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Fibrinogen to be a laboratory screening biomarker for polycystic ovary syndrome(PCOS) patients:a Meta-analysis

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Journal of Reproduction and Contraception 2015年第2期26卷 91-101页

作者： xin JI Bin zhang Chun-mei YING Department of Laboratory Medicine Obstetrics and Gynecology Hospital of Fudan University

Objective To assess the fibrinogen levels in polycystic ovary syndrome （PCOS） patients and to fgure out the potential of fibrinogen to be an early phase laboratory biomarker for PCOS diagnosis. Methods A systemic literature research was performed from databases of Medline via OVID, PubMed, Web of Knowledge and the Cochrane library databases, etc. Fifteen studies including 694 PCOS patients and 548 normal controls were selected after quality assessment. Data of fibrinogen levels, age and body weight were extracted and analyzed systemically. Results Fibrinogen increases in PCOS patients with regard to data poolings of overall studies （mean difference=21.51, 95%CI=3.78-39.25, P=0.02）, National Institutes of Health （NIH）-based studies （mean difference=8. 50, 95%CI=0.91-16. 09, P= 0. 03） and Rotterdam-based studies （mean difference=45.61, 95%CI=12.18-79.03, P=0.007） respectively. PCOS patients are younger （mean difference= -2.15, 95%CI= -3.65 - -0. 64, P=0. 005） and with heavier body weight （mean difference=0.92, 95%CI=0.59- 1.25, P〈0.001） than normal controls. Conclusions Increasing in PCOS patients, fibrinogen might be used as a diagnosis biomarker for PCOS, especially in the population with younger age and heavier body weight, which indicates that fibrinogen might be used as an early phase laboratory screening biomarker in clinical practice.

关键词： fibrinogen polycystic ovary syndrome (PCOS) diagnosis

P300 change and cognitive behavioral therapy in subjects with Internet addiction disorder A 3-month follow-up study

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Neural Regeneration Research 2011年第26期6卷 2037-2041页

作者： Ling Ge Xiuchun Ge Yong Xu Kerang zhang Jing Zhao xin Kong Department of Medical Psychology Shanxi Medical College for Continuing Education Taiyuan 030012 Shanxi Province China Shanxi Cardiovascular Hospital Taiyuan 030024.Shanxi Province China Department of Psychiatry First Hospital of Shanxi Medical University Taiyuan 030001 Shanxi Province China College of Humanities and Social Science Shanxi Medical University Taiyuan 030001 Shanxi Province China

Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls （N2： P = 0.035; P3a： P = 0.031 P3b： P = 0.043） and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b （P3a： P = 0.045; P3b： P = 0.062）. These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective.

关键词： Internet addiction disorder follow-up study college students event-related potential P300 cognitive behavioral therapy

Microstructure evolution and phase transformation of the mushy zone in a quenchedβ-solidifying TiAl alloy

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Journal of Materials Science & Technology 2024年第2期169卷 28-41页

作者： fuqiang zhang Xianfei Ding Leming Xu xin Feng Hai Nan Jianping He Yongfeng Liang Junpin Lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Cast Titanium Alloy R&D Center Beijing Institute of Aeronautical MaterialsBeijing 100095China

This study investigates the phase constitutions and transformations that occur in the mushy zone and in the adjacent phase fields of a directionally solidified Ti-44Al-8Nb-1Cr alloy via quenching *** results indicate that the mushy zone consists of unmeltedβdendrites and interdendritic liquid,whose formation can be attributed to the difference in melting point aroused by local heterogeneity in ***βdendrite is composed of numerous subgrains with various *** quenching,theβdendrite transforms into Widmanstättenαvia a precipitation reaction,owing to the decreasing cooling rate caused by heat transfer from the surrounding ***,after quenching,the interdendritic liquid is transformed intoγ*** the singleβphase field and the lower part of the mushy zone,a massive transformation ofβtoγ***,in theβ+αphase field,bothβandαphases are retained to ambient *** the heating process,the transformation ofα→βgives rise to the formation ofβvariants,which affects the orientation ofβdendrites in the mushy *** growth kinematics of theα→βtransformation was elucidated,revealing the preferential growth directions of111and112forβ***,this study presents an illustration of the formation process of the mushy zone and the microstructural evolution during the heating and quenching process.

关键词： Titanium aluminides Mushy zone Quenching Electron backscattering diffraction Phase transformation

Dynamic energy spectrum and energy deposition in solid target by intense pulsed ion beams

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Nuclear Science and Techniques 2017年第4期28卷 31-37页

作者： Xiao Yu Zheng Liu Jie Shen Yu I. Isakova Hao-Wen Zhong Jie zhang Sha Yan Gao-Long zhang Xiao-fu zhang Xiao-Yun Le School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beihang University Beijing 100191 China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University Beijing 100191 China School of Space and Environment Beihang UniversityBeijing 100191 China Department of Mechanical Engineering Tsinghua University Beijing 100084 China Institute of High Technology Physics Tomsk Polytechnic University Tomsk Russia 634050 Institute of Heavy Ion Physics Peking UniversityBeijing 100871 China

A method for analyzing the dynamic energy spectrum of intense pulsed ion beam(IPIB) was *** influence on beam energy deposition in metal target was studied with IPIB produced by two types of magnetically insulated diodes(MID).The emission of IPIB was described with space charge limitation model,and the dynamic energy spectrum was further analyzed with time-of-flight *** generated by pulsed accelerators of BIPPAB-450(active MID) and TEMP-4M(passive MID) were *** dynamic energy spectrum was used to deduce the power density distribution of IPIB in the target with Monte Carlo simulation and infrared imaging *** effect on the distribution and evolution of thermal field induced by the characteristics of IPIB dynamic energy spectrum was discussed.

关键词： Intense pulsed ion beam Space charge Time-of-flight method Dynamic energy spectrum Power density distribution

Co-exposure of sulfur nanoparticles and Cu alleviate Cu stress and toxicity to oilseed rape Brassica napus L.

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Journal of Environmental Sciences 2023年第2期124卷 319-329页

作者： Haiyan Yuan Qingquan Liu Jiahao fu Yinjie Wang Yongxia zhang Yuming Sun Haiying Tong Om Parkash Dhankher Jiangsu Province and Chinese Academy of Sciences Institute of BotanyNanjing 210014China Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm Nanjing 210014China Stockbridge School of Agriculture University of Massachusetts AmherstMA 01003USA

Experimentswere performed to explore the impact of sulfur nanoparticles(SNPs)on growth,Cu accumulation,and physiological and biochemical responses of oilseed rape(Brassica napus L.)inoculated with 5 mg/L Cu-amended MS medium supplemented with or without 300 mg/L SNPs *** exerted severe phytotoxicity and inhibited plant *** application enhanced the shoot height,root length,and dry weight of shoot and root by 34.6%,282%,41.7%and 37.1%,respectively,over Cu treatment alone,while the shoot and root Cu contents and Cu-induced lipid perodixation as the malondialdehyde(MDA)levels in shoots and roots were decreased by 37.6%,35%,28.4%and 26.8%.further,the increases in superoxide dismutase(SOD),peroxidase(POD),catalase(CAT),ascorbate peroxidase(APX),glutathione reductase(GR)and glutathione S-transferase(GST)enzyme activities caused by Cu stress were mitigated in shoots(10.9%–37.1%)and roots(14.6%–35.3%)with SNPs *** also positively counteracted the negative effects on shoot K,Ca,P,Mg,Mn,Zn and Fe contents and root K,Ca,Mg and Mn contents from Cu exposure alone,and significantly promoted the nutrients accumulation in ***,in comparison with common bulk sulfur particles(BSPs)and sulfate,SNPs showed more positive effects on promoting growth in shoots(6.7%and 19.5%)and roots(10.9%and 15.1%),as well as lowering the shoot Cu content(40.1%and 43.3%)under Cu ***,SNPs application has potential to be a green and sustainable technology for increasing plant productivity and reducing accumulation of toxic metals in heavy metal polluted soils.

关键词： Sulfur nanoparticles(SNPs) Cu stress Oilseed rape Antioxidant enzymes Nutrient elements

Regulating the Electron Localization of Metallic Bismuth for Boosting CO_(2)Electroreduction

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Nano-Micro Letters 2022年第2期14卷 296-310页

作者： Dan Wu Renfei Feng Chenyu Xu Peng-Fei Sui Jiujun zhang Xian-Zhu fu Jing-Li Luo Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Canadian Light Source Inc. SaskatoonSaskatchewan S7N 0X4Canada Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada Institute for Sustainable Energy/College of Science Shanghai UniversityShanghai 200444People’s Republic of China

Electrochemical reduction of CO_(2)to formate is economically attractive but improving the reaction selectivity and activity remains ***,we introduce boron(B)atoms to modify the local electronic structure of bismuth with positive valence sites for boosting conversion of CO_(2)into formate with high activity and selectivity in a wide potential *** combining experimental and computational investigations,our study indicates that B dopant differentiates the proton participations of rate-determining steps in CO_(2)reduction and in the competing hydrogen *** comparing the experimental observations with the density functional theory,the dominant mechanistic pathway of B promoted formate generation and the B concentration modulated effects on the catalytic property of Bi are *** comprehensive study offers deep mechanistic insights into the reaction pathway at an atomic and molecular level and provides an effective strategy for the rational design of highly active and selective electrocatalysts for efficient CO_(2)conversion.

关键词： CO_(2)reduction Bismuth Proton transport Electron localization Boron

Effects of operating conditions on the performance degradation and anode microstructure evolution of anode-supported solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2023年第6期30卷 1181-1189页

作者： xin Yang Zhihong Du Qian zhang Zewei Lyu Shixue Liu Zhijing Liu Minfang Han Hailei Zhao School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Municipal Key Lab for Advanced Energy Materials and Technologies Beijing 100083China Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084China Shenzhen Engineering Research Center for Hydrogen Safety China Nuclear Power Technology Research InstituteShenzhen 518031China

Performance degradation shortens the life of solid oxide fuel cells in practical *** the degradation mechanism is crucial for the continuous improvement of cell *** this work,the effects of cell operating conditions on the terminal voltage and anode microstructure of a Ni-yttria-stabilized zirconia anode-supported single cell were *** microstructure of the anode active area near the electrolyte was characterized by laser optical microscopy and focused ion beam-scanning electron *** depletion at the anode/electrolyte interface region was observed after 100 h discharge *** addition,the long-term stability of the single cell was evaluated at 700℃for 3000 *** an initial decline,the anode-supported single cell exhibits good durability with a voltage decay rate of 0.72%/kh and an electrode polarization resistance decay rate of 0.17%/*** main performance loss of the cell originates from the initial degradation.

关键词： solid oxide fuel cell Ni-YSZ anode focused ion beam Ni migration electrochemical performance

Research progress of CO_(2) capture and mineralization based on natural minerals

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1208-1227页

作者： Chenguang Qian Chunquan Li Peng Huang Jialin Liang xin zhang Jifa Wang Jianbing Wang Zhiming Sun School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China Shanghai Construction Building Material Technology Group Shanghai 200080China

Natural minerals,such as kaolinite,halloysite,montmorillonite,attapulgite,bentonite,sepiolite,forsterite,and wollastonite,have considerable potential for use in CO_(2) capture and mineralization due to their abundant reserves,low cost,excellent mechanical prop-erties,and chemical *** the past decades,various methods,such as those involving heat,acid,alkali,organic amine,amino sil-ane,and ionic liquid,have been employed to enhance the CO_(2) capture performance of natural minerals to attain high specific surface area,a large number of pore structures,and rich active *** research on CO_(2) capture by natural minerals will focus on the full utiliza-tion of the properties of natural minerals,adoption of suitable modification methods,and preparation of composite materials with high specific surface area and rich active *** addition,we provide a summary of the principle and technical route of direct and indirect mineralization of CO_(2) by natural *** process uses minerals with high calcium and magnesium contents,such as forsterite(Mg_(2)SiO_(4)),serpentine[Mg_(3)Si_(2)O(OH)_(4)],and wollastonite(CaSiO_(3)).The research status of indirect mineralization of CO_(2) using hydro-chloric acid,acetic acid,molten salt,and ammonium salt as media is also introduced in *** recovery of additives and high-value-added products during the mineralization process to increase economic benefits is another focus of future research on CO_(2) mineralization by natural minerals.

关键词： natural mineral carbon dioxide capture modification composite material carbon dioxide mineralization

Prognostic model of hepatocellular carcinoma based on cancer grade

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World Journal of Clinical Cases 2023年第27期11卷 6383-6397页

作者： Guo-xin zhang Xiao-Sheng Ding You-Li Wang Department of General Surgery Aviation General HospitalBeijing 100010China Department of Oncology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Hepatocellular carcinoma(HCC)is the most common type of primary liver *** highly invasive biological characteristics and a lack of obvious clinical manifestations,HCC usually has a poor prognosis and ranks fourth in cancer *** aetiology and exact molecular mechanism of primary HCC are still *** To select the characteristic genes that are significantly associated with the prognosis of HCC patients and construct a prognosis model of this *** By comparing the gene expression levels of patients with different cancer grades of HCC,we screened out differentially expressed genes associated with tumour *** protein-protein interaction(PPI)network analysis,we obtained the top 2 PPI networks and hub genes from these differentially expressed *** using least absolute shrinkage and selection operator Cox regression,13 prognostic genes were selected for feature extraction,and a prognostic risk model of HCC was *** The model had significant prognostic ability in *** also analysed the biological functions of these prognostic *** By comparing the gene profiles of patients with different stages of HCC,We have constructed a prognosis model consisting of 13 genes that have important prognostic *** model has good application value and can be explained clinically.

关键词： Hepatocellular carcinoma Prognostic model Bioinformatics Alpha-fetoprotein