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Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats

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World Journal of Gastroenterology 2005年第46期11卷 7254-7260页

作者： Hiroaki Shimizu Noboru Mitsuhashi Masayuki Ohtsuka Hiroshi Ito fumio kimura Satoshi Ambiru Akira Togawa Hiroyuki Yoshidome Atsushi Kato Masaru Miyazaki Department of General Surgery Graduate School of Medicine Chiba University Chiba 260-0856 Japan

AIM： To study the regulatory mechanisms of sinusoida regeneration after partial hepatectomy. METHODS： We invesldgated the expression of angiopoietin （Ang）-1, Ang-2, Tie-2, and vascular endothelial growth factor （VEGF） in regenerating liver tissue by quantitative reverse-transcription polymerase chain reaction （RT- PCR） using a LightCycler （Roche Diagnostics） and also immunohistochemical staining after 70% hepatectomy in rats. In the next step, we isolated liver cells （hepatocytes, sinusoidal endothelial cell （SEC）, Kupffer cell, and hepatic stellate cells （HSC）） from regenerating liver tissue by in situ collagenase perfusion and counterflow elutriation, to determine potential cellular sources of these angiogenic factors after hepatectomy. Proliferation and apoptosis of SECs were also evaluated by proliferating cell nuclear antigen （PCNA） staining and the terminal deoxynucleotidyl transferase d-uridine triphosphate nick end labeling （TUNEL） assay, respectively. RESULTS： VEGF mRNA expression increased with a peak at 72 h after hepatectomy, decreasing thereafter. The expression of Ang-1 mRNA was present at detectable levels before hepatectomy and increased slowly with a peak at 96 h. Meanwhile, Ang-2 mRNA was hardly detected before hepatectomy, but was remarkably induced at 120 and 144 h. In isolated cells, VEGF mRNA expression was found mainly in the hepatocyte fraction. Meanwhile, mRNA for Ang-1 and Ang-2 was found in the SEC and HSC fractions, but was more prominent in the latter. The PCNA labeling index of SECs increased slowly, reaching a peak at 72 h, whereas apoptotic SECs were detected between 120 h and 144 h. CONCLUSION： Ang-Tie system, together with VEGF, plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after hepatectomy. However, the VEGF system plays a more important role in the early phase of sinusoidal regeneration than angiopoietin/Tie system.

关键词： Vascular endothelial cell growth factor Angiopoietin Sinusoidal endothelial cell Hepatectomy Liver regeneration

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新稻田除草剂Paicer

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世界农药 1985年第4期 58-59页

作者： fumio kimura 王鸣华日本石原产业公司中心研究室

在日本,稻田杂草迅速地由一年生转向多年生,在朝鲜、台湾地区也有这种趋势。其原因虽多种多样,但主要因素之一是集中、连续使用同一类型的除草剂。为解决这个问题,到目前为止只有在苗前或苗后连续施药处理,以及广泛使用叶面除草剂,但这... 详细信息

在日本,稻田杂草迅速地由一年生转向多年生,在朝鲜、台湾地区也有这种趋势。其原因虽多种多样,但主要因素之一是集中、连续使用同一类型的除草剂。为解决这个问题,到目前为止只有在苗前或苗后连续施药处理,以及广泛使用叶面除草剂,但这样太耗费劳动力。对于农民来说,要选择适合自己情况的正确的除草剂配方是十分困难的,因此他们渴望能有一种在整个生长季节都可使用的、防除一年生和多年生杂草的新除草剂。

关键词：除草剂杂草 Paicer 稻田水田

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Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2006年第13期12卷 2053-2059页

作者： Hironobu Makino Hiroaki Shimizu Hiroshi Ito fumio kimura Satoshi Ambiru Akira Togawa Masayuki Ohtsuka Hiroyuki Yoshidome Atsushi Kato Hideyuki Yoshitomi Shigeaki Sawada Masaru Miyazaki Department of General Surgery Graduate School of Medicine Chiba UniversityChibaJapan

AIM： To study the effects of obstructive jaundice on liver regeneration after partial hepatectomy. METHODS： Hepatocyte growth factor （HGF）, its receptor, c-Met, vascular endothelial growth factor （VEGF） and transforming growth factor-β1 （TGF-β1） mRNA expression in both liver tissue and isolated liver cells were investigated after biliary obstruction （BO） by quantitative reverse-transcription polymerase chain reaction （RT-PCR） using a LightCycler. Immunohistochemical staining for desmin and e-smooth muscle actin （α-SNA） was also studied. Regenerating liver weight and proliferating cell nuclear antigen （PCNA） labeling index, and growth factor expression were then evaluated after 70% hepatectomy with concomitant internal bUiary drainage in BO rats or sham-operated rats. RESULTS： Hepatic TGF-β1 mRNA levels increased significantly 14 days after BO, and further increased with duration of cholestasis. Meanwhile, HGF and VEGF tended to increase, but was not significant. In cell isolates, TGF-β1 mRNA was found mainly in the hepatic stellate cell （HSC） fraction. Immunohistochemical studies revealed an increased number of HSCs （desmin-positive cells） and activated HSCs （α-SMA-positive cells） in portal areas after BO. In a hepatectomy model, liver regeneration was delayed in BO rats, as compared to sham-operated rats. TGF-β1 mRNA was significantly up-regulated up to 48 h after hepatectomy, and the earlier HGF mRNA peak was lost in BO rats. CONCLUSION： BO induces HSCs proliferation and activation, leading to up-regulation of TGF-β1 mRNA and suppression of HGF mRNA in livers. These altered expression patterns may be strongly involved in delayed liver regeneration after hepatectomy with obstructive jaundice.

关键词： Biliary obstruction Liver regeneration Hepatocyte growth factor Transforming growth factor-β Hepatic stellate cells Hepatectomy

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可持续发展实验住宅——日本积水住宅公司实验住宅案例介绍

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建筑学报 2010年第8期 24-28页

作者：木村文雄（日 fumio kimura）秋本敬子（日 Takako Akimoto）王琋慧日本积水住宅公司

可持续发展实验住宅是在东京城市住宅区中建设的一栋有研究性质的实验住宅,其宗旨是要通过充分利用风、阳光等自然的力量来实现不依赖于机械设备的节能而且舒适的生活。借鉴传统日本住宅的优点,创造重视居住者心理感受的生活环境,并通... 详细信息

可持续发展实验住宅是在东京城市住宅区中建设的一栋有研究性质的实验住宅,其宗旨是要通过充分利用风、阳光等自然的力量来实现不依赖于机械设备的节能而且舒适的生活。借鉴传统日本住宅的优点,创造重视居住者心理感受的生活环境,并通过居住实验证实了该住宅可以让居住者感受到比客观测定的物理环境值更具舒适性的居住品质。

关键词：可持续发展外廊通风天井自动控制节能减排

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Fatigue Property of Additively Manufactured Ti-6Al-4V under Nonproportional Multiaxial Loading

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 76-84页

作者： Yuya kimura fumio Ogawa Takamoto Itoh Graduate School of Science&Engineering Ritsumeikan UniversityShiga 5258577Japan Fracture and Reliability Research Institute Graduate School of Tohoku UniversityMiyagi 9808579Japan Department of Mechani-cal Engineering Ritsumeikan UniversityShiga 5258577Japan

The low cycle fatigue strength properties of the additively manufactured Ti-6Al-4V alloy are experimentally investi-gated under proportional and nonproportional multiaxial *** fatigue tests were conducted using hollow cylinder specimens with and without heat treatments,at room temperature in *** fatigue tests were conducted:one for proportional loading and one for nonproportional *** proportional loading was represented by a push-pull strain path(PP)and the nonproportional loading by a circle strain path(Cl).The failure lives of the additively manufactured specimens were clearly reduced drastically by internal voids and ***,the sizes of the defects were measured,and the defects were found not to cause a reduction in fatigue strength above a critical *** fracture surface was observed using scanning electron microscopy to investigate the fracture mechanisms of the additively manufactured specimens under the two types of strain *** fracture patterns were recognized for each strain paths;however,both showed retention of the crack propagation,despite the presence of numerous defects,probably because of the interaction of the *** crack propagation properties of the materials with numerous defects under nonproportional multiaxial loading were clarified to increase the reliability of the additively manufactured components.

关键词： Additive manufacturing Ti-6Al-4V Low cycle fatigue Multiaxial stress Nonproportional loading Internal defect

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Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps

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World Journal of Gastroenterology 2012年第32期18卷 4308-4316页

作者： Shinya Ishigooka Masahito Nomoto Nobuyuki Obinata Yoshichika Oishi Yoshinori Sato Satoko Nakatsu Midori Suzuki Yoshiko Ikeda Tadateru Maehata Tomoaki kimura Yoshiyuki Watanabe Takashi Nakajima Hiro-o Yamano Hiroshi Yasuda fumio Itoh Department of Internal Medicine Division of Gastroenterology and HepatologySt.Marianna University School of MedicineKawasaki 216-8511Japan Center of Gastroenterology St.Marianna Toyoko HospitalKawasaki 211-0063Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan

AIM:To elucidate the colonoscopic features of serrated lesions of the colorectum using magnifying ***:Broad division of serrated lesions of the colorectum into hyperplastic polyps(HPs),traditional serrated adenomas(TSAs),and sessile serrated adenomas/polyps(SSA/Ps) has been proposed on the basis of recent molecular biological ***,few reports have examined the colonoscopic features of these divisions,including magnified colonoscopic *** study examined 118 lesions excised in our hospital as suspected serrated lesions after magnified observation between January 2008 and September *** characteristics(sex,age),conventional colonoscopic findings(location,size,morphology,color,mucin) and magnified colonoscopic findings(pit pattern diagnosis) were interpreted by five colonoscopists with experience in over 1000 colonoscopies,and were compared with histopathological *** pit patterns were categorized according to Kudo's classification,but a more detailed investigation was also performed using the subclassification [type Ⅱ-Open(type Ⅱ-O),type Ⅱ-Long(type Ⅱ-L),or type Ⅳ-Serrated(type Ⅳ-S)] proposed by kimura T and Yamano ***:Lesions comprised 23 HPs(23/118:19.5%),39 TSAs(39/118:33.1%:with cancer in one case),50 SSA/Ps(50/118:42.4%:complicated with cancer in three cases),and six others(6/118:5.1%).We excluded six others,including three regular adenomas,one hamartoma,one inflammatory polyp,and one juvenile polyp for further *** colonoscopy showed that SSA/Ps were characterized as larger in diameter than TSAs and HPs(SSA/P vs HP,13.62 ± 8.62 mm vs 7.74 ± 3.24 mm,P < 0.001;SSA/Ps vs TSA,13.62 ± 8.62 mm vs 9.89 ± 5.73 mm,P < 0.01);common in the right side of the colon [HPs,30.4%(7/23):TSAs,20.5%(8/39):SSA/P,84.0%(42/50),P < 0.001];flat-elevated lesion [HPs,30.4%(7/23):TSAs,5.1%(2/39):SSA/Ps,90.0%(45/50),P < 0.001];normal-colored or pale imucosa [HPs,34.8%(8/23):TSAs,10.3%(4/39):SSA/Ps,80%(40/50),P < 0.00

关键词： Serrated adenoma Sessile serrated adenoma/polyp Hyperplastic polyps Traditional serrated adenomas Conventional colonoscopy Magnifying colonoscopy Pit patterns Serrated lesions

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High fluoride groundwater with high salinity and fluorite in aquifer sediments in Inner Mongolia, China

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Acta Geochimica 2006年第S1期 103-103页

作者： Kazurou Bandou fumio Kanai Kouichi Terasaki Takahisa Yoshimura Yoh'ichi Sakai Sumie kimura Hiroki Hagiwara Kowa Company Ltd. Niigata Japan Dept. of Geological Science Niigata University Niigata Japan

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High fluoride groundwater with high salinity and fluorite in aquifer sediments in Inner Mongolia, China

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Chinese Journal Of Geochemistry 2006年第B08期25卷 103-103页

作者： Liuchun ZHENG Hanjin LUO Kazurou Bandou fumio Kanai Kouichi Terasaki Takahisa Yoshimura Yoh＇ichi Sakai Sumie kimura Hiroki Hagiwara College of Environmental Sctence and Engineering South Chma University of Technology Guangzhou 510640 China Kowa Company Ltd. Niigata Japan Dept. of Geological Science Niigata University Niigata Japan

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