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Molecular simulation study on the evolution process of hydrate residual structures into hydrate

Chinese Journal of Chemical Engineering 2024年第5期69卷 79-91页

作者： liwei Cheng Yunfei li Jinlong Cui Huibo Qin fulong Ning Bei liu Guangjin Chen Faculty of Engineering China University of GeosciencesWuhan 430074China State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China College of Science Nanchang Institute of TechnologyNanchang 330099China School of Chemical Engineering Guangdong University of Petrochemical TechnologyMaoming 525000China National Center for International Research on Deep Earth Drilling and Resource Development China University of Geosciences(Wuhan)Wuhan 430074China

The clathrate hydrate memory effect is a fascinating phenomenon with potential applications in carbon capture,utilization and storage(CCUS),gas separation,and gas storage as it can accelerate the secondary formation of clathrate hydrate.However,the underlying mechanism of this effect remains unclear.To gain a better understanding of the mechanism,we conducted molecular dynamic simulations to simulate the initial formation and reformation processes of methane hydrate.In this work,we showed the evolution process of hydrate residual structures into hydrate cages.The simulation results indicate that the residual structures are closely related to the existence of hydrate memory effect,and the higher the contribution of hydrate dissociated water to the hydrate nucleation process,the faster the hydrate nucleation.After hydrate dissociation,the locally ordered structures still exist after hydrate dissociation and can promote the formation of cluster structures,thus accelerating hydrate nucleation.Additionally,the nucleation process of hydrate and the formation process of clusters are inseparable.The size of clusters composed of cup-cage structures is critical for hydrate nucleation.The residence time at high temperature after hydrate decomposition will affect the strength of the hydrate memory effect.Our simulation results provide microscopic insights into the occurrence of the hydrate memory effect and shed light on the hydrate reformation process at the molecular scale.

关键词： Memory effect Molecular simulation Hydrate reformation Residual structures

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Grapevine-like high entropy oxide composites boost high-performance lithium sulfur batteries as bifunctional interlayers

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Green Energy & Environment 2024年第3期9卷 565-572页

作者： Huarong Fan Yubing Si Yiming Zhang fulong Zhu Xin Wang Yongzhu Fu College of Chemistry and Center of Green Catalysis Zhengzhou UniversityZhengzhou450001China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China

lithium-sulfur batteries(LSBs)with high energy densities have been demonstrated the potential for energy-intensive demand applications.However,their commercial applicability is hampered by hysteretic electrode reaction kinetics and the shuttle effect of lithium polysulfides(liPSs).In this work,an interlayer consisting of high-entropy metal oxide(Cu_(0.7)Fe_(0.6)Mn_(0.4)Ni_(0.6)Sn_(0.5))O_(4) grown on carbon nanofibers(HEO/CNFs)is designed for LSBs.The CNFs with highly porous networks provide transport pathways for li^(+) and e^(-),as well as a physical sieve effect to limit liPSs crossover.In particular,the grapevine-like HEO nanoparticles generate metal-sulfur bonds with liPSs,efficiently anchoring active materials.The unique structure and function of the interlayer enable the LSBs with superior electrochemical performance,i.e.,the high specific capacity of 1381 mAh g^(-1) at 0.1 C and 561 mAh g^(-1) at 6 C.This work presents a facile strategy for exploiting high-performance LSBs.

关键词： Electrospun carbon nanofibers Grapevine-like morphology Hierarchical physical sieve effect High-entropy induced chemisorption lithium-sulfur battery

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Novel de novo TRPV4 mutation identified in a Chinese family with metatropic dysplasia inhibits chondrogenic differentiation

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Genes & Diseases 2024年第3期11卷 83-86页

作者： Ping Wei Weizhe Shi Tianying Nong Caixia Xian Xia li Zhaohui li Xin li Jianping Wu liyuan Shang fulong Xu Yibo Xu Hongwen Xu Mingwei Zhu Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China Department of Pediatric Orthopedics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China

Metatropicdysplasia(MD,MIM156530)is a rare congenital bone dysplasia primarily characterized by severe platyspondyly with long and wide vertebral bodies and dumbbell deformity of the tubular bones.MD can be caused by heterozygous mutations in the gene encoding transient receptor potential vanilloid family member 4(TRPV4).We identifieda novel de novo mutation,c.2353T>C,in the TRPV4 gene,in a Chinese family with mild MD.

关键词： TRPV4 dysplasia congenital

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Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

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International Journal of Oral Science 2023年第1期15卷 136-147页

作者： Shuang Lei Jian li Jingjun Yu fulong li Yaping Pan Xu Chen Chunliang Ma Weidong Zhao Xiaolin Tang Department of Periodontics School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Pediatric Dentistry School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Preventive Dentistry School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Developmental Cell Biology Key Laboratory of Cell BiologyChina Medical UniversityShenyangChina

Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease(AD). The blood-brain barrier(BBB) is essential for keeping toxic substances from entering brain tissues. However, the effect of P. gingivalis bacteremia on BBB permeability and its underlying mechanism remains unclear. In the present study, rats were injected by tail vein with P. gingivalis three times a week for eight weeks to induce bacteremia. An in vitro BBB model infected with P. gingivalis was also established. We found that the infiltration of Evans blue dye and Albumin protein deposition in the rat brain tissues were increased in the rat brain tissues with P. gingivalis bacteremia and P. gingivalis could pass through the in vitro BBB model. Caveolae were detected after P. gingivalis infection in BMECs both in vivo and in vitro. Caveolin-1(Cav-1) expression was enhanced after P. gingivalis infection.Downregulation of Cav-1 rescued P. gingivalis-enhanced BMECs permeability. We further found P. gingivalis-gingipain could be colocalized with Cav-1 and the strong hydrogen bonding between Cav-1 and arg-specific-gingipain(RgpA) were detected.Moreover, P. gingivalis significantly inhibited the major facilitator superfamily domain containing 2a(Mfsd2a) expression. Mfsd2a overexpression reversed P. gingivalis-increased BMECs permeability and Cav-1 expression. These results revealed that Mfsd2a/Cav-1 mediated transcytosis is a key pathway governing BBB BMECs permeability induced by P. gingivalis, which may contribute to P. gingivalis/virulence factors entrance and the subsequent neurological impairments.

关键词： gingivalis expression inhibited

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Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 254-270页

作者： fulong NAN Wenlong NAN Xin YAN Hui WANG Shasha JIANG Shuyun ZHANG Zhongjie YU Xianjuan ZHANG Fengjun liU Jun li Xiaoqiong ZHOU Delei NIU Yiquan li Wei WANG Ning SHI Ningyi JIN Changzhan XIE Xiaoni CUI He ZHANG Bin WANG Huijun LU Department of Special Medicine Department of Pathogenic BiologySchool of Basic MedicineQingdao UniversityQingdao 266071China China Animal Health and Epidemiology Center Qingdao 266032China Academician Workstation of Jilin Province Changchun University of Chinese MedicineChangchun 130117China Institute of Virology Wenzhou UniversityWenzhou 325035China College of Veterinary Medicine Jilin UniversityChangchun 130012China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun 130122China Sino-Cell Biomed Co. Ltd.Qingdao 266000China

As a potential vectored vaccine,Newcastle disease virus(NDV)has been subject to various studies for vaccine development,while relatively little research has outlined the immunomodulatory effect of the virus in antigen presentation.To elucidate the key inhibitory factor in regulating the interaction of infected dendritic cells(DCs)and T cells,DCs were pretreated with the NDV vaccine strain LaSota as an inhibitor and stimulated with lipopolysaccharide(LPS)for further detection by enzyme-linked immunosorbent assay(EliSA),flow cytometry,immunoblotting,and quantitative real-time polymerase chain reaction(qRT-PCR).The results revealed that NDV infection resulted in the inhibition of interleukin(IL)-12p40 in DCs through a p38 mitogen-activated protein kinase(MAPK)-dependent manner,thus inhibiting the synthesis of IL-12p70,leading to the reduction in T cell proliferation and the secretion of interferon-(IFN-),tumor necrosis factor-α(TNF-α),and IL-6 induced by DCs.Consequently,downregulated cytokines accelerated the infection and viral transmission from DCs to T cells.Furthermore,several other strains of NDV also exhibited inhibitory activity.The current study reveals that NDV can modulate the intensity of the innate-adaptive immune cell crosstalk critically toward viral invasion improvement,highlighting a novel mechanism of virus-induced immunosuppression and providing new perspectives on the improvement of NDV-vectored vaccine.

关键词： Newcastle disease virus Dendritic cells Interleukin-12(IL-12) T cells Immunosuppression

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Postconditioning of stellate ganglion block improves intestinal barrier function by inhibiting autophagy in conscious rats following hemorrhagic shock and resuscitation

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Chinese Medical Journal 2022年第8期135卷 1003-1005页

作者： Zhonghua li Wendi Wang Qi Sun Tingjiao Suo Jiayi Zhai Huibo Du Zhen’ao Zhao fulong li Chunyu Niu Zigang Zhao Institute of Microcirculation Hebei North UniversityZhangjiakouHebei 075000China Basic Medical College Hebei Medical UniversityShijiazhuangHebei 050017China Hebei Key Laboratory of Critical Disease Mechanism and Intervention ShijiazhuangHebei 050017China.

To the Editor:Hemorrhagic shock is a critical pathological process characterized by microcirculation dysfunction and hypoperfusion,with severe consequences of cell damage and organ dysfunction.Intestinal barrier dysfunction is a critical link of distant organ injury caused by hemorrhagic shock.Prophylactic treatment with stellate ganglion block(SGB)significantly reduces hemorrhagic shock-induced intestinal barrier damage.

关键词： hemorrhagic damage inhibiting

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基于5G技术的海上风电通信系统研究

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南方能源建设 2024年第2期11卷 51-58页

作者：李铜林曾甫龙中国能源建设集团广东省电力设计研究院有限公司广东广州510663

[目的]海上风电项目众多设备位于海洋之上,交通不便导致运维检修难度大。海上设备信息的快速、无延迟、安全送达陆上显得格外重要。针对通信系统的特殊需求,文章提出了基于5G技术的海上风电场通信系统方案。[方法]首先建立信号覆盖面大... 详细信息

[目的]海上风电项目众多设备位于海洋之上,交通不便导致运维检修难度大。海上设备信息的快速、无延迟、安全送达陆上显得格外重要。针对通信系统的特殊需求,文章提出了基于5G技术的海上风电场通信系统方案。[方法]首先建立信号覆盖面大、可靠性强的PTN+一体化小基站,再将5G一体化小基站和PTN网关融为一体,通过宽带PTN接入,实现快速、便捷的5G信号覆盖,并采用特定带宽的5G网络,提高通信系统的安全性。[结果]基于PTN+一体化小基站方式的5G通信系统建成后,实现了基于光传输的、支持多业务且利用特定带宽的IP传输。此系统可以帮助规划梳理各风机子系统,实现风机内部全方位信号覆盖,并可以将风机、海上升压站等设备运行状态及数据快速、安全的传输到陆上运维中心,解决风机多子系统、多业务实时安全传输困难的问题。[结论]研究的5G通信系统改善了海上风电通信,并利用特定带宽和新兴技术,实现了海上风电场的通信及时性和可靠性,提高了海上风电场海上运维人员的沟通效率,符合海上风电项目海上设备的通信需求,有望在工程中应用推广。

关键词： 5G技术海上风电通信系统信号一体化小基站

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性朴欲恶心虑论——荀子人性论思想再辨

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理论界 2024年第4期 30-37页

作者：李福龙西北大学中国思想文化研究所

目前荀子的人性论思想是学界探讨的热点话题,但“性”与“心”之间的关系、“性”与“恶”之间的联系、“性”与“善”之间的关联等问题仍有进一步研究的必要。“性朴”是荀子对“人性”总的定义和说明,其内容主要包括“天官”和“天情... 详细信息

目前荀子的人性论思想是学界探讨的热点话题,但“性”与“心”之间的关系、“性”与“恶”之间的联系、“性”与“善”之间的关联等问题仍有进一步研究的必要。“性朴”是荀子对“人性”总的定义和说明,其内容主要包括“天官”和“天情”。由于“官能”生而带有“欲望”,而且“欲望”必然导致“恶”的结果,所以起初人类面临“争夺”“暴乱”和“相亡”的局面。“心”不仅具有“好利”的本能,而且它还具有“思虑”的能力,“思虑”必然有“思虑”的材料,“争夺”“暴乱”和“相亡”就是“思虑”的材料。“圣人”通过“积思虑”和“习伪故”的方式扭转了“争夺”“暴乱”和“相亡”的局面,并且制作“礼乐”和“刑法”来规范人的行为。

关键词：荀子人性论性朴欲恶心虑

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A Grid Interface Current Control Strategy for DC Microgrids

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CES Transactions on Electrical Machines and Systems 2021年第3期5卷 249-256页

作者： Muhannad Alshareef Zhengyu lin fulong li Fei Wang Department of Electronics and Communication Engineering in Al-Qunfudhah Umm al-Qura UniversityMakkahSaudi Arabia the School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLE113TUUnited Kingdom the School of Mechatronic Engineering and Automation Shanghai UniversityBaoshan DistrictShanghai 200444China

In this paper,a grid interface current control strategy is presented for a DC microgrid,which aims to reduce the disturbance from PV generation and the load variation to the main grid without a grid interface converter.The grid interface current is directly controlled by a battery DC-DC converter within the DC microgrid.Based on a comprehensive analysis of the battery DC-DC converter and interface current control,the control system has been mathematically modelled.This enabled two transfer functions to be derived that reflect the dynamic response of the inductor current to the duty cycle variation(inner loop),and the dynamic response of the grid interface current to the inductor current variation(outer loop).Experimental study has been done to assess the effectiveness of the proposed control strategy.The experimental results indicate that the proposed control strategy has a good performance to control the grid interface current without an interface converter,regardless the variations of both PV and the load conditions.

关键词： Battery DC microgrid DC-DC converter photovoltaic(PV)system

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海拔高度对化爆冲击波压力分布规律影响分析

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兵器装备工程学报 2024年第2期45卷 158-165页

作者：李福龙孔德仁王良全赵传荣南京理工大学机械工程学院南京210094 安徽工业大学电气与信息工程学院安徽马鞍山243032

海拔高度会引起空气密度及气压的变化,直接影响冲击波压力在空气介质中的传播分布规律。该项研究采用AUTODYN建立了0、1 000、2 000、3 000、4 500 m等5种海拔高度下爆炸冲击波压力传播规律的有限元数值仿真模型,开展了等效TNT当量为10... 详细信息

海拔高度会引起空气密度及气压的变化,直接影响冲击波压力在空气介质中的传播分布规律。该项研究采用AUTODYN建立了0、1 000、2 000、3 000、4 500 m等5种海拔高度下爆炸冲击波压力传播规律的有限元数值仿真模型,开展了等效TNT当量为10、30、50 kg工况下的数值仿真分析,并对获取的冲击波压力分布规律进行了分析。分析结果表明:海拔高度对冲击波压力具有显著的影响作用,具体表现为在同一等效TNT当量下,随海拔高度的增加,冲击波超压峰值、比冲量都逐渐减小,峰值到达时刻随测点距离增大逐渐提前;并且随等效TNT当量的增加,爆炸冲击波压力峰值和比冲量都逐渐增大,峰值到达时间逐步提前。数值仿真结果与试验结果具有较高的吻合度,该项研究揭示了海拔高度对爆炸冲击波传播分布规律的影响作用,为实际工程测试提供了理论支撑。

关键词：爆炸冲击波海拔高度数值仿真模型压力分布规律

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