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Signal Transduction and Targeted Therapy 2022年第2期7卷 346-348页

作者： Joana barros-Martins Reinhold Förster Berislav Bošnjak Institute of Immunology Hannover Medical School30625 HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625 HannoverGermany German Centre for Infection Research(DZIF) Partner site HannoverHannoverGermany

In a recent study published in Nature,Witkowski et *** that in patients with severe forms of coronavirus disease 2019(COVID-19)deranged tumor growth factor-beta(TGF-β)secretion counteracts interferon-alpha(IFN-α)-induced activation of NK cells by decreasing expression of transcription factor ***,NK cells fail to upregulate the adhesion molecule integrin beta-2(-ß2),which impedes their attachment to and killing of SARS-CoV-2 infected cells.

关键词： interferon cytotoxicity

Delay Times and Clinical Outcomes in Acute Myocardial Infarction: Comparison of Periods before and during the COVID-19 Pandemic—Myocardial Infarction and the Pandemic

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World Journal of Cardiovascular Diseases 2024年第6期14卷 392-400页

作者： Clarice Teixeira Silva Araújo Arnon Salviato Mameri Thúlio Carrera Guarçoni Venturini Marcus Tadeu Aguilar Constantino Matos Igor Morais Araujo Lopes Luiz Gustavo Ribeiro de Carvalho Murad Cleberson Duartes Ovani Guilherme Vassalo Morais Fernanda Venturini de Castro Danielle Lopes Rocha Lucas Crespo de barros Rodolfo Costa Sylvestre Luiz Fernando Machado Barbosa Roberto Ramos Barbosa Internal Medicine Universidade Federal do Esprito Santo (UFES) Vitria Brazil Hospital Santa Casa de Misericrdia de Vitria Vitria Brazil Hospital Santa Rita de Cssia Vitria Brazil Hospital Estadual Dr. Jayme Santos Neves Serra Brazil Grupo Kora Sade Vitria Brazil Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIMABA) Vila Velha Brazil

Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from December 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.

关键词： Myocardial Infarction Primary Percutaneous Coronary Intervention Coronary Reperfusion Pandemic COVID-19

Mechanism of superlubricity of a DLC/Si_(3)N_(4) contact in the presence of castor oil and other green lubricants

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Friction 2022年第10期10卷 1693-1706页

作者： Yun LONG Yang WANG Volker WEIHNACHT Stefan MAKOWSKI Momoji KUBO Jean Michel MARTIN Maria-Isabel DE barros BOUCHET Ecole Centrale de Lyon Laboratory of Tribology and System DynamicsUniversity of LyonEcully 69134France Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Department of Mechanical Systems Engineering Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan Fraunhofer Institute for Material and Beam Technology(IWS) Dresden 01277Germany

To meet the surging needs in energy efficiency and eco-friendly lubricants,a novel superlubricious technology using a vegetable oil and ceramic materials is *** coupling different hydrogen-free amorphous carbon coatings with varying fraction of sp^(2) and sp^(3) hybridized carbon in presence of a commercially available silicon nitride bulk ceramic,castor oil provides superlubricity although the liquid vegetable oil film in the contact is only a few nanometres thick at *** a partial liquid film possibly separating surfaces in contact,local tribochemical reactions between asperities are essential to maintain superlubricity at low *** local pressure activates chemical degradation of castor oil generating graphitic/graphenic-like species on top of asperities,thus helping both the chemical polishing of surface and its chemical passivation by H and OH ***,the formation of the formation of–(CH_(2)–CH_(2))n–noligomers have been evidenced to have a major role in the friction *** simulation unveils that formation of chemical degradation products of castor oil on friction surfaces are favoured by the quantity of sp^(2)-hybridized carbon atoms in the amorphous carbon ***,tuning sp^(2)-carbon content in hydrogen-free amorphous carbon,in particular,on the top layers of the coating,provides an alternative way to control superlubricity achieved with castor oil and other selected green lubricants.

关键词： superlubricity diamond-like carbon(DLC) sp^(2)-hybridized carbon hydrogen passivation castor oil

Reflections on the prevalence of human leukocyte antigen-B27 and human leukocyte antigen-B51 co-occurrence in patients with spondylarthritis

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World Journal of Clinical Cases 2022年第23期10卷 8422-8424页

作者： Jucier Gonçalves Júnior Percival Degrava Sampaio-barros Samuel Katsuyuki Shinjo Division of Rheumatology São Paulo UniversitySão Paulo 01246-903São PauloBrazil

We performed a literature mini-review of the clinical profile of patients with spondylarthritis who are also human leukocyte antigen(HLA)-*** seems to us that patients with HLA-B27 and HLA-B51 are more common in men,Asians and between the third and ninth decades of *** are more likely to develop peripheral joint conditions,with cutaneous manifestations(e.g.,oral ulcers)and ***,more robust epidemiological studies with more accurate methodology and multicenter locations are needed to better map the role of the interaction between HLA-B51 in patients with spondylarthritis.

关键词： HLA-B27 HLA-B51 Ankylosing spondylitis Spondylarthritis Human leukocyte antigen

Robotic cardiac surgery training during residency: Preparing residents for the inevitable future

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 75-77页

作者： Eric E.Vinck Benjamin Smood Leila barros Meindert Palmen Department of Cardiovascular Surgery Cardio VID ClinicPontifical Bolivarian UniversityMedellínColombia Department of Surgery Division of Cardiothoracic SurgeryUniversity of PennsylvaniaPAUnited States Department of Cardiovascular Surgery Santa Casa of Sao PauloSao PauloBrazil Department of Cardiothoracic Surgery Leiden University Medical CenterLeidenNetherlands

Unlike other surgical residency training programs including thoracic surgery, robotic cardiac surgery skilltraining is minimal or absent in residency curricula. A review was conducted to identify residents'exposure to robotic cardiac surgery training based on databases including PubMed, MEDLINE and GoogleScholar. Published papers and cardiothoracic surgical societies with robotic cardiac surgery trainingcourses were reviewed. Robotic cardiac surgery training for residents is almost non-existent. Strategies toestablish proper robotic cardiac surgical training for residents include implementing simulation training,implementing hour requirements and establishing wet/dry lab model training in a progressive *** robot-assisted cardiac surgery becomes increasingly commonplace, it will be imperative to providetraining for residents with dedicated opportunities to develop their skills in robotic cardiac surgery.

关键词： Robotic cardiac surgery Education Residency training

Short-term effect of physical activity on sleep health:A population-based study using accelerometry

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Journal of Sport and Health Science 2022年第5期11卷 630-638页

作者： Andrea Wendt Inácio Crochemore M.da Silva Helen Goncalves Ana Menezes Fernando barros Fernando C.Wehrmeister Post-graduate Program in Epidemiology Federal University of PelotasPelotas 96020-220Brazil

Background:Regular physical activity(PA) is an important behavior in improving sleep ***,the short-term effects of PA on sleep are still *** study aimed to verify the effect of different intensities of PA practiced in different periods of the day on the subsequent sleep night in a population-based cohort of young ***::Prospective analyses were conducted for PA performed during the day and its effect on the following sleep night using data from the22-year follow-up of the 1993 Pelotas Birth Cohort in Brazil(mean age of participants-22.6 years).Wrist-worn accelerometry was usedto measure both PA and sleep *** intensity,we analyzed the sleep effect of light PA(LPA),moderate PA,and vigorous PA,stratified by *** variables were sleep time window(STW;the difference between sleep onset and sleep end),total sleep time(TST;the sum of minutes classified as sleep in STW),and sleep percent(SP;SP=(TST/STW);expressed in percentage).We performed generalized estimating equations using Stata ***::The means of STW,TST,and SP were 443.6 min/day,371.1 min/day,and 84%,*** spent in moderate PA and vigorous PA in the morning and afternoon was not associated with sleep *** men,10 min/day of morning LPA increased TST by2.56 min/*** women,10 min/day of morning LPA increased SP by 0.15 percentage *** LPA also increased SP by 0.09 percentage points for *** PA seems to have an inverse effect on sleep variables for any intensity and both ***::The effect of PA on sleep health is intrinsically related to the period of the day in which it is *** effect magnitude is different between *** better sleep health,it is preferable that PA be performed during the day.

关键词： Accelerometer Exercise Physical activity Population-based study Sleep health

Assessment of alterability of basalt used for riprap by petrographic examination

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第1期11卷 208-213页

作者： Maria Heloisa barros de Oliveira Frascá MHB Geological Services

All engineering projects consist of several steps, and one of the main tasks is to identify and characterize the most important features of rock types that will be excavated, crushed, or mined for any particular usage purpose, from a single residential building to major works of infrastructure. Laboratory investigation on engineering geology is thus conducted in order to determine the most relevant rock properties when designing structures such as mining shafts, tunnels, buildings, or reservoir dams to be built in sites associated with rocks. A wide range of laboratory tests is available, making the correct choice of test methods greatly relevant to determine the key property for the planned use of the rock. This paper is an illustrative case of laboratory testing of basaltic rocks to be used as riprap in a reservoir dam. It shows the important role of the petrographic study carried out to analyze the distribution pattern of smectite clay minerals. Test results are explained for the assessment of rock alterability, an essential aspect for the selection of the most suitable basalt variety for the envisaged conditions of use.

关键词： Rock properties Laboratory testing Test methods Petrographic analysis Smectite clay minerals Basaltic rocks Accelerated weathering tests Alterability

Ultrastructural features of the hypopharyngeal glands in the social wasp Polistes versicolor （Hymenoptera： Vespidae）

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Insect Science 2008年第3期15卷 277-284页

作者： Fabio barros Britto Flavio Henrique Caetano Universidade Estadual Paulista Julio de Mesquita Filho Instituto de Bioci~ncias de Rio Claro - Depto. de Biologia Rio Claro SP Brazil

The wasps of the genus Polistes have been considered the key to understanding the evolution of social behavior in Hymenoptera. Several studies have shown that the development of organized insect societies was accompanied by the evolution of structures like exocrine glands, which became specialized to perform specific functions. This article investigates the ultrastructural and cytochemical features of the hypopharyngeal glands of Polistes versicolor. These glands have been studied in depth in social bees, where they occur only in nurses and produce the royal jelly. Our results＇ revealed that these glands basically did not vary among individuals or between sexes. They are constituted by spherical cells, each with a large nucleus and well-developed rough endoplasmic reticulum. Secretion vesicles are abundant, but lipid droplets were not observed, indicating that these glands may not have a role in pheromone synthesis. Acid phosphatase was detected in lysosomes, and also flee in the cytosol, but did not seem to be related with cell death. Thus, our results suggest that the hypopharyngeal glands ofP. versicolor may not have a specialized social role, but could produce digestive enzymes.

关键词： cellular cycle cytochemistry hypopharyngeal glands morphology Polistes,wasps

Retention of eucalyptus harvest residues reduces soil compaction caused by deep subsoiling

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Journal of Forestry Research 2022年第2期33卷 643-651页

作者： Raphael Oliveira de Melo AymbiréAngeletti da Fonseca Nairam Félix de barros Raphael Bragança Alves Fernandes Rafael da Silva Teixeira Iago Nery Melo Ricardo Previdente Martins Soil Science Department Universidade Federal de ViçosaViçosaMinas GeraisBrazil BRACELL Company AlagoinhasBahiaBrazil

Eucalyptus harvesting,forwarding and soil tillage operations are among the main causes for compaction of forest soils,with potential impacts on *** concern is especially important in areas with soils that are naturally compacted(fragipans and duripans).In these soils,tillage operations include the use of subsoilers that can reach depths of more than one meter and require heavy tractors that exert high pressure on the *** of the ways to try to minimize the effect of this compaction is by retaining harvest *** objective of this study was to evaluate the impacts of eucalyptus harvesting on soil physical attributes,as well as to determine the potential of different types of residue management to reduce compaction from the soil tillage *** experiments were conducted in the same area with a Yellow *** the first experiment,compaction caused by mechanized harvesting with harvester+forwarder was *** the second experiment,different managements of harvest residues were examined as potential modifiers of soil compaction during tillage for new *** this,three managements systems were tested:(1)retention of all harvest residues and litter from the previous rotation(HR+L),(2)retention of litter from the previous rotation(L),and(3)removal of harvest residues and litter from the previous rotation(WR).Before and after harvest,sampling was carried out in the planting rows and inter-rows,and after tillage,samples were collected in the traffic line of the subsoiler-tractor *** both experiments,undisturbed soil samples were collected from the center of the 0-10,10-20,20-40,40-60,and 60-100 cm layers to determine soil density and total *** each period and site of evaluation,mechanical resistance to penetration up to the 60-cm depth was also *** harvesting operation increased soil density at 0-10 and 60-100 cm depths only in the *** of harvest residues and litter(HR+L)after harvesting avoi

关键词： Soil penetration resistance Harvester+forwarder Soil tillage Soil density Cohesive soils

Risk factors and prediction of acute kidney injury after liver transplantation:Logistic regression and artificial neural network approaches

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World Journal of Hepatology 2022年第3期14卷 570-582页

作者： Luis Cesar Bredt Luis Alberto Batista Peres Michel Risso Leandro Cavalcanti de Albuquerque Leite barros Department of Surgical Oncology and Hepatobilary Surgery UnioesteCascavel 85819-110ParanáBrazil Department of Nephrology UnioesteCascavel 85819-110ParanáBrazil Department of Internal Medicine Assis Gurgacz UniversityCascavel 85000ParanáBrazil Department of Hepatobiliary Surgery UnioesteCascavel 85819-110ParanáBrazil

BACKGROUND Acute kidney injury(AKI)has serious consequences on the prognosis of patients undergoing liver ***,artificial neural network(ANN)was reported to have better predictive ability than the classical logistic regression(LR)for this postoperative *** To identify the risk factors of AKI after deceased-donor liver transplantation(DDLT)and compare the prediction performance of ANN with that of LR for this *** Adult patients with no evidence of end-stage kidney dysfunction(KD)who underwent the first DDLT according to model for end-stage liver disease(MELD)score allocation system was *** was defined according to the International Club of Ascites criteria,and potential predictors of postoperative AKI were identified by *** prediction performance of both ANN and LR was *** The incidence of AKI was 60.6%(n=88/145)and the following predictors were identified by LR:MELD score>25(odds ratio[OR]=1.999),preoperative kidney dysfunction(OR=1.279),extended criteria donors(OR=1.191),intraoperative arterial hypotension(OR=1.935),intraoperative massive blood transfusion(MBT)(OR=1.830),and postoperative serum lactate(SL)(OR=2.001).The area under the receiver-operating characteristic curve was best for ANN(0.81,95%confidence interval[CI]:0.75-0.83)than for LR(0.71,95%CI:0.67-0.76).The root-mean-square error and mean absolute error in the ANN model were 0.47 and 0.38,*** The severity of liver disease,pre-existing kidney dysfunction,marginal grafts,hemodynamic instability,MBT,and SL are predictors of postoperative AKI,and ANN has better prediction performance than LR in this scenario.

关键词： Logistic regression Liver transplantation Acute kidney injury Machine learning Artificial neural network