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Clinicopathological characteristics and surgical outcomes of sarcomatoid hepatocellular carcinoma

World Journal of Gastroenterology 2020年第29期26卷 4327-4342页

作者： Jian-Ping Wang Zhi-Gang Yao Ya-Wen Sun Xi-Han Liu Feng-Kai Sun Cun-Hu Lin fu-xin ren Bei-Bei Lv Shuai-Jun Zhang Yang Wang Fan-Ying Meng Shun-Zhen Zheng Wei Gong Jun Liu Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Pathology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Cancer Prevention and Control Research Office of Shandong Province Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117Shandong ProvinceChina Cheeloo College of Medicine Shandong UniversityJinan 250012Shandong ProvinceChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Shandong Medical Imaging Research Institute Shandong UniversityJinan 250021Shandong ProvinceChina Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the sixth most common type of cancer and the fourth leading cause of cancer-related death *** HCC,which contains poorly differentiated carcinomatous and sarcomatous components,is a rare histological subtype of HCC that differs from conventional *** is highly aggressive and has a poor *** clinicopathological characteristics,surgical outcomes and underlying mechanisms of its highly aggressive nature have not been fully *** To examine the clinicopathological characteristics and surgical outcomes of sarcomatoid HCC and explore the histogenesis of sarcomatoid *** In total,196 patients[41 sarcomatoid HCC and 155 high-grade(Edmondson-Steiner grade III or IV)HCC]who underwent surgical resection between 2007 and 2017 were retrospectively *** characteristics and surgical outcomes of sarcomatoid HCC were compared with those of patients with high-grade *** histological composition of invasive and metastatic sarcomatoid HCCs was *** Sarcomatoid HCC was more frequently diagnosed at an advanced stage with a larger tumor and higher rates of nonspecific symptom,adjacent organ invasion and lymph node metastasis than high-grade HCC(all P20 ng/mL;36.6%vs 78.7%,Prence-free survival(5.6 mo vs 16.4 mo,log-rank P<0.0001)and overall survival(10.5 mo vs 48.1 mo,log-rank P<0.0001)than the high-grade *** controlling for confounding factors,the sarcomatoid subtype was identified as an independent predictor of poor *** analyses indicated that invasive and metastatic lesions were mainly composed of carcinomatous *** Sarcomatoid HCC was associated with a more advanced s

关键词： Sarcomatoid hepatocellular carcinoma Histological composition Liver resection Overall survival Recurrence-free survival

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong fu Dian Yu Jane Howe Kaiwen Chen Ning Yan Hao ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier

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氮化硅陶瓷直接凝固注模成型的凝固动力学

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无机材料学报 2000年第5期15卷 862-866页

作者：刘学建黄莉萍古宏晨徐鑫符锡仁中国科学院上海硅酸盐研究所上海200050 华东理工大学技术化学物理研究所上海200237

直接凝固注模成型（ＤＣＣ）是一种新的近净尺寸陶瓷成型工艺；它是通过可控制反应速率的酶催化反应来实现浆料原位固化的．本文将悬浮体流变学与陶瓷浆料的成型工艺学有机结合，通过陶瓷浆料的动态弛豫实验，研究了Ｓｉ３Ｎ４浆料ＤＣ... 详细信息

直接凝固注模成型（ＤＣＣ）是一种新的近净尺寸陶瓷成型工艺；它是通过可控制反应速率的酶催化反应来实现浆料原位固化的．本文将悬浮体流变学与陶瓷浆料的成型工艺学有机结合，通过陶瓷浆料的动态弛豫实验，研究了Ｓｉ３Ｎ４浆料ＤＣＣ成型的凝固动力学．结果表明：“凝固时间”可以成功地描述陶瓷浆料的凝固过程，动态弛豫实验为陶瓷浆料的凝固动力学提供了一条简便可行的研究方法．在Ｓｉ３Ｎ４浆料ＤＣＣ成型工艺条件优化的基础上，制备出了气孔分布均匀的Ｓｉ３Ｎ４坯体．

关键词：氮化硅直接凝固注模成型凝固动力学陶瓷

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Human leukocyte antigen and donor-specific antibodies in liver transplantation

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World Journal of Gastroenterology 2025年第2期31卷 157-160页

作者： Qimudesiren Sha-Na Chen Li-ren Qian School of Clinical Medicine Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Hematology International Mongolian Hospital of Inner MongoliaHohhot 010065Inner Mongolia Autonomous RegionChina Senior Department of Hematology The Fifth Medical Center of PLA General HospitalBeijing 100071China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

In this article,we comment on an article published in a recent issue of the World Journal of *** specifically focus on the roles of human leukocyte antigen(HLA)and donor-specific antibodies(DSAs)in pediatric liver transpl-antation(LT),as well as the relationship between immune rejection after LT and ***,LT remains the standard of care for pediatric patients with end-stage liver disease or severe acute liver ***,acute and chronic re-jection continues to be a significant cause of graft dysfunction and *** mismatch significantly reduces graft survival and increases the risk of acute *** them,D→R one-way mismatch at three loci was significantly related to graft-versus-host disease incidence after *** adverse impact of HLA-DSAs on LT recipients is already ***,the evaluation of HLA and DSA is crucial in pediatric LT.

关键词： Liver transplantation Human leukocyte antigen Donor-specific antibodies De novo donor-specific antibody Antibody-mediated rejection

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Degradation of CTLA-4 balances toxicity and efficacy

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Science Bulletin 2019年第19期64卷 1388-1389页

作者： Zhenhua ren Yang-xin fu The Department of Pathology UT Southwestern Medical CenterDallasTX75235-9072USA The Department of Immunology UT Southwestern Medical CenterDallasTX75235-9072USA

The notorious side effects of anti-CTLA-4 limit its use in the clinic,but what causes the severe side effects remains largely *** et al.[1]elucidated antibody-induced CTLA-4lysosomal degradation as a new mechanism accounting for the severe immunotherapy-related adverse effects and limited efficacy of anti-CTLA-4 ***-4 expresses on regulatory T cells(Tregs)and activated CD8 and CD4 effector cells.

关键词： Degradation CTLA-4 toxicity

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Sintering of monoclinic SrAl_(2)Si_(2)O_(8) ceramics and their Sr immobilization

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International Journal of Minerals,Metallurgy and Materials 2021年第6期28卷 1057-1062页

作者： Jie Luo xin Li fu-jie Zhang Song Chen Ding ren Key Laboratory of Radiation Physics and Technology of Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610065China Nuclear Power Institute of China Chengdu 610005China Department of Radiotherapy Division of Radiation PhysicsState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

Monoclinic SrAl_(2)Si_(2)O_(8) ceramics for Sr immobilization were prepared by a liquid-phase sintering *** sintering temperature,mineral phase composition,microstructure,flexural strength,bulk density,and Sr ion leaching characteristics of the SrAl_(2)Si_(2)O_(8) ceramics were investigated.A crystalline monoclinic SrAl_(2)Si_(2)O_(8) phase formed through liquid-phase sintering at 1223 *** introduction of four flux agents(B_(2)O_(3),CaO·2B_(2)O_(3),SrO·2B_(2)O_(3),and BaO·2B_(2)O_(3))to the SrAl_(2)Si_(2)O_(8) ceramics not only reduced the densification temperature and decreased the volatilization of Sr during high-temperature sintering but also impacted the mechanical properties of the *** consistency tests showed that the leaching concentration of Sr ions in the sample with flux agent B_(2)O_(3) was the lowest,whereas that of Sr ions in the sample with flux agent BaO·2B_(2)O_(3) was the *** results show that the leaching concentration of Sr ions depends largely on the amorphous phase in the ***,the formation of mineral analog ceramics containing Sr is an important factor to improve Sr immobilization.

关键词： low-temperature liquid-phase sintering strontium immobilization monoclinic strontium feldspar flux agent

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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing Shen Qiu-Wan Wei Yi-ren Tian Yun-Zhi Ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

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