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Mobile mini-fluorimeter for antibiotic aptasensing based on surface-plasmonic effect of burlike nanogolds enhanced by digitized imaging diagnosis

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Chinese Chemical Letters 2024年第5期35卷 418-422页

作者： Tiantian Man fulin Zhu Yaqi Huang Yuhao Piao yan Su Shengyuan Deng Ying Wan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Metabolic Engineering and Biosynthesis Technology Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China

Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily *** traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on *** an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and *** key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold ***“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the *** the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive *** by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection ***,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and *** field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.

关键词： Chloramphenicol and enrofloxacin Aptasensor Gold nanoburs Smartphone fluorimetric suite Digitized image postprocessing

Recent innovations in laser additive manufacturing of titanium alloys

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International Journal of Extreme Manufacturing 2024年第3期6卷 2-37页

作者： Jinlong Su fulin Jiang Jie Teng Lequn Chen Ming yan Guillermo Requena Lai-Chang Zhang Y Morris Wang Ilya V Okulov Hongmei Zhu Chaolin Tan College of Materials Science and Engineering Hunan UniversityChangsha 410082People’s Republic of China Singapore Institute of Manufacturing Technology(SIM Tech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Institute of Materials Research German Aerospace Center(DLR)Linder Höhe51147 CologneGermany Centre for Advanced Materials and Manufacturing Edith Cowan University270 Joondalup DriveJoondalupPerthWestern Australia 6027Australia Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 900095United States of America Leibniz Institute for Materials Engineering-IWT Badgasteiner Str.328359 BremenGermany Faculty of Production Engineering University of BremenBadgasteiner Str.128359 BremenGermany Key Laboratory of Hunan Province of Equipment Safety Service Technology under Extreme Environment University of South ChinaHengyangPeople’s Republic of China RWTH Aachen University Metallic Structures and Materials Systems for Aerospace EngineeringD-52062 AachenGermany

Titanium(Ti)alloys are widely used in high-tech fields like aerospace and biomedical *** additive manufacturing(LAM),as an innovative technology,is the key driver for the development of Ti *** the significant advancements in LAM of Ti alloys,there remain challenges that need further research and development *** recap the potential of LAM high-performance Ti alloy,this article systematically reviews LAM Ti alloys with up-to-date information on process,materials,and *** feasible solutions to advance LAM Ti alloys are reviewed,including intelligent process parameters optimization,LAM process innovation with auxiliary fields and novel Ti alloys customization for *** auxiliary energy fields(***,acoustic,mechanical deformation and magnetic fields)can affect the melt pool dynamics and solidification behaviour during LAM of Ti alloys,altering microstructures and mechanical *** kinds of novel Ti alloys customized for LAM,like peritecticα-Ti,eutectoid(α+β)-Ti,hybrid(α+β)-Ti,isomorphousβ-Ti and eutecticβ-Ti alloys are reviewed in ***,machine learning in accelerating the LAM process optimization and new materials development is also *** review summarizes the material properties and performance envelops and benchmarks the research achievements in LAM of Ti *** addition,the perspectives and further trends in LAM of Ti alloys are also highlighted.

关键词： additive manufacturing titanium alloys auxiliary field machine learning aerospace materials lightweight materials novel alloys

A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2S and its applications in living system

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Chinese Chemical Letters 2024年第5期35卷 296-301页

作者： Yudi Cheng Xiao Wang Jiao Chen Zihan Zhang Jiadong Ou Mengyao She fulin Chen Jianli Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi’an 710069China

Sulfydryl-contained(-SH)substances including hydrogen sulfide(H_(2)S),cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play crucial roles in living systems,and their variations are closely associated with various ***,we developed a near-infrared intramolecular charge transfer(ICT)based fluorescent probe Y-NBD,achieving detection of Cys/Hcy and H_(2)S with different fluorescent signals(green-red for Cys/Hcy,red for H_(2)S),large Stokes shifts(∼100/105nm or 191 nm)and high signal-background-ratio,but not responding to GSH.Y-NBD was successfully applied to image exogenous/endogenous Cys/Hcy and H_(2)S in various living cancer cells(HeLa,A549,and HepG2)and in *** not only visualized the transformation pathway of several thiols in HepG2 cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver *** work provides a promising tool for imaging Cys/Hcy and H_(2)S in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.

关键词： Fluorescent probe Near-infrared Hydrogen sulfide Cysteine/homocysteine Large Stokes shift Dicyanoisophorone Drug-induced liver injury

Chemical Constituents and Antitumor Activities of Walnut Green Husk

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Medicinal Plant 2019年第2期10卷 17-20,24页

作者： fulin yan Tiantian YIN School of Pharmacy Sanquan College of Xinxiang Medical University

[Objectives] To identify chemical constituents and antitumor activities of walnut green husk. [Methods] The column chromatography and recrystallization were used to isolate 13 compounds from walnut green husk, and their structures were identified by modern spectroscopy. [Results] The 13 kinds of compounds isolated from walnut green husk were identified as 3, 5-dimethoxy-4-hydroxy benzene carbonic-7-O-β-D-pyranglucose(1), myricananin F(2), β-stitosterol(3), oleanolic acid(4), regiolone(5), asiatic acid(6), hederagenin(7), β-daucosterin(8),(4 R)-4,8-dihydroxy-α-tetralone-4-O-β-D-glucopyranoside(9), 3β, 23-dihydroxy-urs-12-en-28-oic acid(10), ursolic acid(11), syringc acid(12), and Juglanoside B(13). Among these, compounds 1, 2, 6, 7, 9, and 10 were all isolated from this genus of plant for the first time. [Conclusions] Through screening for antitumor activity in vitro, it was found that compound 4 showed strong growth inhibitory activity against the proliferation of human hepatoma cells(HepG-2), and compound 9 had certain growth inhibitory activity against the proliferation of human breast cancer cells(MCF-7).

关键词： Walnut green husk Juglandaceae Chemical constituents Antitumor activities

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粗毛淫羊藿叶绿体基因组及其结构分析

种子 2022年第11期41卷 47-53页

作者：严福林任得强魏升华何顺志贵州中医药大学贵阳550025

本研究通过Illumina HiSeq X-Ten高通量测序平台对粗毛淫羊藿的叶绿体基因组进行测序,并应用生物信息学分析工具对其结构特征进行比较分析。结果表明,粗毛淫羊藿叶绿体基因组大小为156894 bp,具有被子植物典型的环状四分体结构,大单拷贝... 详细信息

本研究通过Illumina HiSeq X-Ten高通量测序平台对粗毛淫羊藿的叶绿体基因组进行测序,并应用生物信息学分析工具对其结构特征进行比较分析。结果表明,粗毛淫羊藿叶绿体基因组大小为156894 bp,具有被子植物典型的环状四分体结构,大单拷贝区(large single copy,LSC)长度为88496 bp,小单拷贝区(small single copy,SSC)长度为16685 bp,2个反向重复区(inverted repeat sequence,IRa/IRb)长度为25809 bp;粗毛淫羊藿叶绿体基因组有133个基因,其中包括85个蛋白编码基因、10个rRNA基因和38个tRNA基因,44个外显子,23个内含子。研究结果丰富了淫羊藿属物种的叶绿体基因组资料,可为淫羊藿属物种的分子标记开发、系统学研究与药材的混伪品鉴定提供参考。

关键词：粗毛淫羊藿叶绿体基因组高通量测序结构分析鉴定

喷丸强化对GH4096合金表面状态和疲劳性能的影响

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稀有金属材料与工程 2024年第6期53卷 1726-1734页

作者：田伟伏宇张少平钟燕付锐李福林中国航发四川燃气涡轮研究院四川成都610500 钢铁研究总院高温材料研究所北京100081

采用S110铸钢丸和Z300陶瓷丸对GH4096合金开展了喷丸强化试验,利用扫描电镜和三维轮廓仪分析了喷丸表面形貌,采用X射线衍射法分析了喷丸表面残余应力,采用扫描电镜EBSD分析了喷丸试样的截面显微组织,并对喷丸试样进行了650℃低周疲劳试... 详细信息

采用S110铸钢丸和Z300陶瓷丸对GH4096合金开展了喷丸强化试验,利用扫描电镜和三维轮廓仪分析了喷丸表面形貌,采用X射线衍射法分析了喷丸表面残余应力,采用扫描电镜EBSD分析了喷丸试样的截面显微组织,并对喷丸试样进行了650℃低周疲劳试验。结果表明:随着喷丸强度的增大喷丸表面的粗糙度升高,相同喷丸强度下陶瓷丸喷丸表面的粗糙度低于铸钢丸喷丸表面的粗糙度。铸钢丸喷丸表面的残余压应力在-860~-1000 MPa之间,随着喷丸强度的增加残余压应力略有降低;陶瓷丸喷丸表面的残余压应力在-1000~-1100 MPa之间,随着喷丸强度的增加残余压应力略有增加。GH4096合金喷丸后表面发生塑性形变,形成弹丸坑形貌,出现晶界弯曲,产生晶格畸变,造成大量位错塞集,形成密集分布的小角度晶界,晶粒取向也随之改变。喷丸强化可提高GH4096合金650℃高温下的低周疲劳寿命,复合喷丸对疲劳寿命的提升效果最明显,相同喷丸强度下陶瓷丸的强化效果优于铸钢丸。喷丸强化后试样的疲劳裂纹多萌生于强化层之下的亚表面,喷丸强化的效果受表面粗糙度、残余应力及强化层深度等共同影响。

关键词： GH4096合金喷丸强化表面形貌残余应力显微组织疲劳性能

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红花龙胆的生态适宜性研究

北方园艺 2022年第23期 120-125页

作者：任得强王仕梅严福林李梅吴之坤魏升华贵州中医药大学药学院贵州贵阳550025

以红花龙胆为试材,拟通过收集红花龙胆的分布信息,结合生态因子,应用最大熵模型MaxEnt研究影响红花龙胆适宜分布的主要生态因子,并预测红花龙胆在中国的潜在适生区,以期为红花龙胆种质资源的筛选、人工栽培和药材质量评价的进一步研究... 详细信息

以红花龙胆为试材,拟通过收集红花龙胆的分布信息,结合生态因子,应用最大熵模型MaxEnt研究影响红花龙胆适宜分布的主要生态因子,并预测红花龙胆在中国的潜在适生区,以期为红花龙胆种质资源的筛选、人工栽培和药材质量评价的进一步研究提供参考依据。结果表明:根据MaxEnt模型预测的AUC值均大于0.9,预测效果极好。生态因子在红花龙胆生长适宜度中所占权重表明,年均降雨量、最冷月最低温、海拔、最冷季度降水量的总贡献率为86.8%。单因子建模分析结果表明,红花龙胆最适宜生长在年均降雨量800~1300 mm、最冷月最低温-3~4℃、海拔1000~2800 m及最冷季度降水量60~95 mm的环境中。适宜区划研究表明,红花龙胆最适生长区为云南北部、四川西部、重庆南部、广西壮族自治区的西部以及贵州省大部分地区。

关键词：红花龙胆最大熵模型生态因子最适生长区

硅胶键合N-丙基氨基磺酸催化合成8-芳基-7,8-二氢-[1,3]二氧杂环戊烯并[4,5-g]苯并吡喃-6-酮类化合物

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有机化学 2011年第8期31卷 1282-1285页

作者：李卫林罗秋燕闫福林新乡医学院药学院新乡453003 新乡医学院药学院第三附属医院新乡453003

120℃、无溶剂条件下,硅胶键合N-丙基氨基磺酸可有效催化芝麻酚、芳香醛和米氏酸三组分"一锅法"合成8-芳基-7,8-二氢-[1,3]二氧杂环戊烯并[4,5-g]苯并吡喃-6-酮类化合物.考察了温度及催化剂用量对产率的影响.产物的结构经1H NMR,13C NMR... 详细信息

120℃、无溶剂条件下,硅胶键合N-丙基氨基磺酸可有效催化芝麻酚、芳香醛和米氏酸三组分"一锅法"合成8-芳基-7,8-二氢-[1,3]二氧杂环戊烯并[4,5-g]苯并吡喃-6-酮类化合物.考察了温度及催化剂用量对产率的影响.产物的结构经1H NMR,13C NMR,质谱和元素分析进行了表征.

关键词：二氧杂环戊烯并[4,5-g]苯并吡喃芝麻酚米氏酸硅胶键和N-丙基氨基磺酸合成

盐渍土环境下考虑耐久性损伤的输电塔风振时程分析

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建筑结构 2024年第8期54卷 74-84页

作者：梁岩赵付林冯浩琪刘昌海郑州大学土木工程学院郑州450001 中国联合工程有限公司杭州310022

长期服役于盐渍土环境下的输电塔耐久性损伤较为严重,当其材料力学性能退化到一定程度时,在强风作用下,输电塔可能会发生破坏,危害线路的安全运行。基于±800kV天中线特高压直流输电工程直线塔,考虑基础钢筋锈蚀、基础混凝土侵蚀、输电... 详细信息

长期服役于盐渍土环境下的输电塔耐久性损伤较为严重,当其材料力学性能退化到一定程度时,在强风作用下,输电塔可能会发生破坏,危害线路的安全运行。基于±800kV天中线特高压直流输电工程直线塔,考虑基础钢筋锈蚀、基础混凝土侵蚀、输电塔杆塔钢材锈蚀以及基础箍筋的约束效应,在ABAQUS有限元软件中建立塔-线-基础耦合模型,研究不同风攻角和材料耐久性损伤对塔身动力响应的影响。结果表明:90°风攻角下塔身顺风向位移最大,为最不利风向基本工况;90°风攻角下输电塔塔顶顺风向位移响应贡献主要以背景分量为主,但共振分量也有一定贡献,主要以输电塔1阶振型频率为主,且随着服役时间的增加,振型频率逐渐降低,相应响应的贡献程度逐渐提高;相同风荷载作用下,随着服役时间的增加,塔身位移逐渐增大,相同服役时间下,随着塔身高度的增加,塔身位移响应峰值增长速度变快,结构振动更加明显,材料耐久性损伤对输电塔的位移响应影响较大。

关键词：输电塔耐久性风攻角谐波叠加法时程分析

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