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Dihydroartemisinin ameliorates innate inflammatory response induced by Streptococcus suis-derived muramidase-released protein via inactivation of TLR4-dependent NF-kB signaling

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1183-1194页

作者： yun ji Kaiji Sun Ying Yang Zhenlong Wu State Key Laboratory of Animal Nutrition and Feeding China Agricultural UniversityBeijing100193China Beijing Advanced Innovation Center for Food Nutrition and Human Health China Agricultural UniversityBeijing100193China

Muramidase-released protein(MRP)is now being recognized as a critical indicator of the virulence and pathogenicity of Streptococcus suis(***).However,the identification of viable therapeutics for *** infection was hindered by the absence of an explicit mechanism for MRP-actuated ***(DhA)is an artemisinin derivative with potential anti-inflammatory *** modulatory effect of DhA on the inflammatory response mediated by the virulence factor MRP remains *** research aimed to identify the signaling mechanism by which MRP triggers the innate immune response in mouse spleen and cultured *** the candidate mechanism in mind,we investigated DhA for its ability to dampen the pro-inflammatory response induced by *** innate immune response in mice was drastically triggered by MRP,manifesting as splenic and systemic inflammation with splenomegaly,immune cell infiltration,and an elevation in pro-inflammatory cytokines.A crucial role for Toll-like receptor 4(TLR4)in coordinating the MRP-mediated inflammatory response via nuclear factor-kappa B(NF-kB)activation was revealed by TLR4 *** addition,NFkB-dependent transducer and activator of transcription 3(STAT3)and mitogen-activated protein kinases(MAPKs)activation was required for the inflammatory signal transduction engendered by ***,we observed an alleviation effect of DhA on the MRP-induced immune response,which referred to the suppression of TLR4-mediated actuation of NF-kB-STAT3/MAPK *** inflammatory response elicited by MRP is relevant to TLR4-dependent NF-kB activation,followed by an increase in the activity of STAT3 or *** mitigates the inflammation process induced by MRP via blocking the TLR4 cascade,highlighting the therapeutic potential of DhA in targeting *** infection diseases.

关键词： Dihydroartemisinin Inflammation Muramidase-released protein Streptococcus suis Toll-like receptor 4

Lung stem cells in regeneration and tumorigenesis

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Journal of Genetics and Genomics 2021年第4期48卷 268-276页

作者： Yuting Chen yun Xue Yujuan jin Hongbin ji State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Pulmonary Hospital Tongji UniversityShanghai 200092China

Adult lung is a highly quiescent organ,with extremely low cell turnover ***,emerging evidences support the occurrence of repair and regeneration in pulmonary epithelia in response to various *** regeneration mainly depends on the proliferation of regionally distributed pulmonary stem cells that re-enter the cell *** lineage-tracing approaches help to track the lung epithelial differentiation and/or de-differentiation path,and single-cell transcriptomic technique reveals the essential molecular signaling involved in lung *** of the molecular signaling that balances quiescence and self-renewal leads to the transformation of lung stem cells,and thus promotes lung cancer ***,different subtypes of lung cancer share common cells of origin and the pathological transition among various subtypes is responsible for drug resistance in the *** this review,we summarize the recent understanding of lung stem cells in regeneration and tumorigenesis as well as related molecular mechanisms,with the hope to provide helpful insights for clinical treatments of respiratory diseases.

关键词： Lung stem cells Lung cancer Regeneration Tumorigenesis Pathological transition

Fabrication and properties of Al matrix composites strengthened by in situ alumina particulates

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Journal of University of Science and Technology Beijing 2006年第3期13卷 263-266页

作者： Gaofeng fu Lan jiang ji Liu Yue Wang School of Materials and Metallurgy Northeastern University Shenyang 110004 China

New aluminum matrix composites strengthened by Al2O3 particulates through stirring cast by adding NH4Al（SO4）2 to the molten aluminum have been fabricated. TEM observation shows that in-situ Al2O3 particulates are generally spherical and they are uniformly distributed in the Al matrix. Dry sliding wear test results show that the volume loss of the unreinforced Al matrix is about three times that of the Al2O3 reinforced metal matrix composite （MMC） and the volume loss of the MMC fabricated by adding Al2O3 is larger than that of the MMC by adding NH4Al（SO4）2. Lubricating sliding wear test results show that the volume loss of the MMCs increases more slowly than that of the matrix with the increasing of the load.

关键词： aluminum matrix composite alumina microstructure wear

Inverse Fluid-solid Interaction Scattering Problem Using Phased and Phaseless Far Field Data

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Acta Mathematicae Applicatae Sinica 2020年第1期36卷 74-94页

作者： Xia ji yun-fei jiA Xiao-dong LIU LSEC Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

We consider the inverse fluid-solid interaction scattering of incident plane wave from the knowledge of the phased and phaseless far field *** the phased data,one direct sampling method for location and shape reconstruction is *** inner product is involved in the computation,which makes it very simple and fast to be *** the help of the factorization of the far field operator,we give a lower bound of the proposed indicator functional for the sampling points inside the elastic *** for the sampling points outside,we show that the indicator functional decays like the Bessel function as the points go away from the boundaries of the elastic *** also show that the proposed indicator functional continuously dependents on the far field patterns,which further implies that the novel sampling method is extremely stable with respect to data *** the phaseless data,to overcome the translation invariance,we consider the scattering of point sources *** adding a reference sound-soft obstacle into the scattering system,we show some uniqueness results with phaseless far field ***,we introduce a phase retrieval algorithm to retrieve the phased data without the additional *** novel phase retrieval algorithm can also be combined with the sampling method for phased *** also design two novel direct sampling methods using the phaseless data ***,some numerical simulations in two dimensions are conducted with noisy data,and the results further verify the effectiveness and robustness of the proposed numerical methods.

关键词： fluid-solid interaction scattering direct sampling method far field pattern phaseless phase retrieval

Performance evaluation of a micro turbo-expander for application in low-temperature solar electricity generation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第3期12卷 207-213页

作者： Gang PEI yun-zhu LI jing LI jie ji Department of Thermal Science and Energy Engineering University of Science and Technology of China Hefei 230026 China

A micro turbo-expander capable of high working speed was specially manufactured for use in an organic Rankine cycle (ORC).A series of tests were executed to examine the performance of the *** the experiment,the machine was tested under different inlet pressure conditions (0.2-0.5 MPa).Data such as the compressed air pressure,temperatures of the inlet and the outlet,rotational speed,and electric power generation were analyzed to discover underlying *** the test,the rotational speed of the machine reached as high as 54 000 r/min,the peak value of the temperature drop between the inlet and the outlet reached 42 ℃,the maximum electric power generated by the motor-generator attached to the machine reached 630 W,and the efficiency of the machine reached 0.43.

关键词： Turbo-expander Solar Low-temperature Performance evaluation

Titanium nitrides as novel reactants for in-situ synthesis of TiB_(2)-based composites with improved properties

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Journal of Materials Science & Technology 2023年第14期145卷 48-55页

作者： ji Zou Huayue Liang jingjing Liu Weimin Wang Fan Zhang Wei ji Zhengyi fu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

A novel in-situ reactive approach based on the reactions among TiN,aluminum and boron has been developed to synthesize TiB_(2)-based composites including TiB_(2)-h BN(TB)and TiB_(2)-h BN-AlN(TBA).fully dense ceramics with fine-grained microstructure were successfully obtained via spark plasma sintering at 1850℃/60 MPa/5 *** analysis suggests h BN flakes were homogenously distributed in the TiB_(2)*** AlN,however,they were elongated into plate-like grains during sintering,in which lots of defects in terms of stacking faults and twinning structures were *** mechanical and thermophysical properties of as-sintered ceramics were comprehensively investigated and ***-corporating AlN significantly improved the flexure strength,hardness,fracture toughness and thermal conductivity of TiB_(2)-h BN *** electrical conductivity of TB(3.06×10^(6)S/m)is larger than that of TBA(2.35×10^(6)S/m)at room temperature,but the value(6×10^(5)S/m)was lower than that of TBA(6.9×10^(5)S/m)at 1173 *** on the measurement of electrical and thermal conductivity,electron and phonon contributions to thermal conductivities of TB and TBA were calculated and their temperature dependences were illustrated.

关键词： Borides Microstructure Spark plasma sintering Mechanical property Thermo-physics property

Uniform Regularity for the Isentropic Compressible Magnetohydrodynamic System

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 410-416页

作者： ji-shan FAN fu-cai LI GEN NAKAMURA Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037China Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics Hokkaido UniversitySapporo 060-0810Japan

In this paper we first establish the uniform regularity of smooth solutions with respect to the viscosity coefficients to the isentropic compressible magnetohydrodynamic system in a periodic domain T;.We then apply ou... 详细信息

关键词： isentropic compressible magnetohydrodynamic system uniform regularity

Mobius Homogeneous Hypersurfaces with One Simple Principal Curvature in S^n+1

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Acta Mathematica Sinica,English Series 2020年第9期36卷 1001-1013页

作者： Ya yun CHEN Xiu ji Tong Zhu LI Department of Mathematics Beijing Institute of TechnologyBeijing 100081P.R.China

Let Mob(S^n+1)denote the Mobius transformation group of S^n+1.A hypersurface f:N^n→S^n+1 is called a Mobius homogeneous hypersurface,if there exists a subgroup G■Mob^(S^n+1)such that the orbit G(p)={Ф(p)Ф∈G}=f(M^n).In this paper,we classify the Mobius homogeneous hypersurfaces in S^n+1 with at most one simple principal curvature up to a M?bius transformation.

关键词： Mobius transformation group isometric transformation group Mobius homogeneous hy-persurfaces homogeneous hypersurfaces

Effects of physical parameter range on dimensionless variable sensitivity in water flooding reservoirs

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Acta Mechanica Sinica 2006年第5期22卷 385-391页

作者： Yu Hu Bai jia Chun Li ji fu Zhou Division of Engineering Sciences Institute of MechanicsChinese Academy of Sciences Beijing 100080 China

The similarity criterion for water flooding reservoir flows is concerned with in the present paper. When finding out all the dimensionless variables governing this kind of flow, their physical meanings are subsequently elucidated. Then, a numerical approach of sensitivity analysis is adopted to quantify their corresponding dominance degree among the similarity parameters. In this way, we may finally identify major scaling law in different parameter range and demonstrate the respective effects of viscosity, permeability and injection rate.

关键词： Physical parameter range Dimensionless variable Sensitivity analysis Water flooding reservoir Two-phase flow in porous media