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Novel zinc alloys for biodegradable surgical staples

World Journal of Clinical Cases 2020年第3期8卷 504-516页

作者： Hizuru Amano Koichi Miyake Akinari Hinoki Kazuki Yokota fumie kinoshita Atsuko Nakazawa Yujiro Tanaka Yasuhiro Seto Hiroo Uchida Department of Pediatric Surgery Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Mitsui Mining and Smelting Co. Ltd.Tokyo 141-0032Japan Department of Pediatric Surgery Nagoya University Graduate School of MedicineNagoya 466-8550Japan Department of Advanced Medicine Nagoya University HospitalNagoya 466-8560Japan Department of Clinical Research Saitama Children’s Medical CenterSaitama 330-8777Japan

BACKGROUND The development of biodegradable surgical staples is desirable as non-biodegradable Ti alloy staples reside in the human body long after wound healing, which can cause allergic/foreign-body reactions, adhesion, or other adverse effects. In order to develop a biodegradable alloy suitable for the fabrication of surgical staples, we hypothesized that Zn, a known biodegradable metal, could be alloyed with various elements to improve the mechanical properties while retaining biodegradability and biocompatibility. Considering their biocompatibility, Mg, Ca, Mn, and Cu were selected as candidate alloying elements, alongside Ti, the main material of clinically available surgical *** To investigate the in vitro mechanical properties and degradation behavior and in vivo safety and feasibility of biodegradable Zn alloy *** Tensile and bending tests were conducted to evaluate the mechanical properties of binary Zn alloys with 0.1–6 wt.% Mg, Ca, Mn, Cu, or Ti. Based on the results,three promising Zn alloy compositions were devised for staple applications(wt.%): Zn-1.0Cu-0.2Mn-0.1Ti(Zn alloy 1), Zn-1.0Mn-0.1Ti(Zn alloy 2), and Zn-1.0Cu-0.1Ti(Zn alloy 3). Immersion tests were performed at 37℃ for 4 wk using fed-state simulated intestinal fluid(Fe SSIF) and Hank’s balanced salt solution(HBSS). The corrosion rate was estimated from the weight loss of staples during immersion. Nine rabbits were subjected to gastric resection using each Zn alloy staple, and a clinically available Ti staple was used for another group of nine rabbits. Three in each group were sacrificed at 1, 4, and 12 wk *** Additions of ≤1 wt.% Mn or Cu and 0.1 wt.% Ti improved the yield strength without excessive deterioration of elongation or bendability. Immersion tests revealed no gas evolution or staple fracture in any of the Zn alloy staples. The corrosion rates of Zn alloy staples 1, 2, and 3 were 0.02 mm/year in HBSS and 0.12, 0.11, and 0.13 mm/year, respective

关键词： Zinc alloy Surgical staple Gastric resection Biodegradability,Biocompatibility Mechanical Strength

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Laparoscopic Kasai portoenterostomy can be a standard surgical procedure for treatment of biliary atresia

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World Journal of Gastrointestinal Surgery 2022年第1期14卷 56-63页

作者： Chiyoe Shirota Akinari Hinoki Takahisa Tainaka Wataru Sumida fumie kinoshita Kazuki Yokota Satoshi Makita Hizuru Amano Yoichi Nakagawa Hiroo Uchida Department of Pediatric Surgery Nagoya University Graduate School of MedicineNagoya 4668550AichiJapan Rare/Intractable Cancer Analysis Research Nagoya University Graduate School of MedicineNagoya 4668550AichiJapan Department of Advanced Medicine Nagoya University HospitalNagoya 466-8560AichiJapan

BACKGROUND Biliary atresia(BA)is a rare pediatric *** To compare the outcomes of laparoscopic portoenterostomy(Lap-PE)with those of laparotomy(Open-PE)at a single *** The surgical outcomes of PE were retrospectively analyzed for patients with a non-correctable type of BA from 2003 to *** Throughout the assessment period,119 patients received PE for BA treatment,including 66 Open-PE and 53 Lap-PE *** the operation duration was longer(medians:for Open-PE,242 min;for Lap-PE,341 min;P80%for both groups for the first half year post surgery,followed by a gradual decrease with time;there were no statistically significant differences in the native liver survival rates for any durations *** Lap-PE could be a standard therapy for BA.

关键词： Laparoscopic Kasai portoenterostomy Biliary atresia Native liver survival Pediatric Liver Transplantation

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Disruption of ectoplasmic specializations between Sertoli cells and maturing spermatids by anti-nectin-2 and anti-nectin-3 antibodies

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Asian Journal of Andrology 2008年第4期10卷 577-584页

作者： Yoshiro Toyama fumie Suzuki-Toyota Mamiko Maekawa Chizuru Ito Kiyotaka Toshimori Department of Anatomy and Developmental Biology Graduate School of Medicine Chiba University Chiba 260-8670Japan

Aim： To understand the biological functions of the ectoplasmic specializations between Sertoli cells and maturing spermatids in seminiferous epithelia. Methods： In order to disrupt the function of the ectoplasmic specializations, nectin-2, which is expressed at the specialization, was neutralized with anti-nectin-2 antibody micro-injected into the lumen of the mouse seminiferous tubule. Anti-nectin-3 antibody was also micro-injected into the lumen in order to neutralize nectin-3, which is expressed at the specialization. Results： The actin filaments at the specialization disappeared, and exfoliation of maturing spermatids was observed by electron microscopy. Conclusion： Nectin-2 was neutralized by anti-nectin-2 antibody and nectin-3 was neutralized by anti-nectin-3 antibody, respectively. Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed. One of the functions of the specialization seems to be to hold maturing spermatids until spermiation.

关键词： ectoplasmic specialization Sertoli cell spermatogenic cell testis actin nectin mice

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Suppression of postprandial blood glucose elevation by buckwheat(Fagpopyrum esculentum) albumin hydrolysate and identification of the peptide responsible to the function

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Food Science and Human Wellness 2022年第4期11卷 992-998页

作者： Kazumi Ninomiya Yusuke Yamaguchi fumie Shinmachi Hitoshi Kumagai Hitomi Kumagai Department of Food Science and Nutrition Kyoritsu Women’s University2-2-1 HitotsubashiChiyoda-kuTokyo 101-8347Japan College of Bioresource Sciences Nihon University1866 KameinoFujisawa-shi 252-0880Japan

The objective of this study is to evaluate the suppressive effect of buckwheat-albumin hydrolysate on postprandial hyperglycemia and identify the peptide responsible to the function. Buckwheat-albumin hydrolysate was prepared by using digestive enzymes and was orally administered to rats together with soluble starch. The blood was taken from the tail vein up to 90 min after oral administration to measure blood-glucose and plasma-insulin levels. The peptide with α-amylase inhibitory activity was purified from the buckwheathydrolysate by gel-filtration chromatography, α-amylase affinity chromatography, and high performance liquid chromatography(HPLC). The amino-acid sequence of the peptide was identified by a protein sequencer and was compared with that in the buckwheat-genome database. Buckwheat-albumin hydrolysate significantly suppressed the elevation of blood glucose level 15 min after starch administration. The amino-acid sequence of the peptide with α-amylase inhibitory activity was YVEPDCGNLGCCYHC in the parental protein of molecular mass 17.8 k Da and theoretical pI 4.77. The amino-acid sequence, molecular weight, and pI of the parental protein in buckwheat albumin were different from those of α-amylase inhibitor in wheat albumin. This study suggests that the novel α-amylase inhibitor identified in buckwheat albumin is a potential candidate for a functional food material to suppress postprandial blood glucose elevation.

关键词： Buckwheat-albumin hydrolysate Bioactive peptide α-Amylase inhibitor Postprandial hyperglycemia Type 2 diabetes

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Isoflavone Regulates Lipid Metabolism via Expression of Related Genes in OVX Rats Fed on a High-fat Diet

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Biomedical and Environmental Sciences 2008年第5期21卷 357-364页

作者： XIAO-LIN NA JUNKO EZAKI fumie SUGIYAMA HONG-BIN CUI AND YOSHIKO ISHIMI Department of Food Nutrition and Hygiene Public Health College Harbin Medical University Harbin 150086 Heilongjiang China Nutritional Epidemiology Program National Institute of Health and Nutrition Tokyo 162-8636 Japan

Objective To investigate the effects of isoflavone on body weight, fat mass, and gene expression in relation to lipid metabolism. Methods Thirty-six female SD rats were ovariectomized or sham-operated and fed on a high-fat diet. Two months later, abdominal incision was made, blood was collected to separate serum, and the liver and adipose tissue were immediately collected and weighed. Some portions of these tissues were frozen in liquid nitrogen and stored at -80℃. Results Ovariectomy （OVX） with a high-fat diet could induce obesity in rats, while treatment with isoflavone significantly inhibited the increase in body weight and fat mass in abdomen. Serum total cholesterol and leptin were significantly decreased in isoflavone group, compared with the OVX group. The mRNA expression of liver fatty acid synthase （FAS） in the OVX group was significantly higher than that in sham-operated group, while this difference was not observed in the isoflavone group. The mRNA expression of liver hormone-sensitive lipase （HSL） in the OVX rats tended to be lower than that in the sham-operated rats. Furthermore, a large amount of isoflavone maintained the mRNA expression at a sham level. Conclusion Isoflavone may prevent obesity induced by ovariectomy with a high-fat diet, in part by modulating gene expression related to lipid metabolism.

关键词： Isoflavone Lipid metabolism Ovariectomy Obesity Gene expression

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THE EFFECT OF FCγ RECEPTOR ON THE PATHOGENESIS OF GRAVES' DISEASE

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Journal of Pharmaceutical Analysis 2004年第2期16卷 190-192页

作者：蒲丹郭辉雒文田刘秋月 Aosai fumie Department of Endocrinology First Hospital of Xi'an Jiaotong University Xi'a n 710061China Department of Infection and HostDefense Chiba University School of MedicineChiba260-8670Japan

Objective To explore the roles of Fcγ recep tor in the pathogenesis of Graves' disease. Methods Fcγ receptor gene knockout mice(Fcγ R KO m ice) which were rooted in C57BL/6 mice and wild type C57BL/6 mice were immunized by hTSH receptor expressing cells (***). 1-2×107 *** cells were peri toneally injected into mice every two weeks for a total of six times. Two weeks after final immunization, mice were killed for measurement of total thyroxine, T RAb and pathological examination. Results The thyroxine level of the immunized Fcγ recept or gene knockout mice was significantly lower than that of the immunized wild ty pe control mice (2.2±0.31 vs. 3.32± 0.59 g·dL -1, P< 0.05 ),but there was no significant difference between immunized Fcγ R KO mic e and non-immunized wild type control group. The TRAb levels of the immunized F γ R KO mice significantly increased compared to those of the immunized wild type mice (21.75±8.21 vs. 14.11±6.21, P< 0.05). The lymphocyte cel ls infiltration and destruction of thyroid follicles were found in the thyroid gland of the immunized Fcγ R KO mice. Conclusion These results suggest that Fcγ receptor may be involved in the pathogenesis of Graves' disease.

关键词： Graves' disease Fcγ receptor gene knockou t thyroid gland

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Successful embolization of an intrahepatic portosystemic shunt using balloon-occluded retrograde transvenous obliteration:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2023-2029页

作者： Hidemasa Saito Satoru Murata fumie Sugihara Tatsuo Ueda Daisuke Yasui Izumi Miki Hiromitsu Hayashi Shin-Ichiro Kumita Department of Radiology Nippon Medical SchoolTokyo 113-8602Japan Center for Interventional Radiology Teikyo University Chiba Medical CenterChiba 299-0011Japan

BACKGROUND A congenital intrahepatic portosystemic shunt(IPSVS)is a rare vascular abnormality that is characterized by an anomalous intrahepatic venous tract that connects the intrahepatic portal vein with the hepatic venous *** encephalopathy is an indication for IPSVS embolization,which is technically challenging because rapid blood flow through shunts can induce the migration of embolization material to systemic *** case report discusses the efficacy of percutaneous balloon-occluded retrograde transvenous obliteration for treating patients with *** SUMMARY A 75-year-old woman presented with a six-month history of repeated hepatic encephalopathy due to an IPSVS without liver *** successfully embolized the IPSVS using percutaneous balloon-occluded retrograde transvenous obliteration with interlocking detachable *** the procedure,the patient exhibited no symptoms of hepatic encephalopathy for 14 *** Balloon-occluded retrograde transvenous obliteration with detachable coils can be effective for the endovascular treatment of an IPSVS.

关键词： Hepatic veins Portal vein Hepatic encephalopathy Endovascular procedures Embolization Therapeutic Case report

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Interventional treatment for unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第37期20卷 13453-13465页

作者： Satoru Murata Takahiko Mine fumie Sugihara Daisuke Yasui Hidenori Yamaguchi Tatsuo Ueda Shiro Onozawa Shin-ichiro Kumita Department of Radiology/Center for Advanced Medical Technology Nippon Medical School

Hepatocellular carcinoma(HCC) is the sixth most common cancer and third leading cause of cancer-related death in the world. The Barcelona clinic liver cancer classification is the current standard classification system for the clinical management of patients with HCC and suggests that patients with intermediate-stage HCC benefit from transcatheter arterial chemoembolization(TACE). Interventional treatments such as TACE, balloon-occluded TACE, drug-eluting bead embolization, radioembolization, and combined therapies including TACE and radiofrequency ablation, continue to evolve, resulting in improved patient prognosis. However, patients with advanced-stage HCC typically receive only chemotherapy with sorafenib, a multi-kinase inhibitor, or palliative and conservative therapy. Most patients receive palliative or conservative therapy only, and approximately 50% of patients with HCC are candidatesfor systemic therapy. However, these patients require therapy that is more effective than sorafenib or conservative treatment. Several researchers try to perform more effective therapies, such as combined therapies(TACE with radiotherapy and sorafenib with TACE), modified TACE for HCC with arterioportal or arteriohepatic vein shunts, TACE based on hepatic hemodynamics, and isolated hepatic perfusion. This review summarizes the published data and data on important ongoing studies concerning interventional treatments for unresectable HCC and discusses the technical improvements in these interventions, particularly for advanced-stage HCC.

关键词： Unresectable Hepatocellular carcinoma Intermediate-stage Advanced-stage Interventional

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Transileocolic endovascular treatment by a hybrid approach for severe acute portal vein thrombosis with bowel necrosis:Two case reports

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World Journal of Clinical Cases 2022年第6期10卷 1876-1882页

作者： Sayaka Shirai Tatsuo Ueda fumie Sugihara Daisuke Yasui Hidemasa Saito Hiroyasu Furuki Shiei Kim Hiroshi Yoshida Shoji Yokobori Hiromitsu Hayashi Shin-ichiro Kumita Department of Radiology Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Radiology Nippon Medical School Musashi Kosugi HospitalKawasaki-shi 211-8533KanagawaJapan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School Tamanagayama HospitalTama-shi 206-8512TokyoJapan Department of Emergency and Critical Care Medicine Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan

BACKGROUND Acute portal vein thrombosis(PVT)with bowel necrosis is a fatal condition with a 50%-75%mortality *** report describes the successful endovascular treatment(EVT)of two patients with severe *** SUMMARY The first patient was a 22-year-old man who presented with abdominal pain lasting 3 *** second patient was a 48-year-old man who presented with acute abdominal *** contrast-enhanced computed tomography,both patients were diagnosed with massive PVT extending to the splenic and superior mesenteric *** treatment(simultaneous necrotic bowel resection and EVT)was performed in a hybrid operating room(OR).EVTs,including aspiration thrombectomy,catheter-directed thrombolysis(CDT),and continuous CDT,were performed via the ileocolic vein under *** portal veins were patent 4 and 6 mo posttreatment in the 22-year-old and 48-year-old patients,*** Hybrid necrotic bowel resection and transileocolic EVT performed in a hybrid OR is effective and safe.

关键词： Bowel necrosis Endovascular treatment Hybrid operating room Hybrid treatment Portal vein thrombosis Transileocolic approach Case report

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Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy

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World Journal of Gastroenterology 2017年第35期23卷 6437-6447页

作者： Izumi Miki Satoru Murata Fumio Uchiyama Daisuke Yasui Tatsuo Ueda fumie Sugihara Hidemasa Saito Hidenori Yamaguchi Ryusuke Murakami Chiaki Kawamoto Eiji Uchida Shin-ichiro Kumita Department of Radiology Center of Advanced MedicineNippon Medical School Department of Radiology Ebina-Sogo Hospital Department of Radiology Tamanagayama HospitalNippon Medical School Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical School Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School

AIM To evaluate the relationship between the location of hepatocellular carcinoma(HCC) and the efficacy of transarterial chemoembolization(TACE).METHODS We evaluated 115 patients(127 nodules), excluding recurrent nodules, treated with TACE between January 2011 and June 2014. TACE efficacy was evaluated according to m RECIST. The HCC location coefficient was calculated as the distance from the central portal portion to the HCC center(mm)/liver diameter(mm) on multiplanar reconstruction images rendered(MPR) to visualize bifurcation of the right and left branches of the portal vein and HCC center. The HCC location coefficient was compared between complete response(CR) and non-CR groups in Child-Pugh grade A and B *** The median location coefficient of HCC among all nodules, the right lobe, and the medial segment was significantly higher in the CR group than in the non-CR group in the Child-Pugh grade A patients(0.82 vs 0.62, P 0.05). On the other hand, in the Child-Pugh grade B patients, the HCC median location coefficient in each lobe and segment was not significantly different between in the CR and in the non-CR *** Improved TACE efficacy may be obtained for HCC in the peripheral zone of the right lobe and the medial segment in Child-Pugh grade A patients.

关键词： Hepatocellular carcinoma location Transarterial chemoembolization efficacy Child-Pugh Modified response evaluation criteria in solid tumors Central zone Peripheral zone

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