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伊曲康唑治疗COPD合并肺部真菌感染的疗效及其作用机制探讨

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医学临床研究 2024年第6期41卷 846-848,852页

作者：侯福建魏召辉赵月伟定州市人民医院呼吸内科河北定州073000

【目的】探讨伊曲康唑治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肺部真菌感染的疗效及其可能作用机制。【方法】回顾性分析2019年1月至2021年12月本院收治的80例COPD合并肺部真菌感染患者的临床资料,根据... 详细信息

【目的】探讨伊曲康唑治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肺部真菌感染的疗效及其可能作用机制。【方法】回顾性分析2019年1月至2021年12月本院收治的80例COPD合并肺部真菌感染患者的临床资料,根据治疗方法不同分为伊曲康唑组(采用伊曲康唑治疗)和氟康唑组(采用氟康唑治疗),每组40例。比较两组住院时间、病死率、不良反应发生率及治疗前后血清肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-1β(IL-1β)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)。【结果】伊曲康唑组住院时间短于氟康唑组(P0.05);治疗后,伊曲康唑组血清TNF-α、IL-2、IL-4、IL-10水平低于氟康唑组(P<0.05),IFN-γ水平高于氟康唑组(P<0.05);伊曲康唑组不良反应发生率为30.00%,显著低于氟康唑组的37.50%,差异具有统计学意义(P<0.05)。【结论】采用伊曲康唑治疗COPD合并肺部真菌感染患者,临床效果较好,其作用机制可能为调节炎症因子水平。

关键词：肺疾病,慢性阻塞性/并发症肺疾病,真菌性/并发症伊曲康唑/药理学治疗结果

Culture and foreign Language Teaching

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中国校外教育 2009年第S3期 196-197页

作者： Lu Xuhong(Jimei university,Xiamen fujian)

This paper argues that cross-cultural communication between Chinese and foreigners often runs into *** factors which block communication lie in culture-governed structures of *** view of the fact that the cultural messages are reflected in people's daily use of language,culture elements should not be overlooked in *** paper attempts to explore the ways of including culture teaching in the language classroom.

关键词： Culture foreign Language Teaching Communication

DIFFERENTIABILITY OF CONVEX FUNCTIONS ON SUBLINEAR TOPOLOGICAL SPACES AND VARIATIONAL PRINCIPLES IN LOCALLY CONVEX SPACES

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Chinese Annals of Mathematics 2005年第4期 124-145页

作者： CHENG LIXIN TENG YANMEI Department of Mathematic, Xiamen university, Xiamen 361005, fujian, China. Department of Mathematic, Beihang university, Beijing 100083, China.

This paper presents a type of variational principles for real valued w lower semicon-tinuous functions on certain subsets in duals of locally convex spaces, and resolve a problem concerning differentiability of convex functions on general Banach spaces. They are done through discussing differentiability of convex functions on nonlinear topological spaces and convexification of nonconvex functions on topological linear spaces.

关键词： Convex function βdifferentiability Variationsl principle Perturbed optimization Banach spaces Locally convex spaces

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肠道微生态与自身免疫性肝炎发生发展的关系

临床肝胆病杂志 2024年第2期40卷 374-379页

作者：夏雨艳曾琼戎李福建黎凤炎李琪唐利瑕张国广西医科大学研究生院南宁530000 中山大学附属第一医院广西医院消化内科南宁530000 广西壮族自治区人民医院(广西医学科学院)消化内科南宁530000

自身免疫性肝炎(AIH)是以慢性肝脏炎症为特点的自身免疫性疾病,发病率逐年升高,社会医疗负担不容小视。肠道微生态正成为自身免疫性疾病研究的热点。近年来认为肠道微生态的改变会引起自身免疫状态、菌群代谢产物和肠道屏障的改变,是AI... 详细信息

自身免疫性肝炎(AIH)是以慢性肝脏炎症为特点的自身免疫性疾病,发病率逐年升高,社会医疗负担不容小视。肠道微生态正成为自身免疫性疾病研究的热点。近年来认为肠道微生态的改变会引起自身免疫状态、菌群代谢产物和肠道屏障的改变,是AIH发病的驱动因素之一。早期诊断和正确的治疗有助于改善AIH患者的预后。本文介绍了AIH患者肠道菌群的特点、肠道微生态失衡对AIH发病机制的影响以及从肠道微生态角度出发简述了相关治疗方案,旨在全面理解和解释肠道微生态在AIH中的作用,了解肠道微生态平衡对AIH致病机制、诊断和治疗的影响。

关键词：肝炎自身免疫性胃肠道微生物组诊断治疗

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Synthesis and Crystal Structure of an Ion- pair Compound: [HL]2[Ni（CN）4]·4H2O (L = 4-（2- Hydroxyphenyl）-1,5, 9-triazacyclododecan-2-one)

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Chinese Journal of Structural Chemistry 2004年第4期23卷 361-365+352页

作者： LI Jian-Ronga, b XIE Ya-Bob CAI Li-Zhena GUO Guo-Conga② BU Xian-Heb② HUANG Jin-Shuna a (State Key Laboratory of Structural Chemistry, fujian Institute of Research on the Structure of Matter, The Chinese Academy of Sciences, Fuzhou, fujian 350002, China) b (Department of Chemistry, Nankai university, Tianjin 300071, China) 中科院福建物质结构所 State Key Laboratory of Structural ChemistryCAS 福建 Fuzhou 350002 Department of Chemistry Nankai University 天津 300071

An ion-pair compound, [HL]2[Ni(CN)4]4H2O 1 has been obtained as an unexpected product when we attempt to prepare a heterometallic cyano-bridged complex by the reaction of GdCl3nH2O, K2Ni(CN)4 and L (L=4-(2-hydroxyphenyl)-1,5,9-triazacyclododecan-2-one) in aqueous solution, and characterized by single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P21/n with a = 12.380(1), b = 9.9637(8), c = 17.087(1) ? ?= 105.947(2)? V = 2026.6(3) ?, Rint = 0.0509, Z = 2, Dc = 1.297 g/cm3, C34H56O8N10Ni, Mr = 791.60, F(000) = 844, m(MoKa) = 0.538 mm1, S = 1.030, the final R = 0.0644 and wR = 0.1299 for 2023 observed reflections with I ≥ 2(I). The title compound 1 contains one anion of [Ni(CN)4]2, two cations of [HL]+ and four packing water molecules, which are held together by the NH···O and OH···O hydrogen bonds to form a three- dimensional framework.

关键词： tetracyanonickelate anion macrocyclic triamine cation crystal structure

Primary Investigation on the Distribution of Mollusca In intertidal zone of Quanzhou, fujian

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Primary Investigation on the Distribution of Mollusca In int...

Synthesis and Crystal Structure of Compound 〔ZnS6(C12H8N2)〕

贝类学会第七次会员代表大会暨第十一次学术讨论会

作者： Jin-Jin Xie Cong-jie Dai Biology Department of Quanzhou Normal university fujian 362000, China

＜正＞ The paper records species, quantity and ecological distributing. There are 125 species of the Coastal Molluscus from Quanzhou of Hujian Province, which belong to3 Classes 45 families and 81 genus. Among them th... 详细信息

关键词： Intertidal zone Mollusca Ecology Quanzhou

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Chinese Journal of Structural Chemistry 2000年第1期 11-14页

作者： CHEN Zhi\|Rong\+a\ LI Jian\|Hui\+b\ LI Hong\|Jun\+a a\ (Department of Chemistry, Fuzhou university, Fuzhou, fujian, 350002) b\ (fujian agriculture university, fujian, 350002) SU Wei\|Ping c\ CAO Rong c c\ (State Key Laboratory of Structural Chemist

The title compound ZnS\-6(C\-\{12\}H\-8N\-2) was obtained by reaction of zinic powder with sulfur and 1,10\|phenathtroline in DMF solvent, and its structure has been determined by single crystal X\|ray diffraction analysis. The crystal data for the compound: triclinic, \$P1, Z=2, a=8.159(2), b=9.485(2), c=11.997(2), α=110.00(3)°,β=99.22(3)°, γ=100.57(3)°, V=832\+3, D\-c\$=1.748g/cm\+3, μ (M\-o K\-α )=0.2219 cm\+\{-1\}, F (000)=440. The structure was refined to \$R=0.0723\$ and \$R\-w=0.0865\$ for 1427 independent observed reflections. The tilte crystal consists of a discrete molecules, in which the core of ZnS\-2N\-2 shows a distorted tetrahedral geometry.

关键词： molecular structure phenathtroline zinic compound synthesis

Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

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Frontiers of Chemical Science and Engineering 2022年第11期16卷 1584-1594页

作者： Na Wang fujian Li Bangyu Fan Suojiang Zhang Lu Bai Xiangping Zhang College of Chemical and Engineering Zhengzhou UniversityZhengzhou 450001China CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex SystemsBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process Engineering and Innovation Academy for Green ManufactureChinese Academy of SciencesBeijing 100190China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China College of Chemistry Nanchang UniversityNanchang 330031China

The separation of rare earth elements is particularly difficult due to their similar physicochemical *** on the tiny differences of ionic radius,solvent extraction has been developed as the“mass method”in industry with hundreds of stages,extremely intensive chemical consumption and large capital *** differences of the ionic magnetic moment among rare earths are greater than that of ionic ***,a novel method based on the large ionic magnetic moment differences of rare earth elements was proposed to promote the separation *** earths were firstly dissolved in the ionic liquid,then the ordering degree of them was improved with the Z-bond effect,and finally the magnetic moment differences between paramagnetic and diamagnetic rare earths in quasi-liquid system were *** the separation of Er/Y,Ho/Y and Er/Ho as examples,the results showed that Er(Ⅲ)and Ho(Ⅲ)containing ionic liquids had obvious magnetic response,while ionic liquids containing Y(Ⅲ)had no *** separation factors of Er/Y and Ho/Y were achieved at 9.0 and 28.82,*** separation via quasi-liquid system strategy provides a possibility of the novel,green,and efficient method for rare earth separation.

关键词： rare earth element different magnetic moment magnetic separation ionic liquid

Effect of Organic Materials on Speciation of Copper inSoil Solution

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Pedosphere 1999年第2期9卷 139-146页

作者： WANG GUO CHEN JIANBIN GU XUNGANG GAO SHAN and CAI HAIYANG(Department of Land and Environmental Science, fujian agricultural university, Fuzhou 350002 (Chica)) DepartmentofLandandEnvironmentalScience FujianAgriculturalUniversityFuzhou350002China DepartmentofL

Incubation of two soils, a red soil derived from granodiorte and a fluvo-aquic soil from alluvial deposit,with rice straw, Chinese milk vetch and pig manure under submerged condition were conducted to study thespecies of Cu in soil solutions as affected by the organic materials. The organic materials increased totalsoluble Cu by raising dissolved organic carbon (DOC) in soil solution when the solution pH values were belowthe range in which Cu deposited quickly. When the solution pH rose to this range, the increase of DOCdid not raise total soluble Cu. Total soluble Cu in all the treatments dropped with incubation time. Afteradding organic materials labile Cu dropped with incubation time and decreased sharply in the pH range ofCu precipitation. Addition of organic materials enhanced slowly labile Cu but depressed the ratio of labileCu to total soluble Cu. Slowly labile Cu decreased with incubation time. Stepwise multiple linear regressionanalysis showed that total soluble Cu was positively correlated with Eh and DOC (P=0.0025), labile Cuwas negatively correlated with pH (P=0.011 8), and slowly labile Cu was positively correlated with Eh andDOC (P=0.002 2). Both the labile and slowly labile Cu were correlated with total soluble Cu at extremelysignificant levels.

关键词： coppert dissolved organic carbon organic material speciation