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Leukocyte cell-derived chemotaxin 2(LECT2)regulates liver ischemia-reperfusion injury

Liver Research 2024年第3期8卷 165-171页

作者： Meng-Qi Dong Yuan Xie Zhi-Liang Tang Xue-Wen Zhao fu-zhen lin Guang-Yu Zhang Zhi-Hao Huang Zhi-Min Liu Yuan lin Feng-Yong Liu Wei-Jie Zhou State Key Laboratory of Organ Failure Research Department of General SurgeryGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal TumorNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Hepato-Biliary-Pancreatic and Hernia Surgery The First People's Hospital of ZhaoqingZhaoqingGuangdongChina Department of Interventional Radiology Senior Department of OncologyFifth Medical Center of PLA General HospitalBeijingChina

Background and aim Hepatic ischemia–reperfusion injury(IRI)is a significant challenge in liver transplantation,trauma,hypovolemic shock,and hepatectomy,with limited effective interventions *** study aimed to investigate the role of leukocyte cell-derived chemotaxin 2(LECT2)in hepatic IRI and assess the therapeutic potential of Lect2-short hairpin RNA(shRNA)delivered through adeno-associated virus(AAV)*** and methods This study analyzed human liver and serum samples from five patients undergoing the Pringle ***2-knockout and C57BL/6J mice were *** IRI was induced by clamping the hepatic *** included recombinant human LECT2(rLECT2)and ***2 expression levels and serum biomarkers including alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine,and blood urea nitrogen(BUN)were *** analysis of liver necrosis and quantitative reverse-transcription polymerase chain reaction were *** Serum and liver LECT2 levels were elevated during hepatic *** LECT2 protein and mRNA levels increased post ***2-knockout mice had reduced weight loss;hepatic necrosis;and serum ALT,AST,creatinine,and BUN ***2 treatment exacerbated weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN).AAV-Lect2-shRNA treatment significantly reduced weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN),indicating therapeutic *** Elevated LECT2 levels during hepatic IRI increased liver *** knockout or shRNA-mediated knockdown of Lect2 reduced liver damage,indicating its therapeutic ***-mediated Lect2-shRNA delivery mitigated hepatic IRI,offering a potential new treatment strategy to enhance clinical outcomes for patients undergoing liver-related surgeries or trauma.

关键词： Hepatic ischemia-reperfusion injury(IRI) Leukocyte cell-derived chemotaxin 2 (LECT2) Adeno-associated virus(AAV)

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Controlling reversible complexation-mediated polymerization(RCMP)via deep eutectic solvents:fast kinetics,narrow molecular weight distribution and mechanistic insights

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Science China Chemistry 2024年第8期67卷 2728-2736页

作者： Xin fu zhen Lu Shen Li zheng-Hong Luo lin-Xi Hou Department of Materials-Oriented Chemical Engineering College of Chemical EngineeringFuzhou UniversityFuzhou 350116China Department of Chemical Engineering School of Chemistry and Chemical EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200030China Chemical Engineering Zhicheng College of Fuzhou UniversityFuzhou 350116China Qingyuan Innovation Laboratory Quanzhou 362801China

The exploitation of new green polymerization avenues for the effective synthesis of polymers by reversible-deactivation radical polymerization plays a critical role in pursuing the development of polymeric *** this work,serials of deep eutectic solvents(DES)with intermolecular-hydrogen-bonding interaction were constructed as catalysts and medium for actuating reversible complexation-mediated polymerization(RCMP)for the first time,yielding methacrylate polymers with high monomer conversion and narrow dispersion molecular weight in both water and oil *** mechanism and elementary reaction of RCMP were explored deeply,revealing that the complexation of initiator with DES to generate radicals was a ratecontrolling step and intermolecular-hydrogen-bond was primary factor to influence polymerization ***,the insights of density functional theory calculations revealed that negative electrostatic potential ensured nucleophilic *** investigation demonstrated the considerable potential of DES for RCMP,which is anticipated for other polymerization applications as a novel medium mode.

关键词： deep eutectic solvent reversible complexation-mediated polymerization intermolecular hydrogen bonding density functional theory elementary reaction steps

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Optical edge-to-screw singularity state conversions

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Photonics Research 2024年第8期12卷 1689-1695页

作者： HAOlin lin JUNHUI JIA GUOHUA LIU YANWEN HU zhen LI zhenQIANG CHEN SHENHE fu Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Guangzhou 510632China Guangdong Provincial Engineering Research Center of Crystal and Laser Technology Guangzhou 510632China

Optical singularity states,which significantly affect propagation properties of light in free space or optical medium,can be geometrically classified into screw and edge *** different types of singularity states do not exhibit direct connection,being decoupled from each other in the absence of external *** we demonstrate a novel optical process in which a higher-order edge singularity state initially nested in the propagating Gaussian light field gradually involves into a screw singularity with a new-born topological charge determined by order of the edge *** considered edge state comprises an equal superposition of oppositely charged vortex and antivortex *** theoretically and experimentally realize this edge-to-screw conversion process by introducing intrinsic vortex–antivortex *** also present a geometrical representation for mapping this dynamical process,based on the higher-order orbital Poincaré*** this framework,the edge-to-screw conversion is explained by a mapping of state evolution from the equator to the north or south pole of the Poincaré*** demonstration provides a novel approach for manipulating singularity state by the intrinsic vortex–antivortex *** presented phenomenon can be also generalized to other wave systems such as matter wave,water wave,and acoustic wave.

关键词： interaction Poincaré wave

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Recent progress in self-propelled particles

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Journal of Hydrodynamics 2024年第1期36卷 61-77页

作者： zhen-yu Ouyang Jian-zhong lin Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo315201China Department of Mechanics State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou310027China

Self-propelled particles are commonly found in a large number of planktonic organisms such as bacteria,fungi,and algae in nature,and researchers have taken a long interest in exploring their swimming mechanisms for more than a *** in the past 20 years,with the development of computational fluid dynamics and flow display technology,as well as the need for the design of synthetic self-propelled particles and micro-swimming devices,self-propelled particles have become the forefront and hotspot of current research in the field of fluid *** paper first introduces the swimming characteristics of common self-propelled particles,leading to a classic“squirmer”type self-propelled particle *** this basis,a systematic introduction and summary of the theoretical and numerical simulation research of“squirmer”will be ***,the main challenges and opportunities faced by the current research will be summarized.

关键词： Self-propelled particles multiphase flow hydrodynamic interaction

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Accurate atomic scanning transmission electron microscopy analysis enabled by deep learning

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Nano Research 2024年第4期17卷 2971-2980页

作者： Tianshu Chu Lei Zhou Bowei Zhang fu-zhen Xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of Ministry of Education East China University of Science and TechnologyShanghai 200237China

Currently,the machine learning(ML)-based scanning transmission electron microscopy(STEM)analysis is limited in the simulative stage,its application in experimental STEM is needed but ***,we built up a universal model to analyze the vacancy defects and single atoms accurately and rapidly in experimental STEM images using a full convolution *** our model,the unavoidable interference factors of noise,aberration,and carbon contamination were fully considered during the training,which were difficult to be considered in the *** toward the simultaneous identification of various vacancy types and low-contrast single atoms in the low-quality STEM images,our model showed rapid process speed(45 images per second)and high accuracy(>95%).This work represents an improvement in experimental STEM image analysis by ML.

关键词： deep learning low-dimensional materials atomic defects single atoms

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Data-driven rational design of single-atom materials for hydrogen evolution and sensing

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Nano Research 2024年第4期17卷 3352-3358页

作者： Lei Zhou Pengfei Tian Bowei Zhang fu-zhen Xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of Ministry of Education East China University of Science and TechnologyShanghai 200237China

Herein we proposed a data-driven high-throughput principle to screen high-performance single-atom materials for hydrogen evolution reaction(HER)and hydrogen sensing by combing the theoretical computations and a topology-based multi-scale convolution kernel machine learning *** the rational training by 25 groups of data and prediction of all 168 groups of single-atom materials for HER and sensing,respectively,a high prediction accuracy(>0.931 R^(2) score)was achieved by our *** show that the promising HER catalysts include Pt atoms in C_(4) and Sc atoms in C_(1)N_(3) coordination ***,Y atoms in C_(4) coordination environment and Cd atoms in C_(2)N_(2)-ortho coordination environment were predicted with great potential as hydrogen sensing *** method provides a way to accelerate the discovery of innovative materials by avoiding the time-consuming empirical principles in experiments.

关键词： machine learning single-atom materials sensing hydrogen evolution

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A Survey on Distributed Network Localization from a Graph Laplacian Perspective

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Journal of Systems Science & Complexity 2024年第1期37卷 273-293页

作者： HAN Zhimin lin Zhiyun fu Minyue Artificial Intelligence Institute School of AutomationHangzhou Dianzi UniversityHangzhou 310018China Shenzhen Key Laboratory of Control Theory and Intelligent Systems School of System Design and Intelligent ManufacturingSouthern University of Science and TechnologyShenzhen 518055China Peng Cheng Laboratory Shenzhen 518000China

Network localization serves as a fundamental component for enabling various position based operations in multi-agent systems,facilitating tasks like target searching and formation control by providing accurate position information for all nodes in the *** localization focuses on the challenge of determining the positions of nodes within a network,relying on the known positions of anchor nodes and internode relative *** the past few decades,distributed network localization has garnered significant attention from *** paper aims to provide a review of main results and advancements in the field of distributed network localization,with a particular focus on the perspective of graph *** to its favorable characteristics,graph Laplacian unifies various network localization,even when dealing with diverse types of internode relative measurements,into a unified protocol framework,which can be constructed by a linear method and ensure the global convergence.

关键词： Distributed network localization graph Laplaian sensor network

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Quasi-periodically Forced Logistic Map with Weak Liouvillean Frequency

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2411-2435页

作者： Jin Hao LIANG lin lin fu Department of Applied Mathematics Nanjing Forestry University School of Mathematics and Statistics Shaoguan University

Consider a class of quasi-periodically forced logistic maps■whereωis an irrational frequency and c(θ) is a specific bimodal *** prove that under weak Liouvillean condition on frequency,the strange non-chaotic attra... 详细信息

关键词： 37C60 37C70 logistic map Lyapunov exponent Quasi-periodically forced strange non-chaotic attractor weak Liouvillean frequency

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Engineering high-performance dielectric chiral shells with enhanced chiral fields for sensitive chiral biosensor

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Rare Metals 2024年第3期43卷 1197-1206页

作者： Yi-Fan Wang Shan-Shan Huang zhen-Dong Dai Shi-lin Xian Xuan-Nan Wu fu-Hua Gao Yi-Dong Hou College of Physics Sichuan UniversityChengdu610065China Graduate School of Sichuan University Sichuan UniversityChengdu610065China

Chiral metamaterials have been a topic of significant research interest in recent years due to their potential for various applications in nanophotonic devices and chiral ***,the intrinsic Ohmic loss in surface plasmonic resonance has limited their practical use,resulting in large light dissipation and weak chiroptical ***,we report on the development of high-performance dielectric chiral shells(DCS)through a two-step Si deposition process on a self-assembled microsphere *** form DCS sample completely oyercomes the cancelation effect originated from the disorder property of the micro-sphere monolayer in macroscale,and at a wavelength of approximately 710 nm,the measured optimal chiral signal(g-factor)and transmittance can reach up to 0.7 and 0.3,*** strong chiroptical effect comes from the asymmetric circular displacement currents(i.e.,magnetic modes)enabled by the specific shell *** chiral shell geometry,electromagnetic properties,sensor sensitivity of chiral molecules and figure of merit are systematically *** DCSs demonstrate highly sensitive detection of chiral biomolecules owing to their easily accessible geometry and enhanced uniform chiral field.

关键词： Dielectric chiral shells(DCS) Si deposition Magnetic resonance Highly sensitive sensor Chiral field

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A New Industrial Intrusion Detection Method Based on CNN-BiLSTM

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Computers, Materials & Continua 2024年第6期79卷 4297-4318页

作者： Jun Wang Changfu Si zhen Wang Qiang fu College of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China

Nowadays,with the rapid development of industrial Internet technology,on the one hand,advanced industrial control systems(ICS)have improved industrial production ***,there are more and more cyber-attacks targeting industrial control *** ensure the security of industrial networks,intrusion detection systems have been widely used in industrial control systems,and deep neural networks have always been an effective method for identifying cyber *** intrusion detection methods still suffer from low accuracy and a high false alarm ***,it is important to build a more efficient intrusion detection *** paper proposes a hybrid deep learning intrusion detection method based on convolutional neural networks and bidirectional long short-term memory neural networks(CNN-BiLSTM).To address the issue of imbalanced data within the dataset and improve the model’s detection capabilities,the Synthetic Minority Over-sampling Technique-Edited Nearest Neighbors(SMOTE-ENN)algorithm is applied in the preprocessing *** algorithm is employed to generate synthetic instances for the minority class,simultaneously mitigating the impact of noise in the majority *** approach aims to create a more equitable distribution of classes,thereby enhancing the model’s ability to effectively identify patterns in both minority and majority *** the experimental phase,the detection performance of the method is verified using two data *** results show that the accuracy rate on the CICIDS-2017 data set reaches 97.7%.On the natural gas pipeline dataset collected by Lan Turnipseed from Mississippi State University in the United States,the accuracy rate also reaches 85.5%.

关键词： Intrusion detection convolutional neural network bidirectional long short-term memory neural network multi-head self-attention mechanism

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