检索结果-南通市图书馆

武汉理工大学学报 2001年第10期23卷 50-52页

作者：撒继铭方长全李浩陈福祥武汉理工大学

介绍了一种 DMC- PID串级控制方法。

关键词：预测控制 DMC 非参数模型 PID 串级控制工业窑炉鲁棒性

A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2021年第5期36卷 913-923页

作者： Yun-Yun Jin Hanwen Lin Liu Cao Wei-chen Wu Yanxi Ji Liubing Du Yiling Jiang Yanchun Xie Kuijie Tong Fan Xing fuxiang Zheng Mang Shi Ji-An Pan Xiaoxue Peng Deyin Guo The Center for Infection and Immunity Study School of MedicineSun Yat-sen UniversityGuangming Science CityShenzhen 518107China

SARS-CoV-2 causes the pandemic of COVID-19 and no effective drugs for this disease are available thus *** to the high infectivity and pathogenicity of this virus,all studies on the live virus are strictly confined in the biosafety level 3(BSL3)laboratory but this would hinder the basic research and antiviral drug development of SARS-CoV-2 because the BSL3 facility is not commonly available and the work in the containment is costly and *** this study,we constructed a reverse genetics system of SARS-CoV-2 by assembling the viral cDNA in a bacterial artificial chromosome(BAC)vector with deletion of the spike(S)*** of the cDNA into cells results in the production of an RNA replicon that keeps the capability of genome or subgenome replication but is deficient in virion assembly and infection due to the absence of S ***,such a replicon system is not infectious and can be used in ordinary biological *** confirmed the efficient replication of the replicon by demonstrating the expression of the subgenomic RNAs which have similar profiles to the wild-type *** mutational analysis of nsp12 and nsp14,we showed that the RNA polymerase,exonuclease,and cap N7 methyltransferase play essential roles in genome replication and sgRNA *** also created a SARS-CoV-2 replicon carrying a luciferase reporter gene and this system was validated by the inhibition assays with known anti-SARS-CoV-2 ***,such a one-plasmid system is biosafe and convenient to use,which will benefit both fundamental research and development of antiviral drugs.

关键词： SARS-CoV-2 Reverse genetics Replicon Antiviral drug screening

First-principles investigation of mechanical and electronic properties of LaAg5 Laves phase under pressure

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2016年第1期34卷 105-112页

作者：高恩强黄福祥陈志谦王兰兰张照超 College of Materials Science & Engineering Chongqing University of Technology Chongqing 400054 China Faculty of Materials and Energy Southwest University Chongqing 400715 China

The effects of applied pressure on the structural, mechanical, and electronic properties of LaAgs compound were investi- gated employing the first-principles method based on the density fimctional theory. The mechanical results demonstrated that bulk modulus, shear modulus and Young＇s modulus presented the linearly increasing dependences on the external pressure; the B/G and Poisson＇s ratio indicated that LaAg5 compound was a ductile material with central forces in interatomic under pressure from 0 to 40 GPa; the universal anisotropic index was performed to investigate the elastic anisotropic of LaAgs. Additionally, the pressure de- pendence of the density of states and Mulliken charge were also discussed. The bonding characterization in LaAg5 was composed of metallic, covalent and ionic. The metallic component was derived from free-electron transferring from Ag-s and Ag-d to Ag-p, and from La-s to La-d. The ionic component was due to the charge movement from La to Ag. The covalent was owing to Ag-p-La-d bonding hybridization and Ag-s-Ag-p in the Ag atomic chains. The covalent and ionic bonds were stronger under pressure but there was no significant change in metallic nature.

关键词： LaAg5 Laves phase elastic properties electric structure density functional theory rare earths

STUDIES ON THE BIODEGRADATION MECHANISM OF β-TRICAICIUM PHOSPHATE CERAMICS

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 1997年第4期12卷 1-6页

作者：阎玉华 Wuhan University of Technology China Res. Ctr. of Med. Mat./Engineering Wuhan University of Technology Wuhan 430070 China Xiehe Hospital Tongji Medical University China 203 Hospital Chinese People's Liberation Army China

In order to clarify the biodegradation mecha-nism of?-tricalcium phosphate (β-TCP) ceramics, In vitro and In vivo experiments have been carried out. Nanometric microelectrodes were applied to measure the pH values in-side and outside phagocytes which were cultured for 72 hours respectively in (β-TCP-bearing and (β-TCP-free medi-um. Radioactive isotope 45 Ca was used to trace the distribu-tion and metabolism process of degraded products. We found that the degradation of (β-TCP ceramics was due to the dis-solving process in body fluid and the degrading process me-diated by cells. After (β-TCP ceramics labelled by 45 Ca were implanted into rabbits,radioactive 45 Ca was tested in blood, faece and organs such as heart, kidney and stomach etc. It was also found in the nearby new bone. So,we think a small part of the degraded products enter the animal's blood and take part in the metabolism of body . Others are reused to form new bone. The reports from clinical application also gave us strong support.

关键词： β-TCP biodegradation metabolism

太阳翼二维展开阶段SADA不同控制状态仿真分析

在线全文

学校读者我要写书评

暂无评论

航天器工程 2019年第5期28卷 70-74页

作者：董富祥陈余军中国空间技术研究院通信卫星事业部

二维二次太阳翼侧板展开将造成太阳翼驱动机构(SADA)产生反向转动。针对太阳翼侧板展开运动引起的太阳翼驱动机构反转问题,采用机电耦合分析方法建立了太阳翼驱动机构加断电两种状态下阻力矩方程,进一步基于单向递推组集建模方法建立了... 详细信息

二维二次太阳翼侧板展开将造成太阳翼驱动机构(SADA)产生反向转动。针对太阳翼侧板展开运动引起的太阳翼驱动机构反转问题,采用机电耦合分析方法建立了太阳翼驱动机构加断电两种状态下阻力矩方程,进一步基于单向递推组集建模方法建立了太阳翼侧板展开期间整星动力学微分代数方程组,分析了太阳翼驱动机构加断电状态下太阳翼二维展开运动对太阳翼和卫星安全的影响。研究表明:侧板展开期间太阳翼驱动机构位置处将会产生大角速度转动,危害太阳翼驱动机构线路安全,建议结合太阳翼驱动机构电路设计,合理选择太阳翼驱动机构加断电策略,并采取措施降低侧板展开到位时刻角速度。

关键词：二维二次展开太阳翼动力学建模仿真展开策略碰撞动力学

0.225+18×0.205CCST钢丝帘线在全钢载重子午线轮胎胎体中的应用

在线全文

学校读者我要写书评

暂无评论

轮胎工业 2024年第8期44卷 487-491页

作者：王天石张春颖毕德伟刘连波陈立强李福香高同舜杨萌王秀梅青岛双星轮胎工业有限公司山东青岛266400 山东大业股份有限公司山东潍坊262218

研究0.225+18×0.205CCST钢丝帘线在全钢载重子午线轮胎胎体中的应用,并与0.17+5×0.215+10×0.235CCST钢丝帘线和0.25+6+12×0.225HT钢丝帘线进行对比。结果表明:采用0.225+18×0.205CCST钢丝帘线的成品轮胎的强度和高速性能相当,耐久... 详细信息

研究0.225+18×0.205CCST钢丝帘线在全钢载重子午线轮胎胎体中的应用,并与0.17+5×0.215+10×0.235CCST钢丝帘线和0.25+6+12×0.225HT钢丝帘线进行对比。结果表明:采用0.225+18×0.205CCST钢丝帘线的成品轮胎的强度和高速性能相当,耐久性能提高,滚动阻力下降,单胎质量减小,综合成本降低。

关键词：钢丝帘线全钢载重子午线轮胎胎体耐久性能滚动阻力成本

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2020年第3期63卷 364-374页

作者： Yingxia Liu Yang Yang Cong Zhang Fengming Huang fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li cheng Feng Zheng Zhang Lifei Wang Ling Peng Li chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou chengyu Jiang Lei Liu Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical CollegeBeijing 100005China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Emergence Department Peking Union Medical College Hospital Beijing 100731China

The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other *** we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,*** 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 *** viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease ***,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung ***,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease ***,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung *** results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.

关键词： 2019-nCoV AngiotensinⅡ ARDS

Nuclear Mechanotransduction in Cellular Mechanobiology and Molecular Mechanomedicine

在线全文

学校读者我要写书评

暂无评论

医用生物力学 2019年第A1期34卷 10-10页

作者： Ning Wang Junwei chen Jian Sun Erfan Mohagheghian fuxiang Wei Department of Mechanical Science and Engineering College of EngineeringUniversity of Illinois at Urbana-ChampaignUrbanaIL61801USA Laboratory for Cellular Biomechanics and Regenerative Medicine Department ofBiomedical EngineeringCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan430074China

It is known that mechanical forces play critical roles in physiology and diseases but the underlying mechanisms remain largely unknown[1].Most studies on the role of forces focus on cell surface molecules and cytoplasmic ***,increasing evidence suggests that nuclear mechanotransduction impacts nuclear activities and *** we have revealed that transgene dihydrofolate reductase(DHFR)gene expression is directly upregulated via cell surface forceinduced stretching of chromatin [2].Here we show that endogenous genes are also upregulated directly by force via *** present evidence on an underlying mechanism of how gene transcription is regulated by *** have developed a technique of elastic round microgels to quantify 3D tractions in vitro and in vivo[3].We report a synthetic small molecule(which has been stiffened structurally)that inhibits malignant tumor repopulating cell growth in a low-stiffness(force)microenvironment and cancer metastasis in mouse models without detectable toxicity[4].These findings suggest that direct nuclear mechanotransduction impacts mechanobiology and mechanomedicine at cellular and molecular levels.

关键词： Nuclear Mechanotransduction Cellular Mechanobiology Molecular Mechanomedicine

复合型阻燃剂对无醛超低密度纤维板性能的影响

在线全文

学校读者我要写书评

暂无评论

林产化学与工业 2019年第3期39卷 87-93页

作者：詹满军陈志林储富祥中国林业科学研究院

采用磷-氮-硼(P-N-B)复合阻燃剂以及豆粕胶黏剂复配异氰酸酯(PMDI)胶黏剂制备无醛超低密度纤维板(NUDF),探讨阻燃剂添加量对无醛超低密度纤维板物理力学性能、甲醛释放量以及阻燃性能的影响。研究结果表明:随着阻燃剂添加量(0~8%)增加,N... 详细信息

采用磷-氮-硼(P-N-B)复合阻燃剂以及豆粕胶黏剂复配异氰酸酯(PMDI)胶黏剂制备无醛超低密度纤维板(NUDF),探讨阻燃剂添加量对无醛超低密度纤维板物理力学性能、甲醛释放量以及阻燃性能的影响。研究结果表明:随着阻燃剂添加量(0~8%)增加,NUDF的物理力学性能和甲醛释放量均有所降低,氧指数逐渐升高,总热释放量降低,纤维板成炭现象更明显,可燃性显著降低。当阻燃剂添加量6%时,NUDF综合性能较优,内结合强度0.41 MPa、静曲强度14.5 MPa,24 h吸水厚度膨胀率8.1%,甲醛释放量2.0μg/g,燃烧长度80 mm,相同测试时间内不易被引燃,氧指数32.5%,600 s总热释放量12 MJ/m^2。纤维板达到GB 8624—2012平板状建筑材料难燃B1~C级,产烟等级满足S1级,具有良好力学性能、环保和阻燃性能。锥形量热分析表明:随着阻燃剂添加量的增加,燃烧过程中基本呈现总热释放量降低、总烟量升高、CO产率增大和CO 2产率减小的趋势。

关键词：阻燃剂超低密度纤维板总热释放量

契合区域产业转型升级的高职一流特色专业群人才培养困境与对策——以湖南省为例

在线全文

学校读者我要写书评

暂无评论

职业技术教育 2022年第26期43卷 12-17页

作者：陈超群胡伏湘长沙商贸旅游职业技术学院长沙410116

通过数据分析与实地调研发现,湖南省高职专业群人才培养取得了规模与质量齐头并进、毕业生就业质量稳步提升以及毕业生创新创业能力后劲十足等成效,但仍存在人才培养类型滞后于产业转型升级速度、人才培养专业结构与产业结构耦合度不强... 详细信息

通过数据分析与实地调研发现,湖南省高职专业群人才培养取得了规模与质量齐头并进、毕业生就业质量稳步提升以及毕业生创新创业能力后劲十足等成效,但仍存在人才培养类型滞后于产业转型升级速度、人才培养专业结构与产业结构耦合度不强、专业群人才培养的师资队伍建设落后于区域产业转型升级速度等现实困境。基于此,从打造一支高水平的“双师型”教师团队、加快教学资源建设、创新教法改革三方面提出契合湖南省产业转型升级的高职一流特色专业群人才培养发展对策。

关键词：高职教育一流特色专业群人才培养产业转型升级湖南省