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M^(6)A modification in cardiovascular disease:With a focus on programmed cell death

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Genes & Diseases 2024年第5期11卷 272-284页

作者： Wen Li yao Liu Ruiyan Xu Yuan Zong Lu He Jun Hu Guohua Li Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseDepartment of PathophysiologyMOE Key Lab of Rare Pediatric DiseasesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Medicine The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Obstetrics and Gynecology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

N^(6)-methyladenosine(m^(6)A)methylation is one of the most predominant internal RNA modifications in eukaryotes and has become a hot spot in the field of epigenetics in recent *** diseases(CVDs)are a leading cause of death *** evidence demonstrates that RNA modifications,such as the m^(6)A modification,are associated with the development and progression of many diseases,including *** increasing body of studies has indicated that programmed cell death(PCD)plays a vital role in ***,the molecular mechanisms underlying m^(6)A modification and PCD in CVDs remain poorly ***,elaborating on the highly complex connections between the m^(6)A mechanisms and different PCD signaling pathways and clarifying the exact molecular mechanism of m^(6)A modification mediating PCD have significant meaning in developing new strategies for the prevention and therapy of *** is great potential for clinical application.

关键词： Apoptosis Autophagy Cardiovascular diseases Ferroptosis N^(6)-methyladenosine Programmed cell death Pyroptosis

TIP60 acetylation of bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation

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Science China(Life Sciences) 2024年第9期67卷 1957-1969页

作者： Mengjie Sun biying Yang Guangwei Xin yao Wang Jia Luo Qing Jiang Chuanmao Zhang The Academy for Cell and Life Health Faculty of Life Science and TechnologyKunming University of Science and TechnologyKunming 650500China The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education College of Life SciencesPeking UniversityBeijing 100871China

Proper function of the centromeres ensures correct attachment of kinetochores to spindle microtubules and faithful chromosome segregation in *** in the integrity and function of centromeres can result in chromosome missegregation and genomic ***1 is essential for the mitotic centromere dynamics,yet the underlying molecular mechanisms remain largely ***,we demonstrate that TIP60 acetylates bub1 at K424 and K431 on kinetochores in early *** acetylation increases the kinase activity of bub1 to phosphorylate centromeric histone H2A at T120(H2Ap T120),which recruits Aurora b and Shugoshin 1(Sgo1)to regulate centromere integrity,protect centromeric cohesion,and ensure the subsequent faithful chromosome *** of the nonacetylated bub1 mutant reduces its kinase activity,decreases the level of H2Ap T120,and disrupts the recruitment of centromere proteins and chromosome congression,leading to genomic instability of daughter *** cells exit mitosis,HDAC1-regulated deacetylation of bub1 decreases H2Ap T120 levels and thereby promotes the departure of centromeric CPC and Sgo1,ensuring timely centromeres ***,our results reveal a molecular mechanism by which the acetylation and deacetylation cycle of bub1 modulates the phosphorylation of H2A at T120 for recruitment of Aurora b and Sgo1 to the centromeres,ensuring faithful chromosome segregation during mitosis.

关键词： acetylation bub1 TIP60 H2ApT120 chromosome segregation

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Magnetic properties of soft magnetic composites prepared by gas-atomized glassy powders from a new Fe-based alloy with high glass-forming ability

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 91-104页

作者： Ranbin Wang Jili Jia You Wu Wenhui Guo Na Chen Yang Shao Kefu yao School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Wuzhen Laboratory Tongxiang 314500China

With a pressing need for high efficiency, low power consumption, and miniaturization of electronics, soft magnetic composites(SMCs) show great potential, especially for applications in key electronic component. However, core loss is still the focused issue for SMCs that hinders their sustainable development and widespread applications. In the present study, high-performance SMCs were fabricated by novel Fe_(74)b_(7)C_(7)P_(7)Si_(3)Mo_(1)Cr_(1) powders with spherical shape and a fully glassy structure, which were successfully prepared by a gas atomization method. The microstructure and high-frequency magnetic properties of these SMCs were studied in detail. To enhance the soft ferromagnetism, the effects of annealing temperature(T_a) and powder size on their performance were clarified. Increasing T_a up to 703 K not only helps to effectively release internal stress in the powders, but also improves the integrity of the insulation layer structure, which is conducive to decreasing the core loss. In addition, reducing the powder size contributes to the overall performance enhancement. Prepared from the powders with the smallest mean particle size and annealed at 703 K, the SMC exhibits optimum property combination of a stable effective permeability of 26.2 up to 1 MHz, a total core loss of 883 kW m^(–3)(100 kHz, 100 mT), and a DC-bias performance of 79.3% under 100 Oe field, which is even comparable to those of the most prominent SMCs reported so far. These results are meaningful for potentially stimulating the development and application of new low-loss SMCs.

关键词： metallic glassy powder soft magnetic composite annealing temperature particle size high-frequency property

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Constructing orthogonally structured graphene nanointerface on SiC nanowires reinforced carbon/carbon composites to boost mechanical strength and strength retention rate

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Journal of Materiomics 2024年第3期10卷 615-623页

作者： yao Guo Shouyang Zhang Qiang Song Fei Zhao Longkang Cong Wei Li Ruimei Yuan State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Fiber Reinforced Light Composite MaterialsNorthwestern Polytechnical UniversityXi'an 710072China Advanced Interdisciplinary Research Center for Flexible Electronics Academy of Advanced Interdisciplinary ResearchXidian UniversityXi'an 710072China

Carbon/carbon composites with higher mechanical strength and better reliability at elevated tempera-tures are urgently needed to satisfy the practical applications *** nanowires(SiCNWs)modified C/C(SC-CC)composites have attracted an abundance of attention for their excellent mechanical *** further boost the mechanical strengths of composites and maximize the reinforcing efficiency of SiCNWs,we introduce orthogonally structured graphene nanosheets(OGNs)into SC-CC composites,in which OGNs are grafted on the SiCNWs via chemical vapor deposition(CVD)method,forming SC-G-CC *** from the nano-interface effects,uniform stress distribution,strong SiCNWs/PyC interfacial bonding and elevated stress propagation efficiency in the PyC matrix are achieved,thus SC-G-CC composites accomplish brilliant mechanical properties before and after 1,600℃ heat *** temperature rises to 2,100℃,SiCNWs lose efficacy,whereas OGNs with excellent thermal stability continue to play the nano-interface role in the PyC ***,SC-G-CC com-posites show better mechanical performance after 2,100℃ heat treatment,and the mechanical strength retention rate(MSR)of interlaminar shear strength,out-of-plane and in-plane compressive strength of SC-G-CC composites reach 61.0%,55.7%and 55.3%,*** work proposes an alternative thought for maximizing the potentiality of nanomaterials and edifies the mechanical modification of composites.

关键词： SiC nanowires Orthogonally structured graphene nanosheets Carbon/carbon composites Mechanical properties Heat treatment

Ochratoxin A induces mitochondrial apoptosis and ferroptosis by inhibiting Sigma-1 receptor to disrupt redox and cholesterol homeostasis

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Food Science and Human Wellness 2024年

作者： Song yao Wenying Chen Hongwei Wang Ruiran Yang yao Zhou Shuangchao Liu Xiaoli Shen School of Public Health， Zunyi Medical University Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes

Ochratoxin A (OTA)， a secondary fungal metabolite known for its nephrotoxic effects， is widespread in various foods and animal feeds. Our recent investigation suggests a correlation between OTA-induced nephrotoxicity and Sigma-1 receptor (Sig-1R)-mediated mitochondrial apoptosis in human proximal tubule epithelial-originated kidney-2 (HK-2) cells. However， the involvement of Sig-1R in OTA-induced nephrotoxicity， encompassing other forms of regulated cell death like ferroptosis， remains unexplored. In this research， cell viability， apoptotic rate， cholesterol levels， mitochondrial glutathione (mGSH) levels， reactive oxygen species (ROS) levels， and protein expressions in HK-2 cells treated with OTA and/or blarcamesine hydrochloride (Anavex 2-73) were evaluated. The results suggest that OTA induces mitochondrial apoptosis and ferroptosis by inhibiting Sig-1R， subsequently promoting sterol regulatory element-binding protein 2 (SREbP2)， 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)， GRAM domain-containing protein 1b (GRAMD1b)， steroidogenic acute regulatory protein， mitochondrial (StARD1)， 78 kDa glucose-regulated protein (GRP78)， CCAAT/enhancer-binding protein (C/EbP) homologous protein (CHOP)， cyclophilin D (CypD)， Cleaved-Caspase-3， b-cell lymphoma-2-associated X protein (bAX)， and long-chain fatty acid-CoA ligase 4 (ACSL4)， inhibiting tumor necrosis factor receptor-associated protein 1 (TRAP1)， mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)， b-cell lymphoma-2-like protein 1 (bCL-XL)， and glutathione peroxidase 4 (GPX4)， reducing mGSH levels， and increasing total cholesterol， mitochondrial cholesterol， and ROS levels. In conclusion， OTA induces mitochondrial apoptosis and ferroptosis by inhibiting Sig-1R， thereby disrupting redox and cholesterol homeostasis in vitro. The regulation of cholesterol homeostasis by Sig-1R and its involvement in OTA-induced mitochondrial apoptosis and ferroptosis are reported here for the first time.

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Spatial and Temporal Distribution Characteristics of Solar Energy Resources in Tibet

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Energy Engineering 2024年第1期121卷 43-57页

作者： Yanbo Shen Yang Gao Yueming Hu Xin yao Wenzheng Yu Yubing Zhang Public Meteorological Service Center China Meteorological AdministrationBeijing100081China Center forWind and Solar Energy Resources China Meteorological AdministrationBeijing100081China School of Applied Meteorology Nanjing University of Information Science&TechnologyNanjing210044China School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjing210044China

The Tibet Plateau is one of the regions with the richest solar energy resources in the *** the process of achieving carbon neutrality in China,the development and utilization of solar energy resources in the region will play an important *** this study,the gridded solar resource data with 1km resolution in Tibet were obtained by spatial correction and downscaling of SMARTS *** this basis,the spatial and temporal distribution characteristics of solar energy resources in the region in the past 30 years(1991–2020)are finely evaluated,and the annual global horizontal radiation resource is *** results show that:1)The average annual global horizontal radiation amount in Tibet is 1816 kWh/m^(2).More than 60%of the area belongs to the“Most abundant”(GHI≥1750 kWh/m^(2))area of China’s solar energy resources category A,and nearly 40%belongs to the“Quite abundant”(1400≤GHIb.2)In space,the solar energy resources in Tibet increased gradually from north to south and from east to ***,Central and Eastern Shigatse,Shannan,and Southwestern Ali are the most abundant cities,with a maximum annual radiation level of 2189 kWh/m2.3)In terms of time,the total horizontal radiation in Tibet was the highest in May and the lowest in December.74%of the total area belongs to the“Very stable”(R_(w)≥0.47)area of solar resource stability category A,and 26%belongs to the“stable”(0.36≤R_(w)bility category *** energy resources in the region show the characteristics of both strong and *** solar energy resources in the region have shown a fluctuating downward trend over the past 30 years,with an average decline of about 12.86(kWh/m2)per decade.4)In terms of solar radiation resources reaching the earth’s surface,the theoretical total amount of annual horizontal radiation in Tibet is about 240.07 billion tons of standard coal or 222.91 billion kilowatts on average.

关键词： Tibet solar resource spatiotemporal distribution

Experimental investigation on pyrolysis products and pore structure characteristics of organic-rich shale heated by supercritical carbon dioxide

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Petroleum Science 2024年第4期21卷 2393-2406页

作者： bai-Shuo Liu Chuan-Jin yao Jia-Long Qi Ya-Qian Liu Liang Xu Jing-Xuan Hou State Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) Key Laboratory of Unconventional Oil & Gas Development (China University of Petroleum (East China)) Ministry of Education School of Petroleum Engineering China University of Petroleum (East China)

The efficient pyrolysis and conversion of organic matter in organic-rich shale,as well as the effective recovery of pyrolysis shale oil and gas,play a vital role in alleviating energy *** state of carbon dioxide（CO2） in the pyrolysis environment of shale reservoirs is the supercritical *** unique supercritical fluid properties not only effectively heat organic matter,displace pyrolysis products and change shale pore structure,but also achieve carbon storage to a certain *** samples were made into powder and three sizes of cores,and nitrogen（N2） and supercritical carbon dioxide（ScCO2）pyrolysis experiments were performed at different final pyrolysis *** properties and mineral characteristics of the pyrolysis products were studied based on gas chromatography analysis,Xray diffraction tests,and mass spectrometry ***,the pore structure characteristics at different regions of cores before and after pyrolysis were analyzed using N2adsorption tests to clarify the impact of fracturing degree on the pyrolysis *** results indicate that the optimal pyrolysis temperature of Longkou shale is about 430℃.Compared with N2,the oil yield of ScCO2pyrolysis is *** pyrolysis oil obtained by ScCO2extraction has more intermediate fractions and higher relative molecular *** ScCO2can effectively improve the pore diameter of shale and its effect is better than that of *** micropores are produced in shale after pyrolysis,and the macropores only are generated in ScCO2pyrolysis environments with temperatures greater than 430℃.The pore structure has different development characteristics at different pyrolysis temperatures,which are mainly affected by the pressure holding of volatile matter and products *** to the surface of the core,the pore development effect inside the core is *** the decrease in core size,the pore diameter,specific surface area,and pore volume of cores all increase after pyrolysis.

关键词： Organic-rich shale Supercritical carbon dioxide In-situ pyrolysis Pore structure Core size and region

Energy partition in laser-induced cavitation bubbles near the rigid wall with a gas-containing hole

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Journal of Hydrodynamics 2024年第3期36卷 435-443页

作者： Dong-qiao He Hai-gang Wen Si-yuan Geng Chen-xi Yang Qiang Zhong Zhi-feng yao College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China PowerChina beijing Engineering Corporation Limited Beijing100024China State Key Laboratory of Efficient Utilization of Agricultural Water Resources Beijing100083China beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System China Agricultural UniversityBeijing100083China

To investigate the energy partition in laser-induced cavitation bubbles near the rigid wall with a gas-containing hole,we utilized a nanosecond resolution photography system based on a Q-switched Nd:YAG laser and conventional industrial camera to carefully observe the transient process of bubble collapse near the rigid wall with a gas-containing *** analyzed the generation of collapse microjets and the emission of collapse shock *** found that the cavitation bubble near the rigid wall with a gas-containing hole collapsed at different times and space,and produced various types of shock *** on the far field pressure information of the shock waves measured by hydrophone,the energy of the shock waves generated by the bubble collapse near the rigid wall with a gas-containing hole is calculated for the first *** results show that the ratio of collapse shock wave energy to bubble energy is approximately between 0.7 and 0.8.

关键词： Energy partition bubble collapse laser-induced shock wave gas-containing hole

Self-Preloading Flexible Attachment Actuator with Multi-Mechanism Hierarchical Structure

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Journal of bionic Engineering 2024年第4期21卷 1830-1846页

作者： Zhouyi Wang Qingsong Yuan Zhiyuan Weng Junsheng yao Xuan Wu Lei Li Weipeng Li Yiping Feng Zhendong Dai College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics210016NanjingChina State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and Astronautics210016NanjingChina Robotics Laboratory China Nanhu Academy of Electronics and Information Technology314000JiaxingZhejiangChina

Flexible attachment actuators are popular in a wide range of applications,owing to their flexibility and highly reliable ***,their reversible adhesion performance depends on the actual effective contact area and peel angle during ***,a good actuator must ensure a uniform and reliable pre-pressure load on an adhesive surface,to increase the effective contact area of the attached surface,thereby maximizing *** study was inspired by fusion bionics for designing a hierarchical attachment structure with vacuum-adsorption and dry-adhesion *** designed structure used the normal force under the negative pressure of a suction cup as a stable source of a pre-pressure *** optimizing the rigid and flexible structural layers of the attachment structure,a load was applied uniformly to the adhesion area;thus,reliable attachment was achieved by *** structure achieved detachment by exploiting the large deformation of a pneumatic structure under a positive *** hierarchical attachment structure achieved up to 85%of the optimal performance of the adhesive *** to its self-preloading and reliable attachment characteristics,the designed structure can be used as an attachment unit in various complex scenarios,such as small,lightweight climbing platforms and the transport of objects in long,narrow pipelines.

关键词： Multi-mechanism attachment Self-preloading Hierarchical structure Adhesion Vacuum adsorption