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敦煌研究 2009年第2期 45-49,122页

作者：蔡副全甘肃陇南师专美术系甘肃陇南746000

甘肃省陇南成县大云寺至今裸露着一处唐宪宗元和九年(814)的《李叔政题壁》墨迹,它是考察唐代题壁书法的重要实证,有着珍贵的文物价值。本文介绍《李叔政题壁》的位置、现状及书法艺术特征,考证作者及其相关问题。

关键词：题壁书陇南成县大云寺唐李叔政

Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance

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Science China(Life Sciences) 2019年第4期62卷 535-543页

作者： Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium Mental Health Center and Psychiatric Laboratory the State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China Tianjin Medical University General Hospital Tianjin Medical UniversityTianjin 300070China Hebei Mental Health Center Baoding 71000China Second Affiliated Hospital of Xinxiang Medical University Xinxiang 453002China Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China Huaxi Biobank West China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China Peking University Sixth Hospital(Institute of Mental Health) Beijing 100191China National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100191China 5Second Xiangya Hospital Central South UniversityChangsha 410011China Beijing Andi ng Hospital Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100088China Beijing HuiLongGuan Hospital Beijing 100096China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214151China Institute of Mental Health Tianjin Anding HospitalTianjin 300070China 不详

Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way.

关键词： MC4R antipsychotics metabolic disturbance

Skeletal Muscle Expresses and Secretes Apolipoprotein A-I

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生物物理学报 2009年第S1期25卷 241-242页

作者： Huina Zhang, Yang Wang, Huimin Na, fuquan Yang, Pingsheng Liu Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Apolipoprotein A-I (apoA-I), the principal apolipoprotein of high density lipoprotein (HDL) particle, has been the subject of intense investigation because of its

关键词： Skeletal Muscle Expresses and Secretes Apolipoprotein A-I

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陀螺经纬仪定向中灵敏部摆动中值的计算模型

辽宁工程技术大学学报（自然科学版） 2009年第2期28卷 195-197页

作者：汤伏全西安科技大学测绘科学与技术学院陕西西安710054

针对逆转点法陀螺经纬仪定向中,陀螺灵敏部摆动周期振幅衰减和摆动过程中重心漂移的特性,利用间接平差原理建立灵敏部摆动中值计算的衰减模型和漂移模型。采用两种数学模型对多组逆转点观测数据计算陀螺灵敏部摆动中值及其中误差。结果... 详细信息

针对逆转点法陀螺经纬仪定向中,陀螺灵敏部摆动周期振幅衰减和摆动过程中重心漂移的特性,利用间接平差原理建立灵敏部摆动中值计算的衰减模型和漂移模型。采用两种数学模型对多组逆转点观测数据计算陀螺灵敏部摆动中值及其中误差。结果表明:在多数情况下,采用衰减模型与现有舒勒公式的计算结果基本相同,计算值的中误差较小。在陀螺摆动状态不理想的情况下,采用漂移模型计算陀螺灵敏部摆动中值则具有较高的精度。

关键词：陀螺定向摆动中值衰减模型漂移模型

Inhibiting ADRB2 signaling suppresses HCC chemoresistance by regulating HIF-1α expression

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Inhibiting ADRB2 signaling suppresses HCC chemoresistance by...

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： fuquan Wu Zhiyu Cao the Eighth Medical Center of PLA General Hospital

Background: Chemoresistance of hepatocellular carcinoma(HCC) is a major clinical *** has been evidence that adrenergic signaling is closely related to tumor progression as well as chemoresistance. The present study aims to determine the function of β2-adrenergic receptor(ADRB2)signaling in chemoresistance of ***: Change in proportion of ADRB2 positive cells in HCC cell lines undergoing chemotherapy was tested. The effects of inhibiting ADRB2 signaling on cisplatin and doxorubicin chemoresistance of HCC cells were then detected via in vitro proliferation and apoptosis assays. Subsequently,the expression of HIF-1α during this process was observed by western-blot assays. Moreover, the efficacy of inhibiting ADRB2 signaling on cisplatin chemoresistance of HCC cells was examined again after HIF-1α ***: The proportion of ADRB2 positive cells in HCC cell lines markedly increased in response to chemotherapy. ICI118,551-mediated inhibition of ADRB2 signaling further reduced the viability of HCC cells undergoing chemotherapy. Meanwhile, HIF-1α was confirmed to be further downregulated. HIF-1α stabilization abolished the effect of blocking ADRB2 signaling on viability suppression of HCC cells undergoing ***: Our data uncovers that inhibiting ADRB2 signaling plays a critical role in suppressing HCC chemoresistance via decreasing HIF-1α expression.

关键词： ADRB2 HCC chemoresistance HIF-1α

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叶昌炽与敦煌文物补说

敦煌研究 2011年第2期 95-103页

作者：蔡副全陇南师范高等专科学校美术系甘肃陇南746000

关于叶昌炽与敦煌文物的接触与研究,吴琦幸《叶昌炽与敦煌研究》、李剑虹《论敦煌失宝及叶昌炽〈缘督庐日记钞〉》等已作过专题论述。然而,吴、李二先生文章仅依据《缘督庐日记钞》并非《缘督庐日记》原本文稿,故还有许多问题需要补充... 详细信息

关于叶昌炽与敦煌文物的接触与研究,吴琦幸《叶昌炽与敦煌研究》、李剑虹《论敦煌失宝及叶昌炽〈缘督庐日记钞〉》等已作过专题论述。然而,吴、李二先生文章仅依据《缘督庐日记钞》并非《缘督庐日记》原本文稿,故还有许多问题需要补充和深入探讨。本文以《缘督庐日记》和相关资料梳理了叶昌炽与敦煌文物接触的前前后后和是是非非。

关键词：敦煌叶昌炽缘督庐日记汪宗翰索允钟补说

Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders

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Signal Transduction and Targeted Therapy 2019年第1期4卷 320-322页

作者： Zhihua Yang Shuang Zhang fuquan Zhang Yao Yao Kwangwoo Kim David Meyre Hongmei Zhang Hai Liao Shuquan Rao Xinhe Huang School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214151China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 10005China Department of Biology Kyung Hee UniversitySeoul 02447Korea Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4K1Canada Department of Pathology and Molecular Medicine McMaster UniversityHamiltonON L8S 4K1Canada Department of Biology Georgia State UniversityAtlantaGA 30303USA

Dear Editor,Major mood disorders,which primarily include bipolar disorder(BD)and major depressive disorder(MDD),are among the most common psychiatric disorders and are recognized as leading causes of morbidity ***,twin and adoption studies have consistently indicated moderate-to-strong genetic contribu-tions to the risk of major mood disorders.1 Genetic association and genome-wide association studies(GWAS)suggest that there is some degree of overlap for some specific disorders but also specific genetic diversity.2 DAOA(D-amino acid oxidase activator),a gene located on human chromosome 13q33.2,plays a crucial role in the central nervous system through binding with DAO(encoding D-amino acid oxidase).Convergent lines of biological evidence suggest that DAOA is an attractive candidate gene for major mood disorders.

关键词： DAO attractive disorders

Overlying water fluoride concentrations influence dissolved organic matter composition and migration from pore water in sediment via bacterial mechanisms

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Environmental Science and Ecotechnology 2022年第2期10卷 23-33页

作者： Xiang Zhu Zibo Wang Yidan Luo Yushen Ma Zhipeng Xu Longmian Wang fuquan Peng Qingqing Pang Yiping Li Fei He Bin Xu Nanjing Institute of Environmental Sciences Ministry of Ecology and EnvironmentNanjing210042PR China China National Environmental Monitoring Centre No8-2 Anwai DayangfangChaoyang DistrictBeijing100012PR China College of Environment Hohai UniversityNanjing210098PR China

Fluoride(F^(-))is widespread in aquatic environments;however,it is not clear whether the fluctuation of F^(-)concentrations in overlying lake water affects the composition and migration of dissolved organic matter(DOM)from sediment.A case study was presented in Sand Lake,China,and an experiment was conducted to analyze the influence of different F^(-)concentrations in overlying water on DOM charac*** resulted in similarities in DOM components between overlying and pore waters,and bacterial activities and enzyme variation resulted in differences between *** F^(-)concentrations in overlying water resulted in a higher pH of pore water,which favored the enrichment of protein-like *** F^(-)concentrations caused lower DOM concentrations and lower maximum fluorescence intensities(Fmax)of protein-like components in pore *** F^(-)concentrations had significantly negative correlations with Shannon indexes(Ptances by decreasing the pH of pore *** and Fusibacter altered the Fmax of protein-like,humic-like,and fulvic-like *** F^(-)concentrations affected the DOM composition and migration due to the response of functional bacterial communities,which were positively correlated with the relative abundance of Thiobacillus and negatively correlated with the relative abundances of Trichococcus and *** high F^(-)concentrations influenced the biosynthesis and degradation of protein-like substances by shifting the abundances of the relevant *** results of this study may provide ideas for investigating DOM cycling under the influence of F^(-),especially in lakes with fluctuations in F^(-)concentrations.

关键词： Fluoride fluctuation Dissolved organic matter Fluorescent components Bacterial abundances Enzyme variation

RESEARCH OF SEMI-PHYSICAL SIMULATION PLATFORM FOR HYDRAULIC SYSTEM BASED ON EASY5

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RESEARCH OF SEMI-PHYSICAL SIMULATION PLATFORM FOR HYDRAULIC ...

Problems in treatment and training of autistic children growing up in China:A follow‐up case report

The 2011 International Conference on Mechanical Engineering and Technology

作者： Jiang Xiaoxia Lin fuquan Jimei University Xiamen Branch of China Classification Society

Introduction of the design method to achieve semi-physical simulation system on the basis of the hydraulic test platform and EASY5 hydraulic system simulation model. Using EASY5 and MATLAB / SIMULIINK co-simulation model, Real-time simulation control was achieved by calling the Windows API Multimedia Timers in MATLAB/SIMULINK to overcome the real-time weaknesses of EASY5;TCP / IP Network Communication was used for data exchange between Simulator and Control machine;man-machine interface of simulator was designed with Visual Basic, to achieve experimental initialization the hardware in the loop simulation system and start the simulation. It can be seen from the test results that t he semi-physical simulation system work well.

关键词： Wheel loader Hydraulic system Hardware in the loop simulation Co-simulation

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Pediatric Investigation 2020年第2期4卷 138-140页

作者： fuquan Liu Shijie Liu Jiabao Chai The Sixth Psychiatric Ward Beijing Changping District Hospital of Integrated Traditional Chinese and Western MedicineBeijingChina Xibeiwang Community Health Center in Haidian District BeijingChina Art Performance Therapy Center Hui Long Guan Clinical Medical SchoolPeking UniversityBeijingChina

Introduction Currently,interventions for children with autism spectrum disorders(ASD)in China are mainly carried out by professionals in rehabilitation institutions and special ***,when autistic children are older,they do not receive effective training and treatment,and there is no specific place in society to accommodate autistic *** hospitals are usually their ultimate *** presentation We report a 22‐year‐old male with *** manifestation and/or intervention from the age of 3 years to now were *** has been hospitalized in the closed ward of a mental hospital since *** This report typically present the current problems in treatment and training of autistic children growing up in ***‐long rehabilitation training is important for every patient with *** policies and resources in China should be optimized in terms of medical treatment and health care,education and training,social assistance,social security,labor employment,and social culture.

关键词： Autism Spectrum Disorders Training of autistic children Parents Training China