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International Journal of Mining Science and Technology 2023年第12期33卷 1437-1449页

作者： fumin liu Peng Lin Zhenhao Xu Ruiqi Shao Tao Han School of Qilu Transportation Shandong UniversityJinan 250061China Geotechnical and Structural Engineering Research Center Shandong UniversityJinan 250061China

The lag in quantitative methods and detection techniques for geologic information has resulted in time-consuming and human-experienced geologic analysis in *** indicators of rocks can be used to identify adverse geology and to explain the intrinsic causes of damage to normal *** study proposes a method to identify adverse geology by extracting and imaging the indicator *** mapping relationship between rock components and geologic bodies is quickly determined by indicator element extraction based on factor analysis,and then the data are gridded for image *** location and size of the target adverse geology are visually identified through the distribution images of the indicator elements,thus reducing data dimensions and analysis time.A non-destructive,in-situ and fast element detection technique in tunnels was adopted to speed up the process of geology *** accuracy of the detection was validated by comparing field and laboratory test *** study further confirms and refines the previous research,and the results provide references for geological,mining and underground projects.

关键词： Adverse geology identification Indicator elements Rock geochemistry Tunnel engineering Geological analysis

Association of plasminogen activator inhibitor-1 4G/5G promoter polymorphism with recurrent cerebral infarction in China’s North Jiangsu Province

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Neural Regeneration Research 2008年第7期3卷 791-794页

作者： Deqin Geng Jijun Zhu Guofang Chen Xianbi Tang Qiaoyun Yang Jizhen Li fumin liu Department of Neurology Affiliated Hospital of Xuzhou Medical College Xuzhou 221002 Jiangsu Province China Department of Neurology Xuzhou Central Hospital Xuzhou 221001 Jiangsu Province China Central Laboratory Affiliated Hospital of Xuzhou Medical College Xuzhou 221002 Jiangsu Province China

BACKGROUND： Many international studies have shown that plasminogen activator inhibitor-1 （PAl-l） 4G/5G promoter polymorphism does not increase the risk for cerebral infarction. OBJECTIVE： Using PCR methodology and agarose electrophoresis to detect PAI-1 4G/5G promoter polymorphism in patients with recurrent cerebral infarction in the North Jiangsu Province of China, and to compare results with healthy subjects and patients with first-occurrence cerebral infarction in the same region. DESIGN, TIME AND SETTING： Non-randomized, concurrent, control trial. A total of 122 cerebral infarction patients were admitted to Xuzhou Medical College Hospital＇s Department of Neurology and Xuzhou Central Hospital＇s Department of Neurology between July 2003 and August 2006. PARTICIPANTS： The patients consisted of 63 males and 59 females, aged （62 ± 10） years. They were divided into first-occurrence （n = 58） and recurrence （n = 64） groups. In addition, 50 healthy subjects that underwent physical examination in the outpatient department, including 26 males and 24 females, aged （60 ±12） years, were selected as controls. METHODS AND MAIN OUTCOME MEASURES： PAl-1 4G/5G promoter polymorphism was detected and analyzed using PCR methodology and agarose electrophoresis. RESULTS： Significant differences were determined in terms of genotypic frequency and allele frequency of PAI-1 4G/5G promoter polymorphism, in patients with first-occurrence or recurrent cerebral infarction, when compared with healthy subjects （P 〈 0.05）. There was, however, no significant difference between the first-occurrence and recurrence groups （P 〉 0.05）. CONCLUSION： PAl- 1 4G/5G promoter polymorphism is genetic risk factor for cerebral infarction in China. However, it may be associated with recurrence of cerebral infarction in patients from the North Jiangsu Province of China.

关键词： plasminogen activator inhibitor- 1 gene polymorphism recurrent cerebral infarction

Machine learning of element geochemical anomalies for adverse geology identification in tunnels

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Journal of Earth Science 2024年

作者： Ruiqi Shao Peng Lin Zhenhao Xu fumin liu Yilong liu School of Qilu Transportation， Shandong University State Key Laboratory for Tunnel Engineering Jinan Institute of Geotechnical and Underground Engineering， Shandong University

Geological analysis， despite being a long-term method for identifying adverse geology in tunnels， has significant limitations due to its reliance on empirical analysis. The quantitative aspects of geochemical anomalies associated with adverse geology provide a novel strategy for addressing these limitations. However， statistical methods for identifying geochemical anomalies are insufficient for tunnel engineering. In contrast， data mining techniques such as machine learning have demonstrated greater efficacy when applied to geological data. Herein， a method for identifying adverse geology using machine learning of geochemical anomalies is proposed. The method was identified geochemical anomalies in tunnel that were not identified by statistical methods. We by employing robust factor analysis and self-organizing maps to reduce the dimensionality of geochemical data and extract the anomaly elements combination (AEC). Using the AEC sample data， we trained an isolation forest model to identify the multi-element anomalies， successfully. We analyzed the adverse geological features based the multi-element anomalies. This study， therefore， extends the traditional approach of geological analysis in tunnels and demonstrates that machine learning is an effective tool for intelligent geological analysis. Correspondingly， the research offers new insights regarding the adverse geology and the prevention of hazards during the construction of tunnels and underground engineering projects.

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Atomistic understanding of interfacial processing mechanism of silicon in water environment:A ReaxFF molecular dynamics simulation

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Frontiers of Mechanical Engineering 2021年第3期16卷 570-579页

作者： Song YUAN Xiaoguang GUO Penghui LI Shuohua ZHANG Ming LI Zhuji JIN Renke KANG Dongming GUO fumin liu Lemin ZHANG Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116024China Beijing Institute of Aerospace Control Device Beijing 100854China

The interfacial wear between silicon and amorphous silica in water environment is critical in numerous ***,the understanding regarding the micro dynamic process is still unclear due to the limitations of ***,reactive force field simulations are utilized to study the interfacial process between silicon and amorphous silica in water environment,exploring the removal and damage mechanism caused by pressure,velocity,and ***,the reasons for high removal rate under high pressure and high velocity are elucidated from an atomic *** results show that the substrate is highly passivated under high humidity,and the passivation layer could alleviate the contact between the abrasive and the substrate,thus reducing the damage and *** addition to more Si-O-Si bridge bonds formed between the abrasive and the substrate,new removal pathways such as multibridge bonds and chain removal appear under high pressure,which cause higher removal rate and severer *** a higher velocity,the abrasive can induce extended tribochemical reactions and form more interfacial Si-O-Si bridge bonds,hence increasing removal *** results reveal the internal cause of the discrepancy in damage and removal rate under different conditions from an atomic level.

关键词： silicon ReaxFF molecular dynamics friction damage

Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro

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Virologica Sinica 2022年第2期37卷 295-298页

作者： Danrong Shi Keda Chen Xiangyun Lu Linfang Cheng Tianhao Weng fumin liu Nanping Wu Lanjuan Li Hangping Yao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Shulan International Medical College Zhejiang Shuren UniversityHangzhou310015China

Dear Editor,The coronavirus disease 2019(COVID-19)outbreak,has spread across the world(Wu et al.,2020).The causative agent of COVID-19,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is highly pathogenic and infectious,which become a major public health hazard that has had a devastating social and economic impact worldwide(Li *** al.,2020).Variants of the virus have emerged that behave differently(CDC2021;Gobeil et al.,2020;Leung et al.,2021).Some of them show increased infectivity(Li *** al.,2020;Zhang et al.,2020)and may escape from neutralizing antibodies(Weisblum et al.,2020).

关键词： interferon acute

贯彻落实《国务院办公厅关于促进全民健身和体育消费推动体育产业高质量发展的意见》推动体育产业成为国民经济支柱性产业

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体育科学 2019年第10期39卷 3-10页

作者：刘扶民国家体育总局经济司

阐释了《国务院办公厅关于促进全民健身和体育消费推动体育产业高质量发展的意见》(简称"《意见》")的起草背景、起草过程、基本框架和主要内容,以"提出一个目标、聚焦两大维度、秉承三大理念、把握四个抓手、实现五项突破、突出六大亮... 详细信息

阐释了《国务院办公厅关于促进全民健身和体育消费推动体育产业高质量发展的意见》(简称"《意见》")的起草背景、起草过程、基本框架和主要内容,以"提出一个目标、聚焦两大维度、秉承三大理念、把握四个抓手、实现五项突破、突出六大亮点"为主线,对《意见》进行了系统、深入的解读。随着中国特色社会主义进入新时代,《意见》必将对我国体育产业的高质量发展带来深远影响,推动体育产业成为国民经济支柱性产业。

关键词：体育产业意见高质量支柱性产业

MICROSTRUCTURE AND REVERSE SHAPE MEMORY EFFECT IN A Cu-Zn-Al ALLOY

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Acta Metallurgica Sinica(English Letters) 1991年第3期4卷 221-224页

作者： DONG Jianxin CHEN fumin CHEN Jinming liu Wenxi Tianjin University,Tianjin,China At pressent he works in Department of materials Science and Technology,University of Science and Technology,Beijing.

The bainite structure in a Cu-Zn-A1 alloy related to the reverse shape memory effect has been observed by means of *** reverse memory effect may be improved by up to one order of magnitude under applied constraint *** widespread propagation of bainite was confirmed to be the diffusion controlled shear process by the parabolic configuration of side interface of bainite plate and the twisting of intersected bainite plates.

关键词： Cu-Zn-Al memory alloy reverse shape memory effect bainitic transformation

X切H∶LiNbO_3光波导的工艺仿真研究

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光子学报 2005年第7期34卷 996-1000页

作者：黄韬金锋刘福民徐宇新中国航天时代电子公司研究院北京100854

对于X切H∶LiNbO3光波导,在532nm和1310nm波长下,用棱镜耦合器进行了工艺仿真研究.对于在150℃,180℃和200℃用苯甲酸质子交换的光波导,分别求得交换厚度与交换时间的关系曲线,在此基础上给出质子交换的扩散系数与交换温度的关系曲线.... 详细信息

对于X切H∶LiNbO3光波导,在532nm和1310nm波长下,用棱镜耦合器进行了工艺仿真研究.对于在150℃,180℃和200℃用苯甲酸质子交换的光波导,分别求得交换厚度与交换时间的关系曲线,在此基础上给出质子交换的扩散系数与交换温度的关系曲线.对于在180℃质子交换并在350℃退火的光波导,给出以交换时间(交换厚度)为参变量的表面折射率增量、有效厚度与退火时间的关系曲线.研究结果可供低损耗α相单模波导的设计和制备做参考.

关键词：铌酸锂光波导质子交换退火

miR-451a对人滋养细胞迁移、侵袭能力的影响

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中国妇产科临床杂志 2017年第3期18卷 227-229页

作者：黄杨刘小云冯霞刘福民徐州医科大学附属医院妇产科 221002 徐州医科大学研究生院徐州医科大学附属医院中心实验室

目的研究miR-451a对人滋养细胞系(HTR-8/SVneo)细胞迁移、侵袭能力的影响。方法以人工合成的寡核苷酸miR-451a模拟物(miR-451a mimics)、miR-451a抑制物(miR-451a inhibitor)分别转染人滋养细胞,过表达与特异性抑制miR-451a;应用逆转录... 详细信息

目的研究miR-451a对人滋养细胞系(HTR-8/SVneo)细胞迁移、侵袭能力的影响。方法以人工合成的寡核苷酸miR-451a模拟物(miR-451a mimics)、miR-451a抑制物(miR-451a inhibitor)分别转染人滋养细胞,过表达与特异性抑制miR-451a;应用逆转录-实时荧光定量聚合酶链反应技术(q RT-PCR)检测转染后miR-451a的表达;应用划痕实验和Transwell小室侵袭实验观察转染前后细胞的迁移和侵袭能力的变化。结果对比空白组及阴性对照组,人滋养细胞转染miR-451a mimics后,miR-451a表达明显升高,细胞迁移、侵袭能力下降;而转染miR-451a inhibitor后,miR-451a表达明显下降,细胞迁移、侵袭能力提高。结论 miR-451a可以抑制人滋养细胞的迁移、侵袭能力。

关键词： microRNA-451a 滋养细胞侵袭

Detection of the long non-coding RNAs NEAT1 and MALAT1 in the peripheral blood of HIV-1 infected patients

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Detection of the long non-coding RNAs NEAT1 and MALAT1 in th...