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Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation

Cellular & Molecular Immunology 2021年第6期18卷 1437-1449页

作者： Tomoaki Koga fumiyuki sasaki Kazuko Saeki Soken Tsuchiya Toshiaki Okuno Mai Ohba Takako Ichiki Satoshi Iwamoto Hirotsugu Uzawa Keiko Kitajima Chikara Meno Eri Nakamura Norihiro Tada Yoshinori Fukui Junichi Kikuta Masaru Ishii Yukihiko Sugimoto Mitsuyoshi Nakao Takehiko Yokomizo Department of Biochemistry Juntendo University Graduate School of MedicineTokyo113-8421Japan Department of Medical Cell Biology Institute of Molecular Embryology and GeneticsKumamoto UniversityKumamoto860-0811Japan Department of Cell Signaling Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo113-8510Japan Department of Pharmaceutical Biochemistry Graduate School of Pharmaceutical SciencesKumamoto UniversityKumamoto862-0973Japan Department of Developmental Biology Graduate School of Medical SciencesKyushu UniversityFukuoka812-8582Japan Laboratory of Genome Research Research Institute for Diseases of Old AgeJuntendo University Graduate School of MedicineTokyo113-8421Japan Division of Immunogenetics Department of Immunobiology and NeuroscienceMedical Institute of BioregulationKyushu UniversityFukuoka812-8582Japan Department of Immunology and Cell Biology Graduate School of Medicine and Frontier BiosciencesOsaka UniversityOsaka565-0871Japan

Leukotriene B4(LTB4)receptor 1(BLT1)is a chemotactic G protein-coupled receptor expressed by leukocytes,such as granulocytes,macrophages,and activated T *** there is growing evidence that BLT1 plays crucial roles in immune responses,its role in dendritic cells remains largely ***,we identified novel DC subsets defined by the expression of BLT1,namely,BLT1hi and BLT1lo *** also found that BLT1hi and BLT1lo DCs differentially migrated toward LTB4 and CCL21,a lymph node-homing chemoattractant,*** generating LTB4-producing enzyme LTA4H knockout mice and CD11c promoter-driven Cre recombinase-expressing BLT1 conditional knockout(BLT1 cKO)mice,we showed that the migration of BLT1hi DCs exacerbated allergic contact *** transcriptome analysis revealed that BLT1hi DCs preferentially induced Th1 differentiation by upregulating IL-12p35 expression,whereas BLT1lo DCs accelerated T cell proliferation by producing ***,the data reveal an unexpected role for BLT1 as a novel DC subset marker and provide novel insights into the role of the LTB4-BLT1 axis in the spatiotemporal regulation of distinct DC subsets.

关键词： LTB4 BLT1 dendritic cells inflammation lipid mediator

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Effects of hydraulic oil and lubricant additives on dynamic friction properties under various reciprocating sliding conditions

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Friction 2020年第2期8卷 471-480页

作者： Shinji KATO Shinya sasaki Engineering Headquarters Automotive ComponentsKYB Corporation2548DolaKani-shiGifu 509-0298Japan Department of Mechanical Engineering Faculty of Engineering Division ITokyo University of Science6-3-1NiijukuKatsushika-kuTokyo 125-8585Japan

The friction characteristics of a shock absorber are very complex because the reciprocating motion is not always *** this study,a device was developed and used to analyze the dynamic friction characteristics under various reciprocating sliding conditions to determine the sliding materials and hydraulic oils that improve the shock absorber *** study describes the influence of hydraulic oil additive on the fine reciprocating friction characteristics of steel and copper *** oils were prepared by blending a paraffinic mineral oil with zinc dithiophosphate(ZnDTP)and polyhydric alcohol ester as *** results show that the dynamic frictional characteristics vary mainly depending on the additive concentration.A specific additive formulation induces a unique amplitude-dependent friction *** addition,the influence of different additives on the lubrication mechanism is investigated based on the instrumental analysis of the friction surface.

关键词： shock absorber dynamic friction reciprocating friction additive zinc dithiophosphate(ZnDTP)

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HYPERGAMES AND BAYESIAN GAMES:A THEORETICAL COMPARISON OF THE MODELS OF GAMES WITH INCOMPLETE INFORMATION

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Journal of Systems Science & Complexity 2012年第4期25卷 720-735页

作者： Yasuo sasaki Kyoichi KIJIMA Graduate School of Decision Science and Technology Tokyo Institute of Technology

The present study discusses the relationships between two independently developed models of games with incomplete information, hypergames （Bennett, 1977） and Bayesian games （Harsanyi, 1967）. The authors first show that any hypergame can naturally be reformulated in terms of Bayesian games in an unified way. The transformation procedure is called Bayesian representation of hypergame. The authors then prove that some equilibrium concepts defined for hypergames are in a sense equivalent to those for Bayesian games. Furthermore, the authors discuss carefully based on the proposed analysis how each model should be used according to the analyzer＇s purpose.

关键词： Bayesian game Bayesian representations of hypergame hypergame incomplete information."

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Hierarchical Hypergames and Bayesian Games:A Generalization of the Theoretical Comparison of Hypergames and Bayesian Games Considering Hierarchy of Perceptions

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Journal of Systems Science & Complexity 2016年第1期29卷 187-201页

作者： sasaki Yasuo KIJIMA Kyoichi School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1AsahidaiNomiIshikawaJapan Department of Value and Decision Science Tokyo Institute of Technology 2-12-1OokayamaMeguro-kuTokyoJapan

This paper discusses the relationship of two independently developed models of games with incomplete information,hierarchical hypergames and Bayesian *** can be considered as a generalization of the previous study on the theoretical comparison of simple hypergames and Bayesian games(sasaki and Kijima,2012) by taking into account hierarchy of perceptions,i.e.,an agent's perception about the other agents' perceptions,and so *** authors first introduce the general way of transformation of any hierarchical hypergames into corresponding Bayesian games,which was called as the Bayesian representation of hierarchical *** authors then show that some equilibrium concepts for hierarchical hypergames can be associated with those for Bayesian games and discuss implications of the results.

关键词： Bayesian games game theory hierarchy of perceptions hypergames incomplete information

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Population synthesis of planet formation using a torque formula with dynamic effects

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Geoscience Frontiers 2017年第2期8卷 215-222页

作者： Takanori sasaki Toshikazu Ebisuzaki Department of Astronomy Kyoto University RIKEN

Population synthesis studies into planet formation have suggested that distributions consistent with observations can only be reproduced if the actual Type Ⅰ migration timescale is at least an order of magnitude longer than that deduced from linear *** past studies considered the effect of the Type I migration of protoplanetary embryos,in most cases they used a conventional formula based on static torques in isothermal disks,and employed a reduction factor to account for uncertainty in the mechanism ***,in addition to static torques,a migrating planet experiences dynamic torques that are proportional to the migration *** dynamic torques can impact on planet migration and predicted planetary *** this study,we derived a new torque formula for Type Ⅰ migration by taking into account dynamic *** formula was used to perform population synthesis simulations with and without the effect of dynamic *** many cases,inward migration was slowed significantly by the dynamic *** the static torque case,gas giant formation was effectively suppressed by Type I migration;however,when dynamic effects were considered,a substantial fraction of cores survived and grew into gas giants.

关键词： Planetary formation Population synthesis Type Ⅰ migration

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Highly active and stable supported Pd catalysts on ionic liquidfunctionalized SBA-15 for Suzuki–Miyaura cross-coupling and transfer hydrogenation reactions

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Green Energy & Environment 2019年第2期4卷 180-189页

作者： Etty N.Kusumawati Takehiko sasaki Department of Chemistry Graduate School of Science The University of Tokyo Institute for Catalysis Hokkaido University Department of Complexity Science and Engineering Graduate School of Frontier Sciences The University of Tokyo

Highly dispersed palladium nanoparticles were synthesized in the presence of immobilized ionic liquid on mesoporous silica ***(2.4 nm)_me-Im@SBA-15 catalyst was prepared by the reduction using NaBH_4 as the reducing agent with controlled feed rate and has been investigated as ligand-free catalyst for Suzuki–Miyaura cross-coupling reaction at room temperature in aqueous solution under *** catalyst was also prepared in situ from PdCl4_me-Im@SBA-15 during the reaction and demonstrated high activity and stability towards nitrobenzene hydrogenation at high temperature. Both catalysts were reusable at least for four recycle processes without significant loss in activity with simple procedure. The catalysts were characterized by TEM, EXAFS, FTIR and XPS.

关键词： Palladium nanoparticle Ionic liquid SBA-15 Suzuki–Miyaura cross-coupling Hydrogenation

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BO_(2)-F^(+)Centers in the Radiation-damaged YCOB Crystals

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Chinese Physics Letters 2000年第12期17卷 896-898页

作者： RUAN Yong-Feng Hiroshi NAKAO Takatomo sasaki Department of Physics Tianjin UniversityTianjin 300072 Department of Electrical Engineering Osaka UniversityOsaka 565-0871Japan

An intense paramagnetic EPR signal generated from x-ray-irradiated,powdered YCOB crystals was observed at the liquid nitrogen temperature for the first *** peaks,located at the positions where the effective g factor equals to 1.992,1.986,1.980,1.974 and 1.965,labeled as A,B,C,D and E respectively,were *** is believed that the peaks A,B,C and D generated from the BO_(2)-F^(+)center which is a single electron trapped in an oxygen vacancy which was originally occupied by an O^(2-)ion bonded to a(BO3)^(3-)anion *** peak E is thought of coming from Y2+ions that are formed by the Y^(3+) ions trapping *** mechanism for the formation of the radiation-induced defects in the YCOB crystals is suggested.

关键词： Crystal occupied trapping

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Varifocal MEMS mirrors for high-speed axial focus scanning:a review

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Microsystems & Nanoengineering 2023年第5期9卷 57-71页

作者： Jaka Pribošek Markus Bainschab Takashi sasaki Silicon Austria Labs VillachAustria

Recent advances brought the performance of MEMS-based varifocal mirrors to levels comparable to conventional ultra-high-speed focusing *** mirrors are becoming capable of high axial resolution exceeding 300 resolvable planes,can achieve microsecond response times,continuous operation above several hundred kHz,and can be designed to combine focusing with lateral steering in a single-chip *** survey summarizes the past 50 years of scientific progress in varifocal MEMS mirrors,providing the most comprehensive study in this field to *** introduce a novel figure of merit for varifocal mirrors on the basis of which we evaluate and compare nearly all reported devices from the *** the forefront of this review is the analysis of the advantages and shortcomings of various actuation technologies,as well as a systematic study of methods reported to enhance the focusing performance in terms of speed,resolution,and shape *** believe this analysis will fuel the future technological development of next-generation varifocal mirrors reaching the axial resolution of 1000 resolvable planes.

关键词： axial mirrors exceeding

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Fibroblasts, an inconspicuous but essential player in colon cancer development and progression

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World Journal of Gastroenterology 2016年第23期22卷 5301-5316页

作者： Naofumi Mukaida Soichiro sasaki Division of Molecular Bioregulation Cancer Research InstituteKanazawa University

Tumor microenvironments have a crucial role in cancer initiation and progression, and share many molecular and pathological features with wound healing process. Unless treated, tumors, however, do not heal in contrast to wounds that heal within a limited time framework. Wounds heal in coordination of a myriad of types of cells, particularly endothelial cells, leukocytes, and fibroblasts. Similar sets of cells also contribute to cancer initiation and progression, and as a consequence, anti-cancer treatment strategies have been proposed and tested by targeting endothelial cells and/or leukocytes. Compared with endothelial cells and leukocytes, less attention has been paid to the roles of cancer-associated fibroblasts(CAFs), fibroblasts present in tumor tissues, because their heterogeneity hinders the elucidation on them at cellular and molecular levels. Here, we will discuss the origin of CAFs and their crucial roles in cancer initiation and progression, and the possibility to develop a novel type of anti-cancer treatment by manipulating the migration and functions of CAFs.

关键词： Angiogenesis Drug resistance Extracellular matrix Immune evasion Transforming growth factor-β Invasion Metastasis

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A minimized fluorescent chemosensor array utilizing carboxylate-attached polythiophenes on a chip for metal ions detection

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Frontiers of Chemical Science and Engineering 2022年第1期16卷 72-80页

作者： Yui sasaki Xiaojun Lyu Zhoujie Zhang Tsuyoshi Minami Institute of Industrial Science The University of TokyoTokyo 153-8505Japan

Chemosensor arrays have a great potential for on-site applications in real-world ***,to fabricate on chemosensor array a number of chemosensors are required to obtain various optical patterns for multianalyte ***,we propose a minimized chemosensor array composed of only two types of carboxylate-functionalized polythiophene derivatives for the detection of eight types of metal *** recognition of the metal ions,the polythiophenes exhibited changes in their fluorescence intensity and various spectral *** both chemosensors have the same polymer backbone and recognition moiety,only the difference in the number of methylene groups contributed to the difference in the fluorescence response ***,the metal ions in aqueous media were successfully discriminated qualitatively and quantitatively by the chemosensor microarray on the glass *** study offers an approach for achieving a minimized chemosensor array just by changing the alkyl chain lengths without the necessity for many receptors and reporters.

关键词： metal ions polythiophene chemosensor array fluorescence pattern recognition

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