检索结果-南通市图书馆

Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)

引用

中国神经肿瘤杂志 2013年第1期11卷 21-21页

作者： Shibui S Narita Y Mizusawa J Beppu t Ogasawara K Sawamura Y Kobayashi H Nishikawa R Mishima K Muragaki Y Maruyama t Kuratsu J Nakamura H Kochi M Minamida Y Yamaki t Kumabe t tominaga t Kayama t Sakurada K Nagane M Kobayashi K Nakamura H Ito t Yazaki t Sasaki H tanaka K takahashi H Asai A todo t Wakabayashi t takahashi J takano S fujimaki t Sumi M Miyakita Y Nakazato Y Sato A Fukuda H Nomura K Department of Neurosurgery and Neuro-Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of *** therapy consists of resection with concomitant *** to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMt).Daily administration of procarbazine(PCZ) has been reported to decrease MGMt *** study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + *** primary endpoint was overall survival(OS).this was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CtR ***: After 111 patients from 19 centers in Japan were enrolled,this study was terminated early because temozolomide was newly approved in *** median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,*** median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,*** 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse ***: the addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM.

关键词：星形细胞母细胞随机试验放疗胶质变性化疗 MGMt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sanidine-olivine-diopside Association in a Metasomatized Garnet Lherzolite Xenolith from Southeastern China

引用

Chinese Journal Of Geochemistry 1992年第1期11卷 55-69页

作者：曹荣龙朱寿华 K.AOKI H.fujimaki Institute of Geochemistry Academia SinicaGuangzhou BranchGuangzhou510640 Institute of Mineralogy Petrologyand Economic GeologyTohoku UniversitySendaiJapan

A garnet lherzolite xenolith hosted in olivine nephelinite from Xilong,Zhejiang Province ,southeastern China, shows clear evidence of modal metasomatism involving a special sanidine-olivine-diopside(SOD) association which was produced by replacement of primary *** fluid responsible for the measomatism was a silica-undersaturated vapour,rich in K,Ba,Sr and *** is suggested that the SOD assemblage is the product of metasomatism of a depleted lherzolite precursor,and formed in the upper mantle prior to entrainment and eruption.

关键词：透长石橄榄石透辉石交代变质作用石榴石铬尖晶石捕虏体中国

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Occurrence of Ibuprofen in the Waters of the Bengal River in Nova Friburgo

引用

Journal of Environmental Science and Engineering(B) 2017年第9期6卷 443-448页

作者： Carla Mariah Oliveira fujimaki Robson Roney Bemardo Biophysics Institute Carlos Chagas Filho Federal University of Rio de Janeiro Rio de Janeiro 21941-902 Brazil Campus Xerem Federal University of Rio de Janeiro Duque de Caxias 25245-390 Brazil

the increasing use of pharmaceuticals throughout the world is generating a new environmental problem where they are found in low concentrations, but the long-term risks to various organisms, as well as human health, are not yet known. these drugs, as well as their metabolites, are introduced into aquatic environments through excretions or discharges and may cause the same exposure as POPs （Persistent Organic Pollutants） due to its continued entry into the environment. the aim of this work is to develop a sensitive analytical method for the detection of ibuprofen and its metabolites in the Bengalas river that crosses the city of Nova Friburgo in the state of Rio de Janeiro. three collection points were analyzed monthly in the river from its source, as well as points of treated water throughout the city. the samples were collected monthly and lyophilized. Subsequently, they were subjected to a solid phase extraction （silica） with the solvent dichloromethane： hexane （1：1; v/v）. the samples were evaporated over a nitrogen atmosphere and subjected to a LC-MS （Liquid Chromatography with Mass Spectrometry） with 5% acetic acid gradient： acetonitrile as the mobile phase. In the search for drugs, there were found ions and fragments of ibuprofen （m/z 206, 205, 177） that were sought and compared to with their standard. these indicators can result in deleterious effects on aquatic life in these bodies of water, as well as on those who use this water from the Bengalas river.

关键词： Ibuprofen Bengalas river pharmaceuticals.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mycotoxins are conventional and novel risk biomarkers for hepatocellular carcinoma

引用

World Journal of Gastroenterology 2013年第17期19卷 2587-2590页

作者： Yasunobu Matsuda toshifumi Wakai Masayuki Kubota Mami Osawa Ayumi Sanpei Shun fujimaki Department of Medical technology Niigata University Graduate Schoo of Health Sciences Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Division of Pediatric Surgery Niigata University Graduate School of Medical and Dental Sciences

Hepatocellular carcinoma (HCC) is a common malignant disease with poor prognosis. to improve the clinical outcome, early diagnosis of HCC arising from nonviral agents and hepatitis virus is important. Among several etiological factors, mycotoxins defined as carcinogens by the International Agency for Research in Cancer (IARC) might be one of the critical risk factors for nonviral HCC. Aflatoxin B1 is the most well-known carcinogenic mycotoxin for HCC, but the role of the other types of mycotoxin remains unclear. Several studies have reported that a chromatographic separation technique based on high-performance liquid chromatography can successfully detect the concentration of mycotoxins in plasma. Recently, serum level of ochratoxin A (OtA), a widely distributed mycotoxin classified as Group 2B by IARC, was evaluated in HCC patients in Egypt. the results suggested that serum OtA levels might be a good biomarker for HCC. In this article, we review recent studies of OtA, and discuss its possible significance as a biomarker of HCC.

关键词： Hepatocellular carcinoma Mycotoxin Aflatoxin Ochratoxin High-performance liquid chromatography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Detection of Influenza Viruses Attached to an Optical Disk

引用

Journal of Biomaterials and Nanobiotechnology 2013年第2期4卷 145-150页

作者： takayuki Shima Makoto fujimaki Akihiro Yoshida Subash C. B. Gopinath Masashi Kuwahara Yoshimichi Ohki Koichi Awazu Department of Electrical Engineering and Bioscience Waseda University Tokyo Japan. Electronics and Photonics Research Institute (ESPRIt) National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Japan

Detection of polystyrene beads with a diameter of 100 nm was conducted using an optical disk drive tester equipped with a laser of 405 nm wavelength and an objective lens with a numerical aperture of 0.65. the polystyrene beads were used to mimic the influenza virus. A grooved disk with a (ZnS)85(SiO2)15/SiO2 layered surface structure was used for the detection. the detection of influenza viruses (A/Udorn/307/1972) with Au nanoparticles was also demonstrated using the optical disk drive tester. In this case, a grooved disk with an indium tin oxide (ItO) film was used. the ItO film functioned both to tune the reflectance of the disk and as an electrically conductive layer for scanning electron microscopy. In both cases, the target substances were successfully recognized in a single scan with a high scanning speed of 4.9 m/s. the results indicate that this optical disk system can be used to detect 100 nm scale substances like influenza viruses, which are smaller than the diffraction limit of the system.

关键词： Influenza Virus Polystyrene Bead Optical Disk Laser Reflectance Sensor Safety and Security

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential mRNA Expression of <i>COX</i>-2 and Proinflammatory Mediators in Patients with Rotator Cuff tears and Osteoarthritis of the Hip

引用

Open Journal of Orthopedics 2019年第11期9卷 254-263页

作者： tomonori Kenmoku Kentaro Uchida Naoshige Nagura Hisako fujimaki Mitsufumi Nakawaki Naonobu takahira Kensuke Fukushima Ryo tazawa Kyoko Muneshige Gen Inoue Masashi takaso Department of Orthopedic Surgery Kitasato University School of Medicine Sagamihara Japan Department of Allied Health Science Kitasato University School of Medicine Sagamihara Japan

Purpose: Bursal inflammation is thought to be a major cause of pain in degenerative rotator cuff tears (RCts). While the expression of proinflammatory mediators, such as COX-2, tNF-α, IL-1β, and IL-6, is crucial for the pathophysiology of osteoarthritis (OA), their role in degenerative RCts remains unknown. the aim of this study was to determine the expression of COX-2 and proinflammatory mediators in the development of RCt-induced pain by comparing their levels in patients with hip OA or RCts. Methods: We included samples obtained from 31 shoulders of 31 patients with RCts and samples from 30 hips of 27 patients with hip OA. the mRNA levels of COX-2, tNF-α, IL-1β, and IL-6 were determined using Rt-PCR, and were compared between the subacromial bursa and hip joints. We also analyzed IL-1β-induced COX-2 expression in the subacromial bursa and synovial blast of the hip. Results: COX-2, IL-1β, and IL-6 expression levels were significantly lower in the subacromial bursa of RCts than in hip OA samples, while no significant difference was observed for tNF-α. No significant difference in the fold increase was observed between subacromial bursa and hip OA samples, even though IL-1β-induced COX-2 expression increased in both samples. Conclusion: Our findings suggest that the main mechanism underlying pain development differs between patients with RCts and those with hip OA.

关键词： Rotator Cuff tear Pain Hip Osteoarthritis tumor Necrosis Factor-α Interleukin (IL)-1β COX-2 IL-6

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

以青森县为例的日本“满洲林业移民”探析

引用

外国问题研究 2005年第Z1期 57-61页

作者：藤卷启森日本青森明星女子短期大学

问题的提起根据日本国策从1932年开始试验性地将“满洲农业移民”送往了“满洲国”,并从1936年开始正式大批派遣“开拓团”。此后,除了农业移民以外,青少年义勇军开拓民、铁道自警村开拓民、烟草开拓民、畜业开拓民、渔业开

关键词：满洲林业日本

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Serum sIL-2R and LDH as markers for primary central nervous system lymphoma （PCNSL）

Serum sIL-2R and LDH as markers for primary central nervous ...

引用

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： takamitsu fujimaki Nahoko Uemiya Kazuhiko MIshima Gohji Fushihara, Hiroaki Neki Kohei Fukuoka tomonari Suzuki Kenji Wakiya, Junichi Adachi takaaki Yanagisawa Masao Matsutani Ryo Nishikawa Department of Neurosurgery Saitama Medical University Hospital Department of Neuro-oncology Saitama Medical University International Medical Center Moroyama-machi Saitama Japan

＜正＞Introduction : Serum markers for lymphoproliferative diseases includes soluble IL-2 receptor alpha（sIL-2R）, Lactate dehydrogenase （LDH） and thymidine kinase. However these markers are non-specific and can be...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

新疆冬小麦地方品种高分子量麦谷蛋白亚基的地理分布及其新发现亚基的特性(英文)

引用

新疆农业科学 2011年第9期48卷 1576-1584页

作者：丛花池田达哉高田兼则谷中美贵子藤卷宏长峰司新疆农业科学院农作物品种资源研究所乌鲁木齐830091 近畿中国四国农业研究中心东京农业大学大学院农学研究科

【目的和方法】为了揭示新疆小麦地方品种高分子量谷蛋白亚基（HMW—GS）的遗传多样性，对新疆北部地区（北疆）、东部地区（东疆）和南部地区（南疆）小麦地方品种HMW—GS的分布进行了研究。【结果】研究表明：新疆小麦地方品种HMW—G... 详细信息

【目的和方法】为了揭示新疆小麦地方品种高分子量谷蛋白亚基（HMW—GS）的遗传多样性，对新疆北部地区（北疆）、东部地区（东疆）和南部地区（南疆）小麦地方品种HMW—GS的分布进行了研究。【结果】研究表明：新疆小麦地方品种HMW—GS等位变异的分布与其地理来源具有密切关系，除Glu-B1位点外，G2u—A1和Glu—D1位点等位变异在北部地区、东部地区和南部地区的分布频率存在显著差异。在Glu—A1位点，Glu—A1c编码的Null亚基出现的频率最高，其次是Glu—A1b编码的2^＊亚基；但在北部地区，几乎所有品种都含有Glu—A1c编码的Null亚基，仅有1个品种含有Glu—A1b编码的2^＊亚基。在Glu-81位点，新疆大多数小麦地方品种含有Glu—B1b编码的7＋8亚基。在Glu—D1位点，新发现的等位基因Glu—D16p（t）编码的2．6亚基在东疆和南疆出现的频率较高，但在北疆出现的频率最低，分别为91％（东疆），61％（南疆），19％（北疆）；等位基因Glu—D1bp（t）在南疆冬小麦地方品种中普遍存在。然而，北疆是以等位基因Glu—D1a编码的2＋12亚基为主，其频率为83％。关于Glu—D1bp（t）的起源，推测可能是在南疆地区自然突变产生，然而由于南疆和东疆荒漠化造成的地理阻碍使其向北疆传播的概率较低，同时抑制了该基因向东亚地区的迁移。【结论】基于DNA序列的氨基酸序列比对，发现Glu—D1bp（t）编码的2．6亚基与Glu—D1al编码的2．2^＊亚基非常相似。

关键词：遗传差异 Glu-D1 Glu-B1 Glu-A1 等位基因频率地区差异制约因素 2.6亚基氨基酸序列

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新疆小麦地方品种资源高分子量麦谷蛋白亚基(HMW-GS)的遗传多样性组成分析

引用

农业生物技术学报 2009年第6期17卷 1070-1074页

作者：丛花池田达哉王宏飞高田兼则章艳凤谷中美贵子长峰司藤卷宏新疆农业科学院农作物品种资源研究所近畿中国四国农业研究中心东京农业大学大学院农学研究科

利用十二烷基硫酸钠聚丙烯酰胺凝胶电泳(SDS-PAGE)技术,分析了源自新疆地区的282份小麦(triticum aestivum L.)地方品种的高分子量麦谷蛋白亚基组成。结果表明,在Glu-A1、Glu-B1和Glu-D1位点上的等位变异分别为3、6和5种,3个位点上的优... 详细信息

利用十二烷基硫酸钠聚丙烯酰胺凝胶电泳(SDS-PAGE)技术,分析了源自新疆地区的282份小麦(triticum aestivum L.)地方品种的高分子量麦谷蛋白亚基组成。结果表明,在Glu-A1、Glu-B1和Glu-D1位点上的等位变异分别为3、6和5种,3个位点上的优势亚基依410次为null、7+8和2+12,其频率分别是75.5%、90.8%和72.0%。在Glu-1位点共检测到20种亚基组合,其中组合(null、7+8、2+12)的频率最高,为52.8%,其次是组合(null、7+8、2.6+12)和(2*、7+8、2+12),其频率分别为14.1%和11.0%,其它亚基组合的频率均低于10%。另外,在Glu-D1位点上还检测到1个新的亚基组合(2.6+12)。在供试的282份新疆地方品种中发现了两份具有优质亚基组合的材料,它们的亚基组成为(2*、7+9、5+10)和(1、7+9、5+10),这些地方品种可作为改良小麦品质性状的重要遗传资源。

关键词：小麦地方品种高分子量麦谷蛋白亚基十二烷基硫酸钠-聚丙烯酰胺凝胶电泳

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：