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Simple Insulin dose Adjustment Using 3-3-1 Algorithm in Japanese Patients with Type 2 diabetes: Start Kanazawa Study (Self-Titration Aggressive Algorithm with Glargine Trial)

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Journal of diabetes Mellitus 2016年第3期6卷 197-203页

作者： Kenji d. furukawa Naoto Yamaaki Aya Fujimoto Kiminori Ohyama Hiroaki Muramoto department of Internal Medicine Japan Community Health care Organization (JCHO) Kanazawa Hospital Kanazawa Japan

We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 patients, 21 patients in the newly-initiated group and 25 patients in the existing BOT group performed dose adjustment using 3-3-1 algorithm. HbA1c was significantly improved 4 weeks after the initiation from 8.5% ± 1.2% at baseline to 7.3% ± 0.7% at the final evaluation (p 0.01, vs. Baseline). The average daily insulin units increased throughout the study period from 10.1 ± 6.7 at baseline to 14.6 ± 8.9 units at the final evaluation. Weight didn’t significantly change throughout the study (p = 0.12). The incidents of hypoglycemia were 0.8/month during the insulin dose self-adjustment period and 0.4/month during the follow-up period. The 3-3-1 algorithm using insulin glargine provided a safe and simple dose adjustment and demonstrated its utility in patients who were newly introduced to insulin treatment as well as who were already on BOT.

关键词： Glargine Self-Titration BOT T2dM Insulin 3-3-1 Algorithm

Characteristics of glucose change in diabetes mellitus generalized through continuous wavelet transform processing:A preliminary study

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World Journal of diabetes 2023年第10期14卷 1562-1572页

作者： Yoichi Nakamura Shinya furukawa Cardiovascular Medicine&diabetology Specified Clinic of Soyokaze CardioVascular Medicine and Diabetes CareMatsuyama 790-0026EhimeJapan Health Services Center Ehime UniversityMatsuyama 790-8577EhimeJapan

BACKGROUNd The continuous glucose monitoring(CGM)system has become a popular evaluation tool for glucose fluctuation,providing a detailed description of glucose change *** hypothesized that glucose fluctuations may contain specific information on differences in glucose change between type 1 diabetes mellitus(T1dM)and type 2 diabetes mellitus(T2dM),despite similarities in change patterns,because of different *** Fourier transform,continuous wavelet transform(CWT)is able to simultaneously analyze the time and frequency domains of oscillating *** To investigate whether CWT can detect glucose fluctuations in *** The 60-d and 296-d glucose fluctuation data of patients with T1dM(n=5)and T2dM(n=25)were evaluated *** data obtained every 15 min for 356 d were *** were assessed by CWT with Morlet form(n=7)as the mother *** methodology was employed to search for limited frequency glucose fluctuation in the daily glucose *** frequency and enclosed area(0.02625 scalogram value)of 18 emerged signals were *** specificity for T1dM was evaluated through multiple regression analysis using items that demonstrated significant differences between them as explanatory *** The high frequency at midnight(median:75 Hz,cycle time:19 min)and middle frequency at noon(median:45.5 Hz,cycle time:32 min)were higher in T1dM vs T2dM(median:73 and 44 Hz;P=0.006 and 0.005,respectively).The area of the>100 Hz zone at midnight to forenoon was more frequent and larger in T1dM vs *** a day,the lower frequency zone(15-35 Hz)was more frequent and the area was larger in T2dM than in *** threedimensional scatter diagrams,which consist of the time of day,frequency,and area of each signal after CWT,revealed that high frequency signals belonging to T1dM at midnight had a loose distribution of wave cycles that were 17-24 *** analysis revealed that the high frequency signal at midnight could c

关键词： Continuous glucose monitoring Pathophysiology Fourier,Pseudo-frequency Contour map Scalogram matrix

dynamic properties of a flexible metal-organic framework exhibiting a unique"picture frame"-like crystal morphology

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Nano Research 2021年第2期14卷 432-437页

作者： Kenji Sumida Nao Horike Shuhei furukawa Institute for Integrated Cell-Material Sciences(WPI-iCeMS) Kyoto UniversityYoshidaSakyo-kuKyoto 606-8501Japan Centre for Advanced Nanomaterials School of Physical SciencesUniversity of AdelaideSA 5005Australia

The precise control of the crystal morphology of metal-organic frameworks(MOFs)enables optimization of its adsorptive properties,as well as enables better integration within functional ***,the influence of such modifications on the dynamic properties of flexible MOFs is poorly understood Here,we report the synthesis of a series of Cu_(2)(bdc)_(2)(bpy)(bdc^(2-)=1,4-benzenedicarboxylate;bpy=4,4,-bipyridine)crystals having an unusual picture frame-like morphology that results from a restriction in the quantity of bpy pillars added to the reaction mixture during the intercalation of the Cu_(2)(bdc)_(2)(MeOH)_(2)*** width of the frames is found to correlate with the quantity of bpy,and importantly,causes the dynamic properties of the resulting Cu_(2)(bdc)_(2)(bpy)material to vary between rigid,elastic,and shape memory *** all,the results demonstrate the potential for the properties of MOFs to be optimized via subtle manipulations in the crystal morphology rather than changes in the overall material composition.

关键词： metal-organic frameworks morphology control framework flexibility shape-memory effect gas sorption

CONTRIBUTION OF MACROSCOPIC dIMENSION EFFECT TO PIEZOELFCTRICITY IN POLYVINYLIdENE FLUORIdE

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Chinese Journal of Polymer Science 1987年第4期5卷 292-297页

作者：闻建勋,TAKEO furukawa Shanghai Institute of Organic Chemistry Academia Sinica Shanghai The Institute of Physical and Chemical Research Japan

In this paper, we have studied the piezoelectricity in the poled uniaxially drawn polyvinylidene fluoride. The piezoelectric constants d31, d32, d33αand Young's moduli 1/s11 and 1/s22have been determined as a function of the remanent polarization Pr. The piezoelectric constants of the samples show a strong in-plane anisotropy. Such an anisotropy is mostly attributable to different Poisson's ratio. It is found that the piezoelectric activity mainly arises from macroscopic dimensional change.

关键词： Piezoelectricity Pyroelectricity Polyvinylidene fluoride.

高分散的Pt促进氨分解中活性Fe_(x)N的形成

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Chinese Journal of Catalysis 2023年第7期50卷 297-305页

作者： Keshia Saradima Indriadi 韩沛杰丁世鹏姚冰清 Shinya furukawa 何迁颜宁新加坡国立大学化学与生物分子工程系新加坡新加坡新加坡国立大学与天津大学联合学院福建福州350207 新加坡国立大学材料科学与工程系新加坡新加坡北海道大学催化研究所札幌日本

在氢经济的背景下,氨分解在制氢中起着重要作用.铁基催化剂因价格低廉且活性适中而备受欢迎,对大规模应用具有吸引力.然而,铁基催化剂向更高活性Fe_(x)N物种的转化较慢,导致诱导期延长.为了解决该问题,本文研究了在氨分解中添加Pt对Fe_(... 详细信息

在氢经济的背景下,氨分解在制氢中起着重要作用.铁基催化剂因价格低廉且活性适中而备受欢迎,对大规模应用具有吸引力.然而,铁基催化剂向更高活性Fe_(x)N物种的转化较慢,导致诱导期延长.为了解决该问题,本文研究了在氨分解中添加Pt对Fe_(x)N形成的影响.结果表明,即使添加少量(0.1 wt%)Pt,也能显著提高Fe_(x)N的形成速率,使其增加3倍以上.Pt通过反溢流促进H_(2)脱附,相反,反溢流暴露出更多发生氮化的Fe表面位点,导致Fe_(x)N的形成.高角度环形暗场扫描透射电子显微镜、X射线衍射和原位X射线吸收光谱表征揭示了Fe2N活性物质的形成.H_(2)程序升温脱附、H_(2)程序升温还原和原位X射线吸收谱证实了氢反溢流和溢流效应的存在.总之,本文加深了对铁催化剂在氨分解中活性物种形成机制的理解,为提高其催化性能提供了一个简单策略.

关键词：氨分解氮化铁氮化 Pt促进氢反溢流

Huge capacity spacial division multiplexing transmission and integrated optical switching technologies(Invited Paper)

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Chinese Optics Letters 2016年第12期14卷 12-16页

作者： Naoya Wada Ben J.Puttnam Ruben S.Luis Werner Klaus Jun Sakaguchi Jose M.d.Mendinueta Yoshinari Awaji Satoshi Shinada Hideaki furukawa National Institute of Information and Communications Technology Tokyo 184-8795 Japan

We review the research and development of beyond Pb/s capacity space-division-multiplexed transmission technology using multi-core optical fibers for satisfying the ever-increasing traffic demand. Moreover, we present an optical packet and circuit integrated network technology to improve switching capacity and flexibility in network nodes for the rapid traffic fluctuation and the data service diversification.

关键词： switching multiplexing satisfying fluctuation traffic packet frames transmit throughput overhead

Identifying Key descriptors for the Single-Atom Catalyzed CO Oxidation

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CCS Chemistry 2022年第10期4卷 3296-3308页

作者： Max J.Hülsey Sambath Baskaran Shipeng ding Sikai Wang Hiroyuki Asakura Shinya furukawa Shibo Xi Qi Yu Cong-Qiao Xu Jun Li Ning Yan department ofChemicalandBiomolecularEngineering NationalUniversityofSingaporeSingapore 117585 department of Chemistry Southern University of Science and TechnologyShenzhen 518055 Joint School of National University of Singapore Tianjin UniversityInternational Campus of Tianjin UniversityBinhai New CityFuzhou 350207 department of Molecular Engineering Graduate School of EngineeringKyoto UniversityKyoto 615-8510615-8245 Elements Strategy Initiative for Catalysts and Batteries(ESICB) Kyoto UniversityKyoto 615-8245 Institute for Catalysis Hokkaido UniversitySapporo 001-0021 Institute for Chemical and Engineering Sciences Agency for ScienceTechnologyand Research in SingaporeSingapore 138634 Shaanxi Key Laboratory of Catalysis Shaanxi University of TechnologyHangzhou 723001 department of Chemistry Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of EducationTsinghua UniversityBeijing 100084

Fundamental knowledge of structure-activity correlations for heterogeneous single-atom catalysts(SACs)is essential in guiding catalytic *** linear scaling relations are powerful for predicting the performance of traditionalmetal catalysts,they appear to fail with the involvement of *** the catalytic CO oxidation activity of different atomically dispersed metals(3d,4d,and 5d)in conjunction with computational modeling enabled us to establish multiple scaling relations between the activity and simply calculated descriptors.

关键词： scaling relations transition metals carbon monoxide single-site catalysts polyoxometalate

海绵作填料在上流式厌氧固定床反应器中厌氧氨氧化

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北京工业大学学报 2009年第12期35卷 1670-1674页

作者：吕鑑张莉 Kenji furukawa 梁小田北京工业大学建筑工程学院北京100124 Graduate School of Science and Technology Kumamoto University 北京市市政工程设计研究总院北京100082

为了研究以海绵作填料进行厌氧氨氧化反应的可行性,在某上流式厌氧固定床反应器中利用人工配制高NH4-N水进行了实验研究.结果表明,利用人工配制废水作为实验用水,在水力停留时间为3.1 h,容积负荷为3.5 kg/(m3.d)时,总氮的去除率可达到7... 详细信息

为了研究以海绵作填料进行厌氧氨氧化反应的可行性,在某上流式厌氧固定床反应器中利用人工配制高NH4-N水进行了实验研究.结果表明,利用人工配制废水作为实验用水,在水力停留时间为3.1 h,容积负荷为3.5 kg/(m3.d)时,总氮的去除率可达到75%.稳态运行时,反应器内部呈碱性,NH4-N去除量、NO2-N去除量与NO3-N的生成量之间的比值为1∶1.21∶0.19.以海绵作填料,与其他填料(新型丙烯酸纤维、聚乙烯醇凝胶)相比,所需启动时间短,操作简便,并能在较短的水力停留时间内高效地处理高浓度的NH4-N废水.

关键词：厌氧氨氧化脱氮亚硝氮硝氮总氮

Successful hepatic resection for recurrent hepatocellular carcinoma after lenvatinib treatment:A case report

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World Journal of Hepatology 2020年第12期12卷 1349-1357页

作者： Hideki Yokoo Hiroyuki Takahashi Masahiro Hagiwara Hiroyoshi Iwata Koji Imai Yoshinori Saito NaotoMatsuno Hiroyuki furukawa division of Hepato-Biliary-Pancreatic Surgery and Transplant Surgery Department of SurgeryAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan department of Gastroenterology Asahikawa-Kosei General HospitalAsahikawa 078-8211HokkaidoJapan

BACKGROUNd Lenvatinib has been shown to be noninferior to sorafenib regarding prognosis and recurrence rate in patients with unresectable hepatocellular carcinoma(HCC)who have not received prior systemic *** patients treated with lenvatinib,40%of cases achieved sufficient tumor reduction to make potential surgery ***,the outcomes of such surgery are *** report a successful case of hepatic resection for recurrent HCC after lenvatinib *** SUMMARY A 69-year-old man underwent right anterior sectionectomy for HCC in segment 8 of the *** months later,he was found to have an intrahepatic HCC recurrence that grew rapidly to 10 cm in diameter with sternal bone *** confirming partial response to lenvatinib administration for 2 mo,a second hepatectomy was *** examination showed that 80%of the tumor was *** patient did not develop any adverse effects under lenvatinib *** was discharged at 25 d after *** therapy for bone metastases continued to be given under lenvatinib,and the patient has remained alive for 1 year after the second *** The prognosis of patients with recurrent HCC may be improved by liver resection combined with prior lenvatinib therapy.

关键词： Conversion to surgery Lenvatinib Recurrent hepatocellular carcinoma Case report Neoadjuvant therapy Molecular targeted therapy