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Safety of laparoscopic surgery in digestive diseases with special reference to antithrombotic therapy: A systematic review of the literature

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World Journal of Clinical Cases 2018年第14期6卷 767-775页

作者： takahisa fujikawa Kenji ando Department of Surgery Kokura Memoria Hospital Department of Cardiology Kokura Memorial Hospital

AIMto elucidate the effect of antithrombotic therapy （Att） on bleeding and thromboembolic complications during or after laparoscopic digestive *** articles or internationally accepted abstracts between 2000 and 2017 were searched from PubMed, Cochrane Database, and Google Scholar, and studies involving laparoscopic digestive surgery and antiplatelet therapy （APt） and/or anticoagulation therapy （ACt） were included after careful review of each study. Data such as study design, type of surgical procedures, antithrombotic drugs used, and surgical outcome （both bleeding and thromboembolic complications） were extracted from each *** published articles and two internationally accepted abstracts were eligible for inclusion in the systematic review. Only one study concerning elective laparoscopic cholecystectomy in patients with peri-operative heparin bridging for ACt showed that the risk of postoperative bleeding was higher compared with those without ACt. the remaining 14 studies reported no signifcant differences in the incidence of bleeding complications between the Att group and the group without Att. the risk of thromboembolic events （tE） associated with laparoscopic digestive surgery in patients receiving Att was not signifcantly higher than those with no Att or interrupted *** t et al . Laparoscopic digestive surgery and antithrombotic therapyCONCLUSIONLaparoscopic digestive surgery in Att-burdened patients for prevention of bleeding and tE showed satisfactory results. the risk of hemorrhagic complication during or after these procedures in patients with continued APt or heparin bridging was not signifcantly higher than in patients with no Att or interrupted APt.

关键词： thromboembolic complication Bleeding complication Laparoscopic surgery Anticoagulation therapy Digestive surgery Antithrombotic therapy Antiplatelet therapy

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高磷喂食诱导运动不耐受并损害小鼠的脂肪酸代谢

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中华高血压杂志 2019年第2期27卷 148-148页

作者：刘青叶鹏 Peri-Okonny PA Baskin KK Iwamoto G Mitchell JH Smith SA Kim HK Szweda LI Bassel-Duby R fujikawa t Castorena CM Richardson J Shelton JM Ayers C Berry JD Malladi VS Hu MC Moe OW Scherer PE Vongpatanasin W

无机磷酸盐(inorganic phosphate,Pi)广泛用作西方饮食中的防腐剂和增味剂。缺乏身体活动是西方社会的共同特征,与心血管病的发病率和死亡率增加有关。目前尚不清楚饮食中Pi过量是否会导致运动不耐受和身体活动缺乏。为了确定人体中Pi... 详细信息

无机磷酸盐(inorganic phosphate,Pi)广泛用作西方饮食中的防腐剂和增味剂。缺乏身体活动是西方社会的共同特征,与心血管病的发病率和死亡率增加有关。目前尚不清楚饮食中Pi过量是否会导致运动不耐受和身体活动缺乏。为了确定人体中Pi过量和体力活动之间的关联,研究者在调整了相关变量后,评估DHS-2(达拉斯心脏研究第2阶段)参与者的血清Pi与活动记录测定的身体活动水平以及心脏磁共振成像的左心室功能之间的关系。

关键词：无机磷酸盐不耐受脂肪酸代谢运动小鼠损害喂食身体活动

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Condensation coefficient of methanol vapor near vapor-liquid equilibrium states

Condensation coefficient of methanol vapor near vapor-liquid...

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the 24th International Symposium on Shock Waves

作者： S.fujikawa t.Yano M.Ichijo K.Iwanami Division of Mechanical Science Graduate School of EngineeringHokkaido UniversitySapporo060-8628Japan

this paper is concerned with the nonequilibrium condensation from a vapor to a liquid phase on the plate endwall of a shock tube behind a reflected shock wave. the growth of a liquid film on the endwall is measured by an optical interferometer using a laser beam. the experiment is carefully conducted on the precisely designed apparatus, and thereby the condensation coefficient of methanol vapor is determined in a wide range of vapor-liquid conditions from near to far from equilibrium states. the result shows that the condensation coefficient increases with the increase of the ratio of number densities of vapor and saturated vapor at the interface.

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Prognostic factors in stage IB gastric cancer

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World Journal of Gastroenterology 2014年第21期20卷 6580-6585页

作者： toru Aoyama takaki Yoshikawa Hirohito fujikawa tsutomu Hayashi takashi Ogata Haruhiko Cho takanobu Yamada Shinichi Hasegawa Kazuhito tsuchida Norio Yukawa takashi Oshima Mari S Oba Satoshi Morita Yasushi Rino Munetaka Masuda Department of Gastrointestinal Surgery Kanagawa Cancer CenterYokohama 241-0815Japan Department of Surgery Yokohama City UniversityYokohama 236-0004Japan Department of Biostatistics and Epidemiology Yokohama City UniversityYokohama 236-0004Japan

AIM:to identify the subset of patients with stage IB gastric cancer with an unfavorable ***:Overall survival(OS)rates were examined in 103 patients with stage IB(t1N1M0 and t2N0M0)gastric cancer between January 2000 and *** and multivariate analyses were performed to identify risk factors using a Cox proportional hazards ***:the OS rates of patients with t1N1 and t2N0 cancer were 89.2%and 94.1%at 5-years,*** univariate and multivariate analyses demonstrated that tumor location was the only significant prognostic *** OS rate was 81.8%at5-years when the tumor was located in the upper third of the stomach and was 95.5%at 5-years when the tumor was located in the middle or lower third of the stomach(P=0.0093).CONCLUSION:these data may suggest that tumor location is associated with survival in patients with stage IB gastric cancer.

关键词： Gastric cancer Stage IB Prognostic factor

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Impact of laparoscopic liver resection on bleeding complications in patients receiving antithrombotics

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 396-404页

作者： takahisa fujikawa Hiroshi Kawamoto Yuichiro Kawamura Norio Emoto Yusuke Sakamoto Akira tanaka Department of Surgery Kokura Memorial HospitalFukuoka 802-8555Japan

to assess the impact of laparoscopic liver resection (LLR) on surgical blood loss (SBL), especially in patients with antithrombotics for thromboembolic risks. MEtHODSConsecutive 258 patients receiving liver resection at our institution between 2010 and 2016 were retrospectively reviewed. Preoperative antithrombotic therapy (Att; antiplatelets and/or anticoagulation) was regularly used in 100 patients (Att group, 38.8%) whereas not used in 158 (non-Att group, 61.2%). Our perioperative management of high thromboembolic risk patients included maintenance of preoperative aspirin monotherapy for patients with antiplatelet therapy and bridging heparin for patients with anticoagulation. In both Att and non-Att groups, outcome variables of patients undergoing LLR were compared with those of patients receiving open liver resection (OLR), and the independent risk factors for increased SBL were determined by multivariate analysis. RESULtSthis series included 77 LLR and 181 OLR. there were 3 thromboembolic events (1.2%) in a whole cohort, whereas increased SBL (≥ 500 mL) and postoperative bleeding complications (BCs) occurred in 66 patients (25.6%) and 8 (3.1%), respectively. Both in the Att and non-Att groups, LLR was significantly related to reduced SBL and low incidence of BCs, although LLR was less performed as anatomical resection. Multivariate analysis showed that anatomical liver resection was the most significant risk factor for increased SBL [risk ratio (RR) = 6.54, P the whole cohort, and LLR also had the significant negative impact (RR = 1/10.0, P the same effects of anatomical resection (RR = 15.77, P the patients in the Att group. CONCLUSIONLLR using the two-surgeon technique is feasible and safely performed even in the Att-burdened patients with thromboembolic risks. Independent from the extent of liver resection, LLR is significantly associated with reduced SBL, both in t

关键词： Laparoscopic liver resection two-surgeon technique Antithrombotic therapy Increased surgical blood loss Bleeding complication

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Evaluation of Psychological Changes on Women Following Coordination Exercises: Immediate Effects of Life Kinetik® Implementation

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Open Journal of therapy and Rehabilitation 2024年第3期12卷 256-262页

作者： Yutaro Hyodo takumi Jiroumaru Hikaru Kitagawa Yasumasa Oka Junko Ochi Nobuko Shichiri takamitsu fujikawa Department of Physical therapy Bukkyo University Kyoto City Japan Kanazawa Orthopaedic and Sports Medicine Clinic Ritto Japan Department of Applied Biology Graduate School of Science and Technology Kyoto Institute of Technology Kyoto City Japan

Objective: this study aimed to evaluate the immediate psychological effects of coordination exercises on women in Japan. Methods: the subjects were 17 adult women (height, 160.1 ± 5.1 cm;weight, 54.3 ± 10.5 kg;age, 57.8 ± 8.3 years) living in the community and attending a fitness club. the subjects performed a coordination exercise called Life Kinetik®. the subjects responded to the two-Dimensional Mood Scale–Short term before and after performing 30 minutes of Life Kinetik®. the results were tabulated and four psychological states were calculated (i.e., vitality, stability, pleasure, and arousal). the pre- and post-implementation results were statistically analyzed using a corresponding t-test. Results: Significant differences were found in activation and arousal levels, but not in stability and comfort levels. Conclusion: the coordination exercise, Life Kinetik®, was found to be an exercise program with potential psychological benefits, as it could change women’s psychological condition to active and excited states.

关键词： Psychological State Life Kinetik® Mood Scale

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基于扩散加权成像的深度学习方法预测喉和下咽癌病人放疗相关根治性治疗的疗效:一项初步研究

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国际医学放射学杂志 2022年第5期45卷 618-618页

作者： H.tomita t.Kobayashi E.takaya S.Mishiro D.Hirahara A.fujikawa 谢永生

摘要目的该初步研究旨在开发一个基于扩散加权成像（DWI）和表观扩散系数图（ADC图）的深度学习（DL）模型，用以预测喉和下咽癌病人接受各种形式放疗相关的根治

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