （IT-ESD） for the treatment of patients with over 20 mm early gastric cancer （EGC）. METHODS： A total of 112 patients with over 10 mm EGC were treated with IT-ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 5 year period from January 2002 to December 2006, including 40 patients with over 20 mm EGC. We compared patient backgrounds, the one-piece resection rate, complete resection （CR） rate, operation time, bleeding rate, perforation rate between patients with over 20 mm EGC [over 20 mm group （21-40 ram）] and the remaining patients （under 20 mm group）. RESULTS： We found no significant difference in the rate of underlying cardiopulmonary disease （over 20 mm group vs under 20 mm group, 5.0% vs 5.6%）, one- piece resection rate （95% vs 96%）, CR rate （85% vs 89%）, operation time （72.3 rain vs 66.5 rain）, bleeding rate （50 vs 4.2%）, and perforation rate （0% vs 1.4%） between the 2 groups. Three patients in each group had submucosal invasion and two in each groups underwent additional surgery. CONCLUSION： There was no significant difference in the outcome resulting from IT-ESD between the 2 groups. Our study proves that IT-ESD is a feasible treatment for patients with over 20 mm mucosal gastric cancer although the long-term outcome should be evaluated in the future.

关键词： Gastric cancer Endoscopic mucosal resection Insulation-tipped diathermic knife Complication

Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development

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World Journal of Hepatology 2015年第19期7卷 2220-2228页

作者： Yasuto Takeuchi fusao ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharma- ceutical Sciences Department of Molecular Hepatology Okayama University Graduate School of Medicine Dentistry and Pharma- ceutical Sciences Department of Internal Medicine Okayama Saiseikai General Hospital Department of Internal Medicine Hiroshima City Hospital Department of Internal Medicine Kagawa Prefectural Central Hospital Department of Internal Medicine Kurashiki Central Hospital Department of Internal Medicine Mihara Red Cross hospital Department of Internal Medicine Fukuyama City Hospital Department of Internal Medicine National Hospital Organization Fukuyama Clinical Center Department of Internal Medicine Mitoyo General Hospital Department of Gastroenterology National Hospital Organization Iwakuni Clinical Center Department of Internal Medicine Sumitomo Besshi Hospital Department of Gastroenterology Tsuyama Central Hospital Health Service Center Okayama University

AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m ***: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients.

关键词： Hepatitis C virus Interferon Hepatocellular carcin

Seroprevalence of Helicobacter pylori in dyspeptic patients and its relationship with HIV infection,ABO blood groups and life style in a university hospital,Northwest Ethiopia

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World Journal of Gastroenterology 2006年第12期12卷 1957-1961页

作者： Feleke Moges Afework Kassu Getahun Mengistu Solomon Adugna Berhanu Andualem Takeshi Nishikawa fusao Ota Department of Microbiology and Parasitology Gondar College of Medicine and Health SciencesUniversity of GondarEthiopia Department of Preventive Environment and Nutrition Institute of Health BiosciencesThe University of TokushimaJapan Department of Internal Medicine Faculty of MedicineAddis Ababa UniversityEthiopia Department of Biochemistry Gondar College of Medicine and Health SciencesUniversity of GondarEthiopia Department of Biology Faculty of Applied Science.University of Gondar.Ethiopia Hokkaido University of Education Sapporo CampusDivision of Medicine and NursingJapan

AIM： To determine the prevalence of Helicobacter pylori （H pylori） among dyspeptic patients and to assess the relationship between Hpylori infection, blood group, HIV infection and life style of the patients. METHODS： In a hospital-based cross-sectional study, patients attending Outpatient Department of University of Gondar Hospital were enrolled. Socio-demographic information was collected using questionnaires. Serum was analyzed for anti-H pylori IgG antibodies using a commercial kit. HIV serostatus was determined by enzyme-linked immunosorbent assay （ELISA）. Blood grouping was performed by slide agglutination tests. RESULTS： A total of 215 dyspeptic patients were included in the study. One hundred and sixteen patients （54%） were females and 99 （46%） were males. Anti-H pylori IgG antibodies were detected in sera of 184 （85.6%） patients. The prevalence was significantly higher in patients aged 50 years and above. Twenty point five percent of the patients were found to be seropositive for HIV. No significant association was found between sex, ABO blood groups, consumption of spicy diets, socioeconomic status and seropositivity for Hpylori. However,alcohol consumption was significantly associated with H pylori serology. CONCLUSION： The prevalence of H pylori infection is associated with a history of alcohol intake and older age. The effect of different diet, alcohol and socioeconomic status as risk factors for H pylori infection needs further study.

关键词： Hpylori Blood group HIV Life style

Forefront Research on Lactic Acid Bacteria in Japan

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Forefront Research on Lactic Acid Bacteria in Japan

小鼠膜联蛋白Ⅱ基因剔除重组子的构建及小鼠无膜联蛋白Ⅱ细胞系的建立(英文)

第四届“益生菌、益生元与健康”国际研讨会

作者： fusao Tomita Director Hokkaido Study Center The University of the Air

Lactic acid bacteria(LAB)can be defined as those bacteria producing lactic acid,and is comprised of diverse genera found to have varied physiological *** is also known that LABis closely associated with human life,esp... 详细信息

关键词： Forefront Research on Lactic Acid Bacteria in Japan

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细胞生物学杂志 2006年第5期28卷 721-725页

作者：侯颖春 Aiko Hirata fusao Hirata 陕西师范大学生命科学学院 College of Pharmacy Sciences Wayne State UniversityDetroitMichigan 48201USA

为了便于对膜联蛋白II(annexinII)的进一步研究以及今后进一步发展膜联蛋白II-/-动物模型,构建了膜联蛋白II基因封闭重组子(pPNT/annexinII/LacZ),筛选了细胞(L5178Y)克隆,并获得了膜联蛋白II-/-稳定细胞克隆(D4,E2)。所获膜联蛋白II-/-... 详细信息

为了便于对膜联蛋白II(annexinII)的进一步研究以及今后进一步发展膜联蛋白II-/-动物模型,构建了膜联蛋白II基因封闭重组子(pPNT/annexinII/LacZ),筛选了细胞(L5178Y)克隆,并获得了膜联蛋白II-/-稳定细胞克隆(D4,E2)。所获膜联蛋白II-/-L5178Y克隆有待于以PCR做进一步鉴定。

关键词：膜联蛋白基因剔除细胞系

Prediction of Earth Pressures on a Pile Group Due to Liquefaction Induced Ground Flow

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Prediction of Earth Pressures on a Pile Group Due to Liquefa...

DC Plasma Technology Applied to Powder Metallurgy: an Overview

The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational MechanicsⅠ

作者： Ryosuke Uzuoka Motoki Kazama Atsushi Yashima fusao Oka Department of Civil Engineering Tohoku University Aoba 06 Sendai 980-8579 Japan Department of Civil Engineering Tohoku University Aoba 06 Sendai 980-8579 Japan Department of Civil Engineering Gifu University Yanagido 1-1 Gifu 501-1193 Japan Department of Civil and-Earth Resources Engineering Yoshida Honmachi Kyoto 606-8501 Japan

Numerous buildings with pile foundation adjacent to quay walls were seriously damaged during the 1995 Hyogo-ken Nanbu earthquake. Among the damaged buildings, many of them tilted and /or settled, in spite of the fact that no significant damage to the superstructure was observed. Field investigations for some damaged buildings showed that the failures of piles within reclaimed layers caused these serious damages. It was suggested that large earth pressures were subjected to the pile due to liquefaction-induced ground flow. However, the mechanism of the earth pressure of a pile group has not yet been clarified, and the precise prediction of the earth pressure is also very difficult.

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Plasma Science and Technology 2013年第1期15卷 70-81页

作者： A. N. KLEIN R. P. CARDOSO H. C. PAVANATI C. BINDER A. M. MALISKA G. HAMMES D. fusao A. SEEBER S. F. BRUNATTO J. L. R. MUZART LabMat (Materials Laboratory) Departamento de Engenharia Mec~nica Universidade Federal de Santa Catarina (UFSC) 88040-900 FlorianSpolis - SC Brazil Departamento de Engenharia Mecanica Universidade Federal do Parana (UFPR) 81531-990 Curitiba- PR Brazil Departamento Academico de Metal-Mecanica Instituto Federal de Santa Catarina (IFSC) 88020-300 Florianopolis - SC Brazil Universidade Tecnologica Federal do Parana (UTFPR) 84016-210 Ponta Grossa - PR Brazil Centro de Ciencia e Tecnologia Universidade de Caxias do Sul 95070-560 Caxias do Sul- RS Brazil

DC plasma is a very promising technology for processing different materials, and is becoming especially interesting when low environmental impact and high-performance treatments are needed. Some of the intrinsic characteristics of DC plasma technology, which make it suitable for powder metallurgy （PM） and powder injection molding （PIM） parts production, are low- pressure processing and plasma environment high reactivity. Moreover it can be considered as a highly competitive green technology. In this work, an overview of some of the important DC plasma techniques applied to PM and PIM parts processing is presented. Emphasis is given to the descriptions of the main characteristics and the technique potentials of plasma-assisted nitriding, plasma-assisted thermal debinding, plasma-assisted sintering, and simultaneously plasma-assisted sintering and surface alloying. The aspects presented and discussed in this paper indicate that DC plasma processes are promising and competitive techniques for PM and PIM parts processing.

关键词： powder metallurgy DC glow discharge plasma nitriding plasma sintering,plasma-assisted thermal debinding surface alloying

Forefront Research on Lactic Acid Bacteria in Japan

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现代食品科技 2005年第4期21卷 137-137页

作者： fusao Tomita Hokkaido Study Center