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Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics

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Nano Research 2022年第2期15卷 1455-1465页

作者： Lijuan Wen Yu Peng Kai Wang Zhihua huang Shiying He Ruiwen Xiong Longping Wu Fengtian Zhang fuqiang Hu National Engineering Research Center for Modernization of Tranditional Chinese Medicine-Hakka Medical Resources Branch College oj PharmacyGannan Medical UniversityGanzhou 341000China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Department of Orthopedics First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Department of Orthopedics Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education Gannan Medical UniversityGanzhou 341000China

Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative treatments.Abnormally elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and prognosis.RNAi interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM cells.This study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R complexes.Ap functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,respectively.Ap-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of GBM.The study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment.

关键词： glioblastoma ROS-responsive siRNA blood brain barrier copolymer

Boosting xenon adsorption with record capacity in microporous carbon molecular sieves

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Science China Chemistry 2023年第2期66卷 601-610页

作者： fuqiang Chen Xinlei huang Liu Yang Zhiguo Zhang Qiwei Yang Yiwei Yang Dan Zhao Qilong Ren Zongbi Bao Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China Division of Electronic Chemicals Institute of Zhejiang University-QuzhouQuzhou324000China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore117585Singapore

Xenon/krypton(Xe/Kr)separation is an important task in industry,yet it remains challenging to develop adsorbents with high Xe/Kr selectivity and adsorption capacity of Xe,especially at low partial pressures.Herein,we report a series of microporous carbon molecular sieves(CMSs)for Xe/Kr separation.Those materials have ideal bimodal pore size distributions that not only provide substantial space for the accommodation of gas molecules,but also allow selective diffusion of gas molecules.Additionally,the carbon frameworks decorated with polar oxygen-containing functional groups afford higher affinity for Xe than Kr,which is proven by density functional theory(DFT)calculations and charge density difference analysis.The optimal CPVDC-700 exhibits a high selectivity of Xe/Kr and,more importantly,a record-high uptake of Xe(2.93 mmol g^(-1))at 0.2 bar and298 K,which is the highest among all the reported carbon adsorbents.Breakthrough experiments confirm the excellent performance of such CMSs for Xe/Kr separation,and the dynamic adsorption uptake of Xe and productivity of high-purity Kr are calculated to be 2.91 mmol g^(-1)and 208 m L g^(-1)(9.29 mmol g^(-1)),respectively,which also set up a new benchmark for Xe/Kr separation of carbon adsorbents.

关键词： adsorption separation xenon krypton carbon molecular sieve bimodal pore size distributions

石英脉型钨多金属矿床的扇状成矿实例及找矿模型

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矿床地质 2024年第3期43卷 613-628页

作者：方贵聪王登红黄长帅杨富强许以明冯佐海李学彪曾强严长华广西隐伏金属矿产勘查重点实验室桂林理工大学广西桂林541004 有色金属矿产勘查与资源高效利用省部共建协同创新中心桂林理工大学广西桂林541004 中国地质科学院矿产资源研究所北京100037 中国有色桂林矿产地质研究院有限公司广西桂林541004 广西壮族自治区地球物理勘察院广西柳州545005 湖南省矿产资源调查所湖南长沙410014 江西大吉山钨业有限公司江西全南341801 湖南省水文地质环境地质调查监测所湖南长沙410131

石英脉型钨矿床是中国数量最多的钨矿床类型,但保有储量消耗迅速,迫切需要创新找矿模型,指导找矿突破。文章结合二十余年的找矿实践,通过详细分析扇状成矿矿床实例,构建了石英脉型钨矿床新的找矿模型。该模型强调赋矿裂隙为岩浆动力成因... 详细信息

石英脉型钨矿床是中国数量最多的钨矿床类型,但保有储量消耗迅速,迫切需要创新找矿模型,指导找矿突破。文章结合二十余年的找矿实践,通过详细分析扇状成矿矿床实例,构建了石英脉型钨矿床新的找矿模型。该模型强调赋矿裂隙为岩浆动力成因,在花岗岩体顶部呈扇状分布型式,岩浆期后热液恰在裂隙张开时充填其中而形成扇状成矿系统;提出“就岩找矿”、“就矿找矿”、“就矿找岩”的地质、地球化学和地球物理标志,指导矿床尺度的勘查工程部署。截至目前,该模型已在广东禾尚田钨锡矿床、广西珊瑚钨锡矿床、广西社垌钨钼矿床、江西盘古山钨铋矿床等获得了验证,找矿成效显著。

关键词：扇状成矿成矿规律找矿模型花岗岩石英脉型钨矿床

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FEM Simulation of the Hydrogen Diffusion in X80 Pipeline Steel During Stacking for Slow Cooling

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Acta Metallurgica Sinica(English Letters) 2014年第3期27卷 416-421页

作者： Zhenyi huang Qi Shi fuqiang Chen Yunfeng Shi School of Metallurgical Engineering Anhui University of Technology Heavy Plate Mill Baoshan Iron and Steel Co. Ltd

The influence of temperature on the hydrogen diffusion behavior in X80 pipeline steel during stacking for slow cooling was studied using electrochemical penetration method, the temperature field and the hydrogen diffusion in this pipeline steel during stacking for slow cooling were simulated by ABAQUS finite element method （FEM） software. The results show that in this process there is a reciprocal relationship between the natural logarithm of hydrogen diffusion coefficient and temperature. The cooling rate decreases gradually with the increase of steel plate thickness. The hydrogen content is higher at high temperature （500-400 ℃） than that in low temperature region （300-100 ℃）. The FEM simulation results are consistent with the experimental ones, and the model can be used to predict the hydrogen diffusion behavior in industrial production of X80 pipeline steel.

关键词： X80 pipeline steel Stacking Slow cooling Hydrogen diffusion Finite element method （FEM） Electrochemical penetration

In situ annealing effects on magnetic properties and variable-range hopping of iron-based ladder material BaFe2S3

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Science China(Physics,Mechanics & Astronomy) 2018年第7期61卷 95-98页

作者： Xuan Zhang Hui Zhang YongHui Ma LingLing Wang JiaNan Chu Tao Hu Gang Mu YuMing Lu ChuanBing Cai fuqiang huang XiaoMing Xie Shanghai Key Laboratory of High Temperature Superconductors Shanghai University Shanghai 200444 China State Key Laboratory of Functional Materials for Informaties Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Center for Excellence in Superconducting Electronics (CENSE) Chinese Academy of Sciences Shanghai 200050 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

All iron-based superconductors,regardless of their detailed crystal structure,share the same conductive Fe_2X_2(X=As,P,Se,and S)layers as the crucial structural unit[1-8].In the Fe_2X_2 layers,edge-shared FeX_4 tetrahedra form a square lattice in quasi-two-dimensional(quasi-2D)planes.One may wonder what kind of properties will be manifested in the quasi-one-dimensional(quasi-1D)counterparts exhibiting an identical coordination as the above-mentioned

关键词：磁性材料梯子退火跳跃可变铁水晶结构

Reducing Packing Factor of Znln2S4 to Promote Photocatalytic Activity

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Chemical Research in Chinese Universities 2020年第6期36卷 1102-1107页

作者： HU Keyan XU Zian LIU Yiting huang fuqiang State Key Laboratory of High-performance Ceramics and Super Fine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050P.R.China School of Mechanical and Electrical Engineering Jingdezhen Ceramic InstituteJingdezhen 333403P.R.China Department of Materials Science and Engineering City University of Hong KongTat Chee AvenueKowloonHong Kong 999077P.R.China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062P.R.China Beijing National Laboratory for Molecular Sciences and State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871P.R.China

Due to the quite sluggish charge-carrier separation in semiconductor photocatalysts,the photocatalytic ac-tivity of these materials is still far inferior than anticipated.Herein,a novel approach to reducing the packing factor(PF)of Znln2S4 semiconductors to improve the charge-carrier separation is offered.The well-crystallized Zn1-xIn2S4-x(x=0,0.05,0.1)powders were productively prepared through solid-state reactions.Their structures were verified by the high-resolution transmission electron microscopy,powder X-ray diffraction,and X-ray photoelectron spectroscopy.The PE values of Zn1-xIn2S4-x(x=0,0.05,0.1)samples were calculated to be 0.***.0.***.and 0.***.respectively.The reduction.of the PF for Zn1-xIn2S4-x with increasing x can promote the separation of photoexcited carriers,and this process was endorsed by their photoelectric response and photoluminescence emission spectra.The Zn0.9In2S3.9 sample with a lower PF value presents roughly 21 times higher photocurrent density and four times higher photodegrading rate of methyl orange than those of pristine ZnIn2S4.

关键词： Charge-carrier separation Packing factor Zm-xIn2S4-r Solid state reaction Photocatalytic activity

A Detected Case of Avian Influenza H9N2 from Influenza-Like Illness Surveillance--Hunan Province, 2020

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China CDC weekly 2020年第36期2卷 700-703页

作者： Siyu Zhang Chaoyang huang Yingying Mo Zhoujian Wu Haizhen Li Yiwei huang fuqiang Liu Lidong Gao Hunan Provincial Center for Disease Control and Prevention ChangshaHunanChina Hunan Provincial Key Laboratory of Microbial Molecular Biology ChangshaHunanChina Xiangxi Tujia and Miao Autonomous Prefectural Center for Disease Control and Prenvention JishouHunanChina Jishou Municipal Center for Disease Control and Prevention JishouHunanChina.

Jishou Municipal Center for Disease Control and Prevention(Jishou CDC)received a phone call at 7:30 a.***.on April 24,2020 from Xiangxi Tujia and Miao Autonomous Prefectural CDC(Xiangxi CDC)that avian influenza A/H9N2 virus was detected by quantitative reverse transcription-polymerase chain reaction(RT-PCR)from the throat swab sample of an influenza-like illness in an outpatient in the Xiangxi Traditional Chinese Medicine Hospital.

关键词： Hunan Xiang illness

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能源材料新时代

无机材料学报 2022年第2期37卷 113-115页

作者：曾海波黄富强南京理工大学材料科学与工程学院新型显示材料与器件工信部重点实验室中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室中国科学院大学材料科学与光电技术学院北京大学化学与分子工程学院稀土材料化学及应用国家重点实验室

人类发展的历史,也是能源变革的历史,人类社会的每一次技术革命无不伴随着对能源认识、开发和利用的创新与进步。当下,我国已经成为全球排名第一的能源生产和消费大国,并且两个总量还在不断攀升。能源技术是解决对传统化石能源过度依赖... 详细信息

人类发展的历史,也是能源变革的历史,人类社会的每一次技术革命无不伴随着对能源认识、开发和利用的创新与进步。当下,我国已经成为全球排名第一的能源生产和消费大国,并且两个总量还在不断攀升。能源技术是解决对传统化石能源过度依赖及环境污染等问题,构建合理的社会能源结构,推进可持续发展,实现“双碳”减排的关键手段。2020年,我国以太阳能、风能为代表的可再生能源增长达到全世界的三分之一,发展迅速。这其中,能源材料是能源工业和能源技术体系中涉及的特殊材料,在实现清洁能源的转化和利用,发展新能源技术,以及支撑整个能源系统中扮演着核心角色。

关键词：能源材料新时代

Synthesis,Structure and magnetic properties of Cr(en)3SbSe4 and Cr(en)2AsSe3

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Synthesis,Structure and magnetic properties of Cr(en)3SbSe4 ...