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Mass spectrometry analysis of melanoma related O-glycans in sera

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Science China Chemistry 2010年第4期53卷 807-811页

作者： BAI Chen1,4, WU Gang1 & ZHAO Liang2,3 1Department of Life Science, fudan university, shanghai 200433, China 2Department of Chemistry, fudan university, shanghai 200433, China 3Institutes of Biomedical Sciences, fudan university, shanghai 200433, China 4Department of Food Science, shanghai Business School, shanghai 200235, China 1. Department of Life Science Fudan University Shanghai 200433 China4. Department of Food Science Shanghai Business School Shanghai 200235 China2. Department of Chemistry Fudan University Shanghai 200433 China3. Institutes of Biomedical Sciences Fudan University Shanghai 200433 China

Glycomics comparison was carried out by screening melanoma serum biomarkers between C57 mice with and without B16 implanted. O-glycans were released from 10 μL sera by β-elimination, purified by Graphitized Carbon Cartridge Solid Phase Extraction (GCC-SPE) and analyzed by MALDI-QIT-TOF-MS. MS raw data were acquired and exported by Launchpad software. MATLAB was then applied for further data analysis. 10 Glycans were considered to have stable changes after B16 implantation and 5 of them were under structural analysis via MS/MS.

关键词： mass spectrometry glycomics melanoma biomarkers

Germline mutation analysis of hPMS2 gene in Chinese families with hereditary nonpolyposis colorectal cancer

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World Journal of Gastroenterology 2010年第30期16卷 3847-3852页

作者： Xia Sheng, Xiao-Yan Zhou, Xiang Du, Tai-Ming Zhang, WeiQi Sheng, Da-Ren Shi, Department of Pathology, shanghai Cancer Center, fudan university, shanghai 200032, China Department of Oncology, shanghai Medical College, fudan university, shanghai 200032, China Heng-Hua Zhou, Department of Pathology, shanghai Ninth People’s Hospital Affi liated to shanghai Jiao Tong university School of Medicine, shanghai 200011, China San-Jun Cai, Department of Abdominal Surgery, Cancer Center, fudan university, shanghai 200032, China Department of Pathology Shanghai Cancer Center Fudan University 270 Dong An Road Shanghai 200032 China. shengweiqi2006@***

AIM: To study the germline mutation of hPMS2 gene in 26 unrelated Chinese hereditary nonpolyposis colorectal cancer (HNPCC) probands and to fulfill the screening strategy for HNPCC in Chinese. METHODS: Genomic DNA was extracted from the peripheral blood. To avoid the interference of pseudogene in detection of the remaining 11 exons (exon 1-5, 9, 11-15), long-range polymerase chain reaction (PCR) was conducted to amplify the complete coding region of hPMS2 gene firstly. Then 1/8 of the PCR productswere used as template to amplify the individual exon respectively and DNA sequencing was done. Direct DNA sequencing of the conventional PCR products of exon 6, 7, 8 and 10 of hPMS2 gene was performed. The same analysis was made in 130 healthy persons without family histories of HNPCC to further investigate the pathological effects of the detected missense mutation. RESULTS: One HNPCC proband fulf illed Bethesda guidelines and was found to carry the germline mutation of hPMS2 gene, which has not been reported in Chinese HNPCC families. It was a missense mutation at c.1532C>T of exon 11. It was detected in three controls as well with an occurrence rate of 2.3% (3/130). Since it could not be found in the PMS2-single nucleotide polymorphism (SNP) database, this missense mutation is a new SNP unreported up to date. Meanwhile, 260 reported SNPs of hPMS2 gene were detected in the 26 HNPCC probands. The 2nd and 5th exons were probably the hot SNP regions of hPMS2 gene in Chinese HNPCC families involving 53.1% of all reported SNP. CONCLUSION: The germline mutation of hPMS2 gene may be rare in Chinese HNPCC families. The 2nd and 5th exons are hot SNP regions of hPMS2 gene.

关键词： Hereditary nonpolyposis colorectal cancer hPMS2 Missense mutation Single nucleotide polymorphism Colorectal cancer

ON SOME CONSTANTS OF QUASICONFORMAL DEFORMATION AND ZYGMUND CLASS

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Chinese Annals of Mathematics,Series B 1995年第3期16卷 325-330页

作者： CHEN JIXIU WEI HANBAI(Institute of Mathematics, fudan university, shanghai 200433, China.) fudan UNIV INST MATHSHANGHAI 200433PEOPLES R CHINA

A real-valued function f(x)on belongs to Zygmund class if its Zygmund norm It is proved that when f ∈, there exists an extension F(z)of f to H = {Imz > 0} such that It is also proved that if f(0)=f(1)= 0,then

关键词： Quasiconformal deformation Zygmund class Beurling-Ahlfors extension.

Hyperbolic positive mass theorem under modified energy condition

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Science China Mathematics 2008年第12期51卷 2189-2197页

作者： XIE NaQing Institute of Mathematics, School of Mathematical Sciences, fudan university, shanghai 200433, China Institute of Mathematics School of Mathematical Sciences Fudan University Shanghai 200433 China

We provide two new positive mass theorems under respective modified energy conditions allowing T00 negative on some compact set for certain modified asymptotically hyperbolic manifolds. This work is analogous to Zhang... 详细信息

关键词： positive mass theorem modified energy condition modified asymptotically hyperbolic 83C40 53C27

Harmonic Maps from Kahler Manifolds

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Acta Mathematica Sinica,English Series 1999年第2期15卷 277-292页

作者： Yuanlong Xin, Institute of Mathematics and LMNS, fudan university, shanghai 200433, P. R. ChinaE-mail: ylxin@fudan, edu. cn Institute of Mathematics and LMNS Fudan University Shanghai P. R. China

Some Liouville type theorems for harmonic maps from Kahler manifolds are obtained. The main result is to prove that a harmonic map from a bounded symmetric domain (except IV（2）) to any Riemannian manifold with finit... 详细信息

关键词： Harmonic map Kahler manifold Bounded symmetric domain

Local connectivity of Julia sets for a family of biquadratic polynomials

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Science China Mathematics 2007年第10期50卷 1477-1492页

作者： Jing L~(1+) Wei-yuan QIU~2 ~1 Department of Basic Education,shanghai Maritime university.shanghai 200000,China ~2 Department of Mathematics,fudan university.shanghai 200433,China 1. Department of Basic Education Shanghai Maritime University Shanghai 200000 China 2. Department of Mathematics Fudan University Shanghai 200433 China

The local connectivity of Julia sets for the family of biquadratic polynomials f_c(z)= (z^2-2c^2)z^2 with a parameter c is *** is proved that for any parameter c,the boundary of the immediately attracting domain of f_... 详细信息

关键词： biquadratic polynomials Julia sets local connectivity

THE UNSTABLE FLOW FROM THE GAP BETWEEN TWO CIRCULAR CYLINDERS

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Journal of Hydrodynamics 1991年第3期3卷 110-115页

作者： Xu You-heng Huang Dong-qun, fudan university, shanghai 200433, P.R.China fudan Univ Shanghai China

The interference of two circular cylinders has been researched for many years. In this study, the research work was concentrated on two cylinders in some special staggered arrangement. The velocity signal was measured with a hot wire anemometer and recorded with a TEAC portable data recorder. The relationship between spectrum and time was established by making 200 spectrum analysis in se- quence. The gap flow is unstable when two cylinders are arranged in L/D=2, T/D=1. Mainly, it can be looked as flow past a single blunt body and the Strouhal number is 0.15, The second peak arises in the power spectrum when the gap flow appears at irregular time interval. Sometimes it may be higher than the first one. The Strouhal num- ber corresponding to the second peak is 0.33. But at most of the time it is lower than the first one and even disap- peared. This is meaningful for exploring the mechanisms of interference induced oscillations in flow past two cylin- ders.

关键词： THE UNSTABLE FLOW FROM THE GAP BETWEEN TWO CIRCULAR CYLINDERS 二止 GAP

An Improved Estimation of the Fixed Point'sNeighborhood in Controlling Discrete Chaotic Systems

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Communications in Nonlinear Science and Numerical Simulation 1998年第3期3卷 193-197页

作者： Enguo GU Jiong RUAN and Zhenxun HUANG(Institution of Mathematics fudan university, shanghai 200433, China) Institution of Mathematics fudan university Shanghai 200433 China

This paper proposes a better method for determining the fixed point'sneighborhood in which the system remain stable when subjected to a linear law. Thevalidity of this method is shown by a theorem on effective local control of nonlinear,chaotic dynamical system, with numerical confirmation. The ways of implementing theobtained theorem in practice are proposed.

关键词： discrete chaotic system neighborhood of fixed point feedback gain matrix

Synchronization of Chaotic Systems byFeedback

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Communications in Nonlinear Science and Numerical Simulation 1999年第2期4卷 162-165页

作者： Xiping ZENG Jiong RUAN Lijuan LI(Department of Mathematics, fudan university, shanghai 200433, China) Department of Mathematics Fudan University Shanghai 200433 China

A sufficient condition of the asymptotical stability of the zero solutionabout the nonautonomous equation dz/dt=A(t)z+o(||z||) .is .presented,in this paper. Furthermore, this sufficient condition is used to analyze the synchronization of chaotic Rosslersystem, a new method without any limitation on the response system in the synchronization is proposed in the meantime,

关键词： synchronization drive-response asymptotical stability