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天津理工学院学报 2001年第4期17卷 57-59页

作者：李静柴富俊赵洁天津理工学院基础教育学院天津300400

以多媒体技术为支持 ,将练习、考评、辅导等功能集于一体 ,开发设计工程制图课程的多功能教学软件 ,以解决教师批改作业量大、反馈周期长、辅导内容限于实际情况的限制难于深入展开等问题。

关键词：题库考评辅导多媒体软件 CAI课件工程制图多功能教学软件中发设计

头痛飞行人员情绪情感状态与心理健康状况的调查

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中国行为医学科学 2008年第4期17卷 351-352页

作者：付兆君徐先荣刘晶崔丽郑军徐蜀宣熊巍中国人民解放军空军总医院空勤科北京100036

目的调查头痛飞行人员情绪情感状态、心理健康状况。方法对因患有头痛住院治疗的飞行人员及来院改装体检的飞行人员进行问卷调查，调查项目包括情绪情感状态自评量表及症状自评量表。结果头痛组飞行人员的消极的情绪情感状态因子紧张-焦... 详细信息

目的调查头痛飞行人员情绪情感状态、心理健康状况。方法对因患有头痛住院治疗的飞行人员及来院改装体检的飞行人员进行问卷调查，调查项目包括情绪情感状态自评量表及症状自评量表。结果头痛组飞行人员的消极的情绪情感状态因子紧张-焦虑[头痛组与对照组分别为（19．65±6．09）分，（6．83±4．00）分]、忧郁．沮丧[分别为（30．06±13．18）分，（6．89±6．26）分]、愤怒-敌意[分别为（20．71±10．44）分，（6．22±4．56）分]、疲惫-惰性[分别为（16．00±5．40）分，（4．00±2．95）分]、困惑-迷茫[分别为（14．71±5．11）分，（4．00±2．35）分]评分均显著高于对照组（均P〈0．01），有力-好动[分别为（8．76±5．85）分，（20．94±4．29）分]评分则显著低于对照组（P〈0．01）。头痛组飞行人员的症状自评量表各项因子分均显著高于睡眠正常组及中国男军人常模（均P〈0．01）。结论头痛飞行人员情绪情感状态及心理健康状况下降。

关键词：头痛飞行人员情绪情感状态心理健康

不同类型学业压力对不同年级高中生执行功能子成分的影响

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心理学报 2025年第1期57卷 18-35页

作者：马超汪彦云付军军赵鑫甘肃省行为与心理健康重点实验室西北师范大学心理学院兰州730070

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交... 详细信息

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交压力对各执行功能成分的负向预测作用逐渐减弱。相比之下,自我压力对高中生的干扰抑制、反应抑制和注意转换能力均显示出了正向预测作用,并随年级的升高而增强。这表明,不同类型学业压力对各执行功能成分的预测作用存在差异,并将随高中生年级的升高而发生变化。本研究所产生的结论对于教育工作者有效制定高中生学业压力应对策略具有重要的启示意义。

关键词：执行功能学业压力高中生结构方程模型

维普期刊数据库博看期刊

飞行员强直性脊柱炎3例临床分析及航空医学鉴定

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解放军医学院学报 2013年第9期34卷 928-930页

作者：熊巍付兆君徐先荣刘晶崔丽空军总医院全军临床航空医学中心北京100142

摘要：目的探讨飞行员强直性脊柱炎的临床诊治及航空医学鉴定原则。方法分析我院2009—2012年诊断为强直性脊柱炎的3例飞行员的临床诊治及航空医学鉴定过程，复习国内外相关文献，提出飞行员强直性脊柱炎的航空医学鉴定原则。结果3例飞... 详细信息

摘要：目的探讨飞行员强直性脊柱炎的临床诊治及航空医学鉴定原则。方法分析我院2009—2012年诊断为强直性脊柱炎的3例飞行员的临床诊治及航空医学鉴定过程，复习国内外相关文献，提出飞行员强直性脊柱炎的航空医学鉴定原则。结果3例飞行员均因长期反复腰背部疼痛人院，病史8个月一5年，疼痛于夜间明显，有晨僵现象，活动后好转。实验室检查示血清HLA—B27阳性，血沉及C反应蛋白正常。骶髂关节x线片及骶髂关节cT均提示骶髂关节炎性改变f1例Ⅱ级，2例Ⅲ级）。根据1984纽约标准，均诊断为强直性脊柱炎，给予口服非甾体类抗炎药物及柳氮磺胺吡啶片等治疗。3例均在治疗后症状明显改善，半年至1年后复查X线片提示病情无明显进展。飞行结论：1例运输机飞行员于确诊半年后停飞。1例歼击教练机飞行员于确诊1年后、1例歼击机飞行员于确诊半年后给予飞行合格结论。结论患强直性脊柱炎的飞行人员，早期诊断及早期治疗十分重要，其飞行结论应根据病情轻重、治疗效果、飞行机种、飞行职务、个人意愿等综合评定，特许飞行的患者需要密切随访。

关键词：强直性脊柱炎航空医学合格鉴定

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang jun-zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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Effects of thiocyanate anions on switching and structure of poly(N-isopropylacrylamide) brushes

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Chinese Physics B 2019年第6期28卷 262-269页

作者： Xin-jun zhao Zhi-fu Gao Xinjiang Laboratory of Phase Transitions and Microstructures of Condensed Matter Physics Yili Normal UniversityYining 835000China Laboratory of Micro-Nano Electro Biosensors and Bionic Devices Yili Normal UniversityYining 835000China Xinjiang Astronomical Observatory Chinese Academy of Sciences150Science 1-StreetUrumqi 830011China

In this work, we investigate the effects of thiocyanate anions on the switching and the structure of poly(Nisopropylacrylamide)(PNIPAM) brushes using a molecular theory. Our model takes into consideration the PNIPAM–anion bonds, the electrostatic effects and their explicit coupling to the PNIPAM conformations. It is found that at low thiocyanate anion concentration, as the anion concentration of thiocyanate increases, thiocyanate anions are more associated with PNIPAM chains through the PNIPAM–anion bonds, which contributes to stronger electrostatic repulsion and leads to an increase of lower critical solution temperature(LCST). By analyzing the average volume fractions of PNIPAM brushes,it is found that the PNIPAM brush presents a plateau structure. Our results show that the thiocyanate anions promote phase segregation due to the PNIPAM–anion bonds and the electrostatic effect. According to our model, the reduction of LCST can be explained as follows: at high thiocyanate anion concentration, with the increase of thiocyanate concentration, more ion bindings occurring between thiocyanate anions and PNIPAM chains will result in the increase of the hydrophobicity of PNIPAM chains;when the increase of electrostatic repulsion is insufficient to overcome the hydrophobic interaction of PNIPAM chains, it will lead to the reduction of brush height and LCST at high thiocyanate anion concentration. Our theoretical results are consistent with the experimental observations, and provide a fundamental understanding of the effects of thiocyanate on the LCST of PNIPAM brushes.

关键词： molecular theory PNIPAM brushes effect of thiocyanate anions

Water quality forecast through application of BP neural network at Yuqiao reservoir

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1482-1487页

作者： zhao Ying NAN jun CUI fu-yi GUO Liang School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China

This paper deals with the study of a water quality forecast model through application of BP neural network technique and GUI (Graphical User Interfaces) function of MATLAB at Yuqiao reservoir in Tianjin. To overcome the shortcomings of traditional BP algorithm as being slow to converge and easy to reach extreme minimum value,the model adopts LM (Leven-berg-Marquardt) algorithm to achieve a higher speed and a lower error rate. When factors affecting the study object are identified,the reservoir's 2005 measured values are used as sample data to test the model. The number of neurons and the type of transfer functions in the hidden layer of the neural network are changed from time to time to achieve the best forecast results. Through simulation testing the model shows high efficiency in forecasting the water quality of the reservoir.

关键词： Water quality forecast BP neural network MATLAB Graphical User Interfaces (GUI)

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor