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DHODH tangoing with GPX4 on the ferroptotic stage

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1948-1949页

作者： fudi wang Junxia Min The First Affiliated Hospital The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangChina The First Affiliated Hospital Institute of Translational MedicineCancer CenterSchool of Public HealthZhejiang University School of MedicineHangzhouChina

Ferroptosis,an iron-dependent form of regulated cell death,is prevented by activity of the glutathione-dependent phospholipid hydroperoxidase GPX4(Glutathione peroxidase 4)in the cytosol and mitochondria,and by the glutathione-independent CoQ10 oxidoreductase FSP1 at the plasma *** their recent paper published in Nature,Mao et *** that DHODH(Dihydroorotate dehydrogenase)coordinates with GPX4 to block ferroptosis in the mitochondrial inner membrane by reducing ubiquinone to form ubiquinol in cancer cells,thus providing a novel targeted strategy for treating cancer.

关键词： CoQ10 death ODH

Copper homeostasis and cuproptosis in health and disease

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4352-4367页

作者： Liyun Chen Junxia Min fudi wang The Fourth Affiliated Hospital The First Affiliated HospitalInstitute of Translational MedicineSchool of Public HealthState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina The First Affiliated Hospital Basic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyangChina

all cell *** the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function,copper homeostasis is tightly *** studies identified a novel copper-dependent form of cell death called cuproptosis,which is distinct from all other known pathways underlying cell *** occurs via copper binding to lipoylated enzymes in the tricarboxylic acid(TCA)cycle,which leads to subsequent protein aggregation,proteotoxic stress,and ultimately cell ***,we summarize our current knowledge regarding copper metabolism,copper-related disease,the characteristics of cuproptosis,and the mechanisms that regulate *** addition,we discuss the implications of cuproptosis in the pathogenesis of various disease conditions,including Wilson’s disease,neurodegenerative diseases,and cancer,and we discuss the therapeutic potential of targeting cuproptosis.

关键词： homeostasis metabolism diseases

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气象管理数据中心设计与实现

气象科技 2024年第4期52卷 508-518页

作者：赵希鹏赵芳王甫棣王帅国家气象信息中心北京100081

为满足气象部门政务数据高效管理和共享应用需求,推动气象政务数据融入国家政务大数据体系,中国气象局依托国家级气象专有云设计、建设了气象部门首个一级集中、四级应用的集约统一的政务数据中心,直接支撑气象政务和业务应用。本文介... 详细信息

为满足气象部门政务数据高效管理和共享应用需求,推动气象政务数据融入国家政务大数据体系,中国气象局依托国家级气象专有云设计、建设了气象部门首个一级集中、四级应用的集约统一的政务数据中心,直接支撑气象政务和业务应用。本文介绍了该数据中心系统的核心架构设计、主要业务功能、关键信息流程、基于气象政务数据特征的数据分类和分层数据体系、关键实现技术、应用成效等。系统的实现采用了一系列的新兴信息技术,包括支持多源异构的数据汇聚、基于策略的数据清洗和整合治理、全局统一的数据服务和接口管理、基于ElasticSearch引擎的全文检索、基于消息驱动的管理应用协同、主备中心数据同步等。作为气象部门政务管理数字化转型升级的数字底座,系统建成后为国省市县四级气象部门提供了一站式的政务数据管理和共享应用服务,在有力支撑中国气象局行政办公、科学决策和履行公共职能中发挥了良好效益。

关键词：气象数字化转型管理数据中心数据体系应用协同

Zooming in and out of ferroptosis in human disease

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Frontiers of Medicine 2023年第2期17卷 173-206页

作者： Xue wang Ye Zhou Junxia Min fudi wang The Second Affiliated Hospital The First Affiliated HospitalInstitute of Translational MedicineSchool of Public HealthState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhou 310058China The First Affiliated Hospital Basic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Department of Endocrinology and Metabolism Ningbo First HospitalNingbo 315000China

Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid *** the past decade,it has been implicated in the pathogenesis of various diseases that together involve almost every organ of the body,including various cancers,neurodegenerative diseases,cardiovascular diseases,lung diseases,liver diseases,kidney diseases,endocrine metabolic diseases,iron-overload-related diseases,orthopedic diseases and autoimmune *** the underlying molecular mechanisms of ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease ***,there are an expanding number of studies suggesting that ferroptosis serves as a bona-fide target for the prevention and treatment of these diseases in relevant pre-clinical *** this review,we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human disease,while providing evidence in support of ferroptosis as a target for the treatment of these *** also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease.

关键词： ferroptosis human disease iron metabolism lipid peroxidation antioxidation

基于情境感知和序列模式挖掘的气象学习资源推荐算法

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气象科技 2024年第1期52卷 37-44页

作者：王帅马景奕周远洋王甫棣国家气象信息中心北京100081 中国气象局气象干部培训学院甘肃分院兰州730000

随着互联网的快速发展,气象部门职工作为学习者可以获得的学习资源得到极大丰富。信息超载导致检索合适的在线学习资源时遇到了困难;学习者在不同学习环境和序列访问模式上也有不同的学习需求。但是,现有的推荐系统,如基于内容的推荐和... 详细信息

随着互联网的快速发展,气象部门职工作为学习者可以获得的学习资源得到极大丰富。信息超载导致检索合适的在线学习资源时遇到了困难;学习者在不同学习环境和序列访问模式上也有不同的学习需求。但是,现有的推荐系统,如基于内容的推荐和协同过滤,没有结合学习者的情境和序列访问模式,推荐结果准确度不高。本文提出了一种结合情境感知、序列模式挖掘和协同过滤算法的混合推荐算法来为学习者推荐学习资源。混合推荐算法中,情境感知被用来整合学习者的情境信息,如知识水平和学习目标;序列模式挖掘被用来对网络日志进行挖掘,发现学习者的序列访问模式;协同过滤被用来根据学习者的情境数据和序列访问模式为目标学习者计算预测并生成建议。实验和应用效果表明,该混合推荐算法推荐的质量和准确性方面优于其他推荐算法。

关键词：推荐系统混合推荐情境感知协同过滤序列模式挖掘

Targeting ferroptosis opens new avenues for the development of novel therapeutics

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4716-4745页

作者： Shumin Sun Jie Shen Jianwei Jiang fudi wang Junxia Min The First Affiliated Hospital Institute of Translational MedicineThe Second Affiliated HospitalSchoolof Public HealthCancer CenterState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina

Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,including altered iron homeostasis,reduced defense against oxidative stress,and abnormal lipid *** studies have provided compelling evidence supporting the notion that ferroptosis plays a key pathogenic role in many diseases such as various cancer types,neurodegenerative disease,diseases involving tissue and/or organ injury,and inflammatory and infectious diseases.

关键词： peroxidation diseases homeostasis

Mechanisms and regulation of defensins in host defense

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3985-4014页

作者： Jie Fu Xin Zong Mingliang Jin Junxia Min fudi wang Yizhen wang Key Laboratory of Molecular Animal Nutrition Ministry of EducationCollege of Animal SciencesZhejiang UniversityHangzhouChina Key Laboratory of Animal Nutrition and Feed Science in Eastern China Ministry of AgricultureHangzhouZhejiang ProvinceChina The First Affiliated Hospital Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310058China The Second Affiliated Hospital School of Public HealthState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina The First Affiliated Hospital Basic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyangChina

As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host *** biological functions in innate immunity,as well as their structure and activity relationships,along with their mechanisms of action and therapeutic potential,have been of great interest in recent *** highlight the key research into the role of defensins in human and animal health,we first describe their research history,structural features,evolution,and antimicrobial ***,we cover the role of defensins in immune homeostasis,chemotaxis,mucosal barrier function,gut microbiota regulation,intestinal development and regulation of cell ***,we discuss their clinical relevance and therapeutic potential in various diseases,including infectious disease,inflammatory bowel disease,diabetes and obesity,chronic inflammatory lung disease,periodontitis and ***,we summarize the current knowledge regarding the nutrient-dependent regulation of defensins,including fatty acids,amino acids,microelements,plant extracts,and probiotics,while considering the clinical application of such ***,the review summarizes the various biological functions,mechanism of actions and potential clinical significance of defensins,along with the challenges in developing defensins-based therapy,thus providing crucial insights into their biology and potential clinical utility.

关键词： immunity homeostasis lung

Macrophage-Mediated Defensive Mechanisms Involving Zinc Homeostasis in Bacterial Infection

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Infectious Microbes & Diseases 2021年第4期3卷 175-182页

作者： Pinanong Na-Phatthalung Junxia Min fudi wang School of Public Health The First Affiliated HospitalInstitute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiangChina

Zinc homeostasis in macrophages is essential for maintaining their antimicrobial functions,and a growing body of evidence indicates that both zinc depletion and excess zinc in myeloid cells decrease bacterial *** macrophages,maintaining intracellular and extracellular zinc levels via zinc transporter proteins,including Slc30a and Slc39a family members,plays an important role in the response to immunological signals and ***,studies have found that macrophages utilize a variety of zinc-modulating mechanisms,thus expanding our knowledge regarding the role that zinc plays in response to bacterial ***,we review recent progress with respect to altered zinc metabolism in macrophages and the consequences with respect to fighting invading pathogens.

关键词： zinc zinc depletion zinc toxicity macrophage bacterial infection

Ferroptosis:an emerging player in immune cells

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Science Bulletin 2021年第22期66卷 2257-2260,M0003页

作者： Shan Xu Junxia Min fudi wang The First Affiliated Hospital School of Public HealthInstitute of Translational MedicineZhejiang University School of MedicineHangzhou 310058China The First Affiliated Hospital Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Ferroptosis is an iron-dependent form of cell death characterized by an accumulation of lipid peroxides.A growing body of recent evidence supports the notion that ferroptosis plays an important role in mediating a wide variety of cellular processes in ***,ferroptosis can play a significant role in mediating various functions in immune cells and ***,we discuss our current understanding regarding the regulatory role of ferroptosis in immune cells,including T cells,B cells,granulocytes,monocytes,and *** addition,we discuss the general effect of immune cell ferroptosis on human pathophysiology and immunotherapies,thereby suggesting new strategies for targeting ferroptosis in order to modulate the immune system and unravel the mechanisms that underlie ferroptosis in the immune response。

关键词：免疫细胞免疫治疗 death