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World Journal of Gastroenterology 2009年第7期15卷 860-864页

作者： Hong Cheng fu-lian hu Department of Gastroenterology Peking University First Hospital Beijing 100034 China

AIM： To compare the efficacy and side effect profiles of three furazolidone and amoxicillin-based quadruple rescue therapies for the eradication of Helicobacter pylori （H pylonS. METHODS： Patients who failed in the Hpylori eradication therapy for at least one course were randomly allocated into three groups. Group A received rebaprazole 10 mg＋ amoxicillin 1 g ＋ furazolidone 100 mg, and bismuth subcitrate 220 mg, twice daily for 1 wk; group B received the same regimen of group A but for 2 wk; and group C received the same regimen of group B, but furazolidone was replaced by furazolidone 100 mg three times daily. To record the side effect profiles at the end of the treatment, Hpylori eradication was assessed with 13C-urea breath test 4 wk after therapy. RESULTS： Sixty patients were enrolled including 28 males, and 20 patients in each group. The average age of the patients was 49.2 years, ranging from 18 to 84 years. H pylori eradication rates with per-protocol analysis were 82%, 89% and 90% in the three groups, respectively. Side effects were found in 11 patients, including mild dizziness, nausea, diarrhea and increased bowel movement. None of the 11 patients needed treatment for their side effects. CONCLUSION： One- or two-week furazolidone and amoxicillin-based quadruple rescue therapy with a low dose furazolidone （100 mg bid） for the eradication of Hpylori is effective. Extending the antibiotic course to 14 d could improve the eradication rates.

关键词： Helicobacter pylori Rescue therapy Quadruple therapy furazolidone Low dose

Interaction or relationship between Helicobacter pylori and non-steroidal anti-inflammatory drugs in upper gastrointestinal diseases

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World Journal of Gastroenterology 2006年第24期12卷 3789-3792页

作者： Kai-Yu Ji fu-lian hu Department of Internal Medicine and Gastroenterology Beijing United Family Hospital Beijing 100016 China Peking University First Hospital Beijing 100034China

According to a meta-analysis, H pylori and non-steroidal anti-inflammatory drugs （NSAID） independently and significantly increase the risk of gastroduodenal ulcer and ulcer bleeding. Their coincidence is frequent, demonstration of a possible relationship and consequent attitude is of important implications. But unfortunately, no consensus has been approved in the past years and their interactions are still controversial. H pylori and NSAID are known to share a number of pathogenic mechanisms, but there is no evidence for the significant synergic action between these two risk factors. Their relationship is independent, additive, synergistic or antagonistic without considering the influence of other factors because studies on this subject are different in almost all aspects of their methodology, including the definition of a NSAID user as well as the types, doses, duration and their indications for NSAID use, as well as their end-points, definition of dyspepsia and regimes used for eradication of H pylori. These might contribute to the conflicting results and opinions. H pylori infection in humans does not act synergistically with NSAID on ulcer healing, and there is no need to eradicate it. This notion is supported by the finding that the eradication of H pylori does not affect NSAID induced gastropathy treated with omeprazole and that H pylori infection induces a strong cyclooxygenase-2 （COX-2） expression resulting in excessive biosynthesis of gastroprotective prostaglandin which in turn counteracts NSAID-induced gastropathy and heals the existing ulcer. Other investigators claimed that H pylori infection acts synergistically with NSAID on ulcer development, and H pylori should be eradicated, particularly at the start of long-term NSAID therapy. Eradication of H pylori prior to NSAID treatment does not appear to accelerate ulcer healing or to prevent recurrent ulcers in NSAID users. However, some recommendations can be drawn from the results of clinical trails.

关键词： Hpylori Aspirin NSAIDs Peptic ulcerdisease Cyclooxygenase-2

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong hu Wenyi lian Kang hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

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北京地区消化性溃疡流行病学分析

世界华人消化杂志 2007年第33期15卷 3518-3523页

作者：成虹胡伏莲袁申元潘国宗北京大学第一医院消化内科北京市100034 北京同仁医院消化内科北京市100730 北京协和医院消化内科北京市100730

目的:了解北京地区消化性溃疡(pepticulcer,PU)的发病特点及变化情况,以及幽门螺杆菌(Helicobacter pylori)与PU的关系,以便为PU的防治工作提供理论依据.方法:研究对象为1999-01-01/12-31在北京29家不同等级医院接受胃镜检查的患者.对... 详细信息

目的:了解北京地区消化性溃疡(pepticulcer,PU)的发病特点及变化情况,以及幽门螺杆菌(Helicobacter pylori)与PU的关系,以便为PU的防治工作提供理论依据.方法:研究对象为1999-01-01/12-31在北京29家不同等级医院接受胃镜检查的患者.对其中经内镜下分期诊断为PU活动期及愈合期的患者采用问卷方式进行调查,调查内容主要包括PU患者的性别、年龄、血型、职业、生活习惯、服药情况以及H pylori感染情况.快速尿素酶试验、病理染色、^(13)C-尿素呼气试验和细菌培养检测H pylori感染,其中任一项检测阳性判断为H pylori感染.结果:采用回顾性研究方法,29家医院共有58546例北京地区患者接受了胃镜检查,PU检出率为13.83%.本次调查总共回收调查表3182份,DU:GU为2.81:***检出率以40-60岁患者中检出率(41.2%)最高,GU比DU者平均年龄大6.4岁.不同血型构成比之间有显著性差异(P=0.006),其中以O型血最多,吸烟者明显高于非吸烟者(P=0.012).在1999年有2992例PU患者接受了H pylori感染检测,感染率为54.9%,不同类型PU间H pylori感染率无显著性差异(P=0.72).2042例患者在首次诊断PU时接受了H pylori感染检测,其中1660例(81.3%)H pylori检测阳性.经Logistic回归分析显示PU的复发主要与不规范治疗及H pylori感染密切相关结论:北京地区PU检出率呈下降趋势,患者首次诊断PU时H pylori感染率明显高于自然人群感染率,但1999年度H pylori感染的检出率较低.年龄、O型血、吸烟和H pylori感染是PU发病的危险因素,PU的复发主要与不规范治疗及H pylori感染密切相关.

关键词：消化性溃疡流行病学幽门螺杆菌

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang JIANG Tian MAO Jin-Song WANG Xiu-Qing hu Xiao-Xin ZHANG Liping fu Nan JIA Tianfang WANG National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

温胃舒、养胃舒预防幽门螺杆菌培养上清液所致小鼠胃黏膜损伤

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世界华人消化杂志 2007年第13期15卷 1505-1509页

作者：牟方宏胡伏莲杨桂彬北京大学航天临床医学院消化科北京市100049 北京大学第一医院消化科北京市100034

目的:研究温胃舒、养胃舒对产毒幽门螺杆菌(Hpylori)浓缩培养上清液(concentrated culture supernatant,CCS)所致小鼠胃黏膜损伤的保护作用.方法:75只健康(?)BALB/c小鼠随机分成5组:生理盐水组(Ⅰ组)、单纯损伤组(Ⅱ组)、硫糖铝保护组(... 详细信息

目的:研究温胃舒、养胃舒对产毒幽门螺杆菌(Hpylori)浓缩培养上清液(concentrated culture supernatant,CCS)所致小鼠胃黏膜损伤的保护作用.方法:75只健康(?)BALB/c小鼠随机分成5组:生理盐水组(Ⅰ组)、单纯损伤组(Ⅱ组)、硫糖铝保护组(Ⅲ组)、温胃舒保护组(Ⅳ组)、养胃舒保护组(Ⅴ组).分别用生理盐水(Ⅰ、Ⅱ组)、硫糖铝(Ⅲ组)和温胃舒(Ⅳ组)及养胃舒Ⅴ组)提前给小鼠灌胃,然后用生理盐水(Ⅰ组)及产毒Hylori菌CCS灌胃(Ⅱ、Ⅲ、Ⅳ、Ⅴ组)灌胃,在光镜及电镜下观察胃黏膜组织学改变,分别测定各组胃黏膜上皮损伤积分(EDS),以评价胃黏膜损伤程度及药物的预防保护效果.结果:单纯损伤组在组织病理和超微结构水平产生明显损害,保护组胃黏膜损害较单纯损伤组明显减轻.Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ组的胃黏膜EDS依次为1.18±0.31,2.47±0.58,1.72±0.73,1.61±0.73,1.56±0.67.单纯损伤组胃黏膜EDS明显高于生理盐水对照组(P0.05).结论:温胃舒、养胃舒对Hylori培养上清液所致的小鼠胃黏膜损伤有明显的预防和保护作用.

关键词：胃黏膜细胞保护幽门螺杆菌温胃舒养胃舒

非甾体抗炎药与结直肠息肉的关系:系统回顾与Meta分析

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世界华人消化杂志 2008年第24期16卷 2724-2733页

作者：王蔚虹刘芳勋王静胡伏莲北京大学第一医院消化内科北京市100034

目的:对已发表的文献进行系统回顾,评价服用非甾体抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)与结肠息肉危险性的关系.方法:检索1966/2007-12数据库PubMed,EMBASE,Cancerlit,ISI以及Cochrane Collaboration controlled trials register收录的文献.若研究的临床和方法学合理,则以随机效应模型统计OR值和95%CI.对研究设计方法、研究人群、药物种类、服用NSAIDs的频率和疗程进行亚组分析.结果:共纳入39篇文献.其中17篇为随机对照临床试验,12篇为病例对照研究,10篇队列研究.NSAIDs显著降低散发性结直肠息肉的发生或复发,随机对照临床试验OR为0.63(95%CI:0.53-0.75,P=0.37),病例对照研究OR值为0.70(95%CI:0.61-0.80,P=0.02),队列研究OR值为0.86(95%CI:0.77-0.96,P=0.02).NSAIDs减少家族性腺瘤型息肉病(FAP)患者息肉的数量和大小.分层分析显示,阿司匹林和其他NSAIDs降低结肠息肉危险性的作用相似,并存在剂量依赖性.结论:NSAIDs减少结直肠息肉的危险性,还需临床研究进一步确定在特殊人群中预防性使用NSAIDs的最佳剂量和疗程.

关键词：非甾体抗炎药结直肠息肉荟萃分析

阿司匹林提高幽门螺杆菌对克拉霉素敏感性的机制

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世界华人消化杂志 2008年第18期16卷 1990-1996页

作者：张孝平王蔚虹田雨高文胡伏莲李江北京大学第一医院消化内科北京市100034

目的:探讨阿司匹林提高幽门螺杆菌(H pylori)对克拉霉素敏感性的机制.方法:二氧化硅法提取细菌基因组DNA,限制性片段长度多态性(PCR-RFLP)检测阿司匹林处理前后23SrRNA突变位点的变化.液体闪烁计数法与SDS-PAGE电泳法分别测定阿司匹林... 详细信息

目的:探讨阿司匹林提高幽门螺杆菌(H pylori)对克拉霉素敏感性的机制.方法:二氧化硅法提取细菌基因组DNA,限制性片段长度多态性(PCR-RFLP)检测阿司匹林处理前后23SrRNA突变位点的变化.液体闪烁计数法与SDS-PAGE电泳法分别测定阿司匹林处理前后H pylori胞内[7-3H]四环素的放射活性和外膜蛋白的变化.实时定量PCR(Taqman探针法)测定编码H pylori孔蛋白基因(hopA、hopB、hopC、hopD和hopE)及外流泵蛋白基因(hefA、hefB和hefC)的变化.结果:阿司匹林不改变H pylori克拉霉素耐药菌株23SrRNA基因的2143A-G突变位点,其增加H pylori胞内放射活性.阿司匹林处理后H pylori外膜蛋白在分子量55-72kDa之间有两条带表达改变,其不改变H pylori孔蛋白基因hopA、hopB、hopC、hopD、hopE及外流泵蛋白基因hefA、hefB、hefC的mRNA水平.结论:阿司匹林可能通过改变H pylori外膜蛋白的表达,提高H pylori外膜对抗生素的通透性,增加H pylori胞体内抗生素浓度.

关键词：幽门螺杆菌阿司匹林克拉霉素实时定量PCR

安速快速检测试剂盒诊断幽门螺杆菌的现症感染

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世界华人消化杂志 2007年第23期15卷 2545-2548页

作者：杨桂彬魏红胡伏莲牟方宏崔梅花北京大学航天临床医学院消化科北京市100049 北京大学第一医院消化科北京市100034

目的:评价安速幽门螺杆菌(H pylori)快速检测卡诊断H pylori现症感染的敏感性及特异性.方法:对154例因上消化道症状进行胃镜检查的患者同时进行快速尿素酶试验及Warthin- Starry银染,同时取指血进行安速快速检测试剂盒检测.以快速尿素... 详细信息

目的:评价安速幽门螺杆菌(H pylori)快速检测卡诊断H pylori现症感染的敏感性及特异性.方法:对154例因上消化道症状进行胃镜检查的患者同时进行快速尿素酶试验及Warthin- Starry银染,同时取指血进行安速快速检测试剂盒检测.以快速尿素酶试验和Warthin-Starry银染同时阳性或阴性作为诊断是否H pylori感染的金标准.结果:和金标准相比较,安速快速检测试剂盒敏感性为92.0%(81/88),特异性为94.0%(47/50).准确率为92.8%(128/138);与RUT相比安速快速检测试剂盒敏感性为89.7%(87/97),特异性为91.2%(52/57),准确性为90.3%(139/154).结论:安速快速检测试剂盒在没有进行根除治疗的患者中能够较好的反应现症感染的情况.临床可用于H pylori现症感染的诊断.

关键词：幽门螺杆菌血清学诊断

泮托拉唑四联5d疗法与7d疗法随机对照研究

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世界华人消化杂志 2007年第30期15卷 3241-3244页

作者：魏红杨桂彬胡伏莲牟方宏崔梅花北京大学航天临床医学院消化科北京市100049 北京大学第一医院消化科北京市100034

目的:比较泮妥拉唑四联5d疗法和7d疗法的Hpylori根除率和症状缓解率.方法:H pylori阳性的胃炎、胃溃疡或十二指肠患者70例随机接受5d(34例)或7d(36例)泮妥拉唑四联疗法:泮妥拉唑40mg、克拉霉素250mg、阿莫西林1.0g和胶体枸橼酸铋钾220 ... 详细信息

目的:比较泮妥拉唑四联5d疗法和7d疗法的Hpylori根除率和症状缓解率.方法:H pylori阳性的胃炎、胃溃疡或十二指肠患者70例随机接受5d(34例)或7d(36例)泮妥拉唑四联疗法:泮妥拉唑40mg、克拉霉素250mg、阿莫西林1.0g和胶体枸橼酸铋钾220 mg,均为2次/d.根除治疗后第4周复查H pylori是否根除,了解症状缓解情况.结果:5d组H pylori根除率为84.8%(PP)和82.4%(ITT),7d组H pylori根除率为88.2%(PP)和83.3%(ITT),5d组疼痛缓解率为72.0%(PP)和69.2%(ITT),7d组疼痛缓解率为83.9%(ITT)和89.7%(PP).按PP及ITT组群分析,两组方案H pylori根除率及疼痛缓解率无明显差异,两组患者均未出现严重不良反应.结论:泮妥拉唑四联5d疗法可以获得较高的H pylori根除率和疼痛缓解率,可以作为H pylori根除治疗的一线治疗方案.

关键词：幽门螺杆菌四联疗法泮妥拉唑根除率症状缓解率