检索结果-南通市图书馆

Development of CONTHAC-3D and hydrogen distribution analysis of HPR1000

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第2期35卷 210-221页

作者： Hui wang jing-jing li Yuan Chang Gong-lin li Ming ding China Nuclear Power Engineering Co.LTD. Beijing 100084China Fundamental Science on Nuclear Safety and Simulation Technology Laboratory Harbin 100049China

An in-house code,CONTHAC-3D,was developed to calculate and analyze thermal-hydraulic phenomena in containments during severe ***-3D is a three-dimensional computational fluid dynamics code that can be applied to predict gas flow,diffusion,and steam condensation in a containment during a severe hypothetical accident,as well as to obtain an estimate of the local hydrogen concentration in various zones of the ***-3D was developed using multiple models to simulate the features of the proprietary systems and equipment of HPR1000 and ACP100,such as the passive cooling system,passive autocatalytic recombiners and the passive air cooling *** validate CONTHAC-3D,a GX6 test was performed at the Battelle Model Containment *** hydrogen concentration and temperature monitored by the GX6 test are accurately predicted by ***,the hydrogen distribution in the HPR1000 containment during a severe accident was *** results show that the hydrogen removal rates calculated using CONTHAC-3D for different types of PARs agree well with the theoretical values,with an error of less than 1%.As the accident progresses,the hydrogen concentration in the lower compartment becomes higher than that in the large space,which implies that the lower compartment has a higher hydrogen risk than the dome and large space at a later stage of the *** amount of hydrogen removed by the PARs placed on the floor of the compartment is small;therefore,raising the installation height of these recombiners appropriately is ***,we do not recommend installing all autocatalytic recombiners at high *** study findings in regard to the hydrogen distribution in the HPR1000 containment indicate that CONTHAC-3D can be applied to the study of hydrogen risk containment.

关键词： Hydrogen risk mitigation Pressurized water reactor HPR1000 Thermal hydraulic CONTHAC-3D

Optimal Bidding Strategy for PV and BESSs in Joint Energy and Frequency Regulation Markets Considering Carbon Reduction Benefits

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 427-439页

作者： jing Bian Yuheng Song Chen ding Jianing Cheng Shiqiang li Guoqing li Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Ministry of Education Northeast Electric Power UniversityJilin 132000China Datang Northeast Electric Power Test&Research Institute Co. Ltd.Changchun 130102China

Photovoltaic(PV)and battery energy storage systems(BESSs)are key components in the energy market and crucial contributors to carbon emission reduction *** systems can not only provide energy but can also generate considerable revenue by providing frequency regulation services and participating in carbon *** study proposes a bidding strategy for PV and BESSs operating in joint energy and frequency regulation markets,with a specific focus on carbon reduction benefits.A two-stage bidding framework that optimizes the profit of PV and BESSs is *** the first stage,the day-ahead energy market takes into account potential real-time forecast *** the second stage,the real-time balancing market uses a rolling optimization method to account for multiple ***,a real-time frequency regulation control method is proposed for the participation of PV and BESSs in automatic generation control(AGC).This is particularly relevant given the uncertainty of grid frequency fluctuations in the optimization model of the real-time balancing *** control method dynamically assigns the frequency regulation amount undertaken by the PV and BESSs according to the control interval in which the area control error(ACE)*** case study results demonstrate that the proposed bidding strategy not only enables the PV and BESSs to effectively participate in the grid frequency regulation response but also yields considerable carbon emission reduction benefits and effectively improves the system operation economy.

关键词： Photovoltaic(PV) battery energy storage system(BESS) energy market carbon market frequency regulation service bidding strategy

N,S,Br co-doped carbon dots:One-step synthesis and fluorescent detection of 6-mercaptopurine in tablet

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第2期14卷 291-293页

作者： Qi wang Ying Cheng lifeng ding Shengling li Jie Zhang Yulan Niu Ziye jing Chemistry&Chemical Engineering Department Taiyuan Institute of TechnologyTaiyuan030008China Department of Anesthesiology First Hospital of Shanxi Medical UniversityTaiyuan030001China

6-mercaptopurine(6-MP),a purine derivative(3,7-dihydropurine-6-thione),has been utilized as an effective immunosuppressive drug for clinically treating leukemia and other autoimmune diseases[1].6-MP and its corresponding metabolites can suppress the function of RnaseH,and thus they are cytotoxic and threaten the human health[2].Therefore,the accurate quantification of 6-MP is *** date,researchers continue to expend considerable effort in developing 6-MP detection *** analysis eliminates disadvantages,such as toxic solvents,expensive equipment.

关键词： purine synthesis eliminate

Bolstering the Mechanical Robustness of Supramolecular Polymer Network by Mechanical Bond

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第10期42卷 1536-1544,I0012页

作者： Yuan-Hao wang jing-Xi Deng Jun Zhao Yi ding li Yang Zhao-Ming Zhang Xu-Zhou Yan School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai200240China

Supramolecular polymer networks(SPNs)are celebrated for their dynamic nature,yet they often exhibit inadequate mechanical *** far,the quest to bolster the mechanical resilience of SPNs while preserving their dynamic character presents a formidable ***,we introduce[2]rotaxane into SPN to serve as another cross-link,which could effectively enhance the mechanical robustness of the polymer network without losing the dynamic *** with SPN,the dually cross-linked network(DPN)demonstrates superior breaking strength,Young’s modulus,puncture force and toughness,underscoring its superior ***,the cyclic tensile tests reveal that the energy dissipation capacity of DPN rivals,and in some cases surpasses,that of SPN,owing to the efficient energy dissipation pathway facilitated by[2]*** addition,benefiting from stable topological structure of[2]rotaxane,DPN exhibits accelerated recovery from deformation,indicating superior elasticity compared to *** strategy elevates the performance of SPNs across multiple metrics,presenting a promising avenue for the development of high-performance dynamic materials.

关键词： Rotaxane cross-links Dually cross-linked network Supramolecular polymer network Host-guest recognition Dynamic materials

Carbon Dots as“On–Off–On”Fluorescence Sensors for Selective and Consecutive Detection of 4-Nitrophenol and Cerium(IV)in Water Samples

在线全文

学校读者我要写书评

暂无评论

Journal of Analysis and Testing 2024年第2期8卷 201-209页

作者： jing Yang Hao liu Yan Huang li li Huajie liu Yaping ding Department of Chemistry College of SciencesShanghai UniversityShanghai200444China School of Chemical Science and Engineering Tongji UniversityShanghai200092China

An“on–off–on”fluorescence sensor was designed for rapidly and consecutively detecting 4-nitrophenol and cerium(IV)without the use of any labeling *** yellow carbon dots were synthesized by a simple one-step hydrothermal approach,and various techniques were applied to investigate the morphology,structure,and optical properties of the carbon *** the optimal experimental conditions,4-nitrophenol rapidly quenched the fluorescence of carbon dots as a result of the inner filter eff ect(IFE).The fluorescence intensity of carbon dots was linear with the concentration of 4-nitrophenol(1–150μmol/L)and the limit of detection was 0.32μmol/*** fluorescence was gradually recovered as the cerium(IV)concentration(0.5–100μmol/L)increased in CDs/4-NP,and the limit of detection was 0.16μmol/*** sensor showed good selectivity and demonstrated high accuracy for the analysis of 4-nitrophenol and cerium(IV)in actual water samples.

关键词： Carbon dots Fluorescence sensor 4-Nitrophenol Cerium(IV) Water samples

Salivary metabolites are promising noninvasive biomarkers of druginduced liver injury

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第18期30卷 2454-2466页

作者： Si-Miao Yu Hao-Cheng Zheng Si-Ci wang Wen-Ya Rong Ping li jing jing Ting-Ting He Jia-Hui li Xia ding Rui-lin wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology of Traditional Chinese Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China The First Clinical Medical College Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Drug-induced liver injury(DIli)is one of the most common adverse events of medication use,and its incidence is ***,early detection of DIli is a crucial challenge due to a lack of biomarkers and noninvasive *** To identify salivary metabolic biomarkers of DIli for the future development of noninvasive diagnostic *** Saliva samples from 31 DIli patients and 35 healthy controls(HCs)were subjected to untargeted metabolomics using ultrahigh-pressure liquid chromatography coupled with tandem mass *** analyses,including partial least squares-discriminant analysis modeling,t tests and weighted metabolite coexpression network analysis(WMCNA),were conducted to identify key differentially expressed metabolites(DEMs)and metabolite *** we utilized least absolute shrinkage and selection operato and random fores analyses for biomarker *** use of each metabolite and metabolite set to detect DIli was evaluated with area under the receiver operating characteristic *** We found 247 differentially expressed salivary metabolites between the DIli group and the HC *** WMCNA,we identified a set of 8 DEMs closely related to liver injury for further prediction ***,the distinct separation of DIli patients and HCs was achieved with five metabolites,namely,12-hydroxydodecanoic acid,3-hydroxydecanoic acid,tetradecanedioic acid,hypoxanthine,and inosine(area under the curve:0.733-1).CONCLUSION Salivary metabolomics revealed previously unreported metabolic alterations and diagnostic biomarkers in the saliva of DIli *** study may provide a potentially feasible and noninvasive diagnostic method for DIli,but further validation is needed.

关键词： Drug-Induced liver injury Salivary Metabolomics Biomarker Weighted metabolite Coexpression network analysis Machine learning Noninvasive Diagnostic method Metabolites

Mental retardation,seizures and language delay caused by new SETD1B mutations:Three case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第2期12卷 383-391页

作者： Le ding li-Wan Wei Tai-Song li jing Chen Department of Neurology Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Chigene(Beijing)Translational Medical Research Center Co.Ltd.Beijing 101111China

BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve *** in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language *** SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B *** individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were *** article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment *** the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had *** treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat *** exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(***1825trp),c.4120C>T(***1374*,593),c.14_15insC(***5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language *** the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of ***,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.

关键词： Neurodevelopmental disorder Seizure SETD1B gene Whole-exome sequencing New mutation Case report

Direct Ischemic Postconditioning Following Stroke Thrombectomy:A Promising Therapy for Reperfusion Injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第7期40卷 1017-1020页

作者： jing wang Lu Yang Longfei Wu Sijie li Changhong Ren Yuchuan ding Ming Wei Xunming Ji Wenbo Zhao Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Wayne State University School of MedicineDetroitMI48201USA Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China Department of Neurosurgery Tianjin Huanhu HospitalTianjin 300222China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Recanalization of occluded vessels and timely reperfusion are the primary therapies for acute ischemic stroke(AIS),with endovascular thrombectomy proven as the most effective therapy for large-vessel recanalization and improved outcomes of AIS ***,despite a high recanalization rate of 90% or even higher,the rate of 3-month functional independence is approximately 50%,while mortality remains around 15%[1].

关键词： mortality acute Therapy

Textured Asymmetric Membrane Electrode Assemblies of Piezoelectric Phosphorene and Ti_(3)C_(2)T_(x)MXene Heterostructures for Enhanced Electrochemical Stability and Kinetics in liBs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第4期16卷 394-414页

作者： Yihui li Juan Xie Ruofei wang Shugang Min Zewen Xu Yangjian ding Pengcheng Su Xingmin Zhang liyu Wei jing‑Feng li Zhaoqiang Chu jingyu Sun Cheng Huang Volta and DiPole Materials Labs College of EnergySoochow Institute for Energy and Materials InnovationS(SIEMIS)Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceKey Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical IndustrySoochow UniversitySuzhou 215006People’s Republic of China School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013People’s Republic of China College of Underwater Acoustic Engineering Harbin Engineering UniversityHarbin 150001People’s Republic of China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201204People’s Republic of China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084People’s Republic of China High Density Materials Technology Center for Flexible Hybrid Electronics Suzhou Institute of Electronic Functional Materials TechnologySuzhou Industrial Technology Research InstituteSuzhou 215151People’s Republic of China Institute of Advanced Materials and Institute of Membrane Science and Technology Jiangsu National Synergistic Innovation Center for Advanced MaterialsSuzhou Laboratory and Nanjing Tech UniversityNanjing 211816People’s Republic of China

Black phosphorus with a superior theoretical capacity(2596 mAh g^(-1))and high conductivity is regarded as one of the powerful candidates for lithium-ion battery(liB)anode materials,whereas the severe volume expansion and sluggish kinetics still impede its applications in *** contrast,the exfoliated two-dimensional phosphorene owns negligible volume variation,and its intrinsic piezoelectricity is considered to be beneficial to the li-ion transfer kinetics,while its positive influence has not been discussed ***,a phosphorene/MXene heterostructure-textured nanopiezocomposite is proposed with even phosphorene distribution and enhanced piezo-electrochemical coupling as an applicable free-standing asymmetric membrane electrode beyond the skin effect for enhanced li-ion *** experimental and simulation analysis reveals that the embedded phosphorene nanosheets not only provide abundant active sites for li-ions,but also endow the nanocomposite with favorable piezoelectricity,thus promoting the li-ion transfer kinetics by generating the piezoelectric field serving as an extra *** waltzing with the MXene framework,the optimized electrode exhibits enhanced kinetics and stability,achieving stable cycling performances for 1,000 cycles at 2 A g^(-1),and delivering a high reversible capacity of 524 m Ah g^(-1)at-20℃,indicating the positive influence of the structural merits of self-assembled nanopiezocomposites on promoting stability and kinetics.

关键词： Phosphorene Nanopiezocomposite Piezo-electrochemical coupling Membrane electrode assembly lithium-ion storage