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sparing effect of robenacoxib on the minimum alveolar concentration for blunting adrenergic response( MAC-BAR) of sevoflurane in dogs.

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畜牧与兽医 2012年第S2期44卷 33-33页

作者： fukui s.tamura j Itami T Ishizuka T Miyoshi K Yamashita K Department of small Animal Clinical sciences Rakuno Gakuen University

Robenacoxib is a newer non-steroidal anti-inflammatory drug (NsAID) and effective for the management of perioperative pain and inflammation. A preoperative administration of robenacoxib is approved in many countries. The preoperative administration of NsAIDs (carprofen or meloxicam) reduces the minimum alveolar concentration (MAC) of sevoflurane during noxious stimulation in dogs (Yamashita et al. 2008). The purpose of this study was to evaluate the effect of robenacoxib on the MAC for blunting adrenergic response (MAC-BAR) of sevoflurane in *** adult healthy beagle dogs were anesthetized to determine the MAC-BAR of sevoflurane on 2-ocassions at least 1-week intervals. In each occasion,the dogs received a subcutaneous injection (sC) of saline (0. 1 ml/kg) or robenacoxib (2 mg/kg) before the MAC-BAR determination. MAC-BAR determination started at 60 minutes after the administration of saline or robenacoxib. MAC-BAR was determined in duplicate for each dog using electrical stimulus applied to the gingival (50 V,50 Hz,10 ms). During the MAC determination,all dogs were mechanically ventilated to maintain the end-tidal CO2within 35 to 40 mmHg and kept warm to maintain esophageal temperature within 37. 5 to 38. 5 ℃. Data were compared between groups using a paired t-test. The level of significance was set at P seline MAC-BAR for sevoflurane was 3. 44 ± 0. 53%. subcutaneous robenacoxib significantly decreased the sevoflurane MAC-BAR by 17% (2. 84 ± 0. 77%,P = 0. 039).Robenacoxib decreased the sevoflurane MAC-BAR when it was administered at the approved preoperative dose (2mg/kg: sC) to dogs. It is expected that the use of robenscoxib as premedication may provide a clinically relevant anesthetic sparing effect similar to carprofen and meloxicam in dogs (Yamashita et al. 2008).

关键词： dogs MAC-BAR robenacoxib sevoflurane sparing effects

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sparing effect of an antiemetic dose of maropitant on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs.

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畜牧与兽医 2012年第S2期44卷 42-42页

作者： tamura j Itami T Ishizuka T fukui s Miyoshi K Yamashita K Department of small Animal Clinical sciences Rakuno Gakuen University

Maropitant a neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug in dogs by blockade of substance P/NK-1 receptor binding in the vomiting center and chemoreceptor trigger zone in the central nervous system. In addition,substance P and NK-1 receptors have been isolated in nociceptive pathways. Therefore,it is expected that maropitant provides analgesic effect and its sparing effect of minimum alveolar concentration (MAC) has been reported in dogs. The purpose of this study was to evaluate the sparing effect of an approved antiemetic dose of maropitant on the MAC for blunting adrenergic response (MAC-BAR) of sevoflurane in *** adult healthy beagle dogs were anesthetized to determine the MAC-BAR of sevoflurane on 2-ocassions at least 1-week intervals. In each occasion,the dogs received a subcutaneous injection (sC) of saline (0. 1 ml/kg) or maropitant (1 mg/kg) before the MAC-BAR determination. MAC-BAR determination started at 60 min after the administration of saline or maropitant. MAC-BAR was determined in duplicate for each dog using electrical stimulus applied to the gingival (50 V,50 Hz,10 ms). During the MAC determination,all dogs were mechanically ventilated to maintain the endtidal CO2within 35 to 40 mmHg and kept warm to maintain esophageal temperature within 37. 5 to 38. 5 ℃. Data were compared between groups using a paired t-test. The level of significance was set at P seline MAC-BAR for sevoflurane was 3. 44 ± 0. 53%. subcutaneous maropitant significantly decreased the sevoflurane MAC-BAR by 17% (2. 88 ± 0. 74%,P = 0. 037).Maropitant decreased the sevoflurane MAC-BAR when administered at the approved antiemetic dose (1 mg/kg:sC) to dogs. It is expected that a preoperative administration of maropitant may produce anesthetic sparing effect in addition to antiemetic effect in dogs.

关键词： maropitant MAC sevoflurane dog

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Effects of controlled ventilation and positioning on cardiopulmonary function in horses anesthetized with total intravenous anesthesia using a drug combination of medetomidine,lidocaine,butorphanol and propofol (MLBP-TIVA)

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畜牧与兽医 2012年第S2期44卷 34-34页

作者： Ishizuka T Itami T tamura j fukui s Miyoshi K Yamashita K Department of small Animal Clinical sciences Rakuno Gakuen University

The purpose of this study was to evaluate effects of controlled ventilation and positioning on cardiopulmonary function in horses anesthetized with total intravenous anesthesia using a drug combination of medetomidine,lidocaine,butorphanol and propofol (MLBP-TIVA).Five healthy adult horses were anesthetized with MLBP-TIVA for 2-hours on 3-occasions at 4-week interval. In each occasion,horses were anesthetized in lateral recumbency with (CV-LR-group) or without controlled ventilation (sB-LRgroup) or in dorsal recumbency with controlled ventilation (CV-DR-group). Anesthesia was induced with lidocaine (1mg/kg: IV) and propofol (3 mg/kg: IV) following premedications with medetomidine (0. 005 mg/kg: IV) and butorphanol (0. 02 mg/kg: IV),and then maintained by constant rate infusions of propofol (6 mg/kg/hr),medetomidine (0. 0035 mg/kg/h),lidocaine (3 mg/kg/h) and butorphanol (0. 024 mg/kg/h). All horses breathed 100% oxygen during anesthesia. In the CV-groups,horses were mechanically ventilated to maintain arterial CO2pressure (PaCO2)within 40 ~ 50 mmHg. Cardiopulmonary parameters were compared between groups using repeated-measures *** level of significance was set at P sB-LR group,cardiovascular parameters were maintained within acceptable ranges (heart rate: 37 ~ 39beats/min,mean arterial blood pressure: 109 ~ 115 mmHg,mean pulmonary arterial pressure [MPAP]: 28 ~ 29 mmHg,mean right atrial pressure [MRAP]: 19 ~ 21 mmHg,cardiac output: 27 ~ 30 L/min) but severe hypercapnia with insufficient oxygenation (PaCO283 ~ 103 mmHg,arterial O2pressure [PaO2]155 ~171 mmHg) was observed. Cardiopulmonary parameters were maintained with acceptable ranges in the both CV groups. In the CV-LR group,significant decreases in heart rate (29 ~ 31 beats/min,P = 0. 020),cardiac output (17 ~ 21 L/min,P = 0. 005) and PaCO2 (42 ~50 mmHg,P =0. 001) and a significant increase in PaO2 (395 ~419 mmHg,P =0. 005) were observed compared to the sB-group. In the CV-DR group,MPAP

关键词： cardiopulmonary function intravenous anesthesia MLBP-TIVA horse

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Evaluation of cardiopulmonary effects of total intravenous anesthesia using a drug combination of medetomidine,lidocaine,butorphanol and propofol (MLBP-TIVA) with or without controlled ventilation and effect of positioning in mechanically ventilated horses

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畜牧与兽医 2012年第S2期44卷 35-35页

作者： Ishizuka T Nagaro T sudo K Itami T tamura j fukui s Miyoshi K Yamashita K. Rakuno Gakuen University

The purpose of this study was to evaluate cardiopulmonary effects of MLBP-TIVA with or without controlled ventilation in horses and to determine effects of positioning on cardiovascular function in mechanically ventilated *** healthy adult horses were anesthetized with MLBP-TIVA for 2-hours on 3-occasions at 4-week interval with (CMV-group) or without controlled mechanical ventilation (sB-group) and in lateral (LR-group) or dorsal (DRgroup) *** was induced with lidocaine (1 mg/kg: IV) and propofol (3 mg/kg: IV) following premedications with medetomidine (0.005 mg/kg: IV) and butorphanol (0.02 mg/kg: IV),and then maintained by propofol infusion combined with constant rate infusions of medetomidine (0.0035 mg/kg/h),lidocaine (3 mg/kg/h)and butorphanol (0.024 mg/kg/h).Data were compared between groups using repeated-measures *** level of significance was set at P s were maintained within acceptable ranges in ***,severe hypercapnia with insufficient oxygenation was observed (PaCO2: 83 ~103 mmHg,arterial O2pressure [PaO2]: 155 ~171 mmHg).In CMV-group,significant decreases in heart rate (29 ~ 31 beats/min,P = 0.020),cardiac output (17 ~ 21 L/min,P= 0.005) and PaCO2 (42 ~ 50 mmHg,P = 0.001) and a significant increase in PaO2 (395 ~ 419 mmHg,P =0.005) were observed compared to *** pulmonary arterial pressure and mean atrial blood pressure were significantly decreased in DR-group compared to LR-group (18 ~ 20 mmHg vs 27 ~ 31 mmHg,P = 0.001 and 8 ~ 9 mmHg vs 15 ~ 17 mmHg,P = 0.003,respectively).Arterial O2pressure was significantly lower in DR-group than in LR-group (171 ~301 mmHg vs 385 ~416 mmHg,P =0.043).Cardiovascular functions were maintained within acceptable range during MLBP-TIVA in *** ventilation is useful for improving hypercapnia and ***,MLBP-TIVA provides a preservation of cardiovascular function leading to compensation for decreased preload in hors

关键词： butorphanol cardiopulmonary effects horses lidocaine medetomidine propofol TIVA

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2017年美国心脏病学会/美国心脏协会血压管理指南血压分类与视网膜动脉粥样硬化的关系

引用

中华高血压杂志 2022年第4期30卷 400-400页

作者： Matsuoka s Kaneko H Yano Y Itoh H fukui A Morita K Kiriyama H Kamon T Fujiu K seki H Michihata N Taisuke j Takeda N Morita H Nakamura s Yokoo T Nishiyama A Node K Yasunaga H Komuro I 袁源(译) 周卫(译) 郑武洪(审校) 不详

本研究旨在探讨2017年美国心脏病学会(American College of Cardiology,ACC)/美国心脏协会(American Heart Association,AHA)血压管理指南定义的血压分类与视网膜动脉粥样硬化患病率之间的关系。方法:使用jMDC数据库进行回顾性观察性横... 详细信息

本研究旨在探讨2017年美国心脏病学会(American College of Cardiology,ACC)/美国心脏协会(American Heart Association,AHA)血压管理指南定义的血压分类与视网膜动脉粥样硬化患病率之间的关系。方法:使用jMDC数据库进行回顾性观察性横断面研究,分析了280 599名未服用任何抗高血压药物的受试者资料。根据2017年ACC/AHA指南和受试者初始健康检查血压数据,分为正常血压(n=159 524),血压升高(n=35 603),1期高血压(n=54 795)或2期高血压(n=30 677)。

关键词：美国心脏病学会美国心脏协会血压管理正常血压动脉粥样硬化抗高血压药物横断面研究血压分类

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利用超导重力仪数据对2004年M_w=9级苏门答腊地震后极低简正模式的高分辨率分析

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世界地震译丛 2006年第4期37卷 5-10页

作者： s. Rosat T. sato Y. Imanishi j. Hinderer Y. tamura H. McQueen M. Ohashi 尚丹（译）郑需要（校）不详防灾科技学院

2004年12月26日苏门答腊-安达曼地震(Mw=9)强烈地激发了低频地震简正模式,为改善极低地震简正模式频率及阻尼测量提供了难得的机会。为改进地球一维密度模型,需对低于1mHz的地震简正模式的频率分裂进行精确估算。本次地震中,首次在超导... 详细信息

2004年12月26日苏门答腊-安达曼地震(Mw=9)强烈地激发了低频地震简正模式,为改善极低地震简正模式频率及阻尼测量提供了难得的机会。为改进地球一维密度模型,需对低于1mHz的地震简正模式的频率分裂进行精确估算。本次地震中,首次在超导重力仪和地震波记录无叠加的情况下观测到2s1。本文报告来自11个观测台测得的超导重力仪数据的分析。单个观测台的超导重力仪记录频谱清晰地显示了0s2分裂成5个完全可分辨的单线,0s3分裂成7个单线。给出的结果表明超导重力仪可为低频地震模式的精确分析提供高质量数据。

关键词：超导重力仪简正模式苏门答腊地震后高分辨率频率分裂观测台阻尼测量

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γ-ray spectroscopy of Hypernuclei:Recent KEK Results and Future Plans at j-PARC

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原子核物理评论 2009年第S1期26卷 34-38页

作者： s.Ajimura K.Aoki M.Dairaku H.Fujioka T.Fukuda K.Futatsugawa K.Hosomi W.Imoto M.Kawai Y.Kakiguchi s.Kinoshita T.Koike N.Maruyama M.Mimori s.Minami Y.Miura K.Miwa Y.Miyagi T.Nagae D.Nakajima H.Noumi K.s hirotori T.suzuki T.Takahashi T.N.Takahashi K.Tanida N.Terada A.Toyoda K.Tsukada M.Ukai H.tamura Department of Physics Osaka University High Energy Accelerator Research Organization (KEK) Department of Physics Kyoto University Department of Physics University of Tokyo Osaka Electro-Communication University Department of Physics Tohoku University RIKEN

In this proceeding,we will first outline the experimental setup and main results of the most recent hypernuclear γ-ray spectroscopy experiment (KEK-E566) performed at KEK-Ps K6 beam line. The main feature and characteristics of this type of research will be emphasised. After that,the approved experimental proposal (E13) at j-PARC facility will be introduced briefly.

关键词： γ-ray spectroscopy hypernuclei

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ΛN张量相互作用的首次观测

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高能物理与核物理 2005年第7期29卷 627-631页

作者：周书华周静孟秋英 s.Ajimura H.Akikawa D.E.Alburger A.Banu R.E.Chrien G.B.Franklin j.Franz O.Hashimoto T.Hayakawa H.Hotchi K.Imai T.Kishimoto M.May D.j.Millener s.Minami Y.Miura T.Miyoshi K.Mizunuma T.Nagae s.N.Nakamura K.Nakazawa Y.Okayasu P.Pile B.P.Quinn A.Rusek Y.sato R.sutter H.Takahashi L.Tang H.tamura K.Tanida M.Ukai L.Yuan 中国原子能科学研究院 Department of Physics Osaka UniversityToyonaka 5560-0043Japan Department of Physics Kyoto UniversityKyoto 606-85023Japan Brookhaven National Laboratory UptonNew York 11973USA GsI Darmstadt D-64291Germany Carnegie Mellon University PittsburghPennsylvania 15213USA Department of Physics University of FreiburgFreiburg 79104Germany Department of Physics Tohoku UniversitySendai 980-8578Japan Institute of Particle and Nuclear studies KEKTsukuba 305-0801Japan Department of Physics Gifu UniversityGifu 501-1193Japan Department of Physics Hampton UniversityHamptonVirginia 23668USA RIKEN Wako 351-0198Japan

在用HYPERBALL进行的16ΛO的γ射线谱学测量中,观察到由16ΛO的6.6MeV1-2激发态跃迁到基态自旋翻转二重态(1-1和0-)之间的两条γ射线.由这两条γ射线的能量差得到基态二重态之间的能量间隔为26.4±1.6(stat)±0.5(syst)keV,并由此推导出... 详细信息

在用HYPERBALL进行的16ΛO的γ射线谱学测量中,观察到由16ΛO的6.6MeV1-2激发态跃迁到基态自旋翻转二重态(1-1和0-)之间的两条γ射线.由这两条γ射线的能量差得到基态二重态之间的能量间隔为26.4±1.6(stat)±0.5(syst)keV,并由此推导出ΛN之间的张量相互作用强度T=0.03MeV.实验还测定了16ΛO的1-2激发态的激发能为6561.7±1.1(stat)±1.7(syst)keV.

关键词：张量观测相互作用强度 γ射线基态自旋激发态能量差激发能谱学跃迁

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Quantifying Electronic Effects in QM and QM/MM Biomolecular Modeling with the fukui Function

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物理化学学报 2018年第1期34卷 81-91页

作者： QI Helena W. KARELINA Maria KULIK Heather j. Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA. Department of Chemistry Massachusetts Institute of Technology Cambridge MA 02139 USA.

Multi-scale quantum-mechanical/molecular-mechanical(QM/MM) and large-scale QM simulation provide valuable insight into enzyme mechanism and structure-property relationships. Analysis of the electron density afforded through these methods can enhance our understanding of how the enzyme environment modulates reactivity at the enzyme active site. From this perspective, tools from conceptual density functional theory to interrogate electron densities can provide added insight into enzyme function. We recently introduced the highly parallelizable fukui shift analysis(FsA) method, which identifies how frontier states of an active site are altered by the presence of an additional QM residue to identify when QM treatment of a residue is essential as a result of quantum-mechanically affecting the behavior of the active site. We now demonstrate and analyze distance and residue dependence of fukui function shifts in pairs of residues representing different non-covalent interactions. We also show how the interpretation of the fukui function as a measure of relative nucleophilicity provides insight into enzymes that carry out s_N2 methyl transfer. The FsA method represents a promising approach for the systematic, unbiased determination of quantum mechanical effects in enzymes and for other complex systems that necessitate multi-scale modeling.

关键词：《物理化学学报》期刊编辑工作发行工作

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Nuclear structure of proton-rich unstable nucleus ^(28)P studied by g-factor measurement

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Chinese Physics C 2009年第S1期33卷 215-217页

作者：郑永男周冬梅 K. Matsuta M. Mihara M. Fukuda D. Nishimura j. Komurasaki D. Ishikawa R. Matsumiya T. Nagatomo T. Izumikawa s. Takahashi H. Hirano T. Ohtsubo s. Momota Y. Nojiri A. Kitagawa M. Kanazawa M. Torikoshi s. sato T. Minamisono j. R. Alonso G. F. Krebs T. j. M. symons 袁大庆左翼范平 T. suzuki 张锡珍朱升云 China Institute of Atomic Energy Department of Physics Osaka University RIKEN Wako Saitama 351-0198 Japan RI Center Niigata University Department of Physics Niigata University Kochi University of Technology National Institute of Radiological sciences Inage-ku Chiba 263-8555 Japan fukui University of Technology Lawrence Berkeley Laboratory Department of Physics Nihon University

Nuclear structure of proton-rich unstable nucleus 28P has been studied by measuring its g-factor for the first time. The g-factor of 28P (Iπ =3+, T1/2=270.3 ms) was measured by means of β-NMR technique combined with the new polarization technique for charge exchange reaction product in the intermediate energy heavy ion collisions. The obtained g-factor of g=0.1028(27) is very much quenched from the schmidt value, but is well reproduced by the shell model (+0.102). In connection with the magnetic moment of the mirror partner and the β-ray transition probability, the orbital angular momenta and intrinsic spins of protons and neutrons have been determined as lp =0.43(29), ln =1.85(29), sp)=0.28(4), and sn =0.44(4).

关键词： 28P β-NMR nuclear magnetic moment exotic nuclei

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