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Calibration of the Solar X-ray Detector on-board the Macao Science Satellite-1B for Soft X-ray Detection

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Science China Earth Sciences 2025年第1期68卷 11-26页

作者： Man-Hei NG Xiaoping zhang jianwu CHEN Yongqiang SHI fuchang ZUO Wenxi PENG Weichun fu Liansheng LI Pengwei LUO Chi-Long TANG Guozheng zhang Zhiwu MEI Li WANG Cunhui LI jiaming OU Yanyan XU State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology China National Space Administration (CNSA) Macau Center for Space Exploration and Science Space Optoelectronic Measurement and Perception Laboratory Beijing Institute of Control Engineering Institute of High Energy Physics Chinese Academy of Sciences Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of Physics

The Solar X-ray Detector(SXD) on-board the Macao Science Satellite-1B(MSS-1B) was successfully launched via the Chinese Long March-2C rocket on 21 May 2023, and commenced operations in early June of the same year. The MSS-1B/Soft X-ray Detection Units(SXDUs) employ two silicon drift detectors(SDDs), providing a wide range of energy spectra spanning from 0.7 to 24 keV. Notably, the SXDUs deliver a high-resolution capability of 0.14 keV@5.9 keV and operate with a time cadence of 1 second. Here, we perform thorough calibrations of the MSS-1B/SXDUs, employing a combination of ground experiments and simulations. In addition, quantitative analysis comparing the flux measurements obtained by the MSS-1B/SXDUs to the data collected by the Geostationary Operational Environmental Satellite(GOES), provides compelling evidence of their consistency. furthermore, the preliminary spectral analysis results showcase the robustness and expected performance of the MSS-1B/SXDUs, unlocking their potential for facilitating the study of dynamic evolution of solar flares. Moreover, the innovative MSS-1B/Solar X-ray Detector facilitates concurrent observations of solar soft and hard X-rays, thereby making valuable contributions to the advancements in solar research.

关键词： Macao Science Satellite-1B (MSS-1B) Calibration Solar X-Ray Detector Spectrometer Soft X-rays Solar flares Solar abundances

Development of a general circumferentially nonuniform heat transfer fuel rod model for subchannel analysis and application to helical fuel rods

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Science China Technological Sciences 2025年

作者： Junsen fu Junlong LI Xiaowen WANG Qi zhang Yao XIAO Hanyang GU School of Mechanical Engineering Shanghai Jiao Tong University Key Laboratory of Nuclear Power Systems and Equipment of the Ministry of Education Shanghai Jiao Tong University National Key Laboratory of Nuclear Reactor Technology Nuclear Power Institute of China State Key Laboratory of Nuclear Power Safety Technology and Equipment Shanghai Jiao Tong University

The subchannel analysis method is one of the most crucial transient safety analysis methods in the thermal design of nuclear reactors. The nonuniformity of circumferential heat transfer is slight in conventional pressurized water reactor (PWR)cores, but it is significant in advanced reactors with wire-wrapped or helical fuel rods. Predicting circumferentially nonuniform heat transfer behavior can be challenging owing to the complex geometry of helical fuel rods. In this study, a general circumferentially nonuniform heat transfer fuel rod (GCNF) model is developed to predict the fuel central temperature and circumferential heat flux and wall temperature. This model incorporates a refined two-dimensional fuel conduction model and circumferential nonuniform shape factor, addressing the dual factors contributing to the circumferential nonuniformity of helical fuel rods. An empirical correlation for the nonuniform shape factor is developed based on the computational fluid dynamics (CFD) results, and it is implemented to the subchannel code. The newly developed model is applied to a helical fuel annulus and validated by comparing the prediction results with CFD data. The maximum wall temperature predicted by the code is 1.15°C lower than the value calculated through CFD. In terms of the heat flux, the maximum value at the inner corner is22 kW lower than that obtained from the CFD prediction. The accurate prediction of circumferentially nonuniform heat transfer in helical fuel, concerning the surface heat flux and cladding temperature, addresses existing shortcomings in helical fuel subchannel analysis methods. Additionally, the capability to predict the fuel central temperature is essential for the safety analysis to determine whether fuel rods are melting. The generality of the model framework allows it to be used for the prediction of circumferential nonuniform heat transfer behavior in other types of fuel assemblies.

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A self-adaptive inorganic in-situ separator by particle crosslinking for nonflammable lithium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 469-480页

作者： jiarui Yang jiuzhou Liu Wenrui Cai Ziyu Zhao Shan Wang Lu He Shanshan Lv Zhiwei Zhu Zhongfeng ji Guojiang Wen Hua Li Yuanming Zhai Xuewei fu Wei Yang Yu Wang College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University

All-safe liquid-state lithium-ion batteries(ASLS-LIBs) is of great interest as they can potentially combine the safety of all-solid-state batteries with the high performance and low manufacturing cost of traditional liquid-state LIBs. However, the practical success of ASLS-LIBs is bottlenecked by the lack of advanced separator technology that can simultaneously realize high performances in puncturing-tolerability,fire-resistance, and importantly, wetting-capability with non-flammable liquid-electrolytes. Here, we propose a concept of inorganic in-situ separator(IISS) by hybrid-sol physical crosslinking directly onto the electrode surface to address the above challenges. Particularly, the hybrid-sol is designed with silica nanoparticles as the building block and poly(vinylidene difluoride) nanoparticles as the crosslinking agent. The critical factors for controlling the IISS microstructures and properties have been systematically investigated. The advantages of the IISS have been confirmed by its fast wetting with various fireresistant liquid-electrolytes, customizable thickness and porous structures, robust interface with planar or three-dimensional(3D)-structured electrodes, and importantly, unexpected self-adaptability against puncturing. Enabled by the above merits, a fire-resistant ASLS-LIB is successfully assembled and demonstrated with stable electrochemical performance. This sol-crosslinked IISS may open an avenue for the studies on the next-generation separator technology, cell assembling, solid electrolyte processing as well as non-flammable secondary batteries.

关键词： Silica nanoparticles

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting zhang Yanlin fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao jianjian Chu Tinglin zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo ji jianhua Zhuang Yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

基于前景理论的网络谣言监管三方演化博弈分析

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情报科学 2018年第10期36卷 84-88页

作者：张金华陈福集张金鑫福州大学经济与管理学院福建福州350108 湖北大学商学院湖北武汉430062

【目的/意义】加强网络谣言监管,有助于净化网络空间,维护社会稳定和谐。【方法/过程】将前景理论引入网络谣言监管三方演化博弈分析过程,构建有别于传统收益矩阵的收益感知矩阵。运用复制动态方程分析造谣者、网络平台运营商和政府三... 详细信息

【目的/意义】加强网络谣言监管,有助于净化网络空间,维护社会稳定和谐。【方法/过程】将前景理论引入网络谣言监管三方演化博弈分析过程,构建有别于传统收益矩阵的收益感知矩阵。运用复制动态方程分析造谣者、网络平台运营商和政府三方博弈策略选择。【结果/结论】该模型不存在稳定演化策略,结合博弈模型和网络谣言监管实际,为网络谣言的监管提出对策建议。

关键词：前景理论演化博弈网络谣言三方博弈

Synthetic control of chiral pore surfaces in covalent organic frameworks for enantioselective separation of chiral drugs

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Science China Chemistry 2025年

作者： Shiguo fu Xiaofeng zhang Kaixuan Wang Linfeng Chen Fan Xia Yong Cui Yan Liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Faculty of Materials Science and Chemistry China University of Geosciences

Enantioselective separations of racemates using porous materials are highly attractive and significant in both fundamental research and technological applications. However, achieving controlled chiral pore surfaces to create the necessary driving force for enantiomer discrimination poses a fundamental challenge. Herein, we demonstrate that chiral covalent organic frameworks(COFs) possess the essential characteristics for effective enantioseparations through synthetic control over pore surfaces. We synthesized three 3D chiral COFs (CCOFs) featuring abundant chiral recognition sites on the pore walls via the condensation of enantiopure dialdehyde of 2,2′-dihydroxy-1,1′-binaphthyl and tetraamine. All CCOFs with high stability exhibit an 11-fold interpenetrated framework with tubular open channels, decorated with dihydroxyl or diethoxyl groups. The CCOFs with dihydroxyl groups serve as solid adsorbents for the adsorptive separation and solid-phase extraction of various chiral 1-phenylethanol-derived enantiomers, particularly racemic drugs, achieving up to 98%enantiomeric excess. In contrast, the CCOF with diethoxy groups is unable to resolve the racemates. These CCOF materials can be recycled and reused without any apparent loss of performance. Density functional theory (DFT) calculations reveal that the enantiospecific recognition arises from the well-organized chiral inner sphere and multiple chiral host-guest interactions.

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施氮量对滴灌高产春大豆根系生长及产量的影响

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干旱地区农业研究 2018年第4期36卷 46-52页

作者：高阳楚光红傅积海张艳伟章建新新疆农业大学农学院新疆乌鲁木齐830052

为揭示施氮量对滴灌高产春大豆根系生长及产量的影响规律,在田间滴灌条件下采用挖掘取样法研究了0 kg·hm^(-2)(N_0)、75 kg·hm^(-2)(N_(75))、150 kg·hm^(-2)(N_(150))、225 kg·hm^(-2)(N_(225))4种施氮量对新大豆27号0~80 cm土层... 详细信息

为揭示施氮量对滴灌高产春大豆根系生长及产量的影响规律,在田间滴灌条件下采用挖掘取样法研究了0 kg·hm^(-2)(N_0)、75 kg·hm^(-2)(N_(75))、150 kg·hm^(-2)(N_(150))、225 kg·hm^(-2)(N_(225))4种施氮量对新大豆27号0~80 cm土层根系干物质量、侧根长度、表面积、根系活性、伤流量、根瘤数、根瘤质量及产量的影响。结果表明:随着施氮量的增加,0~80 cm土层根系总干物质量、侧根总长度、侧根总表面积呈现先增后降的变化趋势,均以N_(150)处理最高,在R_5(始粒期)期分别较N_0增加27.3%、49.46%、38.14%,其中,0~20 cm土层分别较N_0增加27.0%、29.02%、34.24%;R_5期N_(150)单株伤流量较N_0增加176.0%,R_2(盛花期)期0~20、20~40 cm土层根系活力N_(150)分别较N_0增加44.3%、25.1%;R_5期N_(150)单位面积根瘤数及质量分别较N_0减少8.74%、34.6%;施氮可增加产量,以N_(150)产量最高,为4 889.62kg·hm^(-2),氮肥农学利用效率3.58 kg·kg^(-1)。施氮增加产量主要是促进0~20 cm土层根系生长,提高0~40 cm根系活力的结果。

关键词：大豆施氮量根系生长滴灌产量

闭袢靶控输注用于ICU病人镇静及对氧耗的影响

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复旦学报（医学版） 2004年第5期31卷 484-487页

作者：嵇富海张光明诸杜明梁雅芬薛张刚蒋豪复旦大学附属中山医院麻醉科上海200032

目的　观察以脑电双频指数 (BIS)作为反馈控制信号的闭袢靶控输注 (CLTCI)异丙酚和咪唑安定的镇静效果、及对氧耗 (V·O2 )的影响。方法　 32例机械通气的病人 ,随机分为两组 :异丙酚组 (P组 )和咪唑安定组 (M组 ) ,每组 16例 ,P组以BI... 详细信息

目的　观察以脑电双频指数 (BIS)作为反馈控制信号的闭袢靶控输注 (CLTCI)异丙酚和咪唑安定的镇静效果、及对氧耗 (V·O2 )的影响。方法　 32例机械通气的病人 ,随机分为两组 :异丙酚组 (P组 )和咪唑安定组 (M组 ) ,每组 16例 ,P组以BIS作为反馈信号的CLTCI异丙酚进行镇静 ,M组采用CLTCI咪唑安定进行镇静。连续监测血压、心率、呼吸、脉搏血氧饱和度、V·O2 的变化 ,记录BIS、Ramsay评分、诱导时间及异丙酚、咪唑安定诱导剂量、总用量、苏醒时间及不良反应 ,并评价CLTCI系统的性能。结果　完全苏醒时间P组明显短于M组 (P 0 .0 5 % )。结论　以BIS作为反馈控制信号的CLTCI异丙酚和咪唑安定技术用于ICU病人镇静 ,其效果可靠、性能稳定、除可降低氧耗外。

关键词：镇静咪唑安定异丙酚氧耗 ICU病人靶控输注 BIS 性能稳定降低可靠