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Study on the Performance of the GRANDProto300 Particle Detector Array by Simulation

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Research in Astronomy and Astrophysics 2024年第1期24卷 173-177页

作者： fu-lin Dai quan-Bu Gou Xiaoyuan Huang Yi-Qing Guo Key laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Key laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The Giant Radio Array for Neutrino Detection(GRAND)is a proposed large-scale observatory designed to detect cosmic rays,gamma-rays,and neutrinos with energies exceeding 100 Pe *** GRANDProto300 experiment is proposed as the early stage of the GRAND project,consisting of a hybrid array of radio antennas and scintillator *** latter,as a mature and traditional detector,is used to cross-check the nature of the candidate events selected from radio *** this study,we developed a simulation software called G4GRANDProto300,based on the Geant4 software package,to optimize the spacing of the scintillator detector array and to investigate its effective *** analysis was conducted at various zenith angles under different detector spacings,including 300,500,600,700,and 900 *** results indicate that,for large zenith angles used to search for cosmic-ray in the GRAND project,the optimized effective area is with a detector spacing of 500 *** G4GRANDProto300 software that we developed could be used to further optimize the layout of the particle detector array in future work.

关键词： astroparticle physics instrumentation:detectors (ISM:)cosmic rays

Charge-controlled compositional/microstructural regulations and electrochemical actuation performance of bulk nanoporous Ni-Pd alloys

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Rare Metals 2024年第10期43卷 5305-5317页

作者： fu-quan Tan Qing-Guo Bai Bin Yu Jian-Feng Wang Zhong-Hua Zhang Key laboratory for liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and EngineeringShandong University School of Applied Physics and Materials Wuyi University Ira A.fulton School of Engineering Arizona State University

Bulk nanoporous （np） metallic actuators have attracted increasing attention due to their large strain and low stimulation ***,studies focusing upon the combined effect of composition and structure on the actuation performance of metallic actuators are relatively scarce,and its underlying mechanism needs to be clarified Herein,a series of bulk np-NiPd samples with differen compositions and microstructures were fabricated using a dealloying-coarsening-dealloying strategy and chargecontrolled electrochemical dealloying,and the process involves only one component of precursor *** has been found that the np-NiPd cubes show a composition/structure-dependent mechanical property and electrochemical actuation ***,the npNi70Pd30sample with a homogeneously porous structure and good network connectivity exhibits significantly larger strain amplitude and faster strain rate than other hierarchically porous NiPd samples (np-Ni50Pd50and npNi20Pd80).Moreover,the np-Ni70Pd30sample demonstrates good actuation stability with high strain retention after hundreds of ***,the maximum strain amplitude （1.17%） is even comparable to that of advanced leadfree piezoceramic,and the maximum strain rate exceeds those of many reported metallic actuator *** work indicates that good network connectivity plays a vita role in facilitating large/fast strain response in metallic actuators.

关键词： Actuation stability Bulk nanoporous NiPd Electrochemical dealloying Good network connectivity Metallic actuators

A new interacting capillary bundle model on the multiphase flow in micropores of tight rocks

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Petroleum Science 2024年第2期21卷 1099-1112页

作者： Wen-quan Deng Tian-Bo liang Wen-Zhong Wang Hao liu Jun-lin Wu fu-Jian Zhou National Key laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

Surfactants are widely used in the fracturing fluid to enhance the imbibition and thus the oil recovery rate. However, current numerical models cannot capture the physics behind capillary imbibition during the wettability alteration by surfactants. Although the interacting capillary bundle(ICB) model shows potential in characterizing imbibition rates in different pores during wettability alteration, the existing ICB models neglect the influence of wettability and viscosity ratio on the imbibition behavior, making it difficult to accurately describe the oil-water imbibition behavior within the porous media. In this work,a new ICB mathematical model is established by introducing pressure balance without assuming the position of the leading front to comprehensively describe the imbibition behavior in a porous medium under different conditions, including gas-liquid spontaneous imbibition and oil-water *** the pore size distribution of a tight rock is known, this new model can predict the changes of water saturation during the displacement process in the tight rock, and also determine the imbibition rate in pores of different sizes. The water saturation profiles obtained from the new model are validated against the waterflooding simulation results from the CMG, while the imbibition rates calculated by the model are validated against the experimental observations of gas-liquid spontaneous imbibition. The good match above indicates the newly proposed model can show the water saturation profile at a macroscopic scale while capture the underlying physics of the multiphase flow in a porous medium at a microscopic scale. Simulation results obtained from this model indicate that both wettability and viscosity ratio can affect the sequence of fluid imbibition into pores of different sizes during the multiphase flow, where less-viscous wetting fluid is preferentially imbibed into larger pores while more-viscous wetting fluid tends to be imbibed into smaller pores. fur

关键词： Imbibition Multiphase flow Tight rock Interacting capillary bundle model Wettability

Numerical and experimental study of the effects of wind turbine operation on sand-dust transport characteristics

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 97-113页

作者： Gaosheng Ma Hong Han Ye li Deshun li Yan Wang Ning fu quan Zheng Rennian li School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Gansu Provincial Technology Center for Wind Turbines Lanzhou 730050China Key laboratory of Fluid Machinery and Systems Lanzhou 730050China Multiple function Towing Tank laboratory State Key Laboratory of Ocean EngineeringSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Given factors such as reduced land availability for onshore wind farms,wind resource enrichment levels,and costs,there is a growing trend of establishing wind farms in deserts,the Gobi,and other arid ***,the relationship between sanddust weather environments and wind turbine operations has garnered significant *** investigate the impact of wind turbine wakes on sand-dust transportation,this study employs large eddy simulation to model flow fields,coupled with an actuator line model for simulating rotating blades and a multiphase particle in cell model for simulating sand *** research focuses on a horizontal axis wind turbine model and examines the motion and spatiotemporal distribution characteristics of four typical sizes of sand particles in the turbine *** findings reveal that sand particles of varying sizes exhibit a spiral settling pattern after traversing the rotating plane of wind turbine blades,influenced by blade shedding vortex and *** particles tend to cluster in the peripheries of the vortex cores of low vorticity in the wind turbine *** rotation of wind turbines generates a wake vortex structure that causes a significant clustering of sand particles at the tip *** the wake distance increases,the particles that cluster at the turbine's tip gradually spread outward to approximately twice the rotor diameter and then begin to mix with the incoming flow *** turbines have a noticeable impact on sand-dust transportation,hindering their movement to a significant *** average sand-blocking rate exhibits a trend of initially increasing and then decreasing as the wake distance *** its peak,the sand-blocking rate reaches an impressive 67.55%.The presence of wind turbines induces the advanced settling of sand particles,resulting in a“triangular”distribution of the deposition within the ground projection area of the wake.

关键词： wind turbine particle transportation actuator line model dry deposition particle clustering

Copper oxide-modified highly reversible Zn powder anode for aqueous Zn metal batteries

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Rare Metals 2024年第10期43卷 5005-5016页

作者： Guan-Qun liu Biao fu Zhe-Xuan liu lan-Yan li Shu-quan liang Guo-Zhao Fang School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan ProvinceCentral South University School of Science Hunan University of Technology and Business National Energy Metal Resources and New Materials Key laboratory Central South University

With the advantages of mature preparation technology,structural adjustability and suitability for large-scale application,Zn powder anode is considered to be an ideal electrode for realizing low-cost,high-energy-density aqueous Zn metal ***,the high specific surface of Zn powders leads to severe side reactions such as hydrogen evolution and corrosion,thus limiting their widespread use Here,this work develops a novel CuO@Zn powder anode with a synergy effect of surface wrapping and *** powders are uniformly wrapped by small CuO particles due to the strong adsorption between Zn and *** wrapped CuO particles build a good conductive framework to inhibit the structural collapse of the Zn powder caused by corrosion and non-uniform ***,CuO can also be used as a seed to guide the uniform deposition of Zn ions through its strong binding energy with *** a result,the Cu O@Zn anode can maintain a long cyclic life of 900 h at current density of 1 mA·cm-2and capacity of 1 mAh·cm-2,as well as contribute to an excellent capacity retention of 92%after 800cycles for CuO@Zn||NH4V4O10full *** at high current density of 5 A·g-1,the full cell exhibits a specific capacity of more than 200 mAh·g-1after 800 cycles,with a good capacity retention of 89%.This work provides a new idea for developing high-performance Zn powder-based anodes.

关键词： Aqueous Zn metal batteries Copper oxide Surface wrapping Zn anode Zn powder

Analysis of mechanical strengths of extreme line casing joint considering geometric, material, and contact nonlinearities

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Petroleum Science 2024年第3期21卷 1992-2004页

作者： Ji-Yun Zhang Chi Peng Jian-Hong fu quan Cao Yu Su Jian-Yun Pang Zi-Qiang Yu Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina Engineering Technology Research Institute of CNPC Southwest Oil and Gas Field Company Chengdu610017SichuanChina

To address the challenges associated with difficult casing running,limited annular space,and poor cementing quality in the completion of ultra-deep wells,the extreme line casing offers an effective solution over conventional ***,due to its smaller size,the joint strength of extreme line casing is reduced,which may cause failure when running in the *** address this issue,this study focuses on the CST-ZTΦ139.7 mm×7.72 mm extreme line casing and employs the elastic-plastic mechanics to establish a comprehensive analysis of the casing joint,taking into account the influence of geometric and material nonlinearities.A finite element model is developed to analyze the forces and deformations of the extreme line casing joint under axial tension and external collapse *** model investigates the stress distribution of each thread tooth subjected to various tensile forces and external ***,the tensile strength and crushing strength of the extreme line casing joint are determined through both analytical and experimental *** findings reveal that,under axial tensile load,the bearing surface of each thread tooth experiences uneven stress,with relatively high equivalent stress at the root of each thread *** end thread teeth are valuable spots for *** is observed that the critical fracture axial load of thread decreases linearly with the increase of thread tooth *** external pressure,the circumferential stress is highest at the small end of the external thread,leading to yield *** tensile strength of the joint obtained from the finite element model exhibits a relative error of less than 7%compared to the analytical and experimental values,proving the reliability of the finite element *** tensile strength of the joint is 3091.9 k ***,in terms of anti-collapse capability,the joints demonstrate higher resistance to collapse compared to the casing body,which is consistent with the test resul

关键词： Extreme line casing Elastic-plastic mechanics Finite element analysis Tensile strength Collapse strength

Characterizing structural variants based on graph-genotyping provides insights into pig domestication and local adaption

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Journal of Genetics and Genomics 2024年第4期51卷 394-406页

作者： Xin li quan liu Chong fu Mengxun li Changchun li Xinyun li Shuhong Zhao Zhuqing Zheng Key lab of Agricultural Animal Genetics Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of AgricultureCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhanHubei 430070China Institute of Agricultural Biotechnology Jingchu University of TechnologyJingmenHubei 448000China The Cooperative Innovation Center for Sustainable Pig Production WuhanHubei 430070China Hubei Hongshan laboratory WuhanHubei 430070China

Structural variants(SVs),such as deletions(DEls)and insertions(INSs),contribute substantially to pig genetic diversity and phenotypic *** a library of SVs discovered from long-read primary assemblies and short-read sequenced genomes,we map pig genomic SVs with a graph-based method for re-genotyping SVs in 402 *** results demonstrate that those SVs harboring specific trait-associated genes may greatly shape pig domestication and local *** characterization of SVs reveals that some population-stratified SVs may alter the transcription of genes by affecting regulatory *** identify that the genotypes of two DEls(296-bp DEl,chr7:52,172,101e52,172,397;278-bp DEl,chr18:23,840,143 e23,840,421)located in muscle-specific enhancers are associated with the expression of target genes related to meat quality(FSD2)and muscle fiber hypertrophy(lMOD2 and WASl)in *** results highlight the role of SVs in domestic porcine evolution,and the identified candidate functional genes and SVs are valuable resources for future genomic research and breeding programs in pigs.

关键词： Pigs Structural variation Selection signatures Regulatory elements

Casual associations between blood metabolites and colon cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1995-2005页

作者： Ke-Yue Hu Yi-quan Cheng Zhi-long Shi fu-Peng Ren Gang-Feng Xiao Department of Hematology and Oncology Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal *** To investigate causal associations between blood metabolites and colon *** The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal *** primary method of analysis used was the inverse variance weighted *** further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile *** additional analyses were conducted to ensure the reliability and robustness of the *** After rigorous selection for genetic variation,486 blood metabolites were included in the MR *** found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the *** This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk *** other five blood metabolites are protective factors.

关键词： Metabolites Colon cancer Mendelian randomization Genome-wide association studies Casual

A CRISPR/Cas9-based visual toolkit enabling multiplex integration at specific genomic loci in Aspergillus niger

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Synthetic and Systems Biotechnology 2024年第2期9卷 209-216页

作者： Yangyang li Cen li Yishan fu quan Zhang Jianing Ma Jingwen Zhou Jianghua li Guocheng Du Song liu National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing Jiangnan UniversityWuxi214122China Science Center for future Foods Jiangnan UniversityWuxi214122China School of Biotechnology Jiangnan University1800 Lihu RoadWuxi214122China Jiangsu Provisional Research Center for Bioactive Product Processing Technology Jiangnan University1800 Lihu RoadWuxiJiangsu214122China Key laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Life Sciences/Institute of Agro-bioengineeringGuizhou UniversityGuiyang550025China Dalian Research Institute of Petroleum and Petrochemicals SINOPECDalian116000China School of Chemical Engineering Dalian University of TechnologyDalian116000China

Aspergillus niger is a highly versatile fungal strain utilized in industrial *** expression levels of recombinant genes in *** can be enhanced by increasing the copy ***,given the prolonged gene editing cycle of ***,a“one-step”strategy facilitating the simultaneous integration of recombinant genes into multiple genomic loci would provide a definitive *** our previous study,a visual multigene editing system(VMS)was designed to knock out five genes,employing a tRNA-sgRNA array that includes the pigment gene albA and the target *** upon this system,hybrid donor DNAs(dDNAs)were introduced to establish a clustered regularly interspaced short palindromic repeats(CRISPR)-based multiplex integration ***,a CRISPR-Cas9 homology-directed repair(CRISPR-HDR)system was constructed in *** by co-transforming the CRISPR-Cas9 plasmid(with a highly efficient sgRNA)and the dDNA,resulting in precise integration of recombinant xylanase gene xynA into the target loci(theβ-glucosidase gene bgl,the amylase gene amyA,and the acid amylase gene ammA).Subsequently,the length of homology arms in the dDNA was optimized to achieve 100%editing efficiency at each of the three gene *** achieve efficient multiplex integration in ***,the CRISPR plasmid plM2 carrying a sgRNA-tRNA array was employed for concurrent double-strand breaks at multiple loci(bgl,amyA,ammA,and albA).Hybrid dDNAs were then employed for repair,including dDNA1-3(containing xynA expression cassettes without selection markers)and dDNAalbA(for albA knockout).Among the obtained white colonies(RlM2′),23.5%exhibited concurrent replacement of the bgl,amyA,and ammA genes with xynA(three copies).Notably,the xynA activity obtained by simultaneous insertion into three loci was 48.6%higher compared to that obtained by insertion into only the bgl ***,this multiple integration toolkit successfully enhanced the expression of endogenous pectinase pelA and

关键词： Multiplex integration Aspergillus niger CRISPR-Cas9 homologous direct repair White colony