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Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

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Military Medical Research 2022年第1期9卷 53-62页

作者： Yi Wu Xian-Hui Wang Xi-Hua Lif Li-Yuan Song Shi-Long Yu Zhi-Cheng Fang Yu-Quan Liu Le-Yong Yuan Chun-Yan Peng Shen-Yi Zhang Wang Cheng Hong-Chao Ma Li-Feng Wang Jun-Ming Tang yun-fu Wang fu-yun ji Department of Medical Biology School of Basic Medical ScienceHubei University of MedicineShiyan 442000HubeiChina Institute of Biomedical Research Hubei University of MedicineShiyan 442000HubeiChina Institute of Human Respiratory Disease Xinqiao HospitalThe Army Medical University(Third Military Medical University)400037 ChongqingChina Department of Emergency Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina department of Geriatric Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina Department of Immunology School of Basic Medical SciencesHubei University of MedicineShiyan 442000HubeiChina department of Laboratory Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina Hubei Key Laboratory of Embryonic Stem Cell Research School of Basic Medical ScienceHubei University of MedicineShiyan 442000HubeiChina Department of Neurology Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina.

Background:Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and coronavirus disease 2019(COVID-19)***,it is unclear whether mitochondrial DNA(mtDNA)variants,which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production,are associated with COVID-19 ***:A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls(n=615)and COVID-19 patients(n=536).COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography *** exclusion criteria for the healthy controls were any history of disease in the month preceding the study *** variants defining mtDNA haplogroups were identified by PCR-RFLPs and HVS-I sequencing and determined based on mtDNA phylogenetic analysis using Mitomap ***’s t-test was used for continuous variables,and Pearson’s chi-squared test or Fisher’s exact test was used for categorical *** assess the independent effect of each mtDNA variant defining mtDNA haplogroups,multivariate logistic regression analyses were performed to calculate the odds ratios(OR)and 95%confidence intervals(CI)with adjustments for possible confounding factors of age,sex,smoking and diseases(including cardiopulmonary diseases,diabetes,obesity and hypertension)as determined through clinical and radiographic ***:Multivariate logistic regression analyses revealed that the most common investigated mtDNA variations(>10%in the control population)at C5178 a(in NADH dehydrogenase subunit 2 gene,ND2)and A249 d(in the displacement loop region,D-loop)/T6392 C(in cytochrome c oxidase I gene,CO1)/G10310 A(in ND3)were associated with a reduced risk of severe COVID-19(OR=0.590,95%CI 0.428–0.814,P=0.001;and OR=0.654,95%CI 0.45

关键词： Mitochondrial DNA variations Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Risk Han Chinese

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BARMR1-mediated sorafenib resistance is derived through stem-like property acquisition by activating integrin-FAK signaling pathways

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1623-1625页

作者： Xing Rong Guo Meng Ye Shan Yu Huang Zong Li Zhang Yue Yuan Long Jun Dai Jue Wang Xue Peng Zhou fu yun ji Jun Ming Tang Zhong ji Meng Xu Zhi Ruan Hubei Key Laboratory of Embryonic Stem Cell Research Taihe HospitalHubei University of Medicine442000 ShiyanHubeiChina College of Basic Medicine Hubei University of Medicine442000 ShiyanHubeiChina jiangsu Hengrui Medicine Co.Ltd LianyungangChina Department of Neurosurgery Taihe HospitalHubei University of MedicineShiyanChina Department of Surgery University of British ColumbiaVancouverBCCanada Hepatobiliary and Pancreatic Surgery Diagnosis and Treatment Center Taihe HospitalHubei University of MedicineShiyanChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Infectious Diseases Taihe HospitalHubei University of MedicineShiyanChina

Dear Editor,BARMR1(alternatively named FAM92A1 or FAM92A)gene was first identified in 2002 and is a highly conserved gene and widely expressed in most tissues in mammals.1 We first cloned the complete CDS sequence of BARMR1 in 2007,2 which encodes a protein with a Bin-Amphiphysin-Rvs(BAR)*** proteins are known to bind onto lipid membrane surface and generate membrane curvature and have been demonstrated to play diverse roles in cell growth,inflammation and cell migration.

关键词： inflammation property resistance

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The serum ACE levels,not theⅠallele of ACE gene,are associated with high altitude adaptation of native Tibetan population

The serum ACE levels,not theⅠallele of ACE gene,are associa...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： fu-yun ji,fu-Xiang LI,Chang-Zheng WANG,Yan CHEN,Gui-Sheng QIAN~* Institute of Human Respiratory Disease in Second Affiliated Hospital,the Third Military Medical University,Chongqing 400037, China

＜正＞Exposure to a high-altitude environment is characterized by the development of hypobaric hypoxia. Despite this,many populations have been resident at altitudes above 3,000 m for thousands of *** has stimulated interests in understanding whether the long-term altitude resident populations have experienced natural selection of certain specific gene variants beneficial to survival in such hypoxic *** endocrine renin-angiotensin system（RAS） is one of the areas that have received considerable *** can modulate endothelium function through pathways involved in cellular metabolism,proliferation,or *** this system,intron 16 of the angiotensin-converting enzyme（ACE） gene,encoding the key enzyme to cleave angiotensin I to form angiotensinⅡ,which in turn binds to the angiotensinⅡreceptor and induces vasoconstriction,stimulates vascular endothelial growth factor,and regulates the aldosterone pathway,contains an insertion/deletion（I/D polymorphism） polymorphism and found to be associated with circulating and tissue ACE *** ofⅡ,ID and DD show low,medium and high circulating enzyme,*** the past years,many studies have been carried out on the potential roles of the ACE I/D polymorphism in human high altitude adaptation,while with disappointingly inconsistent *** native Tibetans are considered to have adapted uniquely to extreme high altitude conditions of hypobaric hypoxia with many distinct physiologic *** far,no report has compared the distribution of the I allele and the serum ACE levels between native lowlanders Han Chinese and native highlanders Tibetans to investigate whether the I allele of ACE gene and the serum ACE levels contribute to the high altitude adaptation of Tibetans. In this study,we analyzed the distribution of the I polymorphism of ACE gene using regular PCR primers flanking the I/D site and a pair of primers that produce an amplified product only in the presence of the I allele in t

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我国通讯产品扩散的模型分析

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经济数学 2005年第1期22卷 50-56页

作者：胡知能付吉云四川大学工商管理学院成都610064

利用Bass创新扩散模型描述我国无线寻呼和移动电话的扩散过程.通过对无线寻呼和移动电话的历史数据进行模型参数的估计,建立无线寻呼和移动电话的采用者扩散模型,分析无线寻呼被市场淘汰的原因和移动电话的市场前景.

关键词：产品扩散 Bass模型无线寻呼移动电话参数估计

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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汽车空调压缩机怠速噪声诊断及拓扑优化

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吉林大学学报（工学版） 2016年第3期46卷 725-731页

作者：史文库祖庆华陈志勇毛阳何邦颖付吉云黎晓燕吉林大学汽车仿真与控制国家重点实验室长春130022 牡丹江富通汽车空调有限公司产品工程部黑龙江牡丹江157000

针对某国产SUV车型怠速开空调时车内噪声较大的问题,对样车及其压缩机系统进行了试验诊断、分析和改进。通过分析试验获得的车内噪声频谱和压缩机振动频谱,结合压缩机及支架系统的模态计算和试验验证,认定开、关空调噪声差异主要是由压... 详细信息

针对某国产SUV车型怠速开空调时车内噪声较大的问题,对样车及其压缩机系统进行了试验诊断、分析和改进。通过分析试验获得的车内噪声频谱和压缩机振动频谱,结合压缩机及支架系统的模态计算和试验验证,认定开、关空调噪声差异主要是由压缩机工作频率与压缩机及其支架系统一阶固有频率接近产生共振造成的。通过拓扑优化的方法对支架结构进行了加强,提高了压缩机-支架系统的一阶模态频率,避开了怠速开空调时压缩机的工作频率。将改进的支架装车进行试验验证,结果表明：在怠速开空调工况下,改进后的车内噪声比改进前降低了2.3dB（A）,改进效果明显;定置升转速工况试验结果表明：改进后在发动机转速为900-3400r/min时,车内噪声有明显降低。

关键词：车辆工程汽车空调压缩机噪声诊断拓扑优化

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Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou Wei-jin jiang ji Yu Mao-Jun Yao yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

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基于供应中断风险防范的供应商评价研究

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河北工程大学学报（社会科学版） 2014年第2期31卷 34-38页

作者：李继勇付继云蔺正奇河北工程大学经管学院河北邯郸056038 加州大学洛杉矶分校洛杉矶ca90024

供应链业务的全球展开、精益理念的发展,导致企业对供应商的依赖程度逐渐加大。然而,受现实风险因素影响,供应商通常是不可靠的,一旦发生供应中断,将会给企业造成巨大损失。供应商评价是防范供应中断风险的有效措施,为此,建立了基于供... 详细信息

供应链业务的全球展开、精益理念的发展,导致企业对供应商的依赖程度逐渐加大。然而,受现实风险因素影响,供应商通常是不可靠的,一旦发生供应中断,将会给企业造成巨大损失。供应商评价是防范供应中断风险的有效措施,为此,建立了基于供应中断风险防范的供应商评价指标体系,运用熵值法与模糊综合评价法构建评价模型,并通过实例计算出各供应商的综合实力,为企业选择合格供应商提供理论依据。

关键词：供应中断风险供应商评价熵值法模糊综合评价法

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急性心肌梗死相关线粒体基因的生物信息学鉴定与验证

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中国组织工程研究 2025年第31期29卷 6697-6707页

作者：田宇诗付强李冀黑龙江中医药大学基础医学院黑龙江省哈尔滨市150040 黑龙江中医药大学黑龙江省哈尔滨市150040

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性... 详细信息

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性心肌梗死数据集GSE66360,GSE12288,在线粒体蛋白质数据库获取人类线粒体基因集;对急性心肌梗死数据集GSE66360进行差异基因分析及加权基因共表达网络分析,两者取交集后获得基因进行蛋白质-蛋白质相互作用分析、基因本体论和京都基因与基因组百科全书分析;将交集基因与人类线粒体基因取交集以获得差异线粒体基因,对差异线粒体基因进行基因集富集分析和免疫浸润分析,并在外部数据集GSE12288中进行受试者工作特征曲线分析,验证线粒体差异基因的表达特征。结果与结论:①获得急性心肌梗死差异基因548个,差异基因分析及加权基因共表达网络分析显示Blue模块包含基因最多(4992个),二者交集基因共有116个,其中肿瘤坏死因子、白细胞介素1B、白细胞介素6、Toll样受体4和白细胞介素10为核心基因;②基因本体论分析显示生物过程主要涉及炎症反应、肿瘤坏死因子产生的正调控及细胞表面受体信号通路,细胞组成主要涉及三级颗粒膜、质膜外层和质膜等,分子功能主要涉及免疫球蛋白G结合、跨膜信号受体活性及趋化因子活性等,京都基因与基因组百科全书分析显示,这些基因主要涉及肿瘤坏死因子、白细胞介素17及核转录因子κB通路;③共获得8个差异线粒体基因,经过最小绝对收缩和选择算子和比例风险回归模型分析后筛选出4个特征基因,包括佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β,并分别对应了肿瘤蛋白53、氧化磷酸化、硫代谢及甘油磷脂代谢通路;④受试者工作特征曲线分析显示4个特征基因均具有诊断意义,并与静息树突状细胞、幼稚B细胞呈显著负相关性;⑤提示佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β表达特征可作为预测急性心肌梗死中线粒体功能的潜在生物标志物,可进一步提高急性心肌梗死预测的准确性。

关键词：线粒体急性心肌梗死生物信息学机器学习免疫浸润分析氧化应激炎症凋亡

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-yun Zhou Xiao Huang Xin-Yue Li Ming-Ke Wang ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

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