检索结果-南通市图书馆

一种抑制 SDH 网中指针调整抖动的平滑相位泄漏技术

中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Wei Liu fuqiang Cai Yu Han Wang Yanlin Institute of Molecular Biology Medical CollegeThree Gorges University

Introduction It has become increasingly clear that polyamine catabolism can play a dominant role in cellular drug response,apoptosis and the response to stressful stimuli,and contribute to *** a rate-limiting enzyme in polyamine catabolism,human spermidine/spermine n1-acetyltr.nsferase (hSSAT) is a 171-amino acid protein that is coded by Sat1 gene on *** content and the activity of SSAT are normally very low under resting *** factors cause a large and rapid induction of SSAT *** elevating SSAT levels include polyamines,polyamine analogues,hormones,cytokines,and some drugs such as nSAIDs,cisplatins or *** has been reported that induction of SSAT have an potential antitumor effect not only by reducing polyamine content but also by decreasing fatty acid *** this study,we constructed a eukaryotic expressing plasmid *** tr.nsfected by

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

高技术通讯 1998年第2期8卷 5-8页

作者：史富强林孝康冯重熙清华大学电子工程系微波与数字通信国家重点实验室

指针调整会在ＳＤＨ（ＳｙｎｃｈｒｏｎｏｕｓＤｉｇｉｔａｌＨｉａｒａｃｈｙ）网中引入非常大的低频抖动。通常，在解同步器中需要采用指针泄漏技术来抑制这种抖动以使设备满足ＩＴＵ－Ｔ建议Ｇ．７８３的要求。本文给出了一种新颖的... 详细信息

指针调整会在ＳＤＨ（ＳｙｎｃｈｒｏｎｏｕｓＤｉｇｉｔａｌＨｉａｒａｃｈｙ）网中引入非常大的低频抖动。通常，在解同步器中需要采用指针泄漏技术来抑制这种抖动以使设备满足ＩＴＵ－Ｔ建议Ｇ．７８３的要求。本文给出了一种新颖的抑制指针调整抖动的方法，这种方法通过一个数字锁相环对指针抖动进行平滑并将平滑相位调相到一个参考信号上，从而避免了１比特或１／Ｎ比特泄漏中存在的较大的相位量化阶跃。这种方法对指针抖动的泄漏可以近似为一个平滑的过程。对一个ＡＵ－４／Ｅ４实验系统的测试表明，这种方法的抖动抑制性能达到国际先进水平。

关键词：指针调整指针泄漏抖动 SDH网数字通信

体外模拟消化对大米谷蛋白结构及水解产物生物活性的影响

在线全文

学校读者我要写书评

暂无评论

食品科学 2021年第1期42卷 59-66页

作者：石嘉怿张太梁富强南京财经大学食品科学与工程学院江苏南京210046

通过体外模拟消化,研究不同消化时间下谷蛋白结构与抗氧化和血管紧张素转换酶(angiotensinconverting enzyme,ACE)抑制活性的关系。利用内源荧光光谱和傅里叶变换红光谱测定谷蛋白水解过程结构变化。通过测定水解产物抗氧化能力和ACE抑... 详细信息

通过体外模拟消化,研究不同消化时间下谷蛋白结构与抗氧化和血管紧张素转换酶(angiotensinconverting enzyme,ACE)抑制活性的关系。利用内源荧光光谱和傅里叶变换红光谱测定谷蛋白水解过程结构变化。通过测定水解产物抗氧化能力和ACE抑制率表征酶解产物的活性,利用四极杆串联飞行时间质谱鉴定具有抗氧化和ACE抑制活性的组分。结果表明,谷蛋白水解度在2 h内快速增加,随后趋于平缓。水解导致谷蛋白λmax红移且荧光强度增强,α-螺旋含量显著增加、β-折叠相对含量显著降低(Pnhibitory concentration,IC50)为(1.113±0.015)mg/mL,·OH清除率IC50为(0.518±0.053)mg/mL、Fe2+螯合能力IC50为(0.678±0.019)mg/mL。ACE抑制率先增加后降低,在2 h达到最高,IC50为(0.693±0.011)mg/mL。水解度的增加降低了水解物抗氧化能力,但增强了ACE抑制能力。水解物在0.5~2 h抗氧化能力和ACE抑制能力呈现负相关关系,随后抗氧化能力和ACE抑制能力均下降。水解物抗氧化肽和ACE抑制肽分子质量均小于2 kDa,筛选出以VEGGFLFIV为代表抗氧化活性多肽,且ACE抑制肽大部分n-端是疏水性氨基酸或者碱性氨基酸。因此,通过控制谷蛋白体外消化水解度,可制备最优的大米谷蛋白抗氧化或降血压相关功能性产品。

关键词：大米谷蛋白胰蛋白酶抗氧化活性血管紧张素转换酶抑制活性

Integration of nitrogen dynamics into the land surface model *** 2:baseline data and variation of carbon and nitrogen fluxes in China

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2020年第6期13卷 518-526页

作者： DAn Li YAnG Xiujing YAnG fuqiang PEnG Jing LI Yueyue GAO Dongdong JI Jinjun HUAnG Mei Key Laboratory of regional Climate-Envir.nment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina Key Laboratory of Water Cycle and related Land Surface Processes Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingChina Key Laboratory of Ecosystem network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingChina

The spatiotemporal features of carbon and nitrogen fluxes over China between 1979 and 2015were simulated by the Atmosphere–Vegetation Interaction Model(AVIM).The carbon fluxes of gross primary production and net primary production captured the distribution pattern in China better than MODIS and Tr.nDY *** results for.nitrogen deposition and biological nitrogen fixation show the good performance of the AVIM simulation compared with the CMIP6 and CABLE data,with a deposition rate>4 g n m-2yr-1in south *** variation in the gross primary production and net primary production can be up to 300 and 200 g C m-2yr-1in south and southeast China,respectively,and there is a discrepancy between the AVIM and the data from MODIS and *** shows the difficulty in simulating the carbon flux in a monsoon climate region and the importance of coupling the nitrogen–carbon *** standard deviation of nitrogen deposition and biological nitrogen fixation is simulated well by the AVIM and there is a large r.nge in nitrogen deposition of 0.8–1.2 g n m-2yr-1in south *** climatological mean of the fluxes performs better than the variation in the standard deviation and anomaly and this variation in the carbon–nitrogen flux is the key to decreasing bias in future modeling studies.

关键词： AVIM nitrogen dynamics regional scale carbon and nitrogen flux

带延长圆柱形喷管激光推力器推进性能数值研究

在线全文

学校读者我要写书评

暂无评论

强激光与粒子束 2011年第9期23卷 2341-2345页

作者：程富强窦志国李倩装备学院研究生管理大队北京101416 装备学院基础部北京101416

针对抛物形喷管与圆柱形喷管相组合的带延长圆柱形喷管激光推力器模型,通过求解含激光能量源项的流体力学方程组,计算得到了不同单脉冲激光能量条件下3种构形参数对冲量耦合系数和推力的影响。结果显示带延长圆柱形喷管可获得高于600n/M... 详细信息

针对抛物形喷管与圆柱形喷管相组合的带延长圆柱形喷管激光推力器模型,通过求解含激光能量源项的流体力学方程组,计算得到了不同单脉冲激光能量条件下3种构形参数对冲量耦合系数和推力的影响。结果显示带延长圆柱形喷管可获得高于600n/MW的冲量耦合系数,同时表明冲量耦合系数随圆柱喷管长度的增加而增大并趋于饱和,圆柱喷管饱和长度与激光能量呈线性关系。冲量耦合系数随抛物形喷管张角的增大先增大后减小,对于总长度为100mm的喷管,半张角在33°左右时取得最大值且受激光能量的影响很小。冲量耦合系数随点火位置的增大也存在最大值,最大值对应的点火位置与激光能量成线性关系。

关键词：激光推进吸气式单脉冲抛物-圆柱组合喷管冲量耦合系数

Two-dimensional TinCl for capacitive-like lithium-ion storage

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2022年第11期65卷 2942-2948页

作者： Linggang Fan Shaoning Zhang Wujie Dong Jijian Xu Xiangli Che ruizhe Li Hui Bi fuqiang Huang State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectr.nics Engineer.ng University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of rare Earth Materials Chemistry and Applications College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

In this study,TinCl was designed and applied in high-rate lithium-ion batteries(LIBs),and the mechanism of the energy storage in TinCl was *** Ti-n layer serves as the electr.nic conductive unit for its high conductivity,while the polyhedral channels constructed with Cl facilitate the tr.nsmission of Li ions serving as the ionic conductive *** addition,due to the negatively charged nature of Cl,the TinCl anode has a capacitive contribution up to 99.5%at 1 mV *** at a high rate of 50 C,it still retains a remarkable reversible capacity of 202 mA h gafter 1000 *** concept based on the structure design develops new electrode materials with desired properties.

关键词： lithium-ion battery high-rate performance TinCl titanium-based anode

错配修复蛋白状态与不良临床病理特征对结肠癌患者预后的交互作用分析

在线全文

学校读者我要写书评

暂无评论

中华消化外科杂志 2024年第6期23卷 826-835页

作者：李珂璇赵富强吴清彬张峻岭罗双灵胡时栋吴斌李鹤立林国乐邱辉忠陆君阳徐徕王征杜晓辉康亮汪欣王自强刘骞肖毅中国医学科学院北京协和医学院北京协和医院基本外科结直肠专业组北京100730 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院结直肠外科北京100021 四川大学华西临床医学院/华西医院结直肠肿瘤中心成都610041 北京大学第一医院胃肠外科北京100034 中山大学附属第六医院结直肠外科广东省胃肠病学研究所广东省结直肠盆底疾病研究重点实验室广州510655 解放军总医院第一医学中心普通外科北京100853 华中科技大学同济医学院附属协和医院胃肠外科武汉430022

目的探讨错配修复蛋白状态与不良临床病理特征对Ⅰ~Ⅲ期结肠癌患者预后的交互效应。方法采用回顾性队列研究方法。收集2016年1月至2017年12月全国7家医院收治的1650例Ⅰ~Ⅲ期结肠癌患者的临床病理资料;男963例,女687例;年龄为62(53,71)... 详细信息

目的探讨错配修复蛋白状态与不良临床病理特征对Ⅰ~Ⅲ期结肠癌患者预后的交互效应。方法采用回顾性队列研究方法。收集2016年1月至2017年12月全国7家医院收治的1650例Ⅰ~Ⅲ期结肠癌患者的临床病理资料;男963例,女687例;年龄为62(53,71)岁。1650例患者根据错配修复蛋白状态分为错配修复蛋白表达缺失(dMMr)230例与错配修复蛋白表达完整(pMMr)1420例。观察指标:(1)不同错配修复蛋白状态患者的临床病理特征比较。(2)影响dMMr患者生存结局的因素分析。(3)影响pMMr患者生存结局的因素分析。(4)错配修复蛋白状态与不良临床病理特征对生存结局影响的交互作用分析。正态分布的计量资料以x±s表示,组间比较采用独立样本t检验;偏态分布的计量资料以M(Q_(1),Q_(3))表示,组间比较采用Mann-WhitneyU检验。计数资料以绝对数表示,组间比较采用χ^(2)检验或Fisher确切概率法。等级资料采用Mann-WhitneyU检验。缺失值使用随机森林插补法进行数据插补。单因素分析采用COX比例风险回归模型。多因素分析采用COX逐步回归(向前逐步回归法)。乘法交互效应的系数使用COX比例风险回归模型的交互项系数获得。加法交互效应使用交互作用超额相对危险度(rErI)进行评价。结果(1)不同错配修复蛋白状态患者的临床病理特征比较。dMMr和pMMr患者年龄、T分期、淋巴结检出数目、淋巴结检出数目r患者生存结局的因素分析。多因素分析结果显示:T分期、n分期、淋巴结检出数目r患者无病生存的独立因素(风险比=3.548,2.589,6.702,95%可信区间为1.460~8.620,1.064~6.301,1.886~23.813,Pn分期是影响dMMr患者总生存的独立因素(风险比=1.073,10.684,95%可信区间为1.021~1.126,2.311~49.404,Pr患者生存结局的因素分析。多因素分析结果显示:年龄、T分期、n分期、脉管瘤栓是影响pMMr患者无病生存的独立因素(风险比=1.018,2.214,2.598,1.549,95%可信区间为1.006~1.030,1.618~3.030,1.921~3.513,1.118~2.147,Pn分期、高级别肿瘤是影响pMMr患者总生存的独立因素(风险比=1.036,2.080,2.591,1.615,95%可信区间为1.020~1.052,1.407~3.075,1.791~3.748,1.114~2.341,PrErI=-0.033,-1.304,95%可信区间为-0.049~-0.018,-2.462~-0.146)。结论错配修复蛋白状态与不良临床病理特征(淋巴结检出数目r患者中,淋巴结检查数目r患者中,高级别肿瘤对预后不良的提示作用强。

关键词：结肠肿瘤不良病理特征错配修复生存交互作用

Doped, conductive SiO_(2) nanoparticles for large microwave absorption

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2018年第1期7卷 211-219页

作者： Michael Green Zhanqiang Liu Peng Xiang Yan Liu Minjie Zhou Xinyu Tan fuqiang Huang Lei Liu Xiaobo Chen Department of Chemistry University of MissouriKansas CityMO 64110USA State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China College of Materials and Chemical Engineer.ng Hubei Provincial Collaborative Innovation Center for New Energy MicrogridChina Three Gorges UniversityYichang 443002China College of Envir.nment Sichuan Agricultural UniversityChengduSichuan 611130China School of Chemistry and Chemical Engineer.ng Hunan Institute of Science and TechnologyYueyang 414000China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

Although many materials have been studied for the purpose of microwave absorption,SiO_(2) has never been reported as a good *** this study,we present for the first time that doped,microwave conductive SiO_(2) nanoparticles can possess an excellent microwave absorbing performance.A large microwave reflection loss(rL)of−55.09 dB can be *** large microwave absorption originates mainly from electrical relaxation rather than the magnetic relaxation of the incoming microwave *** electrical relaxation is attributed to a large electrical conductivity that is enabled by the incorporation of heterogeneous(n,C and Cl)*** removal of the magnetic susceptibility only results in a negligible influence of the microwave *** contrast,the removal of the heterogeneous atoms leads to a large decrease in the electrical conductivity and microwave absorption ***,the microwave absorption characteristics can be largely adjusted with a change of the thickness,which provides large flexibility for various microwave absorption applications.

关键词： nanoparticles microwave absorption

Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

national Science review 2019年第5期6卷 982-992页

作者： Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-ning Zhou fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi Hefei national Laboratory for Physical Sciences at the Microscale and School of Life SciencesUniversity of Science and Technology of China CAS Key Laboratory of Brain Function and Disease and School of Life Sciences University of Science and Technology of China Institute of Automation Chinese Academy of Sciences University of Chinese Academy of Sciences School of Information Science and Technology University of Science and Technology of China national Engineer.ng Laboratory for Brain-inspired Intelligence Technology and Application University of Science and Technology of China Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences CAS Center for Excellence in Brain Science and Intelligence Technology

The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits, which is of fundamental importance for.neuroscience ***, we describe a new microscopy method of Volumetric Imaging with Synchr.nized on-the-fly-scan and readout(VISo r) for high-throughput, high-quality brain *** synchr.nized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion, the VISo r system effectively eliminates motion blur to obtain undistorted *** continuously imaging moving samples without stopping, the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours, at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation, imaging, 3D image reconstruction and *** approach is compatible with immunofluorescence methods, enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate *** this system, we examined behaviorally relevant whole-brain neur.nal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming *** results indicate the involvement of multiple subcortical areas in stress ***, neur.nal activation in these areas exhibits striking individual variability among differ.nt animals, suggesting the necessity of sufficient cohort size for such studies.

关键词： fluorescence microscopy brain mapping tissue clear.ng immunostaining activity trace mapping