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Integrins and their potential roles in mammalian pregnancy

Journal of Animal science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson Robert C.Burghardt fuller W.Bazer Heewon seo Joe W.Cain Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(ECM) interactions leading to assembly of integrin adhesion complexes(IACs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents sheep

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing sMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： sharon J.Brown Rafael J.Yáñez-Muñoz Heidi R.fuller school of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

spinal muscular atrophy(sMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of sMA was understood in 1995 when loss or impairment of the survival motor neuron 1(sMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,sMN2,which can produce low levels(approximately 10%)of the full-length functional sMN protein,has led to the generation of sMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,sMN2 copy number is used as a proxy for the prediction of disease severity,with higher sMN2 copy number typically being associated with reduced severity of sMA,although this relationship is not absolute:some individuals with low sMN2 copy number have less severe sMA phenotypes and vice ***,the etiology of sMA is further complicated by other factors,such as non-typical nucleotide variants and sMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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伴有室间隔缺损和正常左心室的严重主动脉发育不全或闭锁行一期双心室矫治术的早期效果

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 60-61页

作者： Gruber P.J. fuller s. Cleaver K.M. 张步升 Children's Hospital of Philadelphia Philadelphia Pa United States Dr.

Objective: Biventricular repair of aortic atresia (or severe aortic hypoplasia) is possible in the presence of a ventricular septal defect and normal left ventricle. We considered whether primary biventricular repair was a safe alternative in all cases, even in the presence of interrupted aortic arch. Methods: This was a retrospective analysis of patients who underwent primary biventricular repair consisting of a combination Norwood-type reconstruction of the aortic arch, baffle of the left ventricle to both semilunar roots, and conduit placement from the right ventricle to pulmonary arteries. Results: Between January 1995 and January 2005, a total of 21 patients underwent primary biventricular repair at a median age of 5 days and a median weight of 3.0 kg. Aortic atresia was present in 7 and aortic stenosis in 14; 6 had interrupted aortic arch. All patients with aortic stenosis had annular diameters 3 mm or smaller. Median circulatory arrest time was 55 minutes, aortic crossclamp time was 56 minutes, and total support time was 99 minutes. In-hospital survival was 100%. Postoperative echocardiography in 19 patients demonstrated no significant outflow tract obstruction. Total stay was a median of 17 days. At midterm follow-up, there has been 1 late death, and reoperation has been necessary in 10 cases. Conclusion: Primary biventricular repair is a safe alternative to staged repair in all cases of aortic hypoplasia with ventricular septal defect and normal left ventricle.

关键词：室间隔缺损动脉发育不全双心室矫治术左心室主动脉弓离断辅助循环分期修复术动脉闭锁主动

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Optimization of stealthwatch Network security system for the Detection and Mitigation of Distributed Denial of service (DDos) Attack: Application to smart Grid system

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Communications and Network 2024年第3期16卷 108-134页

作者： Emmanuel s. Kolawole Penrose s. Cofie John H. fuller Cajetan M. Akujuobi Emmanuel A. Dada Justin F. Foreman Pamela H. Obiomon Electrical and Computer Engineering Department Prairie View A&M University Prairie View TX USA

The smart Grid is an enhancement of the traditional grid system and employs new technologies and sophisticated communication techniques for electrical power transmission and distribution. The smart Grid’s communication network shares information about status of its several integrated IEDs (Intelligent Electronic Devices). However, the IEDs connected throughout the smart Grid, open opportunities for attackers to interfere with the communications and utilities resources or take clients’ private data. This development has introduced new cyber-security challenges for the smart Grid and is a very concerning issue because of emerging cyber-threats and security incidents that have occurred recently all over the world. The purpose of this research is to detect and mitigate Distributed Denial of service [DDos] with application to the Electrical smart Grid system by deploying an optimized stealthwatch secure Network analytics tool. In this paper, the DDos attack in the smart Grid communication networks was modeled using stealthwatch tool. The simulated network consisted of secure Network Analytic tools virtual machines (VMs), electrical Grid network communication topology, attackers and Target VMs. Finally, the experiments and simulations were performed, and the research results showed that stealthwatch analytic tool is very effective in detecting and mitigating DDos attacks in the smart Grid system without causing any blackout or shutdown of any internal systems as compared to other tools such as GNs3, Nessi2, NIssT Framework, OMNeT++, INET Framework, ReasE, Ns2, Ns3, M5 simulator, OPNET, PLC & TIA Portal management software which do not have the capability to do so. Also, using stealthwatch tool to create a security baseline for smart Grid environment, contributes to risk mitigation and sound security hygiene.

关键词： smart Grid system Distributed Denial of service (DDos) Attack Intrusion Detection and Prevention systems Detection Mitigation and stealthwatch

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Molecular Oxygen Abundance in Galactic Massive star Formation Regions Based on sWAs Observations

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Research in Astronomy and Astrophysics 2024年第9期24卷 83-98页

作者： Bing-Ru Wang Di Li Paul F.Goldsmith Jingwen Wu Chao-Wei Tsai Donghui Quan Xia Zhang Junzhi Wang Gary J.Melnick Jin-Zeng Li Gary A.fuller Jinjin Xie National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Tsinghua University Beijing 100084China University of Chinese Academy of sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Center for Astrophysics Harvard&Smithsonian60 Garden StreetMS 66CambridgeMA 02138USA Jodrell Bank Center for Astrophysics Department of Physics&AstronomyUniversity of ManchesterOxford RoadManchesterM139PLUK I.Physikalisches Institut University of CologneZülpicher Str.7750937 KölnGermany

Molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar *** estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the submillimiter Wave Astronomy satellite(sWAs)*** obtained an averaged O_(2)spectrum based on this sample using the(sWAs)survey data(O_(2),487.249 GHz,N=3-1,J=3-2).No emission or absorption feature is seen around the supposed central velocity with a total integration time of t_(total)=8.67×10^(3)hr and an rms noise per channel of 1.45 m *** a kinetic temperature T_(kin)=30 K,we derive the 3σupper limit of the O_(2)column density to be 3.3×10^(15)cm^(-2),close to the lowest values reported in Galactic massive star formation regions in previous *** corresponding O_(2)abundance upper limit is6.7×10^(-8),lower than all previous results based on sWAs observations and is close to the lowest reported value in massive star formation *** a galactic scale,our statistical results confirm a generally low O_(2)abundance for Galactic massive star formation *** abundance is also lower than results reported in extragalactic sources.

关键词： IsM:molecules galaxies:abundances IsM:lines and bands Galaxy:abundances

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肾素血管紧张素醛固酮系统抑制剂与新型冠状病毒肺炎感染或住院治疗:一项队列研究

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中华高血压杂志(中英文) 2022年第2期 200-200页

作者： Dublin s Walker RL Floyd Js shortreed sM fuller s Albertson-Junkans L Harrington LB Greenwood-Hickman MA Green BB Psaty BM 袁源郑武洪

Am J Hypertens,2021,34(4):339-347.血管紧张素转换酶抑制药(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体阻滞药(angiotensin receptor blocker,ARB)可能增加新型冠状病毒肺炎(corona virus disease 2019,COVID-19)感染风险或影响疾病的严重程度。先前的研究尚未明确药物剂量对上述风险的影响。方法:本研究为回顾性队列研究,纳入年龄≥18岁且在2020年2月29日之前在美国综合保健系统中注册4个月以上的人群。根据药店数据确认ACEI或ARB当前使用情况,估算药物每日剂量并进行标准化处理。

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头颈部鳞癌的条件生存率

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中国口腔颌面外科杂志 2007年第3期5卷 214-214页

作者： fuller CD Wang s J Thomas CR Jr

头颈部鳞癌（HNsCC）患者生存率的统计通常是从疾病被诊断时开始．但对疾病确诊后生存一段时间的患者很少应用条件生存率（conditional survival，Cs）进行分析，Cs分析能够提供判断患者预后的重要信息。该文旨在应用大规模的癌症数据... 详细信息

头颈部鳞癌（HNsCC）患者生存率的统计通常是从疾病被诊断时开始．但对疾病确诊后生存一段时间的患者很少应用条件生存率（conditional survival，Cs）进行分析，Cs分析能够提供判断患者预后的重要信息。该文旨在应用大规模的癌症数据库寻求Cs参数。对1973～1998年间美国国立癌症研究院（the National Cancer Institute。NCI）的监测、流行病学和最终结果（the surveillance，epidemiology and end-results，sEER）计划（***，and End Results，

关键词：头颈部鳞癌生存率 epidemiology Epidemiology 流行病学 s参数数据库疾病

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Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.fuller Casey L.Egan Tina L.Robinson Nimna Perera Heidy K.Latchman Lauren V.Terry Emma D.McLennan Carolina Chavez Emma L.Burrows John W.scott Robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

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Pregnancy recognition signaling mechanisms in ruminants and pigs

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Journal of Animal science and Biotechnology 2013年第3期4卷 170-179页

作者： fuller W Bazer Department of Animal science Texas A&M University College Station 442D Kleberg Center2471 TAMU Texas 77843-2471 USA

Maternal recognition of pregnancy refers to the requirement for the conceptus（embryo and its associated extraembryonic membranes） to produce a hormone that acts on the uterus and/or corpus luteum（CL） to ensure maintenance of a functional CL for production of progesterone;the hormone required for pregnancy in most *** pregnancy recognition signal in primates is chorionic gonadotrophin which acts directly on the CL via luteinizing hormone receptors to ensure maintenance of functional CL during *** ruminants,interferon tau（IFNT） is the pregnancy recognition *** is secreted during the peri-implantation period of pregnancy and acts on uterine epithelia to silence expression of estrogen receptor alpha and oxytocin receptor which abrogates the oxytocin-dependent release of luteolytic pulses of prostaglandin F2-alpha（PGF） by uterine epithelia;therefore,the CL continues to produce progesterone required for *** conceptuses secrete interferon delta and interferon gamma during the peri-implantation period of pregnancy,but there is no evidence that they are involved in pregnancy recognition ***,pig conceptuses secrete abundant amounts of estrogens between Days 11 to 15 of pregnancy required for maternal recognition of ***,likely in concert with prolactin,prevents secretion of PGF into the uterine venous drainage（endocrine secretion）,but maintains secretion of PGF into the uterine lumen（exocrine secretion） where it is metabolized to a form that is not *** PGF is sequestered within the uterine lumen and unavailable to induce luteolysis,functional CL are maintained for production of *** addition to effects of chorionic gonadotrophin,IFNT and estrogens to signal pregnancy recognition,these hormones act on uterine epithelia to enhance expression of genes critical for growth and development of the conceptus.

关键词： Pregnancy Interferon Tau Estrogen Prostaglandin F2α

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约4900年前东亚和东南亚枢纽地区狩猎采集向农业的转变

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science Bulletin 2024年第1期69卷 103-113页

作者：马敏敏卢敏霞孙瑞朱忠华 Dorian Q.fuller 郭健新何光林杨晓敏谭玲玲芦永秀董佳佳刘睿良杨继帅李波郭天南李小瑞赵东月张颖王传超董广辉 Key Laboratory of Western China’s Environmental systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Zhaotong University Zhaotong 657000China Westlake Laboratory of Life sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical sciences Westlake Institute for Advanced StudyHangzhou 310024China Yunnan Provincial Institute of Cultural Relics and Archaeology Kunming 650118China Institute of Archaeology University College LondonLondon WC1H 0PYUK school of Cultural Heritage Northwest UniversityXi’an 710069China state Key Laboratory of Cellular stress Biology School of Life SciencesXiamen UniversityXiamen 361102China Department of Anthropology and Ethnology Institute of AnthropologySchool of Sociology and AnthropologyXiamen UniversityXiamen 361005China state Key Laboratory of Marine Environmental science Xiamen UniversityXiamen 361102China Westlake Omics(Hangzhou)Biotechnology Co. Ltd.Hangzhou 310024China The Department of Asia British MuseumLondon WC1E 7JWUK Tonghai Cultural Relics Management Yuxi 652700China Group of Alpine Paleoecology and Human Adaptation Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China state Key Laboratory of Tibetan Plateau Earth system Resources and EnvironmentBeijing 100101China Ministry of Education Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200433China

The southward expansion of East Asian farmers profoundly influenced the social evolution of southeast Asia by introducing cereal ***,the timing and routes of cereal expansion in key regions are unclear due to limited empirical *** we report macrofossil,microfossil,multiple isotopic(C/N/sr/O)and paleoproteomic data directly from radiocarbon-dated human samples,which were unearthed from a site in Xingyi in central Yunnan and which date between 7000 and 3300 a *** isotopes reveal the earliest arrival of millet ca.4900 a BP,and greater reliance on plant and animal agriculture was indicated between 3800 and 3300 a *** dietary differences between hunter-gatherer and agricultural groups are also evident in the metabolic and immune system proteins analysed from their skeletal *** results of paleoproteomic analysis indicate that humans had divergent biological adaptations,with and without *** combined application of isotopes,archaeobotanical data and proteomics provides a new approach to documenting dietary and health changes across major subsistence transitions.

关键词： Isotopes Proteomics Yunnan Millet Agricultural origins Human health

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