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Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture

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Genes & Diseases 2024年第3期11卷 427-437页

作者： Yukun Mao Xueying Hou Su fu Jie luan Breast Plastic and Reconstructive Surgery Center Plastic Surgery HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100144China

Capsular contracture is a prevalent and severe complication that affects the post-operative outcomes of patients who receive silicone breast *** present,prosthesis replacement is the major treatment for capsular contracture after both breast augmentation procedures and breast reconstruction following breast cancer ***,the mecha-nism(s)underlying breast capsular contracture remains *** study aimed to identify the biological features of breast capsular contracture and reveal the potential underlying mechanism using RNA *** tissues from 12 female patients(15 breast capsules)were divided into low capsular contracture(LCC)and high capsular contracture(HCC)groups based on the Baker ***,41 lipid metabolism-related genes were identified through enrichment analysis,and three of these genes were identified as candidate genes by SVM-RFE and LASSO *** then compared the proportions of the 22 types of im-mune cells between the LCC and HCC groups using a CIBERSORT analysis and explored the Cor-relation between the candidate hub features and immune ***,PRKAR2B was positively correlated with the differentially clustered immune cells,which were M1 macro-phages and follicular helper T cells(area under the ROC=0.786).In addition,the expression of PRKAR2B at the mRNA or protein level was lower in the HCC group than in the LCC *** molecular mechanisms were identified based on the expression levels in the high and low PRKAR2B *** findings indicate that PRKAR2B is a novel diagnostic biomarker for breast capsular contracture and might also influence the grade and progression of capsularcontracture.

关键词： Biomarker Breastcapsular contracture Immune infiltration Machinelearning algorithms PRKAR2B

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Towards rational design in electrochemical denitrification by analyzing pH dependence

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National Science Review 2024年第6期11卷 223-232页

作者： Huan Li Dong luan Jun Long Xiaoyan fu Jianping Xiao State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

A small fraction of NOx（<1%） always exists in CO2feedstock（e.g. exhausted gas）, which can significantly reduce the efficiency of CO2electroreduction by ～30%. Hence, electrochemical denitrification is the precondi... 详细信息

A small fraction of NOx（further supported by more than 35 experiments over varying catalysts（Fe, Ni, Pd, Cu, Co, Pt and Ag）, partial pressures（20%, 50% and100%） and potentials（from -0.2 to 0.2 V vs. reversible hydrogen electrode）. All in all, the insights herein overturn long-lasting views in the field of NO electroreduction and suggest that rational design should steer away from catalyst engineering toward reactor optimization.

关键词： electrocatalysis denitrification pH-dependence nitric oxide reduction reaction mechanism

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A SPX domain vacuolar transporter links phosphate sensing to homeostasis in Arabidopsis

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Molecular Plant 2022年第10期15卷 1590-1601页

作者： Mingda luan fugeng Zhao Guangfang Sun Min Xu Aigen fu Wenzhi Lan Sheng luan Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationProvincial Key Laboratory of BiotechnologyCollege of Life SciencesNorthwest UniversityXi'an 710069China Institute of future Agriculture Northwest Agriculture and Forestry UniversityYanglingShaanxi 712100China School of Life Sciences Nanjing UniversityNanjingJiangsu 210023China Department of Plant and Microbial Biology University of CaliforniaBerkeleyBerkeleyCA 94720USA

Excess phosphate(Pi)is stored into the vacuole through Pi transporters so that cytoplasmic Pi levels remain stable in plant *** hypothesized that the vacuolar Pi transporters may harbor a Pi-sensing mechanism so that they are activated to deliver Pi into the vacuole only when cytosolic Pi reaches a threshold high *** tested this hypothesis using Vacuolar Phosphate Transporter 1(VPT1),a SPX domain-containing vacuolar Pi transporter,as a *** studies have defined SPX as a Pi-sensing module that binds inositol polyphosphate signaling molecules(InsPs)produced at high cellular Pi *** showed here that Pi-deficient conditions or mutation of the SPX domain severely impaired the transport activity of *** further identified an auto-inhibitory domain in VPT1 that suppresses its transport *** together the results from detailed structure-function analyses,our study suggests that VPT1 is in the auto-inhibitory state when Pi status is low,whereas at high cellular Pi status InsPs are produced and bind SPX domain to switch on VPT1 activity to deliver Pi into the *** thus provides an auto-regulatory mechanism for VPT1-mediated Pi sensing and homeostasis in plant cells.

关键词： VPT1 Pi signaling autoinhibition transport activity inositol phosphates

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Friction Stir Welding of Al Alloy Thin Plate by Rotational Tool without Pin

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Journal of Materials Science & Technology 2011年第7期27卷 647-652页

作者： Liguo Zhang Shude Ji Guohong luan Chunlin Dong Li fu School of Aerospace Engineering Shenyang Aerospace University Shenyang 110136 China China FSW Center Beijing 100024 China Shenyang Aircraft Design & Research Institute Shenyang 110035 China State Key Laboratory for Manufacturing Systems Engineering Xi an Jiaotong University Xi an 710049 China

For friction stir welding （FSW）, a new idea is put forward in this paper to weld the thin plate of Al alloy by using the rotational tool without pin. The experiments of FSW are carried out by using the tools with inner-concave-flute shoulder, concentric-circles-flute shoulder and three-spiral-flute shoulder, respectively. The experimental results show that the grain size in weld nugget zone attained by the tool with three-spiral-flute shoulder is nearly the same while the grain sizes decrease with the decrease of welding velocity. The displacement of material flow in the heat-mechanical affected zone by the tool with three-spiral-flute shoulder is much larger than that by the tool with inner-concave-flute shoulder or concentric-circles–flute shoulder. The above-mentioned results are verified by numerical simulation. For the tool with three-spiral-flute shoulder, the tensile strength of FSW joint increases with the decrease of welding velocity while the value of tensile strength attained by the welding velocity of 20 mm/min and the rotation speed of 1800 r/min is about 398 MPa, which is 80% more than that of parent mental tensile strength. Those verify that the tool with three-spiral-flute shoulder can be used to join the thin plate of Al alloy.

关键词： Friction stir welding Rotational tool without pin Shoulder shape Plastic flow

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IoV and Blockchain-Enabled Driving Guidance Strategy in Complex Traffic Environment

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China Communications 2023年第12期20卷 230-243页

作者： Yuchuan fu Changle Li Tom H.luan Yao Zhang State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Research Institute of Smart Transportation Xidian UniversityXi’an 710071China Northwestern Polytechnical University Xi’an 710072China

Diversified traffic participants and complex traffic environment(e.g.,roadblocks or road damage exist)challenge the decision-making accuracy of a single connected and autonomous vehicle(CAV)due to its limited sensing and computing *** Internet of Vehicles(IoV)to share driving rules between CAVs can break limitations of a single CAV,but at the same time may cause privacy and safety *** tackle this problem,this paper proposes to combine IoV and blockchain technologies to form an efficient and accurate autonomous guidance ***,we first use reinforcement learning for driving decision learning,and give the corresponding driving rule extraction ***,an architecture combining IoV and blockchain is designed to ensure secure driving rule ***,the shared rules will form an effective autonomous driving guidance strategy through driving rules selection and action *** simulation proves that the proposed strategy performs well in complex traffic environment,mainly in terms of accuracy,safety,and robustness.

关键词： autonomous driving guidance blockchain communication range Internet of Vehicles reinforcement learning

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Modeling and simulation of solvent behavior and temperature distribution within long stick propellants with large web thickness undergoing drying

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Defence Technology（防务技术） 2023年第10期28卷 42-55页

作者： Enfa fu Qianling Liu Yu luan Yao Zhu Weidong He Zhenggang Xiao Key Laboratory of Special Energy Materials Ministry of EducationSchool of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing210094People's Republic of China

Drying is a complicated physical process which involves simultaneous heat and mass transfer in the removal of solvents inside *** drying techniques may result in the formation of a hard skin layer near the surface to block the free access of most solvent through for long stick propellants with large web thickness,which lead to lower drying efficiency and worse drying *** study aims to gain a comprehensive understanding of drying process and clarify the mechanism of the blocked layer near the propellant surface.A new three-dimensional coupled heat and mass transfer(3D-CHMT)model was successfully developed under transient *** drying experiment results show that the 3DCHMT model could be applied to describe the drying process well since the relative error of the content of solvent between simulation and experiment values is only 5.5%.The solvent behavior simulation demonstrates that the mass transfer process can be divided into super-fast(SF)and subsequent minorfast(MF)stages,and the SF stage is vital to the prevention of the blocked layer against the free access for solvent molecules inside propellant *** effective solvent diffusion coefficient(Deff)of the propellant surface initially increases from 3.4×10^(-6)to 5.3×10^(-6)m^(2)/s as the temperature increases,and then decreases to 4.1×10^(-8)m^(2)/s at 60-100 *** value of Deffof surface between 0-1.4 mm has a unique trend of change compared with other regions,and it is much lower than that of the internal at100 min under simulation ***,the temperature of the propellant surface increases rapidly at the SF stage(0-100 min)and then very slowly *** the evolution of Deffand temperature distribution demonstrate that the blocked layer near the propellant surface has been formed in the time period of approximately 0-100 min and its thickness is about 1.4 *** mitigate the formation of blocked layer and improve its drying quality of finial prop

关键词： Stick propellants Drying Large web thickness 3D numerical modeling Heat transfer Solvent behavior

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Anisotropic density estimation for photon mapping

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Computational Visual Media 2015年第3期1卷 221-228页

作者： fu-Jun luan Li-Fan Wu Kun Xu TNList Department of Computer Science and Technology Tsinghua University

Photon mapping is a widely used technique for global illumination rendering. In the density estimation step of photon mapping, the indirect radiance at a shading point is estimated through a filtering process using nearby stored photons; an isotropic filtering kernel is usually used. However,using an isotropic kernel is not always the optimal choice, especially for cases when eye paths intersect with surfaces with anisotropic BRDFs. In this paper,we propose an anisotropic filtering kernel for density estimation to handle such anisotropic eye *** anisotropic filtering kernel is derived from the recently introduced anisotropic spherical Gaussian representation of BRDFs. Compared to conventional photon mapping, our method is able to reduce rendering errors with negligible additional cost when rendering scenes containing anisotropic BRDFs.

关键词： photon mapping density estimation anisotropic anisotropic spherical Gaussian

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Annual advances in traditional medicine for tumor therapy in 2019

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Traditional Medicine Research 2020年第2期5卷 90-107页

作者： Xue Yang xin-Yuan luan Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China Department of Hepatobiliary and Pancreatic Surgery(3) Tianjin NanKai HospitalTianjin 300100China

Today,the treatment of tumors remains a difficult *** medicine has been used to treat cancer in different countries ***,while traditional medicine is popular globally,it is not yet accepted by Western medicine as some of the ingredients and the mechanism of action for the therapeutic effect have not been fully ***,scholars studying traditional medicine in the treatment of cancer have strived to solve this *** this review,we summarized the research progress of several traditional medicines used as tumor therapies in 2019 from the PubMed *** of tumors treated with traditional Chinese medicine(TCM)are popular worldwide and obtain the most attention,which attracts more researchers to this *** anti-tumor effects of Chinese herbal medicine-derived phytochemicals,such as polyphenols,polysaccharides,saponins,and alkaloids were the new research targets for *** anti-tumor effects of TCM formula such as Sijunzi decoction,and Xiaopi formula have attracted the most attention in the past *** addition to TCM,we also focused on the anti-tumor studies of other traditional medicines,including Thai traditional medicine,traditional medicine in Sri Lanka,traditional African medicine,traditional Korean medicine,and traditional Japanese medicine.

关键词： Traditional medicine Traditional Chinese medicine Tumor Phytochemicals Formula

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Annual advances of traditional medicine on tumor immunity regulation in 2020

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Traditional Medicine Research 2021年第3期6卷 118-132页

Tumor burden remains a global health problem that threatens human life *** the past few years,the evolution of immune checkpoint inhibitors has represented one of the most successful approaches in the field of tumor *** regulating tumor immune microenvironment or enhancing body immunity have indicated a novel perspective to treat ***,an increased number of scientists have been shifting their research focus to explore the immunity regulation effects of anti-tumor traditional medicine or natural *** this review,we summarize the research progress of traditional medicines on tumor immunity regulation in *** findings suggest that more herbal medicine-derived phytochemicals and formulas were derived from traditional Chinese medicine,and more papers were published in comprehensive *** medicine can comprehensively regulate the tumor immune microenvironment,including natural killer cells,dendritic cells,CD4+/CD8+T lymphocytes,regulatory T cells,myeloid-derived suppressor cells,tumor-associated macrophages,immunosuppressive factors,and immune *** 2020,a greater number of research papers focused on active ingredients and formulas that regulate tumor-associated macrophages and immune *** ingredients such as flavonoids became a global hotspot in *** natural products were also found to exert synergistic anti-tumor activity with immune checkpoint inhibitors,such as ***,a distinct lack of high-quality experimental and clinical studies remains a prevalent and challenging issue that hinders the further development of traditional medicine.

关键词： Traditional medicine Traditional Chinese medicine Natural product Formula Immunity regulation Tumor microenvironment

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Activity and Enantioselectivity of Lipase Immobilized in CTAB Microemulsion-based Gels

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Chemical Research in Chinese Universities 2007年第6期23卷 749-752页

作者： SONG Shao-fang luan Yu-xia LU fu-sui College of Chemistry and Material Science Shandong Agricultural University Taian 271018 P. R. China Institute of Pharmaceutics School of Pharmaceutical Science Shandong University Jinan 250100 P. R. China

Introduction The formation of gelatin-containing mieroemulsionbased gels（MBGs） was first described in 1986 and the physical/structural characterization was carried out by a number of groups with a variety of techniques including tracer diffusion, electrical conductivity, NMR, X-ray and small angle neutron scattering. The MBGs were proposed to comprise an extensive, rigid, interconnected network of gelatin/water rods stabilized by a monolayer of surfactant, in coexistence with a po- pulation of conventional W/O microemulsion droplets.

关键词： Microemulsion-based gels Immobilized lipase Racemic ibuprofen Enantioselectivity Enantiomerie excess

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