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Antiplasmodial mechanism of Lawsonia inermis: An in silico based investigation

infectious diseases Research 2024年第1期5卷 8-26页

作者： Ridwan Abiodun Salaam funmilayo i.d.afolayan department of Zoology University of IbadanIbadan 200005Nigeria.

Background:Lawsonia inermis has been widely reported to be used as an herbal treatment for ***,despite several experimental studies about its antimalarial activities,the approach through which the herbal plant suppresses plasmodium infection is yet to be ***,this study uses computational approaches to understand the biological targets and pathways involved in the antiplasmodial activities of Lawsonia inermis ***:The Gas Chromatography-Mass Spectrometry technique identified the phytocompounds present in the herbal ***,OMiM,and NCBi databases were explored to collate target proteins for further network pharmacology *** phytocompounds were subjected to Absorption,distribution,Metabolism,Excretion and Toxicity(AdMET)and druglikeness *** STRiNG algorithm and Cytoscape were employed to develop and analyze the relationships among target proteins and compounds/targets/pathways network of the putative targets of the *** computational analysis was carried out to identify potential drug ***:Based on the Network Pharmacology studies,phytocompounds in Lawsonia inermis exhibit antiplasmodial activity by interacting with therapeutic genes that play essential roles in metabolism and signaling *** among the genes are MMP9,MAPK1,HMOX1 and ***,the most influenced pathways include the metabolic pathway,Pi3K-Akt signaling pathway,and HiF-1 signaling *** analysis,molecular docking analysis,and molecular dynamics simulation revealed that 3-phenyl-2-isoxazoline and 2-dimethylamino-3’-methoxyacetophenone are recommendable drug leads for Malaria treatment as they form stable and favorable complexes with Matrix metalloproteinase-9(MMP9)***:The 3-phenyl-2-isoxazoline and 2-dimethylamino-3’-methoxyacetophenone phytocompounds from Lawsonia inermis herbal plant are predicted as antimalarial drug candidates and recommended for further wet-lab studies.

关键词： Lawsonia inermis computational studies plasmodium falciparum network pharmacology molecular dynamic

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A review of selected parasitic plants in Nigeria:converting harms to benefits

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Natural Therapy Advances 2024年第3期7卷 14-28页

作者： funmilayo i.d.afolayan Ridwan A.Salaam Ebenezer S.Oladokun Samson d.Adesoye department of Zoology University of IbadanIbadan 200132Nigeria

Parasitic plants are challenging to agricultural crops and forestry development,which are sources of major revenues in several countries,including ***,parasitic plants are important to human society as they have an abundance of bioactive compounds with pharmacological ***,it becomes expedient to know the benefits of these plants and potential means of *** review discusses four selected parasitic plants in Nigeria,namely Viscum album,Striga hermonthica,Tapinanthus bangwensis and Cuscuta *** information about their pharmacological relevance and biocontrol was obtained from credible databases,including the National Library of Medicine,SCOPUS,and Google *** review showed that all four plants have been extensively studied for their antioxidant and antitumor ***,antimicrobial and anti-inflammatory activities are common pharmacological values among parasitic *** are largely due to the presence of abundant beneficial classes of ***,there is an increasing number of biocontrol studies on the use of microorganisms,such as Phaeobotryosphaeria visci,Sphaeropsis visci,Pandoraea pulminicol,Colletotrichum gloeosporioides,and Fusarium oxysporum in controlling and managing these seemingly disastrous *** is hoped that this review will spur further studies into the conservation and proper management of parasitic plants using strategically developed biocontrol.

关键词： parasitic plants pharmacological values biocontrol plant management and control ethnopharmacology

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in silico antiplasmodial effects of phytocompounds derived from Andrographis paniculata on validated drug targets of different stages of Plasmodium falciparum

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infectious diseases Research 2024年第2期5卷 1-11页

作者： funmilayo i.d.afolayan Sayo Ebenezer Oladokun department of Zoology University of IbadanIbadan 200005Nigeria

Background:Andrographis paniculata has been widely reported as an herbal plant for malaria *** increasing rate of resistance to recommended antimalarial drugs has justified the need for a continuous search for new and more potent drugs that target all stages of the Plasmodium falciparum life cycle from natural plant *** study aimed to determine the antiplasmodial effect of phytocompounds derived from *** on the stages of plasmodium ***:Phytocompounds from *** were identified by Gas Chromatography-Mass Spectrophotometry(GCMS)*** phytocompounds were screened for their druggability using Lipinski’s rule of five and subjected to Absorption,distribution,Metabolism,Excretion,Toxicity(AdMET)and druglikeness *** phytocompounds were docked against some validated drug targets at different stages of Plasmodium falciparum(hepatic,asexual,sexual,and vector targets)using PyRx software to analyze the inhibitory potential and protein-ligand ***,the stability and flexibility of the best complexes were assessed through molecular dynamics simulations at 50ns using ***:The 7a-isopropenyl-4,5-dimethyloctahydroinden-4-yl exhibited a higher binding affinity and better stability throughout the simulation period with *** dihydrofolate reductase-thymidylate synthase and Plasmodium falciparum M1 alanyl aminopeptidase for asexual blood stage and gametocyte stage of Plasmodium falciparum,respectively than the existing ***,N-Ethyl-3-methoxy-4-methylphenethylamine was also found to have a higher binding affinity and more stability throughout the simulation period with *** purine nucleoside phosphorylase and Plasmodium falciparum gametocyte surface protein for Hepatic schizonts stage of Plasmodium falciparum and gametocyte transmission blocking stage,respectively,than the existing ***:The 7a-isopropenyl-4,5-dimethyloctahydroinden-4-yl and N-Ethyl-3-methoxy-4

关键词： Plasmodium falciparum drug targets Andrographis paniculata molecular docking molecular dynamics

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Journal of integrative Nursing 2024年第3期6卷 169-177页

作者： Oluwaseyi Abiodun AKPOR ishaq Ajibola afolayan funmilayo Abimbola iBiTOBA Oghenerobor Benjamin AKPOR Olubukola Esther ABiOdUN-OJO department of Nursing Science Afe Babalola UniversityAdo-ekitiEkiti StateNigeria Afe Babalola University Ado-ekitiEkiti StateNigeria

Objective:The study assessed the quality of life(QoL)and coping strategies of patients on hemodialysis in selected hospitals in ilorin,Kwara ***:The study was a descriptive cross-sectional design using a quantitative strategy.A multistage sampling technique was adopted to select 80 *** data were collected using an adapted questionnaire including four sections:sociodemographic characteristics,hemodialysis stressor scale consisting of four stressors,Jaloweic Coping Scale consisting of eight coping strategies,and QoL consisting of four *** data were analyzed using SPSS version ***:Findings from the study revealed that 50%of the participants were between the ages of 18 and 39 years,40%of the participants have been on hemodialysis for 1-2 years,whereas 52.5%had hypertension as a comorbidity.A total of 12.5%,63.8%,and 23.8%of the respondents were categorized as experiencing low,moderate,and high stress due to hemodialysis,*** of the respondents revealed that 49.4%had no problem in self-care *** monthly income(χ^(2)=16.36,P=0.04)was observed to be significantly associated with coping strategies,whereas religion(χ^(2)=11.14,P=0.03)and frequency of hemodialysis(χ^(2)=10.26,P=0.04)were significantly associated with coping ***:All participants experienced stress at varying *** results in marked changes in the quality of patients’life,since it includes a number of modifications and restrictions,which affects patients’health *** study revealed a wide range of information on the psychological and physiological stressors of people under hemodialysis.

关键词： Chronic renal failure coping strategies health-related quality of life hemodialysis

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Are population cycles recovering?

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integrative Zoology 2024年第3期19卷 538-547页

作者： Vasily d.YAKUSHOV Boris i.SHEFTEL A.N.Severtsov institute of Ecology and Evolution of the Russian Academy of Sciences MoscowRussia

The dynamics of populations of small mammals of Central Siberia was *** studies were carried out at the Yenisei ecological station“Mirnoye”of the *** institute of Ecology and Evolution,Russian Academy of *** time series analysis was performed by the wavelet transform using the statistical data processing language *** the 20th century,the dynamics of the population of the community and some of its constituent species(Sorex araneus;***;***;***;***;Craseomys rufocanus;Clethrionomys rutilus;Microtus oeconomus;***)were characterized by a 4-year *** type of dynamics changed to noncyclic by the nineties,but by 2022,four species(***,***,***,and ***)and the community as a whole showed a tendency toward recovery of population *** remaining species were characterized by consistently low numbers with irregular low amplitude fluctuations.

关键词： population cycles small mammals time-series analysis wavelet transform

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Near resonance vibration isolation on a levered-dual response(LEdAR)Coulomb-damped system by differential preloads/offsets in linear springs

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： T.i.TOLUWALOJU C.K.THEiN d.HALiM department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo China Beacons of Excellence Research and innovation institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEdAR)Coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEdAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio Coulomb damping preload tension/compression isolation band/depth offset potential

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Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： i.Sardar M.d.Hossain M.S.Sikder M.N.i.Khan M.R.Rahman Physics discipline Khulna UniversityKhulna9208Bangladesh department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh department ofComputer Science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh Material Science division Atomic Energy CentreDhaka1000Bangladesh

Spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRd),Fourier transform infrared spectroscopy(FTiR),field emission scanning electron microscopy(FESEM),energy dispersive X-ray(EdX),vibrating sample magnetometer(VSM),and an impedance analyzer were used to characterize the structural,magnetic,and dielectric properties of the *** XRd patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increased with the increment of rare earth Eu *** FTiR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FESEM images,and it is increased from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EdX study shows that there is no impurity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EdX Resistivity

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development and testing of a high-power S-band klystron at BiNP SB RAS

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Nuclear Science and Techniques 2024年第7期35卷 58-67页

作者： A.Levichev A.Barnyakov S.Samoylov d.Nikiforov V.ivanov M.Arsentyeva d.Chekmenev O.Pavlov i.Pivovarov Budker institute of Nuclear Physics Lavrentyeva Av.11NovosibirskRussia630090 Novosibirsk State University Pirogova Str.2NovosibirskRussia630090

This paper details the development and testing of the first working prototype of the S-band high-power klystron,accomplished at the Budker institute of Nuclear Physics,Siberian Branch,Russian Academy of Sciences(BiNP SB RAS).Upon testing,the klystron demonstrated the following parameters:an operating frequency of 2856 MHz and a peak power output of 50 *** paper presents the klystron's design,its constituent units,and pertinent processing procedures,along with discussions on the measurement of its parameters.

关键词： Klystron Linear accelerator Electron beam

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A Cross-Sectional Study on the impact of Operation Triple Zero (OTZ) Program on Viral Load Suppression amongst Members of the Adolescent Club in 68 Nigerian Army Reference Hospital Yaba Lagos, Nigeria

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World Journal of AidS 2024年第2期14卷 35-44页

作者： Nkechinyere Harrison ismail Lawal Yakubu Adamu Kehinde Aribisala Adegbenga Olarinoye Uzoamaka Agbaim funmilayo Owolabi dooshima Okonkwo Laura Chittenden Nathan Okeji Centre for infectious disease Clinic 68 Nigerian Army Reference Hospital Lagos Nigeria United States Army Medical Research directorate-Africa Abuja Nigeria Henry Jackson Foundation Medical Research international LTd/GTE Abuja Nigeria Nigerian Ministry of defence Health implementation Program Abuja Nigeria

Background: in Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HiV prevalence of 3.5%. The AYP living with HiV enrolled at the 68 NARHY, Lagos reflects the national challenges with poor viral suppression. The OTZ program aligns with the UNAidS 95-95-95 goals. it seeks to empower AYPLHiV to be in charge of their treatment and commit to triple zero outcomeszero missed appointments, zero missed drugs, and zero viral loads. The purpose of the study was to assess the impact of the OTZ program on viral load suppression among members of the adolescent club in 68 NARHY, Lagos. Method: A cross-sectional retrospective study to evaluate the impact of the OTZ program on the viral load of 53 AYP enrolled in the OTZ program between March 2019 to december 2019 was analyzed. The Percentage of viral load suppression before enrollment compared with 6 and 12 months after enrollment into the OTZ program. The AYP is grouped into 10 - 14, 15 - 19, and 20 - 24 years. Activities conducted were peer driven monthly meetings with the AYP during which the adolescents interacted on issues relating to improving their treatment outcomes, healthcare workers reviewed their clinical status, viral load result, provider peer counseling, and caregivers engagement to support adherence to medication and ARV refills. Results: Before OTZ, 81% aged 10 - 14 years, 75% aged 15 - 19 years, and 25% aged 20 - 24 years were virally suppressed (VL less than 1000 copies/ml). Six months after enrollment, 94% were virally suppressed95% aged 10 - 14 years, 96% aged 15 - 19 years, and 66% aged 20-24 years. Twelve months after enrollment, 96% of AYP were virally suppressed100% aged 10-14 years, 93% aged 15 - 19 years, and 100% aged 20 - 24 years. Males viral load (VL) suppression improved from 79% to 96% and 92%, while females VL suppression improved from 69% to 93% and 100% at 6 and 12 months respectively. Conclusion: The OTZ activities contributed to improved viral l

关键词： impact Operation Triple Zero Adolescent Viral Load Nigeria

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Photosynthetic response to a winter heatwave in leading and trailing edge populations of the intertidal red alga Corallina offi-cinalis(Rhodophyta)

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Acta Oceanologica Sinica 2024年第7期43卷 70-77页

作者： Regina Kolzenburg Federica Ragazzola Laura Tamburello Katy R.Nicastro Christopher d.McQuaid Gerardo i.Zardi UmeåMarine Sciences Centre UmeåUniversity90571 NorrbynSweden University of Portsmouth Institute of Marine SciencePortsmouth PO49LYUK Stazione Zoologica Anton dohrn Genova Marine CenterGenova 16126Italy Stazione Zoologica Anton dohrn Sicily Marine CenterPalermo 90149Italy department of Zoology and Entomology Rhodes UniversityMakhanda(Grahamstown)6139South Africa Centre of Marine Sciences University of AlgarveFaro 8005-139Portugal Laboratoire d’Océanologie et de Géosciences Universitéde LilleLille 59000France Universitéde Caen Normandie Laboratoire de Biologie des Organismes et des Ecosystèmes AquatiquesCaen 14032France

Marine heatwaves(MHWs)caused by anthropogenic climate change are becoming a key driver of change at the ecosystem *** conditions experienced by marine organisms across their distribution,particularly towards the equator,are likely to approach their physiological limits,resulting in extensive mortality and subsequent changes at the population *** at the margins of their species’distribution are thought to be more sensitive to climate-induced environmental pressures than central populations,but our understanding of variability in fitness-related physiological traits in trailing versus leading-edge populations is *** a laboratory simulation study,we tested whether two leading(iceland)and two trailing(Spain)peripheral populations of the intertidal macroalga Corallina officinalis display different levels of maximum potential quantum efficiency(Fv/Fm)resilience to current and future winter MHWs *** study revealed that ongoing and future local winter MHWs will not negatively affect leading-edge populations of ***,which exhibited stable photosynthetic efficiency throughout the *** edge populations showed a positive though non-significant trend in photosynthetic efficiency throughout winter MHWs *** and equatorward populations did not produce significantly different results,with winter MHWs having no negative affect on Fv/Fm of either ***,we found no long-term regional or population-level influence of a winter MHWs on this species’photosynthetic ***,we found no statistically significant difference in thermal stress responses between leading and trailing ***,*** showed a trend towards higher stress responses in southern than northern *** responses rest on a variety of local population traits,they are difficult to predict based solely on thermal pressures.

关键词： marginal population coralline algae climate change ecophysiology photophysiology macroalgae Fv/Fm

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