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Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival

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World Journal of Gastroenterology 2006年第1期12卷 48-53页

作者： Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan Department of Gastroenterology Maebashi Red Cross HospitalMaebashiGunma 371-0014Japan Department of Internal Medicine Isesaki Municipal HospitalIsesakiGunma 372-0817Japan Department of Internal Medicine Kiryu Kousei General HospitalKiryuGunma 376-0024Japan Department of Internal Medicine Tone Chuo HospitalNuraataGunma 378-0053Japan Department of Gastroenterology National Nishigunma HospitalShibukawaGumna 377-0027Japan Department of Gastroenterology Saiseikai Maebashi HospitalMaebashiGunma 371-0821Japan Department of Gastroenterology Public Tomioka General HospitalTomiokaGunma 370-2361Japan Department of Internal Medicine Fuji Heavy Industries Ltd.Health Insurance Society General Ota HospitalOtaGunma 373-0056Japan Department of Gastroenterology Shimada Memorial HospitalFujiokaGunma 375-0024Japan

AIM： To identify the clinical and prognostic features of patients with hepatocellular carcinoma （HCC） aged 80 years or more. METHODS： A total of 1310 patients with HCC were included in this study. Ninety-one patients aged 80 years or more at the time of diagnosis of HCC were defined as the extremely elderly group. Two hundred and thirty-four patients aged 〉/ 50 years but less than 60 years were regarded as the non-elderly group. RESULTS： The sex ratio （male to female） was significantly lower in the extremely elderly group （0.90：1） than in the non-elderly group （3.9：1, P〈 0.001）. The positive rate for HBsAg was significantly lower in the extremely elderly group and the proportion of patients negative for HBsAg and HCVAb obviously increased in the extremely elderly group （P〈 0.001）. There were no significant differences in the following parameters： diameter and number of tumors, Child-Pugh grading, tumor staging, presence of portal thrombosis or ascites, and positive rate for HCVAb. Extremely elderly patients did not often receive surgical treatment （P 〈 0.001） and they were more likely to receive conservative treatment （P〈 0.01）. There were no significant differences in survival curves based on the Kaplan-Meier methods in comparison with the overall patients between the two groups. However, the survival curves were significantly worse in the extremely elderly patients with stage Ⅰ/Ⅱ, stage Ⅰ/Ⅱ and Child-Pugh grade A cirrhosis in comparison with the non-elderly group. The causes of death did not differ among the patients, and most cases died of liverrelated diseases even in the extremely elderly patients. CONCLUSION： In the patients with good liver functions and good performance status, aggressive treatment for HCC might improve the survival rate, even in extremely elderly patients.

关键词： Hepatocellular carcinoma Extremely elderly patients Survival analysis Cause of death

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运用聚乳酸-羟基乙酸共聚物膜-固定化条件培养液引导骨再生的实验研究

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中国口腔医学继续教育杂志 2016年第6期19卷 288-297页

作者： Shuhei Tsuchiya Masahiro Ohmori Kenji Hara Masahito fujio Masayuki lkeno Hideharu Hibi Minoru Ueda 黄明娣不详中山大学附属口腔医院广州市陵园西路56号510060

目的：探讨是否可以通过使用条件培养液（CM）和引导骨再生（GBR）技术加速骨再生。材料与方法：CM取自大鼠骨髓基质干细胞（BMSCs）。CM被固定在聚乳酸一羟基乙酸共聚物（PLGA）膜上．该膜需用0，5mol／L氢氧化钠（NaOH）处理以提高亲... 详细信息

目的：探讨是否可以通过使用条件培养液（CM）和引导骨再生（GBR）技术加速骨再生。材料与方法：CM取自大鼠骨髓基质干细胞（BMSCs）。CM被固定在聚乳酸一羟基乙酸共聚物（PLGA）膜上．该膜需用0，5mol／L氢氧化钠（NaOH）处理以提高亲水性。实验分为4个组：PLGA膜处理①磷酸盐缓冲液（PBS；PBS—M）．②PBS和0．5mol／LNaOH（亲水性处理；PBS-HM），③CM（CM—M）．④CM和0．5mol／LNaOH（CM—HM）。通过扫描电镜观察这些实验性膜。液相色谱-串联质谱法（LC／MS／MS）测定固定在PLGA膜上的来自骨髓间充质干细胞表达的蛋白。细胞增殖实验和碱性磷酸酶（ALP）活性测定分析CM对骨髓间充质干细胞活性的影响。实验性膜被移植到大鼠颅骨骨缺损模型。移植4周和8周后进行显微CT和组织学分析。结果：来自骨髓间充质干细胞的CM可固定于PLGA膜上。PLGA膜的亲水处理可增强CM的固定。LC／MS／MS分析表明．在PLGA膜表面的固定化蛋白质属于细胞外基质蛋白．如胶原蛋白、核心蛋白多糖、纤连蛋白。CM里从PLGA膜释放出的蛋白质．可以促进大鼠骨髓间充质干细胞的细胞增殖和碱性磷酸酶活性。被CM—HM处理过的骨缺损区域新骨形成明显高于被其他组膜处理对应的骨缺损区域。结论：PLGA膜经0.5mol／LNaOH和CM处理后可促进此大鼠颅骨缺损模型的骨再生。

关键词：条件培养液引导骨组织再生组织工程

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Construction of Subsurface Geological Structures Using a Drilling Database: A Case Study for an Intra-Arc Basin, the Osaka Plain, Southwest Japan

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Open Journal of Geology 2013年第2期3卷 39-43页

作者： Minao Sakurai fujio Masuda Graduate School of Science and Engineering Doshisha University Kyoto Japan

Subsurface geological cross sections of 0 - 200 m depth were constructed using a dense drilling database of the Osaka Plain in the intra-arc Osaka Basin of the Japan island arc, an active plate margin. The cross sections revealed the subsurface geological structures and the geometry of folding and faulting in the basin. The comparison between the constructed subsurface cross sections and the seismic sections of the basement and basin fills at a depth of 1500 - 2000 m showed that the basement and shallow subsurface structures are similar;however, the shallow cross sections were of higher resolution than the deep seismic profiles.

关键词： Intra-Arc Basin Subsurface Geological Structure Basement Structure Drilling Database

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PAST DARKNESS AND PRESENT OPENNESS IN FOOD SAFETY IN JAPAN

PAST DARKNESS AND PRESENT OPENNESS IN FOOD SAFETY IN JAPAN

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北京论坛（2006）文明的和谐与共同繁荣—对人类文明方式的思考

作者： fujio Kayama Division of Environmental Medicine Center for Community MedicineJichi Medical University.Shimotsuke CityTochigi329-0498 JAPAN

Due to environmental contamination by heavy metals,Japan has suffered in the past from serious health problems,such as Minamata disease by methyl-mercury,Itai-Itai disease by *** these experiences,Japanese people are very cautious to food safety and sometimes excessively react to food safety *** Japanese government made laws and

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Biological Evaluation of Tissue-Engineered Cartilage Using Thermoresponsive Poly(<i>N</i>-isopropylacrylamide)-Grafted Hyaluronan

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Journal of Biomaterials and Nanobiotechnology 2012年第1期3卷 1-9页

作者： Kazuaki Muramatsu Mika Ide fujio Miyawaki Division of Life Science and Engineering School of Science and Engineering Tokyo Denki University Saitama Japan

In order to contribute to the development of minimally invasive surgery techniques for autologous chondrocyte implantation, a novel self-assembling biomaterial consisting of thermoresponsive poly(N-isopropylacrylamide)-grafted hyaluronan (PNIPAAm-g-HA) has been synthesized as an injectable scaffold for cartilage tissue engineering. The aim of this study was to investigate the efficacy and cytocompatibility of PNIPAAm-g-HA to normal chondrocytes by using reverse transcription-polymerase chain reaction (RT-PCR) analysis and histochemical staining in preliminary in vitro and in vitro experiments. Hematoxylin and eosin staining showed homogeneous distribution of cells in the PNIPAAm-g-HA hydrogel in 3-dimensional in vitro cultivation. Alcian blue staining also indicated that abundant extracellular matrix formation, including acidic glycosaminoglycans, occurred in tissue-engineered cartilage over time in vitro. Cartilage-related gene expression patterns, which were tested in rabbit normal chondrocytes embedded in the hydrogel, were almost maintained for 4 weeks. Transforming growth factor-β1 (TGF-β1) stimulation enhanced the expression of SRY-related HMG box-containing gene 9 (Sox9) and type X collagen genes suggesting promotion of chondrogenic differentiation. Histochemical evaluation showed neocartilage formation following subcutaneous implantation of the chondrocyte-gel mixture in nude mice. Furthermore, TGF-β1 stimulation promoted production and maturation of the extracellular matrix of the in situ tissue engineered hyaline cartilage. These data suggested that PNIPAAm-g-HA could be a promising biomaterial, i.e., a self-assembling and injectable scaffold for cartilage tissue engineering.

关键词： Cartilage Tissue Engineering Hyaluronan Self-Assembly Thermally Responsive Material

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日本根霉IFO5318胞外β-葡萄糖苷酶的纯化及部分特性

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微生物学报 1997年第5期37卷 368-373页

作者：陈向东藤尾雄策武汉大学生命科学学院武汉430072 九州大学食粮化学工学科

采用硫酸铵沉淀及柱层析等步骤纯化了日本根霉IFO5318的β—葡萄糖苷酶,回收率为22％。该酶分子量约为4.0×10~5,由四个相同大小的亚基组成;最适反应温度55℃,最适反应pH5.5;对热较敏感,但能在较大的pH范围内保持稳定。用对硝基苯基—β... 详细信息

采用硫酸铵沉淀及柱层析等步骤纯化了日本根霉IFO5318的β—葡萄糖苷酶,回收率为22％。该酶分子量约为4.0×10~5,由四个相同大小的亚基组成;最适反应温度55℃,最适反应pH5.5;对热较敏感,但能在较大的pH范围内保持稳定。用对硝基苯基—β-D-吡喃葡糖苷为底物,测得的K_m和V_(max)值分别为0.825mg·ml^(-1)和135.4μmol·min^(-1)·mg^(-1)。该酶对纤维二糖的水解能力最强,SDS、Fe^(3+)、Hg^2+)等对酶活力有抑制作用。

关键词：真菌日本根菌 β-葡萄糖苷酶纯化性质

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Saikosaponin-d Prevents the Progression of Mesangioproliferative Glomerulonephritis in Rats

Saikosaponin-d Prevents the Progression of Mesangioprolifera...

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全国中青年中西医结合学术（英语）交流会议

作者： Hiroshi Kawahci fujio Shimizu Department of Cell Biology Institute of Nephrology Niigata University. School of Medicine Niigata

Aims: the preventive effects of Saikosaponin-d (Ssd) on the progression of mesangioproliferative glomerulonephritis, induced by intravenous infection of anti-Thyl monoclonal antibody (mAb) 1-22-3 into uninephrectomized rats, were evaluated. Methods: eighteen rats were divided into three groups of six. One group was treated with phosphate buffered saline (PBS) as a control. The other two groups were treated with Ssd 1.8 mg/kg body weight (BW)/day or 0.6 mg/kg BW/day respectively. Urine samples were collected from the rats in metabolic cages on days 1,4, 8, 14 and 21 after the injection of mAb 1-22-3. Systolic BP (SBP) was tested on days 1, 5, 10, 14 and 18 after the injection. All rats were sacrificed 21 days after the injection of mAb 1-22-3 for blood biochemistry, RNA preparation from isolated glomeruli, and immunofluorescent and light microscopy of the kidney. Results: Ssd suppressed proteinuria, extracellular matrix expansion, crescentic formation as well as inflammatory cell infiltration recognized by mAb OX8, EDI and TRPM3. Especially, Ssd was shown to have highly significant suppressive effect on CD8+ T cells infiltration into the periglomerular and tubulointerstitial areas, as shown in Table 1 and on expression of α-SMA along Bowman’s capsule as shown in Figures 7E and 7F. Conclusion: Saikosapoin-d prevented the progression of mesangioproliferative glomerulonephritis in rats, which might be closely linked to the markedly significant suppressive effects of Ssd on CD8+ T cells infiltration into the periglomerular and tubulointerstitial areas, as well as on the expression of α-SMA along Bowman’s capsule.

关键词： Saikosaponin-d anti-Thy 1 monoclonal antibody mesangioproliferation.

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THE INFLUENCE OF MICROSTRUCTURAL INSTABILITY ON CREEP BEHAVIOR OF A NICKEL-BASE UDEMET 500 SUPERALLOY

THE INFLUENCE OF MICROSTRUCTURAL INSTABILITY ON CREEP BEHAVI...

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第一届国际机械工程学术会议

作者： Kota Sawada fujio Abe National Research Institute for Metals Japan

The creep deformation behavior and its relationship with the microstructural instability during creep were investigated for a nickel-base Udimet 500 superalloy via the creep testing at 800 and 900C for up to 22,000 hours. All of the creep curves under the different test conditions consist of very shorter transient creep and longer acceleration creep. In the tertiary creep region, the acceleration of creep rate occurs in two stages. Moreover, the microstructural evolutions such as the coarsening of βphase, the precipitation of βphase, grain boundary nature and internal nitridation attack were analyzed.

关键词： Creep Udimet 500 superalloy B phase

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Assessment of the efficacy of an advanced tertiary sewage treatment plant to remove biologically active chemicals using endocrine and genotoxicity bioassays

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Emerging Contaminants 2021年第1期7卷 124-131页

作者： Lisa A.Hamilton fujio Shiraishi Daisuke Nakajima Michael Boake Richard P.Lim Olivier Champeau Louis A.Tremblay School of Life Sciences Faculty of ScienceUniversity of TechnologySydney(UTS)PO Box 123BroadwayNSW2007Australia National Institute for Environmental Studies 16-2 OnogawaTsukubaIbaraki305-8506Japan Veolia Water Australia Level 4Bay Centre65 Pirrama RoadPyrmontNSW2009Australia Cawthron Institute Private Bag 2Nelson7042New Zealand School of Biological Sciences University of AucklandPrivate Bag 92019Auckland1142New Zealand

There has been much effort to assess the efficacy of sewage treatment plants to remove chemicals with estrogenic activity,but other modes of toxicity have received less *** study assessed the efficacy of advanced tertiary technologies to remove estrogen receptor(ER),aryl hydrocarbon receptor(AhR),retinoic receptor(RAR)agonists and genotoxicity using recombinant gene *** sewage contained ER,AhR and RAR agonists and was *** sludge treatment removed over 69%of the ER,AhR and RAR aqueous phase *** and biologically activated carbon processes removed genotoxicity and most receptor agonists to below detection *** activity was associated with the semi-polar fraction of the aqueous phase and non-polar phase of the influent(maximum 30%).AhR and RAR activities were found in both the aqueous and particulate phases of *** RAR activity was frequently found in the polar fraction of aqueous and particulate phases of the process *** the influent,the greatest RAR activity was found in the polar fraction of the aqueous phase(>65%).Genotoxic activity was detected in all influent fractions but rapidly *** results showed that ER,AhR and RAR agonists were greatly reduced by the advanced tertiary treatment processes.

关键词： Yeast two-hybrid Analytical chemistry Estrogens Aryl hydrocarbon receptor Retinoic receptor umu genotoxicity bioassay Australia

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Seismic pounding and collapse behavior of neighboring buildings with different natural periods

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Natural Science 2012年第8期4卷 686-693页

作者： Daigoro Isobe Tokiharu Ohta Tomohiro Inoue fujio Matsueda Collaborative Research Center Ashikaga Institute of Technology Ashikaga-shi Japan Division of Engineering Mechanics and Energy University of Tsukuba Tsukuba-shi Japan Kyoryo Consultants Ltd. Tokyo Japan Science Programs Division Japan Broadcasting Corporation Tokyo Japan

Seismic pounding phenomena, particularly the collision of neighboring buildings under long-period ground motion, are becoming a significant issue in Japan. We focused on a specific apartment structure called the Nuevo Leon buildings in the Tlatelolco district of Mexico City, which consisted of three similar buildings built consecutively with narrow expansion joints between the buildings. Two out of the three buildings collapsed completely in the 1985 Mexican earthquake. Using a finite element code based on the adaptively shifted integration (ASI)-Gauss technique, a seismic pounding analysis is performed on a simulated model of the Nuevo Leon buildings to understand the impact and collapse behavior of structures built near each other. The numerical code used in the analysis provides a higher computational efficiency than the conventional code for this type of problem and enables us to address dynamic behavior with strong nonlinearities, including phenomena such as member fracture and elemental contact. Contact release and recontact algorithms are developed and implemented in the code to understand the complex behaviors of structural members during seismic pounding and the collapse sequence. According to the numerical results, the collision of the buildings may be a result of the difference of natural periods between the neighboring buildings. This difference was detected in similar buildings from the damages caused by previous earthquakes. By setting the natural period of the north building to be 25% longer than the other periods, the ground motion, which hada relatively long period of 2 s, first caused the collision between the north and the center buildings. This collision eventually led to the collapse of the centerbuilding, followed by the destruction of the north building.

关键词： Seismic Pounding Collapse Behavior Neighboring Buildings Natural Period Asi-Gauss Technique

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