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Liquid metal as reconnection agent for peripheral nerve injury

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Science Bulletin 2016年第12期61卷 939-947页

作者： fujun liu Yongze Yu Liting Yi Jing liu Beijing Key Laboratory of Cryo-Biomedical Engineering and Key Laboratory of Cryogenics Technical Institute of Physicsand Chemistry Chinese Academy of Sciences Beijing 100190China Department of Biomedical Engineering School of MedicineTsinghua University Beijing 100084 China

This study demonstrated an unconventional way to cure peripheral nerve injury(PNI) with liquid metal gallium employed as the reconnection agent. In vivo experiments were performed, in which transected sciatic nerve of mouse was reconnected by liquid metal *** nerve signals detected was found to be almost the same as those from the complete nerve, where the negative bursting firing caused by PNI was absent on the neural discharge curve after nerve-reconnection surgery. Meanwhile the atrophy tendency of gastrocnemius muscle was distinctly procrastinated according to the results of pathological examinations, which showed fibrillation potentials emerged immediately for mice with PNI but did not emerge until the third month for those received nerve-reconnection surgery. Furthermore, physical properties of gallium were studied, showing that its impedance was slightly influenced by the frequency of transmitted signal and the temperature, which confirmed the stability of gallium in future clinical usage. This technology is expected to perform well in clinical surgery for PNI and even central nervous system injury in the coming time.

关键词： Peripheral nerve injury Liquid metal Nerve repair Neuroprosthetics Muscle atrophy

Spraying printing of liquid metal electronics on various clothes to compose wearable functional device

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Science China(Technological Sciences) 2017年第2期60卷 306-316页

作者： GUI Han TAN SiCong WANG Qian YU Yang liu fujun LIN Ju liu Jing Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing 100084China Beijing Key Lab of Cryo Biomedical Engineering and Key Lab of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Liquid metal printing is emerging as an important tool for making wearable electronics. However, very limited academic efforts were made to fulfill such an increasing need. This paper is dedicated to present relatively complete theoretical and experimental characterizations for liquid metal spraying printing towards developing wearable electronic textile. The practical conditions of liquid metal droplets in the spraying printing process such as the jet velocity, the size distribution of droplets and their evenness degree, the morphology of droplets and their unrolling areas after impacting the substrate are quantified. The dominating factors, including the oxidation of liquid metal and the pressure force on cloth substrate during the impacting process, which ensure liquid metal firmly adhere to the cloth, are clarified. Further, various clothes are comparatively investigated to test their capabilities in printing liquid metal conductors, where the resistance difference can be over thousand-fold. In addition to interpreting the basic mechanisms and performances of the spraying printing, two programmable flexible circuits with specifically designed functions such as blinking LED lighting and wireless infrared temperature measurement via current manufacture technology were also demonstrated and evaluated for their washable ability. With the realization of wearable modules via liquid metal printing technology, it can be expected that flexible functional devices on cloth fabricated quickly and directly would witness more broad applications in the coming time.

关键词： liquid metal wearable electronics spraying printing electronic cloth health care

Origin of Tafoni in the Late Cretaceous Aeolian Sandstones,Danxiashan UNESCO Global Geopark,South China

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Acta Geologica Sinica(English Edition) 2019年第2期93卷 451-463页

作者： CHEN liuqin GUO Fusheng liu fujun XU Huan DING Ting liu Xin State Key Laboratory of Nuclear Resources and Environment East China University of Technology Shandong Provincial Key Laboratory of Depositional Mineralization & Sedimentary Mineral Shandong University of Science and Technology School of Earth Sciences East China University of Technology

Tafoni occur generally in granular rocks around the world, but their origin remains controversial. In this study,the roles of lithology, micro–climate, and organism in tafoni development are investigated in the Danxiashan UNESCO Global Geopark of South China. The Jinshiyan Temple and Luyitang sites along the Jinjiang River are chosen to conduct tafoni morphometry, bedrock petrography, and micro–climate analyses. The research methods used in this study include field observations and measurements, Voronoi diagrams, polarizing microscopic and scanning electron microscopic(SEM)image analysis, and meteorological detection. The tafoni are mostly 2–10 cm in length and elliptical in shape. The Late Cretaceous Jinshiyan sandstones are characterized by a grain–to–grain contact fabric and moderate sorting with a high proportion of soluble grains and cements. The Voronoi diagrams developed through the Arc GIS software are largely consistent with the tafoni openings. Moreover, owing to exposure to solar insolation, the external temperature values are higher than the internal ones, while the external relative humidity values are lower than the internal ones. Therefore, the permeable Jinshiyan sandstones are fundamental for tafoni development, while the abundant moisture from the Jinjiang River and frequent rains is favorable for salt weathering in tandem with biological activities. At last, a five–stage development model is proposed for the tafoni progression in the study area.

关键词： tafoni aeolian sandstone salt weathering moisture Danxia landscape

LRRC25 plays a key role in all-trans retinoic acid-induced granulocytic differentiation as a novel potential leukocyte differentiation antigen

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Protein & Cell 2018年第9期9卷 785-798页

作者： Weili liu Ting Li Pingzhang Wang Wanchang liu fujun liu Xiaoning Mo Zhengyang liu Quansheng Song Ping Lv Guorui Ruan Wenling Han Department of Immunology School of Basic Medical Sciences Key Laboratory of Medical Immunology (Ministry of Health) Peking University Health Science Center Beijing 100191 China Peking University Center for Human Disease Genomics Beijing 100191 China Institute of Hematology Peking University People's Hospital Beijing 100044 China

Leukocyte differentiation antigens （LDAs） play important roles in the immune system, by serving as surface markers and participating in multiple biological activities, such as recognizing pathogens, mediating membrane signals, interacting with other cells or systems, and regulating cell differentiation and activation. Data mining is a powerful tool used to identify novel LDAs from whole genome. LRRC25 （leucine rich repeat-containing 25） was predicted to have a role in the function of myeloid cells by a large-scale ＂omics＂ data analysis. Further experimental validation showed that LRRC25 is highly expressed in primary myeloid cells, such as granulocytes and monocytes, and lowly/intermediately expressed in B cells, but not in T cells and almost all NK cells. It was down-regulated in multiple acute myeloid leukemia （AML） cell lines and bone marrow cells of AML patients and up-regulated after all-trans retinoic acid （ATRA）-mediated granulocytic differentiation in AML cell lines and acute promyelocytic leukemia （APL; AML-M3, FAB classification） cells. Localization analysis showed that LRRC25 is a type I transmembrane molecule. Although ectopic LRRC25 did not promote spontaneous differentiation of NB4 cells, knockdown of LRRC25 by siRNA or shRNA and knockout of LRRC25 by the CRISPR-Cas9 system attenuated ATRA-induced termi- nal granulocytic differentiation, and restoration of LRRC25 in knockout cells could rescue ATRA-induced granulocytic differentiation. Therefore, LRRC25, a potential leukocyte differentiation antigen, is a key regulator of ATRA-induced granulocytic differentiation.

关键词： LRRC25 differentiation antigen granulocytic differentiation ATRA AML

Administration of B7-H3 targeted chimeric antigen receptor-T cells induce regression of glioblastoma

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1119-1121页

作者： Xin Tang Yuelong Wang Jianhan Huang Zongliang Zhang fujun liu Jianguo Xu Gang Guo Wei Wang Aiping Tong Liangxue Zhou Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina State Key Laboratory of Biotherapy West China HospitalWest Chino Medical SchoolSichuan UniversityChengduSichuan ProvinceChina

Dear Editor,Nowadays,glioblastoma(GBM)was the most common and lethal form of primary intracranial *** standard-of-care therapy,GBM still exhibited a poor prognosis with 5-years survival rate less than 5%.Recent years,adoptive CAR-T therapy came to be a novel immunotherapy in treating malignant *** progress has been made by CD19 targeted CAR-T cells against refractory B cell *** studies also reported about the clinical potential of CAR-T therapy targeting IL13Ra2 and EGFRvlll in treating GBM.1,2 However,limited numbers of therapeutic targets in GBM may preclude it from progress and being popularized.B7-H3(CD276)has been found to be overexpressed by many tumors and tumor-infiltrating dendritic cell.3 Our previous studies suggested the potent anti-tumor effect of B7-H3 targeted CAR-T cells against GBM in preclinical models.

关键词： targeted clinical therapy

Analysis on Tourism Environment of Mt. Longhushan Scenic Area

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Analysis on Tourism Environment of Mt. Longhushan Scenic Are...

Acoustic experimental study of two types of rock from the Tibetan Plateau under the condition of freeze-thaw cycles

2011 International Conference on Applied Social Science(ICASS 2011)

作者： liu fujun GUO Fusheng ZENG Hua East China Institute of Technology

There are three reasons mainly caused the tourism environmental problems of *** Scenic Area, including natural factors, non-tourist human activities, and tourist activities. In order to develop the *** into a harmonious, civilized and high-grade resort, the relevant measures shall be taken specifically to improve the tourism environment.

关键词： Mt Longhushan Tourism Environment Countermeasures and Suggestions

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Research in Cold and Arid Regions 2012年第1期4卷 21-27页

作者： Hua liu fujun Niu ZhiYing Xu ZhanJu Lin Jian Xu State Key Laboratory of Frozen Soil Engineering CoM and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou Gansu 730000 China

Under the condition of freeze-thaw cycles, two types of rocks （granite and andesite）, used as slope protection for the Qinghai-Tibet Railway, were tested according to the special climatic conditions in the Tibetan Plateau, and their various damage processes in ap- pearance were carefully observed. Observation results show that damage of andesite was more serious than that of granite. Using an acoustic instrument, ultrasonic velocity was tested. The changing trends of velocity with the number of freeze-thaw cycles were analyzed, and the freeze-thaw cycle damaging the physical and mechanical properties of rocks can be seen. According to the changing trends of ultrasonic velocity with the number of freeze-thaw cycles, mechanical parameters of rocks, such as dynamic elasticity modulus, Poisson＇s ratio, and dynamic bulk modulus were analyzed. It is found that they all have declining trends as the number of fi＇eeze-thaw cycles increases, and in particular, when the cycle number reaches a certain extent, the Poisson＇s ratio of rocks begins to become negative.

关键词： freeze-thaw cycle granite andesite ultrasonic wave physical and mechanical properties

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中国特色社会主义宗教理论的发展逻辑及启示

世界宗教文化 2020年第4期 26-32页

作者：刘福军北京联合大学马克思主义学院

中国特色社会主义宗教理论的形成和发展有着重要的内在逻辑及启示,可概括为“七个得来、七个必须”。这一理论是在五千多年的中华文明传承发展中得来的,必须坚持我国宗教中国化方向。这一理论是在五百多年的社会主义宗教观演变进程中得... 详细信息

中国特色社会主义宗教理论的形成和发展有着重要的内在逻辑及启示,可概括为“七个得来、七个必须”。这一理论是在五千多年的中华文明传承发展中得来的,必须坚持我国宗教中国化方向。这一理论是在五百多年的社会主义宗教观演变进程中得来的,必须坚持用马克思主义立场观点方法认识和对待宗教。这一理论是在近代以来中国宗教同外部世界的关系及其对中国社会的影响的历史总结中得来的,必须坚持独立自主自办原则。这一理论是在建党以来宗教工作历史经验提炼中得来的,必须坚持党对宗教工作的领导。这一理论是在新中国成立以来宗教问题认识历程中得来的,必须积极引导宗教与社会主义社会相适应。这一理论是在改革开放以来宗教政策体系丰富完善中得来的,必须全面贯彻党的宗教工作基本方针。这一理论是在进入新时代以来宗教工作创新推进中得来的,必须深入贯彻习近平总书记关于宗教工作的重要论述。

关键词：中国共产党中国特色社会主义宗教理论发展逻辑启示

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箱式路面体系车辆通过性机理分析

农业机械学报 2007年第2期38卷 26-29页

作者：范华林刘福君清华大学工程力学系解放军63956部队

为了评价机械化路面器材对车辆安全通行的保障能力,根据箱式路面器材的结构和受力特点进行结构简化,探讨铰接箱式路面体系与土壤相互作用模型。在沉陷计算的基础上分析集中载荷和均布载荷条件下行驶阻力和挂钩牵引系数的计算公式,提出... 详细信息

为了评价机械化路面器材对车辆安全通行的保障能力,根据箱式路面器材的结构和受力特点进行结构简化,探讨铰接箱式路面体系与土壤相互作用模型。在沉陷计算的基础上分析集中载荷和均布载荷条件下行驶阻力和挂钩牵引系数的计算公式,提出铰接箱式路面体系车辆通过性评判方法,分析了附着系数、地基参数、结构尺寸对路面器材车辆通过性的影响。

关键词：车辆通过性箱式路面器材沉陷挂钩牵引系数