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Assessment of the potential interactions between favipiravir and radiocontrast agents

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World Journal of radiology 2024年第5期16卷 128-135页

作者： Sonay aydin Ozlem Celik aydin Mesut Furkan Yazar Huseyin Aydemir Mecit Kantarci Sureyya Barun Department of radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of Pharmacology Gazi UniversityFaculty of MedicineErzincan 24100Türkiye Department of radiology Bilecik Education and Reseach HospitalBilecik 11230Türkiye Department of radiology Atatürk UniversityFaculty of MedicineErzurum 25030Türkiye

BACKGrOUND In cases of coronavirus disease 2019(COVID-19),favipiravir is commonly included to the therapy *** interactions between favipiravir and other COVID-19 therapy drugs are frequently ***,no research on possible drug interactions between Favipiravir and radiocontrast agents,which have become almost crucial in diagnostic processes while not being part of the treatment,has been *** To determine potential medication interactions between Favipiravir and radiocontrast *** The study comprised patients who were taking Favipiravir for COVID-19 therapy and underwent a contrast-enhanced computed tomography(CT)or magnetic resonance imaging(MrI)test while taking the *** computerized patient files of the cases included in the study,as well as the pharmacovigilance forms in the designated hospital,were evaluated for this *** The study included the evaluation of data from 1046 *** study sample's mean age was 47.23±9.48 *** mean age of cases with drug interactions was statistically significant greater than that of cases with no drug interactions(P=0.003).When evaluated with logistic regression analysis,a 1-year raises in age increases the risk of developing drug interactions by 1.63 times(P=0.023).There was no statistically significant difference in the occurrence of medication interactions between the sexes(P=0.090).Possible medication interactions were discovered in 42 cases(4%).CONCLUSION The findings of this study revealed that the most notable findings as a result of the combined use of contrast agents and favipiravir were increased creatinine and transaminase values,as well as an increase in the frequency of nausea and *** majority of drug interactions discovered were modest enough that they were not reflected in the *** interactions become more common as people get older.

关键词： Favipiravir Iohexol Gadoxetic acid Meglumine gadoterate Drug interactions

Complementary comments on metastatic liver lesions with exceptional and rare cases

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World Journal of Gastroenterology 2024年第7期30卷 770-773页

作者： Kemal Bugra Memis Sonay aydin Department of radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24000Turkey

Liver metastases can appear in different forms in magnetic resonance *** to popular belief,while radiologists report hypovascular or hypervascular metastatic lesions,exceptional examples may be detected in various *** aim of this article is to improve this review by presenting rare and atypical examples of liver metastasis,as well as cases that might potentially be misdiagnosed as metastases during the process of differential diagnosis.

关键词： Hepatic lesions Magnetic resonance imaging Liver metastases Echinococcus alveolaris Prostate adenocarcinoma Appendix neuroendocrine tumor

Assessment of large-scale multiple forest disturbance susceptibilities with AutoML framework: an Izmir regional Forest Directorate case

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Journal of Forestry research 2024年第4期35卷 73-88页

作者： remzi Eker Kamber Can Alkiş Abdurrahim Aydın Department of Forest Engineering Faculty of ForestryIzmir KatipÇelebi University35620 IzmirTurkey Graduate School of Natural and Applied Sciences Izmir KatipÇelebi University35620 IzmirTurkey Department of Forest Engineering Faculty of ForestryDüzce University81620 DüzceTurkey

Disturbances such as forest fires,intense winds,and insect damage exert strong impacts on forest ecosystems by shaping their structure and growth dynamics,with contributions from climate ***,there is a need for reliable and operational methods to monitor and map these disturbances for the development of suitable management *** susceptibility assessment using machine learning methods has increased,most studies have focused on a single ***,there has been limited exploration of the use of“Automated Machine Learning(AutoML)”in the *** this study,susceptibility assessment for multiple forest disturbances(fires,insect damage,and wind damage)was conducted using the PyCaret AutoML framework in the Izmir regional Forest Directorate(rFD)in *** AutoML framework compared 14 machine learning algorithms and ranked the best models based on AUC(area under the curve)*** extra tree classifier(ET)algorithm was selected for modeling the susceptibility of each disturbance due to its good performance(AUC values>0.98).The study evaluated susceptibilities for both individual and multiple disturbances,creating a total of four susceptibility maps using fifteen driving factors in the *** to the results,82.5%of forested areas in the Izmir rFD are susceptible to multiple disturbances at high and very high ***,a potential forest disturbances map was created,revealing that 15.6%of forested areas in the Izmir rFD may experience no damage from the disturbances considered,while 54.2%could face damage from all three *** SHAP(Shapley Additive exPlanations)methodology was applied to evaluate the importance of features on prediction and the nonlinear relationship between explanatory features and susceptibility to disturbance.

关键词： AutoML Forest disturbances Forest fire Insect Susceptibility Wind

Interobserver and intraobserver reliability of skull base angles measured on magnetic resonance images

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World Journal of Clinical Cases 2024年第34期12卷 6687-6695页

作者： Volkan Kizilgoz Sonay aydin Huseyin Aydemir Papatya Keles Mecit Kantarci Department of radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24000Türkiye Department of Anatomy University of Health SciencesHamidiye Faculty of Medicineİstanbul 34674Türkiye

BACKGrOUND Determination of platybasia and basilar kyphosis are significant parts of routine cranial magnetic resonance(Mr)*** situations may explain a patient’s symptoms or may be associated with other *** To indicate the interobserver and intraobserver reliability of the skull base angles(SBA)(Koenigsberg standard)and modified SBA(mSBA)measurement *** In total,391 patients who had undergone cranial Mr imaging were re-assessed regarding the SBA *** SBA and mSBA techniques were used on Mr *** reviewers independently measured the same angles twice within a 15-day interval,using different *** correlation coefficient(ICC)was calculated to reveal the intraobserver and interobserver *** There was an excellent agreement between reviewers regarding both angle measurements(ICC was 0.998 for SBA and mSBA).Excellent agreement levels were also observed for intraobserver *** was 0.998 for SBA and 0.999 for mSBA for reviewer *** was 0.997 for SBA and 0.999 for mSBA according to the measurement results of reviewer *** SBA and mSBA values were observed for females compared to *** was no correlation between SBA and age for ***,a negative and low-level correlation was observed between mSBA values and age for both *** SBA and mSBA measurements indicated excellent agreement regarding interobserver and intraobserver *** study results showed that SBA angles were reliable measurement techniques to be used on Mr images.

关键词： Magnetic resonance imaging radiography Skull base angles Platybasia Observer reliability

Characteristics of the imaging diagnosis of alveolar echinococcosis

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2748-2754页

作者： Sonay aydin Baris Irgul Kemal Bugra Memis Volkan Kızılgoz Mecit Kantarci Department of radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of radiology Erzurum Ataturk UniversityErzurum 25000Türkiye

Alveolar echinococcosis(AE)primarily manifests in the liver and exhibits charac-teristics resembling those of slow-growing malignant *** Echino-coccus multilocularis infection can be *** infiltrating the vascular systems,biliary tracts,and the hilum of the liver,it might lead to various *** to its ability to infiltrate neighbouring tissues or metastasize to distant organs,AE can often be mistaken for *** present a concise overview of the epi-demiological and pathophysiological characteristics of AE,as well as the clinical manifestations of the *** article primarily examines the imaging charac-teristics of AE using various imaging techniques such as ultrasonography,com-puted tomography(CT),magnetic resonance imaging,diffusion-weighted ima-ging,and virtual non-enhanced dual-energy *** additionally examined the contribution of radiography in the diagnosis,treatment,and monitoring of the condition.

关键词： Alveolar echinococcosis Echinococcus multilocularis Virtual non-enhanced dual-energy computed tomography Percutaneous cyst drainage Cyst infection Interven-tional radiology

起泡剂对气泡大小和疏水矿物浮选性能的影响（英文）

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Journal of Central South University 2024年第07期 2280-2299页

作者： Gül?ah GüVEN Berivan TUN? ?.Beste aydin Gülay BULUT Mineral Processing Engineering Department Faculty of Mines Istanbul Technical University research Center Metso Outotec

起泡剂通过防止气泡合并来抑制气泡长大，从而产生稳定的泡沫。气泡和粒子的碰撞概率随着气泡的减少而显著增大。在相同体积系统中，大气泡分布产生的气泡较少，小气泡分布产生的气泡较多。本研究旨在将两相体系的泡沫表征参数与三相体... 详细信息

起泡剂通过防止气泡合并来抑制气泡长大，从而产生稳定的泡沫。气泡和粒子的碰撞概率随着气泡的减少而显著增大。在相同体积系统中，大气泡分布产生的气泡较少，小气泡分布产生的气泡较多。本研究旨在将两相体系的泡沫表征参数与三相体系的煤和滑石粉浮选行为相关联。为此，用甲基异丁基碳醇（MIBC）、异辛醇（2乙基己醇）、松油、Dowfroth 250泡沫剂研究单起泡剂体系和双起泡剂体系对气泡聚集的抑制作用。根据单起泡剂的结果，在最低临界聚集浓度为6×10-6时，异辛醇的气泡最小，Sauter平均直径为0.80 mm。通过混合起泡剂Dowfroth 250和松油，气泡尺寸显著减小到0.45 mm。在煤浮选中，单起泡剂和多起泡剂共混物的回收率最高，在两相体系中气泡尺寸最小，但在滑石浮选中没有发现这种关系。

关键词：浮选起泡剂混合物气泡尺寸煤和滑石浮选

Long-term vision-threatening complications of phakic intraocular lens implantation for high myopia

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 376-380页

作者： Isil Bahar Sayman Muslubas Baran kandemir Ayse Yesim aydin Oral Suleyman Kugu Metin Dastan Eye Clinic Hakkari Government Hospital Eye Clinic Dr.Lütfi Kirdar Kartal Education and Training Hospital Eye Clinic Kars Government Hospital

AIMTo report the long-term vision-threatening complications in patients who underwent phakic intraocular lens (pIOLs) implantation for high myopia.

关键词： phakic intraocular lens high myopia complications corneal decompensation rhegmatogenous retinal detachment

High temperature tensile,compression and creep behavior of recycled short carbon fibre reinforced AZ91 magnesium alloy fabricated by a high shearing dispersion technique

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Journal of Magnesium and Alloys 2021年第5期9卷 1773-1787页

作者： Sinan kandemir Sarkis Gavras Hajo Dieringa Department of Mechanical Engineering Izmir Institute of Technology35430UrlaIzmirTurkey Helmholtz-Zentrum Hereon MagIC-Magnesium Innovation CentreMax-Planck-Straße 121502GeesthachtGermany Helmholtz-Zentrum Hereon Institute of Metallic BiomaterialsMax-Planck-Straße 121502GeesthachtGermany Helmholtz-Zentrum Hereon Institute of Materials and Process DesignMax-Planck-Straße 121502GeesthachtGermany

The present study seeks the feasibility of using short carbon fibres recycled from polymer matrix composites as alternative to virgin carbon fibres in the reinforcement of magnesium *** microstructures,high temperature mechanical and creep properties of AZ91 alloy and its composites with various recycled carbon fibre contents(2.5 and 5 wt.%)and lengths(100 and 500μm)were investigated in the temperature range of 25-200℃.The microstructural characterization showed that the high shear dispersion technique provided the cast composites with finer grains and relatively homogenous distribution of *** materials tested displayed different behaviour depending on the type of *** general,while enhancements in the mechanical properties of composites is attributed to the load bearing and grain refinement effects of fibres,the fluctuations in the properties were discussed on the basis of porosity formation,relatively high reinforcement content leading to fibre clustering and interlayer found between the matrix and reinforcement compared to those of AZ91 *** compressive creep tests revealed similar or higher minimum creep rates in the recycled carbon fibre reinforced AZ91 in comparison to the unreinforced AZ91.

关键词： Metal matrix composites Magnesium alloys recycled carbon fibre High-shear dispersion Microstructure Mechanical properties Creep

Therapeutic utility of immunosuppressive TrEM2+macrophages:an important step forward in potentiating the immune checkpoint inhibitors

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Signal Transduction and Targeted Therapy 2020年第1期5卷 262-263页

作者： fulya Koksalar Alkan Hasan Korkaya research Institute for Health Sciences and Technologies Istanbul Medipol UniversityIstanbulTurkey Georgia Cancer Center Department of Biochemistry and Molecular BiologyMedical College of GeorgiaAugusta UniversityAugustaGA 30912USA

In a recent article published in Cell,Molgora et al.1 reported that a subset of tumor-infiltrating macrophages with TrEM2 expression creates an immunosuppressive microenvironment that promotes tumor growth while suppressing anti-tumor immune *** these TrEM2+macrophages via genetic ablation of the gene or specific antibodies against the protein reduces tumor growth in animal models;however,it further attenuates tumor growth when combined with immune checkpoint inhibitors(ICI)by promoting the expression of immunostimulatory molecules(Fig.1).

关键词： al immune Therapeutic