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Journal of Mountain Science 2016年第2期13卷 213-222页

作者： fumitoshi imaizumi Satoshi TSUCHIYA Okihiro OHSAKA Department of Environment and Forest Resources Science Faculty of AgricultureShizuoka University

Although information regarding the initiation processes of debris flows is important for the development of mitigation measures,field data regarding these processes are scarce.We conducted field observations of debris-flow initiation processes in the upper Ichinosawa catchment of the Ohya landslide,central Japan.On 19 June 2012,our videocamera monitoring systems recorded the moment of debris-flow initiation on channel deposits(nine surges) and talus slopes(eight surges).The initiation mechanisms of these surges were classified into three types by analyzing the video images: erosion by the surface flow,movement of deposits as a mass,and upward development of the fluid area.The first type was associated with the progress of surface flow from the upper stream on unsaturated channel deposits.The second type was likely caused by an increase in the pore water pressure associated with the rising in the groundwater level in channel deposits;a continuous water supply from the upper stream by the surface flow might have induced this saturation.The third type was associated with changes in the downstream topography caused by erosion.The flow velocity of most surges was less than 3 m s^(-1) and they usually stopped within 100 m from the initiation point.Surges with abundant pore fluid had a higher flow velocity(about 3- 5 m s^(-1)) and could travel for alonger duration.Our observations indicate that the surface flow plays an important role in the initiation of debris flows on channel deposits and talus slopes.

关键词：滑坡泥石流现场观测堆积过程地下水位上升河道沉积孔隙流体泥石流滑坡视频摄像头

Effects of liraglutide on metabolic syndrome in WBN/Kob diabetic fatty rats supplemented with a high-fat diet

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Animal Models and Experimental Medicine 2020年第1期3卷 62-68页

作者： Noriyuki Kaji Yoshiichi Takagi Satomi Matsuda Anna Takahashi Sakurako Fujio fumitoshi Asai Laboratory of Veterinary Pharmacology School of Veterinary MedicineAzabu UniversityKanagawaJapan

Background:Liraglutide,a GLP-1 receptor agonist,has recently been used to treat metabolic syndrome(MS)because of its anti-diabetic and anti-obesity effects.We have previously shown that Wistar Bonn Kobori diabetic and fatty(WBN/Kob-Leprfa,WBKDF)rats fed a high-fat diet(HFD)developed MS including marked obesity,hyperglycemia,and dyslipidemia.To obtain further information on WBKDF-HFD rats as a severe MS model,we performed a pharmacological investigation into the anti-MS effects of liraglutide in this model.Methods:Seven-week-old male WBKDF-HFD rats were allocated to three groups(n=8 in each group):a vehicle group,a low-dose liraglutide group,and a high-dose liraglutide group.They received subcutaneous injections of either saline or liraglutide at doses of 75 or 300μg/kg body weight once daily for 4 weeks.Results:Results showed that liraglutide treatment reduced body weight gain and food intake in a dose-dependent manner.The marked hyperglycemia and the glucose tolerance were also significantly ameliorated in the liraglutide-treated groups.Moreover,liraglutide also reduced the plasma triglyceride concentration and liver fat accumulation.Conclusions:The present study demonstrated that liraglutide could significantly alleviate MS in WBKDF-HFD rats,and the reaction to liraglutide is similar to human patients with MS.WBKDF-HFD rats are therefore considered to be a useful model for research on severe human MS.

关键词： diabetes mellitus liraglutide metabolic syndrome models animal obesity

Peritoneovenous shunt for intractable ascites due to hepatic lymphorrhea after hepatectomy

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World Journal of Gastrointestinal Surgery 2011年第1期3卷 16-20页

作者： Yoshihiro Inoue Michihiro Hayashi fumitoshi Hirokawa Atsushi Takeshita Nobuhiko Tanigawa Department of General and Gastroenterological Surgery Osaka Medical College Hospital Department of Pathology Osaka Medical College Hospital

A peritoneovenous shunt has become one of the most effi cient procedures for intractable ascites due to liver cirrhosis.A case of intractable ascites due to hepatic lymphorrhea after hepatectomy for hepatocellular carcinoma that was successfully treated by the placement of a peritoneovenous shunt is presented.A 72-year-old Japanese man underwent partial resection of the liver for hepatocellular carcinoma associated with hepatitis C viral infection.After hepatectomy,a considerable amount of ascites ranging from 800-4600 mL per day persisted despite conservative therapy,including numerous infusions of albumin and plasma protein fraction and administration of diuretics.Since the patient's general condition deteriorated,based on the diagnosis of intractable hepatic lymphorrhea,a subcutaneous peritoneovenous shunt was inserted.The patient's postoperative course was uneventful and the ascites decreased rapidly,with serum total protein and albumin levels and hepatic function improving accordingly.For intractable ascites due to hepatic lymphorrhea after hepatectomy,we recommend the placement of a peritoneovenous shunt as a procedure that can provide immediate effectiveness without increased surgical risk.

关键词： Peritoneovenous shunt Surgical procedure Intractable ascites Hepatic lymphorrhea Hepatocellular carcinoma

Pharmaceutical properties of insulin conjugate with glucuronylglucosyl-β-cyclodextrin

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 120-121页

作者： Mari Sugio Tatsunori Hirotsu Taishi Higashi Keiichi Motoyama fumitoshi Hirayama Kaneto Uekama Hidetoshi Arima Graduate School of Pharmaceutical Sciences Kumamoto University5-1 Oe-honmachiChuo-kuKumamotoJapan Program for Leading Graduate Schools“HIGO(Health Life Science:Interdisciplinary and Glocal Oriented)Program ”Kumamoto University5-1 Oe-honmachiChuo-kuKumamotoJapan Faculty of Pharmaceutical Sciences Sojo University4-22-1 IkedaNishi-kuKumamotoJapan Kumamoto University KumamotoJapan

In the clinical field,insulin has been used for treatment of diabetes.However,insulin often shows low physicochemical stability,adsorption onto tubes and enzymatic degradation in injection site or blood.Previously,we demonstrated that cyclodextrins(CyDs),especially branchedβ-CyDs,improve the pharmaceutical properties of insulin through complexation with its aromatic residues.However,little has been reported on the insulin conjugate with branchedβ-CyD.In the present study,to improve the pharmaceutical properties of insulin,we newly prepared 6-Ο-α-(4-Ο-α-D-glucuronyl)-D-glucosyl-β-CyD(GUG-β-CyD)conjugate with insulin,and evaluated its thermal or enzymatic stability and adsorption onto glass or polypropylene tube[1].

关键词： Glucuronylglucosyl-β-cyclodextrin Insulin Conjugate Stability Adsorption

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World Journal of Clinical Cases 2019年第21期7卷 3553-3561页

作者： Takeshi Mizusawa Kenya Kamimura Hiroki Sato Takeshi Suda Hiroyuki Fukunari Go Hasegawa Osamu Shibata Shinichi Morita Akira Sakamaki Junji Yokoyama Yu Saito Yoshihisa Hori Yuduru Maruyama fumitoshi Yoshimine Takahiro Hoshi Shinichi Morita Tsutomu Kanefuji Masaaki Kobayashi Shuji Terai Department of Internal Medicine Niigata Prefectural Tokamachi HospitalTokamachiNiigata 948-0065Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan Department of Gastroenterology and Hepatology Uonuma Institute of Community Medicine Niigata University HospitalMinami UonumaNiigata 949-7302Japan Department of Surgery Niigata Prefectural Tokamachi HospitalTokamachiNiigata 948-0065Japan Department of Pathology Uonuma Institute of Community Medicine Niigata University HospitalMinami UonumaNiigata 949-7302Japan Department of Internal Medicine Tokamachi Central ClinicTokamachiNiigata 948-0065Japan

BACKGROUND Immunosuppression is effective in treating a number of diseases,but adverse effects such as bone marrow suppression,infection,and oncogenesis are of concern.Methotrexate is a key immunosuppressant used to treat rheumatoid arthritis.Although it is effective for many patients,various side effects have been reported,one of the most serious being methotrexate-related lymphoproliferative disorder.While this may occur in various organs,liver involvement is rare.Information on these liver lesions,including clinical characteristics,course,and imaging studies,has not been summarized to date.CASE SUMMARY We present a case of 70-year-old woman presented with a 2-wk history of fever and abdominal pain.She had had rheumatoid arthritis for 5 years and was being treated with medication including methotrexate.Contrast-enhanced computed tomography revealed multiple low density tumors in the liver and the histological analyses showed significant proliferation of lymphocytes in masses that were positive on immunohistochemical staining for CD3,CD4,CD8,and CD79a but negative for CD20 and CD56.Staining for Epstein-Barr virus-encoded RNA was negative.And based on these findings,the liver tumors were diagnosed as Methotrexate-related lymphoproliferative disorders.A timedependent disappearance of the liver tumors after stopping methotrexate supported the diagnoses.CONCLUSION The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder.

关键词： Arthritis Rheumatoid Methotrexate Malignant lymphoma Case report

Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis

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World Journal of Gastroenterology 2005年第20期11卷 3085-3090页

作者： Hiroyuki Hanai Takayuki Iida Ken Takeuchi fumitoshi Watanabe Yasuhiko Maruyama Masataka Kikuyama Tatsuo Tanaka Kenji Kondo Kou Tanaka Kenji Takai Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of Medicine HamamatsuJapan Department of Gastroenterology Fujieda Municipal General Hospital FujiedaJapan Department of Gastroenterology Hamamatsu Rosai Hospital Hamamatsu Japan Tanaka Clinic Shizuoka Japan SRL Inc. Tokyo Japan

AIM: To investigate the clinical efficacy of leukocytapheresis (LCAP) in patients with active ulcerative colitis (UC), and to elucidate the mechanisms by determining the changes in the cytokine levels in the peripheral blood and of the functions of the peripheral blood leukocytes in these patients.METHODS: The subjects were 19 patients with active UC, with a mean clinical activity index (CAI) of 9.2. The LCAP was conducted using Cellsorba E. In each session of LCAP, 2-3 L of blood at the flow rate of 30-50 mL/min was processed. The treatment was carried out in approximately 1-h sessions, once a week, for 5-10 wk. Blood samples for determination of the cytokine levels were collected from the inflow side of the column (site of dehematization; at the start of LCAP) and outflow side of the column (at the end of LCAP). Blood samples for the determination of reactive-oxygen-producing cells were collected from the peripheral blood before and after LCAP.RESULTS: LCAP resulted in clinical improvement in all the 19 patients of UC recruited for this study. Remission (CAI: ≤4) was noted in 15 (79%) of the 19 patients. The blood level of the pro-inflammatory cytoline IL-6 was found to be decreased following treatment by LCAP, and the level of the anti-inflammatory cytokine IL-10 at the outflow side of the LCAP column was found to be significantly elevated as compared to that at the inflow side of the column. The reactive-oxygen-producing granulocytes in the peripheral blood of UC patients was increased as compared to that in healthy persons and the increase was found to be decreased following treatment by LCAP.CONCLUSION: LCAP exerted a high therapeutic efficacy in patients with active UC. Our findings suggest that LCAP is associated with enhanced production of the inhibitory cytokine IL-10 to indirectly inhibit the functions of the inflammatory leukocytes, and that inflammation is also considerably attenuated by the direct removal of reactiveoxygen-producing neutrophils from the peripheral blood.

关键词：氧化反应粒性白细胞 IL-10 外周血溃疡性大肠炎

Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis

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World Journal of Gastroenterology 2006年第21期12卷 3393-3399页

作者： Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi fumitoshi Watanabe Hamamatsu South Hospital Center for Gastroenterology and IBD Research Department Endoscopic and Photodynamic Medicine Hamamatsu UniversityHamamatsuJapan Hamamatsu Medical Centre Hamamatsu Japan Seirei General Hospital Hamamatsu Japan Department Endoscopic and Photodynamic Medicine Hamamatsu University HamamatsuJapan Hamamatsu Rosai Hospital Hamamatsu Japan Fujueda General Hospital Fujieda Japan Hamamatsu Insurance Hospital Hamamatsu Japan Immunoresearch Laboratories Takasaki Japan Yasuhiko Maruyama Fujueda General Hospital FujiedaJapan

瞄准：调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra， IL-10， IL-6 和 IL-18 的传播层次之间的关系。方法：IL-1ra， IL-10， IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量，吝啬的蔡是 11.1，从 5-25 ；并且是的... 详细信息

瞄准：调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra， IL-10， IL-6 和 IL-18 的传播层次之间的关系。方法：IL-1ra， IL-10， IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量，吝啬的蔡是 11.1，从 5-25 ；并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果：我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827， P < 0.001 ) ， IL-6 (r = 0.785， P < 0.001 ) 并且 IL-18 (r = 0.791， P < 0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗， 31 个病人中的 24 个完成了宽恕，所有 4 cytokines 的层次掉在健康控制里到层次。进一步， IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。

关键词：等离子体细胞活素类肠溃疡白细胞介素

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中日早期电影比较研究与电影史教育

艺术学研究（辑刊） 2014年第1期8卷 561-566页

作者：刈间文俊施丽佳(整理) 日本东京大学不详

一、早期日本电影史与早期中国电影史非常感谢这次论坛给我这个发言的机会。我觉得非常荣幸,因为一直在日本从事中国电影研究,今天能有这样的机会跟各位学者交流感到非常高兴。我先简单介绍一下我自己是怎么搞电影研究的。可以这么说,... 详细信息

一、早期日本电影史与早期中国电影史非常感谢这次论坛给我这个发言的机会。我觉得非常荣幸,因为一直在日本从事中国电影研究,今天能有这样的机会跟各位学者交流感到非常高兴。我先简单介绍一下我自己是怎么搞电影研究的。可以这么说,本来我不是专门研究中国电影的人,我是专门研究中国文化、文学的。我当年上日本东京大学的时候还没有机会到中国留学,我一直在日本学的中文,其实我的中文完全是靠电影来学的,因为当时根本没有机会接触中国人,也没有机会接触中国的实际情况,那是70年代。所以当时我在日本就是看中国电影来学中文,也没有多少教材,因为我当年最好的中文教材就是背毛主席语录。

关键词：电影史日本东京大学早期中国电影早期电影中国电影研究中文教材

Surgical treatment for abdominal actinomycosis: A report of two cases

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World Journal of Gastrointestinal Surgery 2010年第12期2卷 405-408页

作者： Michihiro Hayashi Mitsuhiro Asakuma Soichiro Tsunemi Yoshihiro Inoue Tetsunosuke Shimizu Koji Komeda fumitoshi Hirokawa Atsushi Takeshita Yutaro Egashira Nobuhiko Tanigawa Department of General and Gastroenterological Surgery Osaka Medical College Hospital2-7 DaigakumachiTakatsuki City

Since actinomycosis sometimes causes an abdominal tumor which mimics malignancy, treatment strategy varies from case to case. We herein report two cases which were treated with a combination of antibiotics and surgical intervention. Both patients presented with an intra-abdominal tumor lesion mimicking malignant disease after an appendectomy for acute appendicitis. Case 1 received surgical extirpation of the abdominal tumor in the liver and kidney twice since the clinical diagnosis of actinomycosis was not made. In contrast, case 2 was successfully treated by a combination of antibiotics and laparoscopic surgery following the experience of case 1. When a high probability diagnosis can be made, a laparoscopic approach is a useful and effective option to treat this condition.

关键词： Abdominal actinomycosis Surgical therapy Laparoscopic surgery Single port surgery

ABeF3（A=Na,K,Rb,Cs）体系中Eu2+的f→f跃迁发射

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中国稀土学报 1985年第2期 53-58页

作者：石春山高橋勝绪安部文敏中国科学院长春应用化学研究所日本理化学研究所日本理化学研究所

合成了一系列Eu2+激活的碱金属氟化物一氟化铍复合氟化物(ABeF3∶Eu2+)磷光体。观察到了f→f跃迁引起的Eu2+很强的锐线发射,尖峰位于360nm附近。随碱金属原子电负性减小,峰值向短波方向稍有移动。得到了与A.S.T.M一致的结晶学数据。穆... 详细信息

合成了一系列Eu2+激活的碱金属氟化物一氟化铍复合氟化物(ABeF3∶Eu2+)磷光体。观察到了f→f跃迁引起的Eu2+很强的锐线发射,尖峰位于360nm附近。随碱金属原子电负性减小,峰值向短波方向稍有移动。得到了与A.S.T.M一致的结晶学数据。穆斯堡尔谱和电子能谱结果表明,体系中有少许Eu3+与Eu2+共存。

关键词：跃迁发射 A=Na,K,Rb,Cs ABeF3 Eu 磷光体穆斯堡尔谱激发光谱碱金属原子电子能谱配位数