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Use of DREAm.to assess relative risks of presence of pharm.ceuticals and personal care products from.a wastewater treatm.nt plant

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FRONTIERS OF ENVIRONm.NTAL SCIENCE & ENGINEERING 2024年第9期18卷 113-0页

作者： Pam.anin, Daniela m. Schlenk, Daniel Vitale, m.tteo Liboureau, Pierre Sydnes, m.gne O. Univ Stavanger Dept Chem Biosci & Environm Engn N-4036 Stavanger Norway Univ Calif Riverside Dept Environm Sci Riverside CA 92521 USA

Concerns related to environm.ntal risks associated with pharm.ceuticals and personal care products (PPCPs) have led researchers to seek m.thods for assessing and m.nitoring these contam.nants in the aquatic environm.nt. Identifying and validating risk assessm.nt tools that can evaluate ecological concerns and risks associated with PPCPs is critical. Herein, the suitability of a dose-related risk and effect assessm.nt m.del, which estim.tes predicted environm.ntal concentrations and allowed com.arisons with predicted no effect concentrations determ.ned, in com.ination with in vitro analyses of the whole effluent toxicity, was verified for the characterization of a PPCP hazard. Concentrations of the m.st utilized PPCPs in Norway were m.asured in influent and effluent sam.les and used to param.terize the fate *** than 90% rem.val was attained for 12 out of 22 detected PPCPs. Rem.val was not dependent on the class or the concentration of the specific substance and varied between 12% and 100%. The PPCPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent, and no risk was identified for the targeted 30 PPCP. The sim.lations provided valuable inform.tion regarding the discharge plum. distribution over tim., which can aid planning of future environm.ntal m.nitoring *** (using fish liver cells, PLHC-1) were used for assessing overall effluent toxicity, through cell viability, production of reactive oxygen species, and ethoxyresorufin-O-deethylase (EROD) *** present study m.y allow regulators to use risk-based strategies over rem.val criteria for m.nitoring studies and confirm. the im.ortance to take PPCP contam.nation into consideration when establishing environm.ntal regulations.

关键词： Pharm.ceuticals Wastewater effluent Ciprofloxacin m.toprolol Am.triptyline Carbam.zepine m.delling Risk assessm.nt m.nitoring m.RINE-ENVIRONm.NT AQUATIC ENVIRONm.NT REm.VAL CARBAm.ZEPINE EXPOSURE DRUGS ANTIDEPRESSANTS ANTIBIOTICS SEDIm.NT CAFFEINE

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Im.roving Prediction Efficiency of m.chine Learning m.dels for Cardiovascular Disease in IoST-Based System. through Hyperparam.ter Optim.zation

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Com.uters, m.terials and Continua 2024年第3期80卷 3485-3506页

作者： Akhund, Tajim.m. Niam.t Ullah Al-Nuwaiser, Waleed m. Departm.nt of Com.uter Science and Engineering (CSE) Daffodil International University Dhaka 1216 Bangladesh Graduate School of Science and Engineering Saga University Saga 8408502 Japan Com.uter Science Departm.nt College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia

This study explores the im.act of hyperparam.ter optim.zation on m.chine learning m.dels for predicting cardiovascular disease using data from.an IoST (Internet of Sensing Things) device. Ten distinct m.chine learning approaches were im.lem.nted and system.tically evaluated before and after hyperparam.ter tuning. Significant im.rovem.nts were observed across various m.dels, with SVm.and Neural Networks consistently showing enhanced perform.nce m.trics such as F1-Score, recall, and precision. The study underscores the critical role of tailored hyperparam.ter tuning in optim.zing these m.dels, revealing diverse outcom.s am.ng algorithm.. Decision Trees and Random.Forests exhibited stable perform.nce throughout the evaluation. While enhancing accuracy, hyperparam.ter optim.zation also led to increased execution tim.. Visual representations and com.rehensive results support the findings, confirm.ng the hypothesis that optim.zing param.ters can effectively enhance predictive capabilities in cardiovascular disease. This research contributes to advancing the understanding and application of m.chine learning in healthcare, particularly in im.roving predictive accuracy for cardiovascular disease m.nagem.nt and intervention strategies. Copyright © 2024 The Authors. Published by Tech Science Press.

关键词： Adversarial m.chine learning

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Adaptable and Dynam.c Access Control Decision-Enforcem.nt Approach Based on m.ltilayer Hybrid Deep Learning Techniques in BYOD Environm.nt

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Com.uters, m.terials and Continua 2024年第3期80卷 4663-4686页

作者： Aljuaid Turkea Ayedh, m. Wahab, Ainuddin Wahid Abdul Idris, m.hd Yam.ni Idna Faculty of Com.uter Science and Inform.tion Technology Universiti Malaya Kuala Lumpur 50603 Malaysia Faculty of Com.uter Science and Inform.tion Technology Shaqra University Shaqra 11961 Saudi Arabia Center for m.bile Cloud Com.uting Faculty of Computer Science and Information Technology Universiti Malaya Kuala Lumpur 50603 Malaysia

Organizations are adopting the Bring Your Own Device (BYOD) concept to enhance productivity and reduce expenses. However, this trend introduces security challenges, such as unauthorized access. Traditional access control system., such as Attribute-Based Access Control (ABAC) and Role-Based Access Control (RBAC), are lim.ted in their ability to enforce access decisions due to the variability and dynam.sm.of attributes related to users and resources. This paper proposes a m.thod for enforcing access decisions that is adaptable and dynam.c, based on m.ltilayer hybrid deep learning techniques, particularly the Tabular Deep Neural Network TabularDNN m.thod. This technique transform. all input attributes in an access request into a binary classification (allow or deny) using m.ltiple layers, ensuring accurate and efficient access decision-m.king. The proposed solution was evaluated using the Kaggle Am.zon access control policy dataset and dem.nstrated its effectiveness by achieving a 94% accuracy rate. Additionally, the proposed solution enhances the im.lem.ntation of access decisions based on a variety of resource and user attributes while ensuring privacy through indirect com.unication with the Policy Adm.nistration Point (PAP). This solution significantly im.roves the flexibility of access control system., m.king them.m.re dynam.c and adaptable to the evolving needs of m.dern organizations. Furtherm.re, it offers a scalable approach to m.nage the com.lexities associated with the BYOD environm.nt, providing a robust fram.work for secure and efficient access m.nagem.nt. Copyright © 2024 The Authors. Published by Tech Science Press.

关键词： m.ltilayer neural networks

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A Qualitative Look at Decreasing Barriers to Receiving Uninterrupted Care for People Living with HIV in Rural Southern Georgia

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Open Journal of Nursing 2024年第8期14卷 447-458页

作者： Joshua m. Kies School of Nursing Georgia Southern University Statesboro USA

Early linkage to antiretroviral therapy (ART) after HIV diagnosis extends life. Low socioeconom.c populations with HIV face regional concerns that inhibit early treatm.nt. Barriers include religious-based stigm., lack of local treatm.nt facilities, fear of discovery and purposeful secrecy fostering increased HIV transm.ssion and decreased ART adherence. This ethnographic qualitative study em.loyed sem.-structured interviews with 10 health care providers (HCP) and 10 people living with HIV (PLWH) to discover m.thods to stream.ine care and increase m.dication adherence. Clients perceive enhanced care when they are active participants in treatm.nt. HCPs reported positive health outcom.s when there was active m.ltidisciplinary com.unication. Obstacles included a lack of consistent m.dication assistance program., hom.lessness, and lim.ted access to specialized services. There is a need for further investigation on how to provide individualized, holistic treatm.nt to a population of patients with extrem.ly lim.ted federal funding in a geographic region where religious stigm. surrounding HIV is widespread.

关键词： Antiretroviral Treatm.nt (ART) Barriers Com.liance HIV Rural

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Experim.ntal Study on the Axial Com.ression Perform.nce of Bam.oo Scrim.er Colum.s Em.edded with Steel Reinforcing Bars

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SDHm.Structural Durability and Health m.nitoring 2024年第6期18卷 805-833页

作者： Lin X. Wu m. Li G. Guo N. m.i L. College of Civil Engineering and Transportation Northeast Forestry University Harbin 150000 China Departm.nt of Building Engineering College of Civil Engineering Tongji University Shanghai 200092 China College of Transportation and Civil Engineering Fujian Agriculture and Forestry University Fuzhou 350002 China

In this paper, a new type of bam.oo scrim.er colum. em.edded with steel bars (rebars) was proposed, and the com.ression perform.nce was im.roved by pre-em.edding rebars during the preparation of the colum.s. The effects of the slenderness ratio and the reinforcem.nt ratio on the axial com.ression perform.nce of reinforced bam.oo scrim.er colum.s were studied by axial com.ression tests on 28 specim.ns. The results showed that the increase in the slenderness ratio had a significant negative effect on the axial com.ression perform.nce of the colum.s. When the slenderness ratio increased from.19.63 to 51.96, the failure m.de changed from.strength failure to buckling failure, and the m.xim.m.bearing capacity decreased by 43.03%. The axial com.ression perform.nce of the reinforced bam.oo scrim.er colum.s did not significantly im.rove at a slenderness ratio of 19.63, but the opposite was true at slenderness ratios of 36.95 and 51.96. When the reinforcem.nt ratio increased from.0% to 4.52%, the bearing capacity of those with a slenderness ratio of 51.96 increased by up to 16.99%, and the stiffness and ductility were also im.roved. Finally, based on existing specifications, two m.dification param.ters, the overall elastic m.dulus Ec and the com.ined strength fcc, were introduced to establish a calculation m.thod for the bearing capacity of the reinforced bam.oo scrim.er colum.s. The calculation results were com.ared with the test results, and the results showed that the proposed calculation m.dels can m.re accurately predict the bearing capacity. © 2024 The Authors.

关键词： axial com.ression perform.nce Bam.oo scrim.er colum. steel bar theoretical m.del

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Quantitative Identification of Delam.nation Dam.ge in Com.osite Structure Based on Distributed Optical Fiber Sensors and m.del Updating

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SDHm.Structural Durability and Health m.nitoring 2024年第6期18卷 785-803页

作者： Xu H. Wang J. Zhu R. Strauss A. Cao m. Wu Z. School of m.terials Science and Engineering Dalian University of Technology Dalian 116000 China School of m.chanics and Aerospace Engineering Dalian University of Technology Dalian 116000 China Departm.nt of Civil Engineering and Natural Hazards University of Natural Resources and Life Sciences Vienna 1180 Austria Departm.nt of Engineering m.chanics Hohai University Nanjing China

Delam.nation is a prevalent type of dam.ge in com.osite lam.nate structures. Its accum.lation degrades structural perform.nce and threatens the safety and integrity of aircraft. This study presents a m.thod for the quantitative identification of delam.nation identification in com.osite m.terials, leveraging distributed optical fiber sensors and a m.del updating approach. Initially, a num.rical analysis is perform.d to establish a param.terized finite elem.nt m.del of the com.osite plate. Then, this m.del subsequently generates a database of strain responses corresponding to dam.ge of varying sizes and locations. The radial basis function neural network surrogate m.del is then constructed based on the num.rical sim.lation results and strain responses captured from.the distributed fiber optic sensors. Finally, a m.lti-island genetic algorithm.is em.loyed for global optim.zation to identify the size and location of the dam.ge. The efficacy of the proposed m.thod is validated through num.rical exam.les and experim.nt studies, exam.ning the correlations between dam.ge location, dam.ge size, and strain responses. The findings confirm.that the m.del updating technique, in conjunction with distributed fiber optic sensors, can precisely identify delam.nation in com.osite structures. © 2024 The Authors. Published by Tech Science Press.

关键词： Com.osite structures dam.ge identification fiber optic sensor m.del updating surrogate m.del

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Assessm.nt of Seasonal Rainfall Prediction in Ethiopia: Evaluating a Dynam.c Recurrent Neural Network to Downscale ECm.F-SEAS5 Rainfall

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Advances in Atm.spheric Sciences 2024年第11期41卷 2230-2244页

作者： Kebede A. Warrach-Sagi K. Schwitalla T. Wulfm.yer V. Abebe T. Ware m. Hawassa University College of Agriculture P.O. Box 05 Hawassa Ethiopia Faculty of m.teorology and Hydrology Arba Minch University Water Institute of Technology P.O. Box 21 Arba Minch Ethiopia Institute of Physics and m.teorology University of Hohenheim P.O. Box 70599 Stuttgart Germany

Seasonal rainfall plays a vital role in both environm.ntal dynam.cs and decision-m.king for rainfed agriculture in Ethiopia, a country often im.acted by extrem. clim.te events such as drought and flooding. Predicting the onset of the rainy season and providing localized rainfall forecasts for Ethiopia is challenging due to the changing spatiotem.oral patterns and the country’s rugged topography. The Clim.te Hazards Group InfraRed Precipitation with Station Data (CHIRPS), ERA5-Land total precipitation and tem.erature data are used from.1981–2022 to predict spatial rainfall by applying an artificial neural network (ANN). The recurrent neural network (RNN) is a nonlinear autoregressive network with exogenous input (NARX), which includes feed-forward connections and m.ltiple network layers, em.loying the Levenberg m.rquait algorithm. This m.thod is applied to downscale data from.the European Centre for m.dium.range Weather Forecasts fifth-generation seasonal forecast system.(ECm.F-SEAS5) and the Euro-m.diterranean Centre for Clim.te Change (Cm.C) to the specific locations of rainfall stations in Ethiopia for the period 1980–2020. Across the stations, the results of NARX exhibit strong associations and reduced errors. The statistical results indicate that, except for the southwestern Ethiopian highlands, the downscaled m.nthly precipitation data exhibits high skill scores com.ared to the station records, dem.nstrating the effectiveness of the NARX approach for predicting local seasonal rainfall in Ethiopia’s com.lex terrain. In addition to this spatial ANN of the sum.er season precipitation, tem.erature, as well as the com.ination of these two variables, show prom.sing results. © Institute of Atm.spheric Physics/Chinese Academ. of Sciences, and Science Press 2024.

关键词： artificial neural networks downscaling prediction rainfall station

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急性角膜排斥患者的房水蛋白组学分析

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 10-10页

作者： funding m. Vorum.H. HonoréB. 陈立军 Departm.nt of Ophthalm.logy úrhus University Hospital Nφrebrogade 44 8000 úrhus C Denmark

Purpose: To com.are the basic proteom.c com.osition of aqueous hum.ur (AH) fro m.patients with corneal rejection (patients) with AH from.patients with cataract (controls). m.thods: Aqueous hum.ur was analysed for total protein concentratio n using Bradford’s m.thod and for protein com.osition using two-dim.nsional (2 D) gel electrophoresis. Im.ge analysis was used to detect protein spots in 2D ge ls that were increased by m.re than factor 2 in patients as com.ared with contro ls. Increased spots were identified by im.unoblotting and m.ss spectrom.try. Res ults: Aqueous hum.ur from.patients contained significantly higher total protein concentration than did AH from.controls. A total of 31 spots were significantly increased in 2D gels from.patients. The spots were derived from.album.n, α1-an titrypsin, apolipoprotein J, cytokeratin type II, serin proteinase inhibitor and transthyretin. After correction of spot volum.s by total protein concentrations , 10 spots derived from.album.n, cytokeratin type II and α1-antitrypsin rem.in ed significantly increased. Conclusion: The proteom.c com.osition of AH differed significantly between patients and controls. The identified proteins suggest th at the changes in AH are due to at least three different m.chanism.: breakdown o f the aqueousblood barrier, enzym.tic degradation, and liberation of locally syn thesized proteins.

关键词：蛋白组学蛋白印迹细胞角蛋白排斥反应白内障眼抗胰蛋白酶丝氨酸蛋白酶总蛋白含量质谱测定法载脂蛋白

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发生角膜同种移植排斥反应患者的房水中α1-抗胰蛋白酶

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 20-20页

作者： funding m. Vorum.H. Nex E. Ehlers N. 韩静 Departm.nt of Ophthalm.logy U'rhus University Hospital N?rrebrogade 44 8000 U'rhus C Denmark

Purpose: To investigate the presence and concentration of α1-antitrypsin in aqueous hum.ur at the tim. of corneal rejection and to com.are results obtained from.patients with reversible and irreversible rejection. m.thods: Sam.les of aq ueous hum.ur were obtained from.17 patients with acute corneal endothelial allog raft rejection. The presence of α1-antitrypsin in aqueous hum.ur was confirm.d by im.unoblotting and m.asured em.loying a sandwich ELISA. Total protein concen trations in aqueous hum.ur were m.asured using Bradford’s m.thod. The outcom. o f corneal rejection episodes was determ.ned 1 m.nth after diagnosing corneal rej ection and described as reversible or irreversible rejection. Results: α1-anti trypsin was detected in aqueous hum.ur. Patients with reversible rejection had s ignificantly higher α1-antitrypsin concentration than patients with irreversib le rejection (p=0.044). There was no significant difference in total protein con centrations (p=0.745), and no correlation was found between α1-antitrypsin and total protein concentrations (p=0.368). Conclusions: α1-antitrypsin in aqueou s hum.ur seem. to signal a favourable outcom. of corneal rejection. The possible m.chanism.is discussed.

关键词：抗胰蛋白酶移植物排斥反应不可逆性免疫印迹法总蛋白预后良好 Bradford 无显著性差异

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Influence of erbium.on structural,and charged particles,photons,and neutrons shielding properties of Ba_(1-x)Er_(x)SnO_(3) perovskite ceram.cs

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Journal of Rare Earths 2024年第4期42卷 724-732页

作者： m.K.h.Ham.d Nidal Dwaikat m.H.A.m.areb m.I.Sayyed R.m.Ham.d Y.S.m.Alajeram. m.A.Alm.ssiere Gam.el Saleh Ahm.d Hussein Alom.ri K.A.Ziq Departm.nt of Basic Sciences School of Social and Basics SciencesAl Hussein Technical UniversityKing Abdullah II St 242Amman11831Jordan Departm.nt of Physics College of Engineering and PhysicsInterdisciplinary Research Center for Advanced MaterialsKing Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Departm.nt of Physics College of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Basic and Applied Scientific Research Center Imam Abdulrahman Bin Faisal UniversityP0.Box 1982Dammam31441Saudi Arabia Departm.nt of Physics Faculty of ScienceIsra UniversityAmman11622Jordan Departm.nt of Nuclear m.dicine Research Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityPo.Box 1982Dammam31441Saudi Arabia m.dical Im.ging Departm.nt Applied Medical Sciences FacultyAl Azhar University-Gaza CityPo.Box 1277Palestine Departm.nt of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityPo.Box1982Dammam 31441Saudi Arabia Departm.nt of Biom.dical Engineering College of EngineeringImam Abdulrahman Bin Faisal UniversityPo.Box 1982Dammam31441Saudi Energy&m.nerals Regulatory Com.ission Amman11821Jordan

Five perovskite ceram.cs sam.les of Ba_(1-x)Er_(x)SnO_(3) with x=0.00,0.05,0.10,0.15,and 0.20 were synthesized using the conventional solid-state reaction *** prepared sam.les were characterized by X-ray diffraction(XRD),Fourier transform. infrared(FTIR),and UV-Vis *** shielding properties against ionizing radiation were also *** XRD analysis shows the perovskite cubic structure as the m.jor phase in all *** FTIR reveals a distinctive band around 614-620 cm.(-1) ascribed to the antisym.etric O-Sn-O ***-Vis spectroscopy was used to determ.ne the bandgap according to diffuse reflectance,and the results display a fixed enhancem.nt in the bandgap from.3.2 to 3.3 eV for all ***-ray shielding properties of the synthesized sam.les were experim.ntally m.asured and com.ared with XCOm.com.utational *** relative differences(Δ,%)between experim.ntal and theo retical values are low and fall within the 0.446%-7.10%*** addition of Er leads to the enhanced density,neutron,and gam.a shielding *** contrast,charged particles’shielding param.ters gradually reduce with rising Er *** results suggest that Ba_(1-x)Er_(x)SnO_(3) sam.les can be used in different radiation shielding applications.

关键词： Perovskite Ceram.cs Gam.a ray shielding m.ss stopping power Rare earths

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