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A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex

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Signal Transduction and Targeted Therapy 2022年第3期7卷 635-637页

作者： fugang duan Yifan Wang Taoyu Chen Zhu Zhu Meng Yu Hui Dai Shangen Zheng Yinying Lu Tingting Li Xiaoyan Qiu Department of Immunology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China NHC Key Laboratory of Medical Immunology Peking University Health Science CenterBeijing 100191China Key Laboratory of Molecular Immunology Chinese Academy of Medical SciencesBeijing 100191China Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science CenterBeijing W0191China Department of Transfusion General Hospital of Central Theater Command of the People's Liberation ArmyWuhanHubei 430070China Comprehensive Liver Cancer Center The 5th Medicine Center of PLA General HospitalBeijing 100039China

Dear Editor,COVID-19(Coronavirus Disease 2019)is a disease caused by the single-stranded sense RNA virus SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),which has caused a global public health crisis.1 However,so far no effective serum marker has been found as a biomarker for COVID-19 diagnosis,except that viral nucleic acid detection is an effective evidence of SARS-CoV-2 infection.

关键词： diagnosis acute respiratory

基于Openocd的嵌入式软件开发平台的研究和设计

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计算机测量与控制 2010年第2期18卷 470-472,478页

作者：段富刚施展上海理工大学光学与电子信息工程学院上海200093

在以Openocd为调试代理的基础上,研究一种嵌入式源码级编译调试开发平台,并在多目标机上实现;该开发平台以Eclipse为调试前端,实现了与通用远程调试器GDB的无缝集成,并以Openocd作为调试代理,可以通过JTAG接口实现对目标机上目标程序的... 详细信息

在以Openocd为调试代理的基础上,研究一种嵌入式源码级编译调试开发平台,并在多目标机上实现;该开发平台以Eclipse为调试前端,实现了与通用远程调试器GDB的无缝集成,并以Openocd作为调试代理,可以通过JTAG接口实现对目标机上目标程序的源代码调试;阐述了基于Openocd的嵌入式软件源码级交叉调试技术,讨论了宿主机/目标机开发模式中源码级调试的原理和方法。

关键词： Openocd JTAG GDB调试 Eclipse嵌入式软件

Profiling of high-throughput T cell repertoire indicates T cell immune response after SARS-CoV-2 infection

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Profiling of high-throughput T cell repertoire indicates T c...

基于PXA255嵌入式平台的MPEG-4编码研究和实现

第十四届全国免疫学学术大会

作者： fugang duan Yifan Wang Zhu Zhu Hui Dai Meng Yu jing Huang Xiaoyan Qiu Peking University Health Science Center

Corona Virus Disease 201 9(COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavirus.T cells play an important role in the body’s fighting against the virus invasion,and T-cell receptor(TCR) is crucial in T cell-mediated virus ***,little has been known about differences in the T cell repertoires between COVID-19 patients with different convalescent phase and healthy controls during SARS-CoV-2 *** this study,we used 5’RACE technology and V(D)J sequencing to conduct comparative analyses of TCR repertoire profile between COVID-19 patients with different convalescent phase and healthy *** TCR clustering and CDR3 annotation were exploited to further discover groups of patient-specific TCR clonotypes with potential SARS-CoV-2 antigen *** firstly identified CD4and CD8T-cell clones with certain clonal expansion after infection,and then observed the preferential recombination usage of V(D) J gene segments in CD4 and CD8T-cell of COVID-19 patients with different convalescent *** importantly,the TRBV6-5-TRBD2-TRBJ2-7 combination with high frequency were shared between CD4and CD8 T-cell of different COVID-19 ***,we found the dominant characteristic motifs of CDR3 sequence between recovered COVID-19 and healthy *** study provides novel insights on TCR in COVID-19 with diffe rent convalescent phase,which contribute to our understanding of the immune response induced by SARS-CoV-2.

关键词： SARS-CoV-2 COVID-19 T cell receptor CDR3 Immune memory

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计算机测量与控制 2010年第2期18卷 459-462页

作者：刘增水段富刚上海电子信息职业技术学院上海201411

文章介绍了基于Xscale处理器(PXA255)的嵌入式开发平台上实现MPEG-4编码技术;整个系统分为视频信号采集、编码、存储、发送、PC机上解码验证;通过FS-PXA255I开发板上的USB接口实现视频信号的采集,利用PXA255处理器完成输入图像的MPEG-4... 详细信息

文章介绍了基于Xscale处理器(PXA255)的嵌入式开发平台上实现MPEG-4编码技术;整个系统分为视频信号采集、编码、存储、发送、PC机上解码验证;通过FS-PXA255I开发板上的USB接口实现视频信号的采集,利用PXA255处理器完成输入图像的MPEG-4软件编码;阐述系统总体结构和各部分功能特点,着重介绍MPEG-4编码部分在嵌入式系统上的编码算法。

关键词： PXA255 MPEG-4 VOP Sprite编码

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硫铁矿制酸装置净化工序技术改造

硫酸工业 2009年第4期 38-39页

作者：段付岗陕西华山化工集团有限公司复肥厂陕西华县714100

陕西华山化工集团有限公司复肥厂80kt／a硫铁矿制酸装置于1988年建成投产，采用弱氧焙烧、稀酸洗净化、“3＋2”两转两吸工艺。经过多年的扩能改造，2007年硫酸产量达到154．9kt。2008年5-6月净化工序实施技术改造，以消除生产瓶颈、节... 详细信息

陕西华山化工集团有限公司复肥厂80kt／a硫铁矿制酸装置于1988年建成投产，采用弱氧焙烧、稀酸洗净化、“3＋2”两转两吸工艺。经过多年的扩能改造，2007年硫酸产量达到154．9kt。2008年5-6月净化工序实施技术改造，以消除生产瓶颈、节约资源、实现硫酸装置污水零排放。改造达到了预期效果，经济效益和环境效益良好。

关键词：硫酸生产净化工序技术改造清洁生产